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Items: 1 to 50 of 537

1.

Virus-induced autophagic degradation of STAT2 as a mechanism for interferon signaling blockade.

Avia M, Rojas JM, Miorin L, Pascual E, Van Rijn PA, Martín V, García-Sastre A, Sevilla N.

EMBO Rep. 2019 Oct 11:e48766. doi: 10.15252/embr.201948766. [Epub ahead of print]

PMID:
31603272
2.

Differential modulation of innate immune responses in human primary cells by influenza A viruses carrying human or avian non-structural 1 proteins.

Monteagudo PL, Muñoz-Moreno R, Fribourg M, Potla U, Mena I, Marjanovic N, Hartmann BM, Sealfon SC, García-Sastre A, Ramos I, Fernández-Sesma A.

J Virol. 2019 Oct 9. pii: JVI.00999-19. doi: 10.1128/JVI.00999-19. [Epub ahead of print]

3.

TIV Vaccination Modulates Host Responses to Influenza Virus Infection that Correlate with Protection against Bacterial Superinfection.

Choi A, Christopoulou I, Saelens X, García-Sastre A, Schotsaert M.

Vaccines (Basel). 2019 Sep 12;7(3). pii: E113. doi: 10.3390/vaccines7030113.

4.

Bat influenza viruses transmit among bats but are poorly adapted to non-bat species.

Ciminski K, Ran W, Gorka M, Lee J, Malmlov A, Schinköthe J, Eckley M, Murrieta RA, Aboellail TA, Campbell CL, Ebel GD, Ma J, Pohlmann A, Franzke K, Ulrich R, Hoffmann D, García-Sastre A, Ma W, Schountz T, Beer M, Schwemmle M.

Nat Microbiol. 2019 Sep 16. doi: 10.1038/s41564-019-0556-9. [Epub ahead of print]

PMID:
31527796
5.

Moving from Empirical to Rational Vaccine Design in the 'Omics' Era.

Sharma M, Krammer F, García-Sastre A, Tripathi S.

Vaccines (Basel). 2019 Aug 14;7(3). pii: E89. doi: 10.3390/vaccines7030089. Review.

6.

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1.

Ramos I, Smith G, Ruf-Zamojski F, Martínez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, García-Sastre A, Fernandez-Sesma A.

J Virol. 2019 Sep 30;93(20). pii: e00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15.

7.

Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1.

Palomino-Segura M, Perez L, Farsakoglu Y, Virgilio T, Latino I, D'Antuono R, Chatziandreou N, Pizzagalli DU, Wang G, García-Sastre A, Sallusto F, Carroll MC, Neyrolles O, Gonzalez SF.

Nat Microbiol. 2019 Jul 29. doi: 10.1038/s41564-019-0506-6. [Epub ahead of print]

PMID:
31358982
8.

Characterization of swine-origin H1N1 canine influenza viruses.

Wang G, Dos Anjos Borges LG, Stadlbauer D, Ramos I, Bermúdez González MC, He J, Ding Y, Wei Z, Ouyang K, Huang W, Simon V, Fernandez-Sesma A, Krammer F, Nelson MI, Chen Y, García-Sastre A.

Emerg Microbes Infect. 2019;8(1):1017-1026. doi: 10.1080/22221751.2019.1637284.

PMID:
31287780
9.

Structural basis for influenza virus NS1 protein block of mRNA nuclear export.

Zhang K, Xie Y, Muñoz-Moreno R, Wang J, Zhang L, Esparza M, García-Sastre A, Fontoura BMA, Ren Y.

Nat Microbiol. 2019 Oct;4(10):1671-1679. doi: 10.1038/s41564-019-0482-x. Epub 2019 Jul 1.

PMID:
31263181
10.

Severe influenza pneumonitis in children with inherited TLR3 deficiency.

Lim HK, Huang SXL, Chen J, Kerner G, Gilliaux O, Bastard P, Dobbs K, Hernandez N, Goudin N, Hasek ML, García Reino EJ, Lafaille FG, Lorenzo L, Luthra P, Kochetkov T, Bigio B, Boucherit S, Rozenberg F, Vedrinne C, Keller MD, Itan Y, García-Sastre A, Celard M, Orange JS, Ciancanelli MJ, Meyts I, Zhang Q, Abel L, Notarangelo LD, Snoeck HW, Casanova JL, Zhang SY.

