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Items: 1 to 50 of 72

1.

Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection.

Radzio-Basu J, Council O, Cong ME, Ruone S, Newton A, Wei X, Mitchell J, Ellis S, Petropoulos CJ, Huang W, Spreen W, Heneine W, García-Lerma JG.

Nat Commun. 2019 May 1;10(1):2005. doi: 10.1038/s41467-019-10047-w.

2.

Ultra-long-acting removable drug delivery system for HIV treatment and prevention.

Kovarova M, Benhabbour SR, Massud I, Spagnuolo RA, Skinner B, Baker CE, Sykes C, Mollan KR, Kashuba ADM, García-Lerma JG, Mumper RJ, Garcia JV.

Nat Commun. 2018 Oct 8;9(1):4156. doi: 10.1038/s41467-018-06490-w.

3.

Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.

McKinnon LR, Liebenberg LJ, Yende-Zuma N, Archary D, Ngcapu S, Sivro A, Nagelkerke N, Garcia Lerma JG, Kashuba AD, Masson L, Mansoor LE, Karim QA, Karim SSA, Passmore JS.

Nat Med. 2018 May;24(4):491-496. doi: 10.1038/nm.4506. Epub 2018 Feb 26.

4.

On the Death Rate of Abortively Infected Cells: Estimation from Simian-Human Immunodeficiency Virus Infection.

Ke R, Cong ME, Li D, García-Lerma JG, Perelson AS.

J Virol. 2017 Aug 24;91(18). pii: e00352-17. doi: 10.1128/JVI.00352-17. Print 2017 Sep 15.

5.

Antiretroviral Drug Activity in Macaques Infected during Pre-Exposure Prophylaxis Has a Transient Effect on Cell-Associated SHIV DNA Reservoirs.

Cong ME, Pau CP, Heneine W, García-Lerma JG.

PLoS One. 2016 Nov 2;11(11):e0164821. doi: 10.1371/journal.pone.0164821. eCollection 2016.

6.

Chemoprophylaxis With Oral Emtricitabine and Tenofovir Alafenamide Combination Protects Macaques From Rectal Simian/Human Immunodeficiency Virus Infection.

Massud I, Mitchell J, Babusis D, Deyounks F, Ray AS, Rooney JF, Heneine W, Miller MD, García-Lerma JG.

J Infect Dis. 2016 Oct 1;214(7):1058-62. doi: 10.1093/infdis/jiw312. Epub 2016 Jul 27.

PMID:
27465645
7.

Combination Emtricitabine and Tenofovir Disoproxil Fumarate Prevents Vaginal Simian/Human Immunodeficiency Virus Infection in Macaques Harboring Chlamydia trachomatis and Trichomonas vaginalis.

Radzio J, Henning T, Jenkins L, Ellis S, Farshy C, Phillips C, Holder A, Kuklenyik S, Dinh C, Hanson D, McNicholl J, Heneine W, Papp J, Kersh EN, García-Lerma JG.

J Infect Dis. 2016 May 15;213(10):1541-5. doi: 10.1093/infdis/jiw002. Epub 2016 Jan 6.

8.

Brief Report: HIV-1 Evolution in Breakthrough Infections in a Human Trial of Oral Pre-exposure Prophylaxis With Emtricitabine and Tenofovir Disoproxil Fumarate.

Ruone S, Paxton L, McLaurin T, Taylor A, Hanson D, Heneine W, Brooks JT, García-Lerma JG.

J Acquir Immune Defic Syndr. 2016 Jun 1;72(2):129-32. doi: 10.1097/QAI.0000000000000921.

9.

Nondaily preexposure prophylaxis for HIV prevention.

Anderson PL, García-Lerma JG, Heneine W.

Curr Opin HIV AIDS. 2016 Jan;11(1):94-101. doi: 10.1097/COH.0000000000000213. Review.

10.

Efficacy of topical tenofovir against transmission of a tenofovir-resistant SHIV in macaques.

Dobard CW, Sharma S, Cong ME, West R, Makarova N, Holder A, Pau CP, Hanson DL, Novembre FJ, Garcia-Lerma JG, Heneine W.

