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Best matches for García-Sáez AJ[au]:

Bax and Bak Pores: Are We Closing the Circle? Cosentino K et al. Trends Cell Biol. (2017)

Apoptotic foci at mitochondria: in and around Bax pores. Ugarte-Uribe B et al. Philos Trans R Soc Lond B Biol Sci. (2017)

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium. Ros U et al. Cell Rep. (2017)

Search results

Items: 1 to 50 of 75

1.

Quantification of the Interactions Between BCL-2 Proteins by Fluorescence Correlation Spectroscopy.

Murad F, Garcia-Saez AJ.

Methods Mol Biol. 2019;1877:337-350. doi: 10.1007/978-1-4939-8861-7_20.

PMID:
30536014
2.

Single event visualization of unconventional secretion of FGF2.

Dimou E, Cosentino K, Platonova E, Ros U, Sadeghi M, Kashyap P, Katsinelos T, Wegehingel S, Noé F, García-Sáez AJ, Ewers H, Nickel W.

J Cell Biol. 2018 Nov 23. pii: jcb.201802008. doi: 10.1083/jcb.201802008. [Epub ahead of print]

PMID:
30470711
3.

AFM to Study Pore-Forming Proteins.

Unsay JD, García-Sáez AJ.

Methods Mol Biol. 2019;1886:191-202. doi: 10.1007/978-1-4939-8894-5_10.

PMID:
30374868
4.

Scanning Fluorescence Correlation Spectroscopy for Quantification of the Dynamics and Interactions in Tube Organelles of Living Cells.

Unsay JD, Murad F, Hermann E, Ries J, García-Sáez AJ.

Chemphyschem. 2018 Oct 18. doi: 10.1002/cphc.201800705. [Epub ahead of print]

PMID:
30335213
5.

Topology of active, membrane-embedded Bax in the context of a toroidal pore.

Bleicken S, Assafa TE, Stegmueller C, Wittig A, Garcia-Saez AJ, Bordignon E.

Cell Death Differ. 2018 Nov;25(10):1717-1731. doi: 10.1038/s41418-018-0184-6. Epub 2018 Sep 5.

PMID:
30185826
6.

MIM through MOM: the awakening of Bax and Bak pores.

Cosentino K, García-Sáez AJ.

EMBO J. 2018 Sep 3;37(17). pii: e100340. doi: 10.15252/embj.2018100340. Epub 2018 Aug 22. No abstract available.

PMID:
30135068
7.

Early activation of CD95 is limited and localized to the cytotoxic synapse.

Sánchez MF, Murad F, Gülcüler Balta GS, Martin-Villalba A, García-Sáez AJ, Carrer DC.

FEBS J. 2018 Aug;285(15):2813-2827. doi: 10.1111/febs.14518. Epub 2018 Jun 19.

PMID:
29797791
8.

Bax retrotranslocation potentiates Bcl-xL's antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance.

Hantusch A, Das KK, García-Sáez AJ, Brunner T, Rehm M.

Cell Death Dis. 2018 Apr 1;9(4):430. doi: 10.1038/s41419-018-0464-6.

9.

The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.

Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B.

Cell Death Dis. 2018 Feb 19;9(3):286. doi: 10.1038/s41419-018-0312-8.

10.

Bcl-2 proteins: Unraveling the details of a complex and dynamic network.

Bleicken S, Garcia-Saez AJ.

Mol Cell Oncol. 2017 Oct 30;5(1):e1384880. doi: 10.1080/23723556.2017.1384880. eCollection 2018.

11.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

12.

Drp1 polymerization stabilizes curved tubular membranes similar to those of constricted mitochondria.

Ugarte-Uribe B, Prévost C, Das KK, Bassereau P, García-Sáez AJ.

J Cell Sci. 2018 Apr 19;132(4). pii: jcs208603. doi: 10.1242/jcs.208603.

13.

Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization Mechanism.

Artetxe I, Ugarte-Uribe B, Gil D, Valle M, Alonso A, García-Sáez AJ, Goñi FM.

Biophys J. 2017 Aug 22;113(4):860-868. doi: 10.1016/j.bpj.2017.06.071.

14.

Bax, Bak and beyond - mitochondrial performance in apoptosis.

Peña-Blanco A, García-Sáez AJ.

FEBS J. 2018 Feb;285(3):416-431. doi: 10.1111/febs.14186. Epub 2017 Sep 4. Review.

PMID:
28755482
15.

Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation.

Bleicken S, Hantusch A, Das KK, Frickey T, Garcia-Saez AJ.

Nat Commun. 2017 Jul 13;8(1):73. doi: 10.1038/s41467-017-00086-6.

16.

Apoptotic foci at mitochondria: in and around Bax pores.

Ugarte-Uribe B, García-Sáez AJ.

Philos Trans R Soc Lond B Biol Sci. 2017 Aug 5;372(1726). pii: 20160217. doi: 10.1098/rstb.2016.0217. Review.

17.

Improving certainty in single molecule imaging.

Danial JS, García-Sáez AJ.

