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Items: 27

1.

HoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes.

Zhong X, Prinz A, Steger J, Garcia-Cuellar MP, Radsak M, Bentaher A, Slany RK.

Blood Adv. 2018 Nov 27;2(22):3137-3148. doi: 10.1182/bloodadvances.2018025866.

2.

The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis.

Hetzner K, Garcia-Cuellar MP, Büttner C, Slany RK.

Blood. 2018 Feb 8;131(6):662-673. doi: 10.1182/blood-2017-11-815035. Epub 2017 Dec 7.

PMID:
29217648
3.

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.

Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, Misiak D, Bäumer N, Cui C, Göllner S, Oellerich T, Serve H, Garcia-Cuellar MP, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein HU, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hébert J, Sauvageau G, Pabst C, Hüttelmaier S, Müller-Tidow C.

Nat Cell Biol. 2017 Jul;19(7):844-855. doi: 10.1038/ncb3563. Epub 2017 Jun 26.

PMID:
28650479
4.

Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes.

Garcia-Cuellar MP, Büttner C, Bartenhagen C, Dugas M, Slany RK.

Cell Rep. 2016 Apr 12;15(2):310-22. doi: 10.1016/j.celrep.2016.03.018. Epub 2016 Mar 31.

5.

Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia.

Garcia-Cuellar MP, Steger J, Füller E, Hetzner K, Slany RK.

Haematologica. 2015 Jul;100(7):905-13. doi: 10.3324/haematol.2015.124032. Epub 2015 Apr 24.

6.

Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation.

Steger J, Füller E, Garcia-Cuellar MP, Hetzner K, Slany RK.

Leukemia. 2015 Apr;29(4):901-8. doi: 10.1038/leu.2014.287. Epub 2014 Sep 25.

PMID:
25252870
7.

Efficacy of cyclin-dependent-kinase 9 inhibitors in a murine model of mixed-lineage leukemia.

Garcia-Cuellar MP, Füller E, Mäthner E, Breitinger C, Hetzner K, Zeitlmann L, Borkhardt A, Slany RK.

Leukemia. 2014 Jul;28(7):1427-35. doi: 10.1038/leu.2014.40. Epub 2014 Jan 21.

PMID:
24445865
8.

MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells.

Maethner E, Garcia-Cuellar MP, Breitinger C, Takacova S, Divoky V, Hess JL, Slany RK.

Cell Rep. 2013 May 30;3(5):1553-66. doi: 10.1016/j.celrep.2013.03.038. Epub 2013 Apr 25.

9.

The homeodomain region controls the phenotype of HOX-induced murine leukemia.

Breitinger C, Maethner E, Garcia-Cuellar MP, Slany RK.

Blood. 2012 Nov 8;120(19):4018-27. doi: 10.1182/blood-2011-10-384685. Epub 2012 Sep 18.

PMID:
22990017
10.

HOX genes regulate Rac1 activity in hematopoietic cells through control of Vav2 expression.

Breitinger C, Maethner E, Garcia-Cuellar MP, Schambony A, Fischer KD, Schilling K, Slany RK.

Leukemia. 2013 Jan;27(1):236-8. doi: 10.1038/leu.2012.166. Epub 2012 Jun 20. No abstract available.

PMID:
22713647
11.

Leukemogenic transformation by HOXA cluster genes.

Bach C, Buhl S, Mueller D, García-Cuéllar MP, Maethner E, Slany RK.

Blood. 2010 Apr 8;115(14):2910-8. doi: 10.1182/blood-2009-04-216606. Epub 2010 Feb 3.

PMID:
20130239
12.

Misguided transcriptional elongation causes mixed lineage leukemia.

Mueller D, García-Cuéllar MP, Bach C, Buhl S, Maethner E, Slany RK.

PLoS Biol. 2009 Nov;7(11):e1000249. doi: 10.1371/journal.pbio.1000249. Epub 2009 Nov 24.

13.

Identification of protein interaction partners by the yeast two-hybrid system.

Garcia-Cuellar MP, Mederer D, Slany RK.

Methods Mol Biol. 2009;538:347-67. doi: 10.1007/978-1-59745-418-6_18.

PMID:
19277583
14.

Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.

Bach C, Mueller D, Buhl S, Garcia-Cuellar MP, Slany RK.

Oncogene. 2009 Feb 12;28(6):815-23. doi: 10.1038/onc.2008.443. Epub 2008 Dec 8.

PMID:
19060922
15.

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.

Mueller D, Bach C, Zeisig D, Garcia-Cuellar MP, Monroe S, Sreekumar A, Zhou R, Nesvizhskii A, Chinnaiyan A, Hess JL, Slany RK.

Blood. 2007 Dec 15;110(13):4445-54. Epub 2007 Sep 12.

16.

The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin.

Zeisig DT, Bittner CB, Zeisig BB, García-Cuéllar MP, Hess JL, Slany RK.

Oncogene. 2005 Aug 18;24(35):5525-32.

PMID:
15856011
17.

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.

Zeisig BB, Milne T, García-Cuéllar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK.

Mol Cell Biol. 2004 Jan;24(2):617-28.

18.

The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell.

Zeisig BB, García-Cuéllar MP, Winkler TH, Slany RK.

Oncogene. 2003 Mar 20;22(11):1629-37.

PMID:
12642866
19.

Transcriptional activation is a key function encoded by MLL fusion partners.

Zeisig BB, Schreiner S, García-Cuéllar MP, Slany RK.

Leukemia. 2003 Feb;17(2):359-65.

PMID:
12592336
20.

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation.

Birke M, Schreiner S, García-Cuéllar MP, Mahr K, Titgemeyer F, Slany RK.

Nucleic Acids Res. 2002 Feb 15;30(4):958-65.

21.

MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation.

Schreiner S, Birke M, García-Cuéllar MP, Zilles O, Greil J, Slany RK.

Cancer Res. 2001 Sep 1;61(17):6480-6.

22.

The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3.

García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK.

Oncogene. 2001 Jan 25;20(4):411-9.

23.

ENL, the MLL fusion partner in t(11;19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t(10;11)+.

García-Cuéllar MP, Schreiner SA, Birke M, Hamacher M, Fey GH, Slany RK.

Oncogene. 2000 Mar 30;19(14):1744-51.

24.

The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator.

Schreiner SA, García-Cuéllar MP, Fey GH, Slany RK.

Leukemia. 1999 Oct;13(10):1525-33.

25.
26.

Yeast viral 20 S RNA is associated with its cognate RNA-dependent RNA polymerase.

García-Cuéllar MP, Esteban LM, Fujimura T, Rodríguez-Cousiño N, Esteban R.

J Biol Chem. 1995 Aug 25;270(34):20084-9.

27.

Association of yeast viral 23 S RNA with its putative RNA-dependent RNA polymerase.

Esteban LM, Fujimura T, García-Cuéllar M, Esteban R.

J Biol Chem. 1994 Nov 25;269(47):29771-7.

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