Retrovirology. 2015 Aug 8;12:69. doi: 10.1186/s12977-015-0195-z.

11.

Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach.

Vishwanathan SA, Burgener A, Bosinger SE, Tharp GK, Guenthner PC, Patel NB, Birse K, Hanson DL, Westmacott GR, Henning TR, Radzio J, Garcia-Lerma JG, Ball TB, McNicholl JM, Kersh EN.

J Virol. 2015 Sep;89(18):9167-77. doi: 10.1128/JVI.00263-15. Epub 2015 Jun 24.

12.

Protection Against Rectal Chimeric Simian/Human Immunodeficiency Virus Transmission in Macaques by Rectal-Specific Gel Formulations of Maraviroc and Tenofovir.

Dobard CW, Taylor A, Sharma S, Anderson PL, Bushman LR, Chuong D, Pau CP, Hanson D, Wang L, Garcia-Lerma JG, McGowan I, Rohan L, Heneine W.

J Infect Dis. 2015 Dec 15;212(12):1988-95. doi: 10.1093/infdis/jiv334. Epub 2015 Jun 12.

13.

Repeated Vaginal SHIV Challenges in Macaques Receiving Oral or Topical Preexposure Prophylaxis Induce Virus-Specific T-Cell Responses.

Tsegaye TS, Butler K, Luo W, Radzio J, Srinivasan P, Sharma S, Aubert RD, Hanson DL, Dobard C, Garcia-Lerma JG, Heneine W, McNicholl JM, Kersh EN.

J Acquir Immune Defic Syndr. 2015 Aug 1;69(4):385-94. doi: 10.1097/QAI.0000000000000642.

14.

Pharmacokinetic profile of raltegravir, elvitegravir and dolutegravir in plasma and mucosal secretions in rhesus macaques.

Massud I, Martin A, Dinh C, Mitchell J, Jenkins L, Heneine W, Pau CP, García-Lerma JG.

J Antimicrob Chemother. 2015 May;70(5):1473-81. doi: 10.1093/jac/dku556. Epub 2015 Jan 27.

15.

The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge.

Radzio J, Spreen W, Yueh YL, Mitchell J, Jenkins L, García-Lerma JG, Heneine W.

Sci Transl Med. 2015 Jan 14;7(270):270ra5. doi: 10.1126/scitranslmed.3010297.

PMID:
25589631
16.

Using geospatial modelling to optimize the rollout of antiretroviral-based pre-exposure HIV interventions in Sub-Saharan Africa.

Gerberry DJ, Wagner BG, Garcia-Lerma JG, Heneine W, Blower S.

Nat Commun. 2014 Dec 2;5:5454. doi: 10.1038/ncomms6454.

17.

Depot-medroxyprogesterone acetate does not reduce the prophylactic efficacy of emtricitabine and tenofovir disoproxil fumarate in macaques.

Radzio J, Hanley K, Mitchell J, Ellis S, Deyounks F, Jenkins L, Heneine W, García-Lerma JG.

J Acquir Immune Defic Syndr. 2014 Dec 1;67(4):365-9. doi: 10.1097/QAI.0000000000000340.

18.

A polyvalent Clade B virus-like particle HIV vaccine combined with partially protective oral preexposure prophylaxis prevents simian-human immunodeficiency virus Infection in macaques and primes for virus-amplified immunity.

Ross TM, Pereira LE, Luckay A, McNicholl JM, García-Lerma JG, Heneine W, Eugene HS, Pierce-Paul BR, Zhang J, Hendry RM, Smith JM.

AIDS Res Hum Retroviruses. 2014 Nov;30(11):1072-81. doi: 10.1089/AID.2014.0030. Epub 2014 Jul 29.

19.

Tenofovir diphosphate concentrations and prophylactic effect in a macaque model of rectal simian HIV transmission.

Anderson PL, Glidden DV, Bushman LR, Heneine W, García-Lerma JG.

J Antimicrob Chemother. 2014 Sep;69(9):2470-6. doi: 10.1093/jac/dku162. Epub 2014 May 26.

20.

SHIV susceptibility changes during the menstrual cycle of pigtail macaques.