J Exp Med. 2019 Sep 2;216(9):2038-2056. doi: 10.1084/jem.20181621. Epub 2019 Jun 19.

PMID:
31217193
11.

N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses.

Broszeit F, Tzarum N, Zhu X, Nemanichvili N, Eggink D, Leenders T, Li Z, Liu L, Wolfert MA, Papanikolaou A, Martínez-Romero C, Gagarinov IA, Yu W, García-Sastre A, Wennekes T, Okamatsu M, Verheije MH, Wilson IA, Boons GJ, de Vries RP.

Cell Rep. 2019 Jun 11;27(11):3284-3294.e6. doi: 10.1016/j.celrep.2019.05.048.

12.

TIPICO IX: report of the 9th interactive infectious disease workshop on infectious diseases and vaccines.

Martinón-Torres F, Bosch X, Rappuoli R, Ladhani S, Redondo E, Vesikari T, García-Sastre A, Rivero-Calle I, Gómez-Rial J, Salas A, Martín C, Finn A, Butler R.

Hum Vaccin Immunother. 2019 Jun 3:1-11. doi: 10.1080/21645515.2019.1609823. [Epub ahead of print]

PMID:
31158041
13.

Snatch-and-Grab Inhibitors to Fight the Flu.

García-Sastre A.

Cell. 2019 May 30;177(6):1367. doi: 10.1016/j.cell.2019.05.033.

PMID:
31150614
14.

An HER2-Displaying Virus-Like Particle Vaccine Protects from Challenge with Mammary Carcinoma Cells in a Mouse Model.

Nika L, Cuadrado-Castano S, Asthagiri Arunkumar G, Grünwald-Gruber C, McMahon M, Koczka K, García-Sastre A, Krammer F, Grabherr R.

Vaccines (Basel). 2019 May 20;7(2). pii: E41. doi: 10.3390/vaccines7020041.

15.

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model.

Liu WC, Nachbagauer R, Stadlbauer D, Solórzano A, Berlanda-Scorza F, García-Sastre A, Palese P, Krammer F, Albrecht RA.

Front Immunol. 2019 Apr 10;10:756. doi: 10.3389/fimmu.2019.00756. eCollection 2019.

16.

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface.

Bangaru S, Lang S, Schotsaert M, Vanderven HA, Zhu X, Kose N, Bombardi R, Finn JA, Kent SJ, Gilchuk P, Gilchuk I, Turner HL, García-Sastre A, Li S, Ward AB, Wilson IA, Crowe JE Jr.

Cell. 2019 May 16;177(5):1136-1152.e18. doi: 10.1016/j.cell.2019.04.011.

PMID:
31100268
17.

Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein.

Bailey MJ, Broecker F, Freyn AW, Choi A, Brown JA, Fedorova N, Simon V, Lim JK, Evans MJ, García-Sastre A, Palese P, Tan GS.

J Virol. 2019 Jun 28;93(14). pii: e00405-19. doi: 10.1128/JVI.00405-19. Print 2019 Jul 15.

PMID:
31043537
18.

Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism.

Miorin L, Laurent-Rolle M, Pisanelli G, Co PH, Albrecht RA, García-Sastre A, Morrison J.

J Virol. 2019 Jun 28;93(14). pii: e00151-19. doi: 10.1128/JVI.00151-19. Print 2019 Jul 15.

19.

Chimeric Hemagglutinin-Based Influenza Virus Vaccines Induce Protective Stalk-Specific Humoral Immunity and Cellular Responses in Mice.

Choi A, Bouzya B, Cortés Franco KD, Stadlbauer D, Rajabhathor A, Rouxel RN, Mainil R, Van der Wielen M, Palese P, García-Sastre A, Innis BL, Krammer F, Schotsaert M, Mallett CP, Nachbagauer R.

Immunohorizons. 2019 Apr 1;3(4):133-148. doi: 10.4049/immunohorizons.1900022.

20.

Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase.

Westera L, Jennings AM, Maamary J, Schwemmle M, García-Sastre A, Bortz E.

Adv Virol. 2019 Mar 19;2019:8512363. doi: 10.1155/2019/8512363. eCollection 2019.