Curr Opin Struct Biol. 2017 Oct;46:24-30. doi: 10.1016/j.sbi.2017.04.007. Epub 2017 May 5. Review.

PMID:
28482279
18.

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium.

Ros U, Peña-Blanco A, Hänggi K, Kunzendorf U, Krautwald S, Wong WW, García-Sáez AJ.

Cell Rep. 2017 Apr 4;19(1):175-187. doi: 10.1016/j.celrep.2017.03.024.

19.

Determinants of BH3 Sequence Specificity for the Disruption of Bcl-xL/cBid Complexes in Membranes.

Das KK, Shalaby R, García-Sáez AJ.

ACS Chem Biol. 2017 Apr 21;12(4):989-1000. doi: 10.1021/acschembio.6b01084. Epub 2017 Feb 17.

PMID:
28170214
20.

The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID.

Fernández-Marrero Y, Bleicken S, Das KK, Bachmann D, Kaufmann T, Garcia-Saez AJ.

FEBS J. 2017 Mar;284(5):711-724. doi: 10.1111/febs.14008. Epub 2017 Feb 1.

21.

Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore-forming activity.

Mesa-Galloso H, Delgado-Magnero KH, Cabezas S, López-Castilla A, Hernández-González JE, Pedrera L, Alvarez C, Peter Tieleman D, García-Sáez AJ, Lanio ME, Ros U, Valiente PA.

Protein Sci. 2017 Mar;26(3):550-565. doi: 10.1002/pro.3104. Epub 2017 Feb 23.

22.

Bax and Bak Pores: Are We Closing the Circle?

Cosentino K, García-Sáez AJ.

Trends Cell Biol. 2017 Apr;27(4):266-275. doi: 10.1016/j.tcb.2016.11.004. Epub 2016 Dec 5. Review.

23.

Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study.

Unsay JD, Cosentino K, Sporbeck K, García-Sáez AJ.

Biochim Biophys Acta Biomembr. 2017 Jan;1859(1):17-27. doi: 10.1016/j.bbamem.2016.10.007. Epub 2016 Oct 15.

24.

Pushing the size limit of de novo structure ensemble prediction guided by sparse SDSL-EPR restraints to 200 residues: The monomeric and homodimeric forms of BAX.

Fischer AW, Bordignon E, Bleicken S, García-Sáez AJ, Jeschke G, Meiler J.

J Struct Biol. 2016 Jul;195(1):62-71. doi: 10.1016/j.jsb.2016.04.014. Epub 2016 Apr 27.

25.

MOMP in the absence of BH3-only proteins.

García Sáez AJ, Villunger A.

Genes Dev. 2016 Apr 15;30(8):878-80. doi: 10.1101/gad.281519.116.

26.

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

Navarro G, Cordomí A, Zelman-Femiak M, Brugarolas M, Moreno E, Aguinaga D, Perez-Benito L, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, García-Sáez AJ, McCormick PJ, Franco R.

BMC Biol. 2016 Apr 5;14:26. doi: 10.1186/s12915-016-0247-4.

27.

cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities.

Bleicken S, Hofhaus G, Ugarte-Uribe B, Schröder R, García-Sáez AJ.

Cell Death Dis. 2016 Feb 25;7:e2121. doi: 10.1038/cddis.2016.34.

28.

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores.

Salvador-Gallego R, Mund M, Cosentino K, Schneider J, Unsay J, Schraermeyer U, Engelhardt J, Ries J, García-Sáez AJ.

EMBO J. 2016 Feb 15;35(4):389-401. doi: 10.15252/embj.201593384. Epub 2016 Jan 18.

29.

Membrane Disintegration Caused by the Steroid Saponin Digitonin Is Related to the Presence of Cholesterol.

Sudji IR, Subburaj Y, Frenkel N, García-Sáez AJ, Wink M.

Molecules. 2015 Nov 9;20(11):20146-60. doi: 10.3390/molecules201119682.

30.

Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes.

Cosentino K, Ros U, García-Sáez AJ.

Biochim Biophys Acta. 2016 Mar;1858(3):457-466. doi: 10.1016/j.bbamem.2015.09.013. Epub 2015 Sep 12. Review.

31.

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers.

Unsay JD, Cosentino K, García-Sáez AJ.

J Vis Exp. 2015 Jul 22;(101):e52867. doi: 10.3791/52867.

32.

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species.

Subburaj Y, Cosentino K, Axmann M, Pedrueza-Villalmanzo E, Hermann E, Bleicken S, Spatz J, García-Sáez AJ.

Nat Commun. 2015 Aug 14;6:8042. doi: 10.1038/ncomms9042.

33.

Differences in activity of actinoporins are related with the hydrophobicity of their N-terminus.

Ros U, Rodríguez-Vera W, Pedrera L, Valiente PA, Cabezas S, Lanio ME, García-Sáez AJ, Alvarez C.

Biochimie. 2015 Sep;116:70-8. doi: 10.1016/j.biochi.2015.06.024. Epub 2015 Jun 29.

PMID:
26134716
34.

More Than a Pore: The Interplay of Pore-Forming Proteins and Lipid Membranes.