Kersh EN, Henning T, Vishwanathan SA, Morris M, Butler K, Adams DR, Guenthner P, Srinivasan P, Smith J, Radzio J, Garcia-Lerma JG, Dobard C, Heneine W, McNicholl J.

J Med Primatol. 2014 Oct;43(5):310-6. doi: 10.1111/jmp.12124. Epub 2014 Apr 29.

21.

Physiologic doses of depot-medroxyprogesterone acetate do not increase acute plasma simian HIV viremia or mucosal virus shedding in pigtail macaques.

Radzio J, Hanley K, Mitchell J, Ellis S, Deyounks F, Jenkins LT, Hanson D, Heneine W, García-Lerma JG.

AIDS. 2014 Jun 19;28(10):1431-9. doi: 10.1097/QAD.0000000000000294.

PMID:
24759208
22.

Postexposure protection of macaques from vaginal SHIV infection by topical integrase inhibitors.

Dobard C, Sharma S, Parikh UM, West R, Taylor A, Martin A, Pau CP, Hanson DL, Lipscomb J, Smith J, Novembre F, Hazuda D, Garcia-Lerma JG, Heneine W.

Sci Transl Med. 2014 Mar 12;6(227):227ra35. doi: 10.1126/scitranslmed.3007701.

23.

Lack of prophylactic efficacy of oral maraviroc in macaques despite high drug concentrations in rectal tissues.

Massud I, Aung W, Martin A, Bachman S, Mitchell J, Aubert R, Solomon Tsegaye T, Kersh E, Pau CP, Heneine W, García-Lerma JG.

J Virol. 2013 Aug;87(16):8952-61. doi: 10.1128/JVI.01204-13. Epub 2013 Jun 5.

24.

Prophylactic efficacy of oral emtricitabine and tenofovir disoproxil fumarate combination therapy against a tenofovir-resistant simian/human immunodeficiency virus containing the K65R mutation in macaques.

Cong ME, Mitchell J, Sweeney E, Bachman S, Hanson DL, Heneine W, García-Lerma JG.

J Infect Dis. 2013 Aug 1;208(3):463-7. doi: 10.1093/infdis/jit189. Epub 2013 Apr 30.

25.

Susceptibility to repeated, low-dose, rectal SHIVSF162P3 challenge is independent of TRIM5 genotype in rhesus macaques.

Butler K, Morgan JS, Hanson DL, Adams D, Garcia-Lerma JG, Heneine W, Ellenberger D, Hendry RM, McNicholl J, Johnson WE, Kersh EN.

AIDS Res Hum Retroviruses. 2013 Jul;29(7):1091-4. doi: 10.1089/AID.2012.0383. Epub 2013 Mar 29.

26.

Prevention of vaginal SHIV transmission in macaques by a coitally-dependent Truvada regimen.

Radzio J, Aung W, Holder A, Martin A, Sweeney E, Mitchell J, Bachman S, Pau CP, Heneine W, García-Lerma JG.

PLoS One. 2012;7(12):e50632. doi: 10.1371/journal.pone.0050632. Epub 2012 Dec 4.

27.

Animal models of antiretroviral prophylaxis for HIV prevention.

García-Lerma JG, Heneine W.

Curr Opin HIV AIDS. 2012 Nov;7(6):505-13. doi: 10.1097/COH.0b013e328358e484. Review.

PMID:
22964889
28.

Reduced inflammation and CD4 loss in acute SHIV infection during oral pre-exposure prophylaxis.

Kersh EN, Luo W, Zheng Q, Adams DR, Hanson D, Youngpairoj AS, Cong ME, Butler K, Hendry RM, McNicholl JM, Heneine W, Garcia-Lerma JG.

J Infect Dis. 2012 Sep 1;206(5):770-9. doi: 10.1093/infdis/jis422. Epub 2012 Jun 27.

29.

Limited SHIV env diversification in macaques failing oral antiretroviral pre-exposure prophylaxis.

Zheng Q, Ruone S, Switzer WM, Heneine W, García-Lerma JG.

Retrovirology. 2012 May 9;9:40. doi: 10.1186/1742-4690-9-40.

30.

Factors limiting the transmission of HIV mutations conferring drug resistance: fitness costs and genetic bottlenecks.

