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Items: 34

1.

An appraisal of natural products active against parasitic nematodes of animals.

Garcia-Bustos JF, Sleebs BE, Gasser RB.

Parasit Vectors. 2019 Jun 17;12(1):306. doi: 10.1186/s13071-019-3537-1. Review.

2.

Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro.

Jiao Y, Preston S, Garcia-Bustos JF, Baell JB, Ventura S, Le T, McNamara N, Nguyen N, Botteon A, Skinner C, Danne J, Ellis S, Koehler AV, Wang T, Chang BCH, Hofmann A, Jabbar A, Gasser RB.

Int J Parasitol Drugs Drug Resist. 2019 Apr;9:59-71. doi: 10.1016/j.ijpddr.2018.12.007. Epub 2018 Dec 30.

3.

Functional screening of selective mitochondrial inhibitors of Plasmodium.

Gomez-Lorenzo MG, Rodríguez-Alejandre A, Moliner-Cubel S, Martínez-Hoyos M, Bahamontes-Rosa N, Gonzalez Del Rio R, Ródenas C, Fuente J, Lavandera JL, García-Bustos JF, Mendoza-Losana A.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):295-303. doi: 10.1016/j.ijpddr.2018.04.007. Epub 2018 May 9.

4.

Malaria Parasites in a Hungry Host: Kinases and Host Caloric Restriction Brought Together.

Garcia-Bustos JF, Doerig C.

Trends Parasitol. 2017 Nov;33(11):831-832. doi: 10.1016/j.pt.2017.08.007. Epub 2017 Sep 8.

PMID:
28923378
5.

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.

Martínez-Hoyos M, Perez-Herran E, Gulten G, Encinas L, Álvarez-Gómez D, Alvarez E, Ferrer-Bazaga S, García-Pérez A, Ortega F, Angulo-Barturen I, Rullas-Trincado J, Blanco Ruano D, Torres P, Castañeda P, Huss S, Fernández Menéndez R, González Del Valle S, Ballell L, Barros D, Modha S, Dhar N, Signorino-Gelo F, McKinney JD, García-Bustos JF, Lavandera JL, Sacchettini JC, Jimenez MS, Martín-Casabona N, Castro-Pichel J, Mendoza-Losana A.

EBioMedicine. 2016 Jun;8:291-301. doi: 10.1016/j.ebiom.2016.05.006. Epub 2016 May 8.

6.

A new in vivo screening paradigm to accelerate antimalarial drug discovery.

Jiménez-Díaz MB, Viera S, Ibáñez J, Mulet T, Magán-Marchal N, Garuti H, Gómez V, Cortés-Gil L, Martínez A, Ferrer S, Fraile MT, Calderón F, Fernández E, Shultz LD, Leroy D, Wilson DM, García-Bustos JF, Gamo FJ, Angulo-Barturen I.

PLoS One. 2013 Jun 25;8(6):e66967. doi: 10.1371/journal.pone.0066967. Print 2013.

7.

Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

Ballell L, Bates RH, Young RJ, Alvarez-Gomez D, Alvarez-Ruiz E, Barroso V, Blanco D, Crespo B, Escribano J, González R, Lozano S, Huss S, Santos-Villarejo A, Martín-Plaza JJ, Mendoza A, Rebollo-Lopez MJ, Remuiñan-Blanco M, Lavandera JL, Pérez-Herran E, Gamo-Benito FJ, García-Bustos JF, Barros D, Castro JP, Cammack N.

ChemMedChem. 2013 Feb;8(2):313-21. doi: 10.1002/cmdc.201200428. Epub 2013 Jan 10.

8.

Antimalarial drug resistance and early drug discovery.

Garcia-Bustos JF, Gamo FJ.

Curr Pharm Des. 2013;19(2):270-81. Review.

PMID:
22973885
9.

P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action.

Sanz LM, Crespo B, De-Cózar C, Ding XC, Llergo JL, Burrows JN, García-Bustos JF, Gamo FJ.

PLoS One. 2012;7(2):e30949. doi: 10.1371/journal.pone.0030949. Epub 2012 Feb 23.

10.

Global phenotypic screening for antimalarials.

Guiguemde WA, Shelat AA, Garcia-Bustos JF, Diagana TT, Gamo FJ, Guy RK.

Chem Biol. 2012 Jan 27;19(1):116-29. doi: 10.1016/j.chembiol.2012.01.004. Review.

11.

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R.

