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Items: 1 to 50 of 515

1.

Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy.

Brown JA, Singh G, Acklin JA, Lee S, Duehr JE, Chokola AN, Frere JJ, Hoffman KW, Foster GA, Krysztof D, Cadagan R, Jacobs AR, Stramer SL, Krammer F, García-Sastre A, Lim JK.

Immunity. 2019 Jan 30. pii: S1074-7613(19)30028-7. doi: 10.1016/j.immuni.2019.01.005. [Epub ahead of print]

PMID:
30737148
2.

Broadly cross-reactive, non-neutralizing antibodies against the influenza B virus hemagglutinin demonstrate effector function dependent protection against lethal viral challenge in mice.

Arunkumar GA, Ioannou A, Wohlbold TJ, Meade P, Aslam S, Amanat F, Ayllon J, García-Sastre A, Krammer F.

J Virol. 2019 Jan 9. pii: JVI.01696-18. doi: 10.1128/JVI.01696-18. [Epub ahead of print]

PMID:
30626682
3.

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ.

Cell. 2018 Dec 13;175(7):1931-1945.e18. doi: 10.1016/j.cell.2018.11.028.

PMID:
30550790
4.

Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.

Zhang K, Shang G, Padavannil A, Wang J, Sakthivel R, Chen X, Kim M, Thompson MG, García-Sastre A, Lynch KW, Chen ZJ, Chook YM, Fontoura BMA.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12218-E12227. doi: 10.1073/pnas.1818012115. Epub 2018 Dec 11.

PMID:
30538201
5.

ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes.

Uccellini MB, García-Sastre A.

Cell Rep. 2018 Dec 4;25(10):2784-2796.e3. doi: 10.1016/j.celrep.2018.11.030.

6.

Erratum: Sunwoo, S.-Y. et al. A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies. Vaccines 2018, 6(3), 64.

Sunwoo SY, Schotsaert M, Morozov I, Davis AS, Li Y, Lee J, McDowell C, Meade P, Nachbagauer R, García-Sastre A, Ma W, Krammer F, Richt JA.

Vaccines (Basel). 2018 Nov 27;6(4). pii: E80. doi: 10.3390/vaccines6040080.

7.

Packaging of the Influenza Virus Genome Is Governed by a Plastic Network of RNA- and Nucleoprotein-Mediated Interactions.

Bolte H, Rosu ME, Hagelauer E, García-Sastre A, Schwemmle M.

J Virol. 2019 Feb 5;93(4). pii: e01861-18. doi: 10.1128/JVI.01861-18. Print 2019 Feb 15.

PMID:
30463968
8.

FACS-Mediated Isolation of Neuronal Cell Populations From Virus-Infected Human Embryonic Stem Cell-Derived Cerebral Organoid Cultures.

Janssens S, Schotsaert M, Manganaro L, Dejosez M, Simon V, García-Sastre A, Zwaka TP.

Curr Protoc Stem Cell Biol. 2019 Feb;48(1):e65. doi: 10.1002/cpsc.65. Epub 2018 Oct 24.

PMID:
30358129
9.

Influenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting.

Zhang L, Wang J, Muñoz-Moreno R, Kim M, Sakthivel R, Mo W, Shao D, Anantharaman A, García-Sastre A, Conrad NK, Fontoura BMA.

J Virol. 2018 Sep 26. pii: JVI.01634-18. doi: 10.1128/JVI.01634-18. [Epub ahead of print]

PMID:
30258002
10.

A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies.

Sunwoo SY, Schotsaert M, Morozov I, Davis AS, Li Y, Lee J, McDowell C, Meade P, Nachbagauer R, García-Sastre A, Ma W, Krammer F, Richt JA.

Vaccines (Basel). 2018 Sep 14;6(3). pii: E64. doi: 10.3390/vaccines6030064.

11.

Influenza virus infection causes global RNAPII termination defects.

Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, Ma Y, Rialdi A, Albrecht R, Fenouil R, Sánchez-Aparicio MT, Ayllon J, Ravisankar S, Haddad B, Ho JSY, Low D, Jin J, Yurchenko V, Prinjha RK, Tarakhovsky A, Squatrito M, Pinto D, Allette K, Byun M, Smith ML, Sebra R, Guccione E, Tumpey T, Krogan N, Greenbaum B, van Bakel H, García-Sastre A, Marazzi I.

Nat Struct Mol Biol. 2018 Sep;25(9):885-893. doi: 10.1038/s41594-018-0124-7. Epub 2018 Sep 3.

PMID:
30177761
12.

Transcription Elongation Can Affect Genome 3D Structure.

Heinz S, Texari L, Hayes MGB, Urbanowski M, Chang MW, Givarkes N, Rialdi A, White KM, Albrecht RA, Pache L, Marazzi I, García-Sastre A, Shaw ML, Benner C.

Cell. 2018 Sep 6;174(6):1522-1536.e22. doi: 10.1016/j.cell.2018.07.047. Epub 2018 Aug 23.

PMID:
30146161
13.

Transcriptome Analysis of Infected and Bystander Type 2 Alveolar Epithelial Cells during Influenza A Virus Infection Reveals In Vivo Wnt Pathway Downregulation.

Hancock AS, Stairiker CJ, Boesteanu AC, Monzón-Casanova E, Lukasiak S, Mueller YM, Stubbs AP, García-Sastre A, Turner M, Katsikis PD.

J Virol. 2018 Oct 12;92(21). pii: e01325-18. doi: 10.1128/JVI.01325-18. Print 2018 Nov 1.

PMID:
30111569
14.

Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus.

Rodríguez Pulido M, Sánchez-Aparicio MT, Martínez-Salas E, García-Sastre A, Sobrino F, Sáiz M.

PLoS Pathog. 2018 Jun 29;14(6):e1007135. doi: 10.1371/journal.ppat.1007135. eCollection 2018 Jun.

15.

Influenza.

Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, García-Sastre A.

Nat Rev Dis Primers. 2018 Jun 28;4(1):3. doi: 10.1038/s41572-018-0002-y. Review. No abstract available.

PMID:
29955068
16.

Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.

Thompson MG, Muñoz-Moreno R, Bhat P, Roytenberg R, Lindberg J, Gazzara MR, Mallory MJ, Zhang K, García-Sastre A, Fontoura BMA, Lynch KW.

Nat Commun. 2018 Jun 19;9(1):2407. doi: 10.1038/s41467-018-04779-4.

17.

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.

Yang S, Xu M, Lee EM, Gorshkov K, Shiryaev SA, He S, Sun W, Cheng YS, Hu X, Tharappel AM, Lu B, Pinto A, Farhy C, Huang CT, Zhang Z, Zhu W, Wu Y, Zhou Y, Song G, Zhu H, Shamim K, Martínez-Romero C, García-Sastre A, Preston RA, Jayaweera DT, Huang R, Huang W, Xia M, Simeonov A, Ming G, Qiu X, Terskikh AV, Tang H, Song H, Zheng W.

Cell Discov. 2018 Jun 5;4:31. doi: 10.1038/s41421-018-0034-1. eCollection 2018.

18.

Emergence and Evolution of Novel Reassortant Influenza A Viruses in Canines in Southern China.

Chen Y, Trovão NS, Wang G, Zhao W, He P, Zhou H, Mo Y, Wei Z, Ouyang K, Huang W, García-Sastre A, Nelson MI.

MBio. 2018 Jun 5;9(3). pii: e00909-18. doi: 10.1128/mBio.00909-18.

19.

Erratum: Author Correction: Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus.

Ma J, Lee J, Liu H, Mena I, Davis AS, Sunwoo SY, Lang Y, Duff M, Morozov I, Li Y, Yang J, García-Sastre A, Richt JA, Ma W.