Wagner BG, Garcia-Lerma JG, Blower S.

Sci Rep. 2012;2:320. doi: 10.1038/srep00320. Epub 2012 Mar 19.

31.

Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue.

Dobard C, Sharma S, Martin A, Pau CP, Holder A, Kuklenyik Z, Lipscomb J, Hanson DL, Smith J, Novembre FJ, García-Lerma JG, Heneine W.

J Virol. 2012 Jan;86(2):718-25. doi: 10.1128/JVI.05842-11. Epub 2011 Nov 9.

32.

Measuring enzymatic HIV-1 susceptibility to two reverse transcriptase inhibitors as a rapid and simple approach to HIV-1 drug-resistance testing.

Hoffmann D, Garcia AD, Harrigan PR, Johnston IC, Nakasone T, García-Lerma JG, Heneine W.

PLoS One. 2011;6(7):e22019. doi: 10.1371/journal.pone.0022019. Epub 2011 Jul 20.

33.

Delayed maturation of antibody avidity but not seroconversion in rhesus macaques infected with simian HIV during oral pre-exposure prophylaxis.

Curtis KA, Kennedy MS, Luckay A, Cong ME, Youngpairoj AS, Zheng Q, Smith J, Hanson D, Heneine W, Owen SM, García-Lerma JG.

J Acquir Immune Defic Syndr. 2011 Aug 15;57(5):355-62. doi: 10.1097/QAI.0b013e3182234a51.

PMID:
21637113
34.

Protection against rectal transmission of an emtricitabine-resistant simian/human immunodeficiency virus SHIV162p3M184V mutant by intermittent prophylaxis with Truvada.

Cong ME, Youngpairoj AS, Zheng Q, Aung W, Mitchell J, Sweeney E, Hanson DL, Hendry RM, Dobard C, Heneine W, García-Lerma JG.

J Virol. 2011 Aug;85(15):7933-6. doi: 10.1128/JVI.00843-11. Epub 2011 Jun 1.

35.

T cell chemo-vaccination effects after repeated mucosal SHIV exposures and oral pre-exposure prophylaxis.

Kersh EN, Adams DR, Youngpairoj AS, Luo W, Zheng Q, Cong ME, Aung W, Mitchell J, Otten R, Hendry RM, Heneine W, McNicholl J, Garcia-Lerma JG.

PLoS One. 2011 Apr 26;6(4):e19295. doi: 10.1371/journal.pone.0019295.

36.

Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors.

García-Lerma JG, Aung W, Cong ME, Zheng Q, Youngpairoj AS, Mitchell J, Holder A, Martin A, Kuklenyik S, Luo W, Lin CY, Hanson DL, Kersh E, Pau CP, Ray AS, Rooney JF, Lee WA, Heneine W.

J Virol. 2011 Jul;85(13):6610-7. doi: 10.1128/JVI.00311-11. Epub 2011 Apr 27.

37.

Generation and mucosal transmissibility of emtricitabine- and tenofovir-resistant SHIV162P3 mutants in macaques.

Cong ME, Youngpairoj AS, Aung W, Sharma S, Mitchell J, Dobard C, Heneine W, Garcia-Lerma JG.

Virology. 2011 Apr 10;412(2):435-40. doi: 10.1016/j.virol.2011.01.038. Epub 2011 Feb 21.

38.

Dried blood spots for HIV-1 drug resistance and viral load testing: A review of current knowledge and WHO efforts for global HIV drug resistance surveillance.

Bertagnolio S, Parkin NT, Jordan M, Brooks J, García-Lerma JG.

AIDS Rev. 2010 Oct-Dec;12(4):195-208. Review.

PMID:
21179184
39.

Minority HIV mutation detection in dried blood spots indicates high specimen integrity and reveals hidden archived drug resistance.

Wei X, Youngpairoj AS, Garrido C, Zahonero N, Corral A, de Mendoza C, Heneine W, Johnson JA, Garcia-Lerma JG.

J Clin Virol. 2011 Feb;50(2):148-52. doi: 10.1016/j.jcv.2010.11.006. Epub 2010 Dec 3.

PMID:
21130027
40.

HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis.

