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Items: 1 to 50 of 87

1.

A Mechano-Activated Cell Reporter System as a Proxy for Flow-Dependent Endothelial Atheroprotection.

Slegtenhorst BR, Fajardo Ramirez OR, Zhang Y, Dhanerawala Z, Tullius SG, García-Cardeña G.

SLAS Discov. 2018 Sep;23(8):869-876. doi: 10.1177/2472555218761101. Epub 2018 Mar 2.

PMID:
29498892
2.

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association.

Daugherty A, Tall AR, Daemen MJAP, Falk E, Fisher EA, García-Cardeña G, Lusis AJ, Owens AP 3rd, Rosenfeld ME, Virmani R; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Basic Cardiovascular Sciences.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):e131-e157. doi: 10.1161/ATV.0000000000000062. Epub 2017 Jul 20. Review.

PMID:
28729366
3.

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association.

Daugherty A, Tall AR, Daemen MJAP, Falk E, Fisher EA, García-Cardeña G, Lusis AJ, Owens AP 3rd, Rosenfeld ME, Virmani R; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Basic Cardiovascular Sciences.

Circ Res. 2017 Sep 1;121(6):e53-e79. doi: 10.1161/RES.0000000000000169. Epub 2017 Jul 20. Review.

PMID:
28729353
4.

Hemodynamic Control of Endothelial Cell Fates in Development.

García-Cardeña G, Slegtenhorst BR.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:633-648. Review.

PMID:
27712101
5.

Development of a biomimetic microfluidic oxygen transfer device.

Gimbel AA, Flores E, Koo A, García-Cardeña G, Borenstein JT.

Lab Chip. 2016 Aug 16;16(17):3227-34. doi: 10.1039/c6lc00641h.

6.

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis.

Gimbrone MA Jr, García-Cardeña G.

Circ Res. 2016 Feb 19;118(4):620-36. doi: 10.1161/CIRCRESAHA.115.306301. Review.

7.

A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms.

Malaspinas O, Turjman A, Ribeiro de Sousa D, Garcia-Cardena G, Raes M, Nguyen PT, Zhang Y, Courbebaisse G, Lelubre C, Zouaoui Boudjeltia K, Chopard B.

J Theor Biol. 2016 Apr 7;394:68-76. doi: 10.1016/j.jtbi.2015.12.022. Epub 2016 Jan 21.

PMID:
26802480
8.

A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity.

Yuan L, Chan GC, Beeler D, Janes L, Spokes KC, Dharaneeswaran H, Mojiri A, Adams WJ, Sciuto T, Garcia-Cardeña G, Molema G, Kang PM, Jahroudi N, Marsden PA, Dvorak A, Regan ER, Aird WC.

Nat Commun. 2016 Jan 8;7:10160. doi: 10.1038/ncomms10160.

9.

Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.

Diaz MF, Li N, Lee HJ, Adamo L, Evans SM, Willey HE, Arora N, Torisawa YS, Vickers DA, Morris SA, Naveiras O, Murthy SK, Ingber DE, Daley GQ, García-Cardeña G, Wenzel PL.

J Exp Med. 2015 May 4;212(5):665-80. doi: 10.1084/jem.20142235. Epub 2015 Apr 13.

10.

Recent insights into the cellular biology of atherosclerosis.

Tabas I, García-Cardeña G, Owens GK.

J Cell Biol. 2015 Apr 13;209(1):13-22. doi: 10.1083/jcb.201412052. Review.

11.

Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards.

French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams D, García-Cardeña G, Sipp D, Oh S, Loring JF, Rao MS, Reeve B, Wall I, Carr AJ, Bure K, Stacey G, Karp JM, Snyder EY, Brindley DA.

Stem Cells Transl Med. 2015 Mar;4(3):217-23. doi: 10.5966/sctm.2014-0233. Epub 2015 Feb 3. Review.

12.

KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins.

Marrone G, Maeso-Díaz R, García-Cardena G, Abraldes JG, García-Pagán JC, Bosch J, Gracia-Sancho J.

Gut. 2015 Sep;64(9):1434-43. doi: 10.1136/gutjnl-2014-308338. Epub 2014 Dec 10.

PMID:
25500203
13.

Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter.

Okada Y, Funahashi N, Tanaka T, Nishiyama Y, Yuan L, Shirakura K, Turjman AS, Kano Y, Naruse H, Suzuki A, Sakai M, Zhixia J, Kitajima K, Ishimoto K, Hino N, Kondoh M, Mukai Y, Nakagawa S, García-Cardeña G, Aird WC, Doi T.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1531-8. doi: 10.1161/ATVBAHA.114.303818. Epub 2014 May 22.

14.

Functional vascular endothelium derived from human induced pluripotent stem cells.

Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G.

Stem Cell Reports. 2013 Jul 25;1(2):105-13. doi: 10.1016/j.stemcr.2013.06.007. eCollection 2013.

15.

Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation.