NPJ Vaccines. 2018 May 17;3:19. doi: 10.1038/s41541-018-0054-8. eCollection 2018.

20.

A viral-vectored RSV vaccine induces long-lived humoral immunity in cotton rats.

Grieves JL, Yin Z, Garcia-Sastre A, Mena I, Peeples ME, Risman HP, Federman H, Sandoval MJ, Durbin RK, Durbin JE.

Vaccine. 2018 Jun 18;36(26):3842-3852. doi: 10.1016/j.vaccine.2018.04.089. Epub 2018 May 18.

PMID:
29779923
21.

Novel triple-reassortant influenza viruses in pigs, Guangxi, China.

He P, Wang G, Mo Y, Yu Q, Xiao X, Yang W, Zhao W, Guo X, Chen Q, He J, Liang M, Zhu J, Ding Y, Wei Z, Ouyang K, Liu F, Jian H, Huang W, García-Sastre A, Chen Y.

Emerg Microbes Infect. 2018 May 16;7(1):85. doi: 10.1038/s41426-018-0088-z.

22.

Author Correction: SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses.

Dornfeld D, Dudek AH, Vausselin T, Günther SC, Hultquist JF, Giese S, Khokhlova-Cubberley D, Chew YC, Pache L, Krogan NJ, Garcia-Sastre A, Schwemmle M, Shaw ML.

Sci Rep. 2018 May 14;8(1):7782. doi: 10.1038/s41598-018-25858-y.

23.

An Immunocompetent Mouse Model of Zika Virus Infection.

Gorman MJ, Caine EA, Zaitsev K, Begley MC, Weger-Lucarelli J, Uccellini MB, Tripathi S, Morrison J, Yount BL, Dinnon KH 3rd, Rückert C, Young MC, Zhu Z, Robertson SJ, McNally KL, Ye J, Cao B, Mysorekar IU, Ebel GD, Baric RS, Best SM, Artyomov MN, Garcia-Sastre A, Diamond MS.

Cell Host Microbe. 2018 May 9;23(5):672-685.e6. doi: 10.1016/j.chom.2018.04.003.

PMID:
29746837
24.

Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors.

Capuzzi SJ, Sun W, Muratov EN, Martínez-Romero C, He S, Zhu W, Li H, Tawa G, Fisher EG, Xu M, Shinn P, Qiu X, García-Sastre A, Zheng W, Tropsha A.

J Med Chem. 2018 Apr 26;61(8):3582-3594. doi: 10.1021/acs.jmedchem.8b00035. Epub 2018 Apr 17.

PMID:
29624387
25.

Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways.

Yang Y, Riccio P, Schotsaert M, Mori M, Lu J, Lee DK, García-Sastre A, Xu J, Cardoso WV.

Dev Cell. 2018 Mar 26;44(6):752-761.e4. doi: 10.1016/j.devcel.2018.03.001.

PMID:
29587145
26.

Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain.

Janssens S, Schotsaert M, Karnik R, Balasubramaniam V, Dejosez M, Meissner A, García-Sastre A, Zwaka TP.

mSystems. 2018 Feb 6;3(1). pii: e00219-17. doi: 10.1128/mSystems.00219-17. eCollection 2018 Jan-Feb.

27.

Influenza B virus reverse genetic backbones with improved growth properties in the EB66® cell line as basis for vaccine seed virus generation.

White KM, Ayllon J, Mena I, Potenski A, Krammer F, García-Sastre A.

Vaccine. 2018 Feb 21;36(9):1146-1153. doi: 10.1016/j.vaccine.2018.01.050. Epub 2018 Feb 1.

PMID:
29395518
28.

SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses.

Dornfeld D, Dudek AH, Vausselin T, Günther SC, Hultquist JF, Giese S, Khokhlova-Cubberley D, Chew YC, Pache L, Krogan NJ, Garcia-Sastre A, Schwemmle M, Shaw ML.

Sci Rep. 2018 Feb 1;8(1):2092. doi: 10.1038/s41598-018-20458-2. Erratum in: Sci Rep. 2018 May 14;8(1):7782.