21.

Editorial overview: Emerging viruses: interspecies transmission: Expect the unexpected.

García-Sastre A, Richt JA.

Curr Opin Virol. 2019 Feb;34:iii-vi. doi: 10.1016/j.coviro.2019.02.003. Epub 2019 Mar 21. No abstract available.

PMID:
30904411
22.

MHC class II proteins mediate cross-species entry of bat influenza viruses.

Karakus U, Thamamongood T, Ciminski K, Ran W, Günther SC, Pohl MO, Eletto D, Jeney C, Hoffmann D, Reiche S, Schinköthe J, Ulrich R, Wiener J, Hayes MGB, Chang MW, Hunziker A, Yángüez E, Aydillo T, Krammer F, Oderbolz J, Meier M, Oxenius A, Halenius A, Zimmer G, Benner C, Hale BG, García-Sastre A, Beer M, Schwemmle M, Stertz S.

Nature. 2019 Mar;567(7746):109-112. doi: 10.1038/s41586-019-0955-3. Epub 2019 Feb 20.

PMID:
30787439
23.

Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy.

Brown JA, Singh G, Acklin JA, Lee S, Duehr JE, Chokola AN, Frere JJ, Hoffman KW, Foster GA, Krysztof D, Cadagan R, Jacobs AR, Stramer SL, Krammer F, García-Sastre A, Lim JK.

Immunity. 2019 Mar 19;50(3):751-762.e5. doi: 10.1016/j.immuni.2019.01.005. Epub 2019 Feb 5.

PMID:
30737148
24.

Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice.

Asthagiri Arunkumar G, Ioannou A, Wohlbold TJ, Meade P, Aslam S, Amanat F, Ayllon J, García-Sastre A, Krammer F.

J Virol. 2019 Mar 5;93(6). pii: e01696-18. doi: 10.1128/JVI.01696-18. Print 2019 Mar 15.

25.

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ.

Cell. 2018 Dec 13;175(7):1931-1945.e18. doi: 10.1016/j.cell.2018.11.028.

PMID:
30550790
26.

Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.

Zhang K, Shang G, Padavannil A, Wang J, Sakthivel R, Chen X, Kim M, Thompson MG, García-Sastre A, Lynch KW, Chen ZJ, Chook YM, Fontoura BMA.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12218-E12227. doi: 10.1073/pnas.1818012115. Epub 2018 Dec 11.

27.

ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes.

Uccellini MB, García-Sastre A.

Cell Rep. 2018 Dec 4;25(10):2784-2796.e3. doi: 10.1016/j.celrep.2018.11.030.

28.

Erratum: Sunwoo, S.-Y. et al. A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies. Vaccines 2018, 6(3), 64.

Sunwoo SY, Schotsaert M, Morozov I, Davis AS, Li Y, Lee J, McDowell C, Meade P, Nachbagauer R, García-Sastre A, Ma W, Krammer F, Richt JA.

Vaccines (Basel). 2018 Nov 27;6(4). pii: E80. doi: 10.3390/vaccines6040080.

29.

Packaging of the Influenza Virus Genome Is Governed by a Plastic Network of RNA- and Nucleoprotein-Mediated Interactions.

Bolte H, Rosu ME, Hagelauer E, García-Sastre A, Schwemmle M.

J Virol. 2019 Feb 5;93(4). pii: e01861-18. doi: 10.1128/JVI.01861-18. Print 2019 Feb 15.

30.

FACS-Mediated Isolation of Neuronal Cell Populations From Virus-Infected Human Embryonic Stem Cell-Derived Cerebral Organoid Cultures.

Janssens S, Schotsaert M, Manganaro L, Dejosez M, Simon V, García-Sastre A, Zwaka TP.

Curr Protoc Stem Cell Biol. 2019 Feb;48(1):e65. doi: 10.1002/cpsc.65. Epub 2018 Oct 24.

PMID:
30358129
31.

Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.

Zhang L, Wang J, Muñoz-Moreno R, Kim M, Sakthivel R, Mo W, Shao D, Anantharaman A, García-Sastre A, Conrad NK, Fontoura BMA.

J Virol. 2018 Nov 27;92(24). pii: e01634-18. doi: 10.1128/JVI.01634-18. Print 2018 Dec 15.