Giantsos-Adams KM, Koo AJ, Song S, Sakai J, Sankaran J, Shin JH, Garcia-Cardena G, Dewey CF Jr.

Cell Mol Bioeng. 2013 Jun;6(2):160-174. Epub 2013 Feb 20.

16.

In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology.

Koo A, Nordsletten D, Umeton R, Yankama B, Ayyadurai S, García-Cardeña G, Dewey CF Jr.

Biophys J. 2013 May 21;104(10):2295-306. doi: 10.1016/j.bpj.2013.03.052.

17.

Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-β autocrine signaling to promote monocyte recruitment.

Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN.

Immunity. 2013 May 23;38(5):1025-37. doi: 10.1016/j.immuni.2013.01.012. Epub 2013 Apr 25.

18.

Flow is critical for maintaining a protective phenotype in renal proximal tubular cells.

Timsit MO, Adams WJ, Laguna-Fernandez A, Ichimura T, Bonventre JV, García-Cardeña G, Tullius SG.

Am J Transplant. 2013 Jun;13(6):1617-8. doi: 10.1111/ajt.12242. Epub 2013 Apr 25. No abstract available.

19.

Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells.

Koo A, Dewey CF Jr, García-Cardeña G.

Am J Physiol Cell Physiol. 2013 Jan 15;304(2):C137-46. doi: 10.1152/ajpcell.00187.2012. Epub 2012 Oct 31.

20.

The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins.

Marrone G, Russo L, Rosado E, Hide D, García-Cardeña G, García-Pagán JC, Bosch J, Gracia-Sancho J.

J Hepatol. 2013 Jan;58(1):98-103. doi: 10.1016/j.jhep.2012.08.026. Epub 2012 Sep 16.

PMID:
22989565
21.

Novel stem cell-based drug discovery platforms for cardiovascular disease.

Adams WJ, García-Cardeña G.

J Biomol Screen. 2012 Oct;17(9):1117-27. Epub 2012 Aug 1. Review.

PMID:
22853930
22.

Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis.

Gimbrone MA Jr, García-Cardeña G.

Cardiovasc Pathol. 2013 Jan-Feb;22(1):9-15. doi: 10.1016/j.carpath.2012.06.006. Epub 2012 Jul 18. Review.

23.

Flow-dependent endothelial function and kidney dysfunction.

Timsit MO, García-Cardeña G.

Semin Nephrol. 2012 Mar;32(2):185-91. doi: 10.1016/j.semnephrol.2012.02.004. Review.

PMID:
22617767
24.

Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers.

Russo L, Gracia-Sancho J, García-Calderó H, Marrone G, García-Pagán JC, García-Cardeña G, Bosch J.

Hepatology. 2012 Mar;55(3):921-30. doi: 10.1002/hep.24755. Epub 2012 Jan 13.

PMID:
22031447
25.

The vascular origin of hematopoietic cells.

Adamo L, García-Cardeña G.

Dev Biol. 2012 Feb 1;362(1):1-10. doi: 10.1016/j.ydbio.2011.09.008. Epub 2011 Sep 16. Review.

26.

Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a.

Wu W, Xiao H, Laguna-Fernandez A, Villarreal G Jr, Wang KC, Geary GG, Zhang Y, Wang WC, Huang HD, Zhou J, Li YS, Chien S, Garcia-Cardena G, Shyy JY.

Circulation. 2011 Aug 2;124(5):633-41. doi: 10.1161/CIRCULATIONAHA.110.005108. Epub 2011 Jul 18.

27.

Directed stem cell differentiation by fluid mechanical forces.

Adamo L, García-Cardeña G.

Antioxid Redox Signal. 2011 Sep 1;15(5):1463-73. doi: 10.1089/ars.2011.3907. Epub 2011 May 11. Review.

28.

Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver.

Gracia-Sancho J, Russo L, García-Calderó H, García-Pagán JC, García-Cardeña G, Bosch J.

Gut. 2011 Apr;60(4):517-24. doi: 10.1136/gut.2010.220913. Epub 2010 Nov 26.

PMID:
21112949
29.

Flow cessation triggers endothelial dysfunction during organ cold storage conditions: strategies for pharmacologic intervention.

Gracia-Sancho J, Villarreal G Jr, Zhang Y, Yu JX, Liu Y, Tullius SG, García-Cardeña G.

Transplantation. 2010 Jul 27;90(2):142-9. doi: 10.1097/TP.0b013e3181e228db.

30.

Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.

Bu DX, Tarrio M, Grabie N, Zhang Y, Yamazaki H, Stavrakis G, Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, Aikawa M, García-Cardeña G, Lichtman AH.

J Clin Invest. 2010 Jun;120(6):1961-70. doi: 10.1172/JCI41384. Epub 2010 May 3.

31.

Hemodynamic environments from opposing sides of human aortic valve leaflets evoke distinct endothelial phenotypes in vitro.

Weinberg EJ, Mack PJ, Schoen FJ, García-Cardeña G, Kaazempur Mofrad MR.