29.

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection.

Canton J, Fehr AR, Fernandez-Delgado R, Gutierrez-Alvarez FJ, Sanchez-Aparicio MT, García-Sastre A, Perlman S, Enjuanes L, Sola I.

PLoS Pathog. 2018 Jan 25;14(1):e1006838. doi: 10.1371/journal.ppat.1006838. eCollection 2018 Jan.

30.

Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling.

Sánchez-Aparicio MT, Feinman LJ, García-Sastre A, Shaw ML.

J Virol. 2018 Feb 26;92(6). pii: e01960-17. doi: 10.1128/JVI.01960-17. Print 2018 Mar 15.

31.

Specific Mutations in the PB2 Protein of Influenza A Virus Compensate for the Lack of Efficient Interferon Antagonism of the NS1 Protein of Bat Influenza A-Like Viruses.

Aydillo T, Ayllon J, Pavlisin A, Martinez-Romero C, Tripathi S, Mena I, Moreira-Soto A, Vicente-Santos A, Corrales-Aguilar E, Schwemmle M, García-Sastre A.

J Virol. 2018 Mar 14;92(7). pii: e02021-17. doi: 10.1128/JVI.02021-17. Print 2018 Apr 1.

32.

Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein.

White KM, Abreu P Jr, Wang H, De Jesus PD, Manicassamy B, García-Sastre A, Chanda SK, DeVita RJ, Shaw ML.

ACS Infect Dis. 2018 Feb 9;4(2):146-157. doi: 10.1021/acsinfecdis.7b00120. Epub 2018 Jan 4.

33.

Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus.

Ma J, Lee J, Liu H, Mena I, Davis AS, Sunwoo SY, Lang Y, Duff M, Morozov I, Li Y, Yang J, García-Sastre A, Richt JA, Ma W.

NPJ Vaccines. 2017 Dec 4;2:33. doi: 10.1038/s41541-017-0034-4. eCollection 2017. Erratum in: NPJ Vaccines. 2018 May 17;3:19.

34.

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies.

Nachbagauer R, Liu WC, Choi A, Wohlbold TJ, Atlas T, Rajendran M, Solórzano A, Berlanda-Scorza F, García-Sastre A, Palese P, Albrecht RA, Krammer F.

NPJ Vaccines. 2017 Sep 14;2:26. doi: 10.1038/s41541-017-0026-4. eCollection 2017.

35.

Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death.

Hartmann BM, Albrecht RA, Zaslavsky E, Nudelman G, Pincas H, Marjanovic N, Schotsaert M, Martínez-Romero C, Fenutria R, Ingram JP, Ramos I, Fernandez-Sesma A, Balachandran S, García-Sastre A, Sealfon SC.

Nat Commun. 2017 Dec 5;8(1):1931. doi: 10.1038/s41467-017-02035-9.

36.

Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression.

Doğanay S, Lee MY, Baum A, Peh J, Hwang SY, Yoo JY, Hergenrother PJ, García-Sastre A, Myong S, Ha T.

Integr Biol (Camb). 2017 Nov 13;9(11):857-867. doi: 10.1039/c7ib00146k.

37.

TRIM25 in the Regulation of the Antiviral Innate Immunity.

Martín-Vicente M, Medrano LM, Resino S, García-Sastre A, Martínez I.

Front Immunol. 2017 Sep 22;8:1187. doi: 10.3389/fimmu.2017.01187. eCollection 2017. Review.

38.

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.

Kuss-Duerkop SK, Wang J, Mena I, White K, Metreveli G, Sakthivel R, Mata MA, Muñoz-Moreno R, Chen X, Krammer F, Diamond MS, Chen ZJ, García-Sastre A, Fontoura BMA.

PLoS Pathog. 2017 Sep 27;13(9):e1006635. doi: 10.1371/journal.ppat.1006635. eCollection 2017 Sep.