Supervie V, García-Lerma JG, Heneine W, Blower S.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12381-6. doi: 10.1073/pnas.1006061107. Epub 2010 Jun 28.

41.

Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.

García-Lerma JG, Cong ME, Mitchell J, Youngpairoj AS, Zheng Q, Masciotra S, Martin A, Kuklenyik Z, Holder A, Lipscomb J, Pau CP, Barr JR, Hanson DL, Otten R, Paxton L, Folks TM, Heneine W.

Sci Transl Med. 2010 Jan 13;2(14):14ra4. doi: 10.1126/scitranslmed.3000391.

42.

Oral pre-exposure prophylaxis for HIV prevention.

García-Lerma JG, Paxton L, Kilmarx PH, Heneine W.

Trends Pharmacol Sci. 2010 Feb;31(2):74-81. doi: 10.1016/j.tips.2009.10.009. Epub 2009 Dec 4. Review.

PMID:
19963288
43.

On-line coupling of anion exchange and ion-pair chromatography for measurement of intracellular triphosphate metabolites of reverse transcriptase inhibitors.

Kuklenyik Z, Martin A, Pau CP, Holder A, Youngpairoj AS, Zheng Q, Cong ME, Garcia-Lerma JG, Heneine W, Pirkle JL, Barr JR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 1;877(29):3659-66. doi: 10.1016/j.jchromb.2009.09.007. Epub 2009 Sep 11.

PMID:
19783232
44.

Repeated rectal SHIVSF162P3 exposures do not consistently induce sustained T cell responses prior to systemic infection in the repeat-low dose preclinical macaque model.

Kersh EN, Luo W, Adams DR, Srinivasan P, Smith JM, Promadej-Lanier N, Ellenberger D, Garcia-Lerma JG, Butera S, Otten R.

AIDS Res Hum Retroviruses. 2009 Sep;25(9):905-17. doi: 10.1089/aid.2008.0287.

PMID:
19689194
45.

Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine.

Parikh UM, Dobard C, Sharma S, Cong ME, Jia H, Martin A, Pau CP, Hanson DL, Guenthner P, Smith J, Kersh E, Garcia-Lerma JG, Novembre FJ, Otten R, Folks T, Heneine W.

J Virol. 2009 Oct;83(20):10358-65. doi: 10.1128/JVI.01073-09. Epub 2009 Aug 5.

46.

Effect of mobile phase pH and organic content on LC-MS analysis of nucleoside and nucleotide HIV reverse transcriptase inhibitors.

Kuklenyik Z, Martin A, Pau CP, Garcia-Lerma JG, Heneine W, Pirkle JL, Barr JR.

J Chromatogr Sci. 2009 May-Jun;47(5):365-72.

PMID:
19476704
47.

Rapid decline in the efficiency of HIV drug resistance genotyping from dried blood spots (DBS) and dried plasma spots (DPS) stored at 37 degrees C and high humidity.

García-Lerma JG, McNulty A, Jennings C, Huang D, Heneine W, Bremer JW.

J Antimicrob Chemother. 2009 Jul;64(1):33-6. doi: 10.1093/jac/dkp150. Epub 2009 Apr 29.

48.

Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques.

Kersh EN, Luo W, Adams DR, Mitchell J, Garcia-Lerma JG, Butera S, Folks T, Otten R.

J Antimicrob Chemother. 2009 Apr;63(4):758-62. doi: 10.1093/jac/dkp008. Epub 2009 Feb 13.

PMID:
19218272
49.

Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques.

Kersh EN, Luo W, Adams DR, Mitchell J, Garcia-Lerma JG, Heneine W, Folks TM, Butera S, Otten RA.

AIDS Res Hum Retroviruses. 2008 Apr;24(4):543-6. doi: 10.1089/aid.2007.0222.

PMID:
18370590
50.

HIV-1 drug resistance genotyping from dried blood spots stored for 1 year at 4 degrees C.

Youngpairoj AS, Masciotra S, Garrido C, Zahonero N, de Mendoza C, García-Lerma JG.

J Antimicrob Chemother. 2008 Jun;61(6):1217-20. doi: 10.1093/jac/dkn100. Epub 2008 Mar 15.

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