Cardiovasc Eng. 2010 Mar;10(1):5-11. doi: 10.1007/s10558-009-9089-9.

32.

Machine perfusion or cold storage in organ transplantation: indication, mechanisms, and future perspectives.

Yuan X, Theruvath AJ, Ge X, Floerchinger B, Jurisch A, García-Cardeña G, Tullius SG.

Transpl Int. 2010 Jun;23(6):561-70. doi: 10.1111/j.1432-2277.2009.01047.x. Epub 2010 Jan 13. Review.

33.

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells.

Villarreal G Jr, Zhang Y, Larman HB, Gracia-Sancho J, Koo A, García-Cardeña G.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):984-9. doi: 10.1016/j.bbrc.2009.12.002. Epub 2009 Dec 5.

34.

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype.

Gracia-Sancho J, Villarreal G Jr, Zhang Y, García-Cardeña G.

Cardiovasc Res. 2010 Feb 1;85(3):514-9. doi: 10.1093/cvr/cvp337. Epub 2009 Oct 8.

35.

Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate.

Borenstein JT, Tupper MM, Mack PJ, Weinberg EJ, Khalil AS, Hsiao J, García-Cardeña G.

Biomed Microdevices. 2010 Feb;12(1):71-9. doi: 10.1007/s10544-009-9361-1.

PMID:
19787455
36.

Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression.

Young A, Wu W, Sun W, Benjamin Larman H, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G.

Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1902-8. doi: 10.1161/ATVBAHA.109.193540. Epub 2009 Aug 20. Erratum in: Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):e325. Larman, Harry B [corrected to Benjamin Larman, H];García-Cardeña, Guillermo [added]; Shyy, John Y [added].

37.

Biomechanical forces promote embryonic haematopoiesis.

Adamo L, Naveiras O, Wenzel PL, McKinney-Freeman S, Mack PJ, Gracia-Sancho J, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, García-Cardeña G, Daley GQ.

Nature. 2009 Jun 25;459(7250):1131-5. doi: 10.1038/nature08073. Epub 2009 May 13.

38.

AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts.

Adamo L, Zhang Y, García-Cardeña G.

BMC Pharmacol. 2009 Feb 12;9:2. doi: 10.1186/1471-2210-9-2.

39.

Organ procurement and perfusion before transplantation.

Tullius SG, García-Cardeña G.

N Engl J Med. 2009 Jan 1;360(1):78-80. doi: 10.1056/NEJMe0809215. No abstract available.

PMID:
19118308
40.

Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling.

Mack PJ, Zhang Y, Chung S, Vickerman V, Kamm RD, García-Cardeña G.

J Biol Chem. 2009 Mar 27;284(13):8412-20. doi: 10.1074/jbc.M804524200. Epub 2008 Dec 1.

41.

Regulation of arterial-venous differences in tumor necrosis factor responsiveness of endothelial cells by anatomic context.

Liu M, Kluger MS, D'Alessio A, García-Cardeña G, Pober JS.

Am J Pathol. 2008 Apr;172(4):1088-99. doi: 10.2353/ajpath.2008.070603. Epub 2008 Feb 21.

42.

Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall.

Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW.

Circ Res. 2007 Aug 3;101(3):234-47. Review.

PMID:
17673684
43.

Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.

Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, Gimbrone MA Jr.

Circ Res. 2007 Sep 28;101(7):723-33. Epub 2007 Aug 2.

PMID:
17673673
44.

Gene expression changes evoked in a venous segment exposed to arterial flow.

Abeles D, Kwei S, Stavrakis G, Zhang Y, Wang ET, García-Cardeña G.

J Vasc Surg. 2006 Oct;44(4):863-70.

45.

Biomechanical modulation of endothelial phenotype: implications for health and disease.

García-Cardeña G, Gimbrone MA Jr.

Handb Exp Pharmacol. 2006;(176 Pt 2):79-95. Review.

PMID:
16999225
46.

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.

Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA Jr, García-Cardeña G.

J Clin Invest. 2006 Jan;116(1):49-58. Epub 2005 Dec 8.

47.

Statins exert endothelial atheroprotective effects via the KLF2 transcription factor.

Parmar KM, Nambudiri V, Dai G, Larman HB, Gimbrone MA Jr, García-Cardeña G.

J Biol Chem. 2005 Jul 22;280(29):26714-9. Epub 2005 May 4.

48.

Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function.

Lin Z, Kumar A, SenBanerjee S, Staniszewski K, Parmar K, Vaughan DE, Gimbrone MA Jr, Balasubramanian V, García-Cardeña G, Jain MK.

Circ Res. 2005 Mar 18;96(5):e48-57. Epub 2005 Feb 17.

PMID:
15718498
49.

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.

Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, Kamm RD, García-Cardeña G, Gimbrone MA Jr.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14871-6. Epub 2004 Oct 4.

50.

Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site.

Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ.

J Thorac Cardiovasc Surg. 2004 Oct;128(4):552-61.

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