39.

Human interactome of the influenza B virus NS1 protein.

Patzina C, Botting CH, García-Sastre A, Randall RE, Hale BG.

J Gen Virol. 2017 Sep;98(9):2267-2273. doi: 10.1099/jgv.0.000909. Epub 2017 Sep 4.

40.

Ten Strategies of Interferon Evasion by Viruses.

García-Sastre A.

Cell Host Microbe. 2017 Aug 9;22(2):176-184. doi: 10.1016/j.chom.2017.07.012. Review.

41.

Constitutive resistance to viral infection in human CD141+ dendritic cells.

Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JB, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, García-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka AK, Manel N.

Sci Immunol. 2017 Jul 7;2(13). pii: eaai8071. doi: 10.1126/sciimmunol.aai8071.

42.

Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Potential Target Antigens and Critical Aspects for a Universal Influenza Vaccine.

Krammer F, García-Sastre A, Palese P.

Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7). pii: a028845. doi: 10.1101/cshperspect.a028845. Review.

PMID:
28663209
43.

Loss of Sendai virus C protein leads to accumulation of RIG-I immunostimulatory defective interfering RNA.

Sánchez-Aparicio MT, Garcin D, Rice CM, Kolakofsky D, García-Sastre A, Baum A.

J Gen Virol. 2017 Jun;98(6):1282-1293. doi: 10.1099/jgv.0.000815. Epub 2017 Jun 20.

44.

Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model.

Duehr J, Wohlbold TJ, Oestereich L, Chromikova V, Amanat F, Rajendran M, Gomez-Medina S, Mena I, tenOever BR, García-Sastre A, Basler CF, Munoz-Fontela C, Krammer F.

J Virol. 2017 Jul 27;91(16). pii: e00652-17. doi: 10.1128/JVI.00652-17. Print 2017 Aug 15.

45.

Antagonism of type I interferon by flaviviruses.

Miorin L, Maestre AM, Fernandez-Sesma A, García-Sastre A.

Biochem Biophys Res Commun. 2017 Oct 28;492(4):587-596. doi: 10.1016/j.bbrc.2017.05.146. Epub 2017 May 31. Review.

46.

Inactivated influenza virus vaccines: the future of TIV and QIV.

Schotsaert M, García-Sastre A.

Curr Opin Virol. 2017 Apr;23:102-106. doi: 10.1016/j.coviro.2017.04.005. Epub 2017 May 12. Review.

47.

The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity.

Rialdi A, Hultquist J, Jimenez-Morales D, Peralta Z, Campisi L, Fenouil R, Moshkina N, Wang ZZ, Laffleur B, Kaake RM, McGregor MJ, Haas K, Pefanis E, Albrecht RA, Pache L, Chanda S, Jen J, Ochando J, Byun M, Basu U, García-Sastre A, Krogan N, van Bakel H, Marazzi I.

Cell. 2017 May 4;169(4):679-692.e14. doi: 10.1016/j.cell.2017.04.021.

48.

Correction: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A.

J Exp Med. 2017 May 1;214(5):1559. doi: 10.1084/jem.2015028204172017c. Epub 2017 Apr 18. No abstract available.

49.

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.

Luthra P, Aguirre S, Yen BC, Pietzsch CA, Sanchez-Aparicio MT, Tigabu B, Morlock LK, García-Sastre A, Leung DW, Williams NS, Fernandez-Sesma A, Bukreyev A, Basler CF.

MBio. 2017 Apr 4;8(2). pii: e00368-17. doi: 10.1128/mBio.00368-17.

50.

Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity.

Bardina SV, Bunduc P, Tripathi S, Duehr J, Frere JJ, Brown JA, Nachbagauer R, Foster GA, Krysztof D, Tortorella D, Stramer SL, García-Sastre A, Krammer F, Lim JK.

Science. 2017 Apr 14;356(6334):175-180. doi: 10.1126/science.aal4365. Epub 2017 Mar 30.

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