32.

A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies.

Sunwoo SY, Schotsaert M, Morozov I, Davis AS, Li Y, Lee J, McDowell C, Meade P, Nachbagauer R, García-Sastre A, Ma W, Krammer F, Richt JA.

Vaccines (Basel). 2018 Sep 14;6(3). pii: E64. doi: 10.3390/vaccines6030064. Erratum in: Vaccines (Basel). 2018 Nov 27;6(4):.

33.

Influenza virus infection causes global RNAPII termination defects.

Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, Ma Y, Rialdi A, Albrecht R, Fenouil R, Sánchez-Aparicio MT, Ayllon J, Ravisankar S, Haddad B, Ho JSY, Low D, Jin J, Yurchenko V, Prinjha RK, Tarakhovsky A, Squatrito M, Pinto D, Allette K, Byun M, Smith ML, Sebra R, Guccione E, Tumpey T, Krogan N, Greenbaum B, van Bakel H, García-Sastre A, Marazzi I.

Nat Struct Mol Biol. 2018 Sep;25(9):885-893. doi: 10.1038/s41594-018-0124-7. Epub 2018 Sep 3.

PMID:
30177761
34.

Transcription Elongation Can Affect Genome 3D Structure.

Heinz S, Texari L, Hayes MGB, Urbanowski M, Chang MW, Givarkes N, Rialdi A, White KM, Albrecht RA, Pache L, Marazzi I, García-Sastre A, Shaw ML, Benner C.

Cell. 2018 Sep 6;174(6):1522-1536.e22. doi: 10.1016/j.cell.2018.07.047. Epub 2018 Aug 23.

35.

Transcriptome Analysis of Infected and Bystander Type 2 Alveolar Epithelial Cells during Influenza A Virus Infection Reveals In Vivo Wnt Pathway Downregulation.

Hancock AS, Stairiker CJ, Boesteanu AC, Monzón-Casanova E, Lukasiak S, Mueller YM, Stubbs AP, García-Sastre A, Turner M, Katsikis PD.

J Virol. 2018 Oct 12;92(21). pii: e01325-18. doi: 10.1128/JVI.01325-18. Print 2018 Nov 1.

36.

Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus.

Rodríguez Pulido M, Sánchez-Aparicio MT, Martínez-Salas E, García-Sastre A, Sobrino F, Sáiz M.

PLoS Pathog. 2018 Jun 29;14(6):e1007135. doi: 10.1371/journal.ppat.1007135. eCollection 2018 Jun.

37.

Influenza.

Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, García-Sastre A.

Nat Rev Dis Primers. 2018 Jun 28;4(1):3. doi: 10.1038/s41572-018-0002-y. Review. No abstract available.

PMID:
29955068
38.

Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.

Thompson MG, Muñoz-Moreno R, Bhat P, Roytenberg R, Lindberg J, Gazzara MR, Mallory MJ, Zhang K, García-Sastre A, Fontoura BMA, Lynch KW.

Nat Commun. 2018 Jun 19;9(1):2407. doi: 10.1038/s41467-018-04779-4.

39.

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.

Yang S, Xu M, Lee EM, Gorshkov K, Shiryaev SA, He S, Sun W, Cheng YS, Hu X, Tharappel AM, Lu B, Pinto A, Farhy C, Huang CT, Zhang Z, Zhu W, Wu Y, Zhou Y, Song G, Zhu H, Shamim K, Martínez-Romero C, García-Sastre A, Preston RA, Jayaweera DT, Huang R, Huang W, Xia M, Simeonov A, Ming G, Qiu X, Terskikh AV, Tang H, Song H, Zheng W.

Cell Discov. 2018 Jun 5;4:31. doi: 10.1038/s41421-018-0034-1. eCollection 2018.

40.

Emergence and Evolution of Novel Reassortant Influenza A Viruses in Canines in Southern China.

Chen Y, Trovão NS, Wang G, Zhao W, He P, Zhou H, Mo Y, Wei Z, Ouyang K, Huang W, García-Sastre A, Nelson MI.

MBio. 2018 Jun 5;9(3). pii: e00909-18. doi: 10.1128/mBio.00909-18.

41.