Ros U, García-Sáez AJ.

J Membr Biol. 2015 Jun;248(3):545-61. doi: 10.1007/s00232-015-9820-y. Epub 2015 Jun 19. Review.

PMID:
26087906
35.

Formation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfaces.

Müller HM, Steringer JP, Wegehingel S, Bleicken S, Münster M, Dimou E, Unger S, Weidmann G, Andreas H, García-Sáez AJ, Wild K, Sinning I, Nickel W.

J Biol Chem. 2015 Apr 3;290(14):8925-37. doi: 10.1074/jbc.M114.622456. Epub 2015 Feb 18.

36.

A single herpesvirus protein can mediate vesicle formation in the nuclear envelope.

Lorenz M, Vollmer B, Unsay JD, Klupp BG, García-Sáez AJ, Mettenleiter TC, Antonin W.

J Biol Chem. 2015 Mar 13;290(11):6962-74. doi: 10.1074/jbc.M114.627521. Epub 2015 Jan 20.

37.

Toxicity of an α-pore-forming toxin depends on the assembly mechanism on the target membrane as revealed by single molecule imaging.

Subburaj Y, Ros U, Hermann E, Tong R, García-Sáez AJ.

J Biol Chem. 2015 Feb 20;290(8):4856-65. doi: 10.1074/jbc.M114.600676. Epub 2014 Dec 18.

38.

Structural model of active Bax at the membrane.

Bleicken S, Jeschke G, Stegmueller C, Salvador-Gallego R, García-Sáez AJ, Bordignon E.

Mol Cell. 2014 Nov 20;56(4):496-505. doi: 10.1016/j.molcel.2014.09.022. Epub 2014 Oct 30.

39.

Scanning fluorescence correlation spectroscopy on biomembranes.

Hermann E, Ries J, García-Sáez AJ.

Methods Mol Biol. 2015;1232:181-97. doi: 10.1007/978-1-4939-1752-5_15.

PMID:
25331137
40.

Dynamin-related protein 1 (Drp1) promotes structural intermediates of membrane division.

Ugarte-Uribe B, Müller HM, Otsuki M, Nickel W, García-Sáez AJ.

J Biol Chem. 2014 Oct 31;289(44):30645-56. doi: 10.1074/jbc.M114.575779. Epub 2014 Sep 18.

41.

New biophysical methods to study the membrane activity of Bcl-2 proteins.

Bleicken S, García-Sáez AJ.

Methods Mol Biol. 2014;1176:191-207. doi: 10.1007/978-1-4939-0992-6_16.

PMID:
25030929
42.

Mitochondrial alterations in apoptosis.

Cosentino K, García-Sáez AJ.

Chem Phys Lipids. 2014 Jul;181:62-75. doi: 10.1016/j.chemphyslip.2014.04.001. Epub 2014 Apr 13. Review.

PMID:
24732580
43.

Automated analysis of giant unilamellar vesicles using circular Hough transformation.

Hermann E, Bleicken S, Subburaj Y, García-Sáez AJ.

Bioinformatics. 2014 Jun 15;30(12):1747-54. doi: 10.1093/bioinformatics/btu102. Epub 2014 Feb 18.

PMID:
24554630
44.

Membranes in motion: mitochondrial dynamics and their role in apoptosis.

Ugarte-Uribe B, García-Sáez AJ.

Biol Chem. 2014 Mar;395(3):297-311. doi: 10.1515/hsz-2013-0234. Review.

PMID:
24184992
45.

Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size.

Bleicken S, Landeta O, Landajuela A, Basañez G, García-Sáez AJ.

J Biol Chem. 2013 Nov 15;288(46):33241-52. doi: 10.1074/jbc.M113.512087. Epub 2013 Oct 7.

46.

Scanning fluorescence correlation spectroscopy in model membrane systems.

Unsay JD, García-Sáez AJ.

Methods Mol Biol. 2013;1033:185-205. doi: 10.1007/978-1-62703-487-6_13.

PMID:
23996179
47.

Cardiolipin effects on membrane structure and dynamics.

Unsay JD, Cosentino K, Subburaj Y, García-Sáez AJ.

Langmuir. 2013 Dec 23;29(51):15878-87. doi: 10.1021/la402669z. Epub 2013 Sep 10.

PMID:
23962277
48.

Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.

Bleicken S, Wagner C, García-Sáez AJ.

Biophys J. 2013 Jan 22;104(2):421-31. doi: 10.1016/j.bpj.2012.12.010.

49.

Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid.

Jalmar O, François-Moutal L, García-Sáez AJ, Perry M, Granjon T, Gonzalvez F, Gottlieb E, Ayala-Sanmartin J, Klösgen B, Schwille P, Petit PX.

PLoS One. 2013;8(2):e55250. doi: 10.1371/journal.pone.0055250. Epub 2013 Feb 13.

50.

The secrets of the Bcl-2 family.

García-Sáez AJ.

Cell Death Differ. 2012 Nov;19(11):1733-40. doi: 10.1038/cdd.2012.105. Epub 2012 Aug 31. Review.

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