Erratum: Author Correction: Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus.

Ma J, Lee J, Liu H, Mena I, Davis AS, Sunwoo SY, Lang Y, Duff M, Morozov I, Li Y, Yang J, García-Sastre A, Richt JA, Ma W.

NPJ Vaccines. 2018 May 17;3:19. doi: 10.1038/s41541-018-0054-8. eCollection 2018.

42.

A viral-vectored RSV vaccine induces long-lived humoral immunity in cotton rats.

Grieves JL, Yin Z, Garcia-Sastre A, Mena I, Peeples ME, Risman HP, Federman H, Sandoval MJ, Durbin RK, Durbin JE.

Vaccine. 2018 Jun 18;36(26):3842-3852. doi: 10.1016/j.vaccine.2018.04.089. Epub 2018 May 18.

43.

Novel triple-reassortant influenza viruses in pigs, Guangxi, China.

He P, Wang G, Mo Y, Yu Q, Xiao X, Yang W, Zhao W, Guo X, Chen Q, He J, Liang M, Zhu J, Ding Y, Wei Z, Ouyang K, Liu F, Jian H, Huang W, García-Sastre A, Chen Y.

Emerg Microbes Infect. 2018 May 16;7(1):85. doi: 10.1038/s41426-018-0088-z.

44.

Author Correction: SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses.

Dornfeld D, Dudek AH, Vausselin T, Günther SC, Hultquist JF, Giese S, Khokhlova-Cubberley D, Chew YC, Pache L, Krogan NJ, Garcia-Sastre A, Schwemmle M, Shaw ML.

Sci Rep. 2018 May 14;8(1):7782. doi: 10.1038/s41598-018-25858-y.

45.

An Immunocompetent Mouse Model of Zika Virus Infection.

Gorman MJ, Caine EA, Zaitsev K, Begley MC, Weger-Lucarelli J, Uccellini MB, Tripathi S, Morrison J, Yount BL, Dinnon KH 3rd, Rückert C, Young MC, Zhu Z, Robertson SJ, McNally KL, Ye J, Cao B, Mysorekar IU, Ebel GD, Baric RS, Best SM, Artyomov MN, Garcia-Sastre A, Diamond MS.

Cell Host Microbe. 2018 May 9;23(5):672-685.e6. doi: 10.1016/j.chom.2018.04.003.

46.

Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors.

Capuzzi SJ, Sun W, Muratov EN, Martínez-Romero C, He S, Zhu W, Li H, Tawa G, Fisher EG, Xu M, Shinn P, Qiu X, García-Sastre A, Zheng W, Tropsha A.

J Med Chem. 2018 Apr 26;61(8):3582-3594. doi: 10.1021/acs.jmedchem.8b00035. Epub 2018 Apr 17.

47.

Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways.

Yang Y, Riccio P, Schotsaert M, Mori M, Lu J, Lee DK, García-Sastre A, Xu J, Cardoso WV.

Dev Cell. 2018 Mar 26;44(6):752-761.e4. doi: 10.1016/j.devcel.2018.03.001.

48.

Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain.

Janssens S, Schotsaert M, Karnik R, Balasubramaniam V, Dejosez M, Meissner A, García-Sastre A, Zwaka TP.

mSystems. 2018 Feb 6;3(1). pii: e00219-17. doi: 10.1128/mSystems.00219-17. eCollection 2018 Jan-Feb.

49.

Influenza B virus reverse genetic backbones with improved growth properties in the EB66® cell line as basis for vaccine seed virus generation.

White KM, Ayllon J, Mena I, Potenski A, Krammer F, García-Sastre A.

Vaccine. 2018 Feb 21;36(9):1146-1153. doi: 10.1016/j.vaccine.2018.01.050. Epub 2018 Feb 1.

PMID:
29395518
50.

SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses.

Dornfeld D, Dudek AH, Vausselin T, Günther SC, Hultquist JF, Giese S, Khokhlova-Cubberley D, Chew YC, Pache L, Krogan NJ, Garcia-Sastre A, Schwemmle M, Shaw ML.

Sci Rep. 2018 Feb 1;8(1):2092. doi: 10.1038/s41598-018-20458-2. Erratum in: Sci Rep. 2018 May 14;8(1):7782.

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