Chem Biol. 2011 Dec 23;18(12):1602-10. doi: 10.1016/j.chembiol.2011.09.016.

12.

A new molecular approach for cidal vs static antimalarial determination by quantifying mRNA levels.

Bahamontes-Rosa N, Rodríguez-Alejandre A, González-del-Rio R, García-Bustos JF, Mendoza-Losana A.

Mol Biochem Parasitol. 2012 Feb;181(2):171-7. doi: 10.1016/j.molbiopara.2011.11.003. Epub 2011 Nov 17.

PMID:
22108433
13.

Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen.

Sanz LM, Jiménez-Díaz MB, Crespo B, De-Cozar C, Almela MJ, Angulo-Barturen I, Castañeda P, Ibañez J, Fernández EP, Ferrer S, Herreros E, Lozano S, Martínez MS, Rueda L, Burrows JN, García-Bustos JF, Gamo FJ.

Antimicrob Agents Chemother. 2011 Dec;55(12):5740-5. doi: 10.1128/AAC.05188-11. Epub 2011 Oct 3.

14.

Phenotypic screens, chemical genomics, and antimalarial lead discovery.

Garcia-Bustos JF, Gamo FJ.

PLoS Pathog. 2011 Aug;7(8):e1002156. doi: 10.1371/journal.ppat.1002156. Epub 2011 Aug 18. No abstract available.

15.

Thousands of chemical starting points for antimalarial lead identification.

Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DV, Kumar V, Hasan S, Brown JR, Peishoff CE, Cardon LR, Garcia-Bustos JF.

Nature. 2010 May 20;465(7296):305-10. doi: 10.1038/nature09107.

PMID:
20485427
16.

Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis.

Rullas J, García JI, Beltrán M, Cardona PJ, Cáceres N, García-Bustos JF, Angulo-Barturen I.

Antimicrob Agents Chemother. 2010 May;54(5):2262-4. doi: 10.1128/AAC.01423-09. Epub 2010 Feb 16.

17.

Candida albicans infection enhances immunosuppression induced by cyclophosphamide by selective priming of suppressive myeloid progenitors for NO production.

Angulo I, Jiménez-Díaz MB, García-Bustos JF, Gargallo D, de las Heras FG, Muñoz-Fernández MA, Fresno M.

Cell Immunol. 2002 Jul-Aug;218(1-2):46-58.

PMID:
12470613
18.

Development of a homologous transformation system for the opportunistic human pathogen Aspergillus fumigatus based on the sC gene encoding ATP sulfurylase.

De Lucas JR, Domínguez AI, Higuero Y, Martínez O, Romero B, Mendoza A, Garcia-Bustos JF, Laborda F.

Arch Microbiol. 2001 Jul;176(1-2):106-13.

PMID:
11479709
19.

Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate.

Dopazo J, Mendoza A, Herrero J, Caldara F, Humbert Y, Friedli L, Guerrier M, Grand-Schenk E, Gandin C, de Francesco M, Polissi A, Buell G, Feger G, García E, Peitsch M, García-Bustos JF.

Microb Drug Resist. 2001 Summer;7(2):99-125.

PMID:
11442348
20.

Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution.

Gomez-Lorenzo MG, Spahn CM, Agrawal RK, Grassucci RA, Penczek P, Chakraburtty K, Ballesta JP, Lavandera JL, Garcia-Bustos JF, Frank J.

EMBO J. 2000 Jun 1;19(11):2710-8.

21.

Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice.

Angulo I, de las Heras FG, García-Bustos JF, Gargallo D, Muñoz-Fernández MA, Fresno M.

Blood. 2000 Jan 1;95(1):212-20.

22.

Translation elongation factor 2 is encoded by a single essential gene in Candida albicans.

Mendoza A, Serramía MJ, Capa L, García-Bustos JF.

Gene. 1999 Mar 18;229(1-2):183-91.

PMID:
10095118
23.

Translation elongation factor 2 is part of the target for a new family of antifungals.

Capa L, Mendoza A, Lavandera JL, Gómez de las Heras F, García-Bustos JF.

Antimicrob Agents Chemother. 1998 Oct;42(10):2694-9.

24.

Ribosomal P-protein stalk function is targeted by sordarin antifungals.

Gómez-Lorenzo MG, García-Bustos JF.

J Biol Chem. 1998 Sep 25;273(39):25041-4.

25.

PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus.

Garcia-Bustos JF, Marini F, Stevenson I, Frei C, Hall MN.

EMBO J. 1994 May 15;13(10):2352-61.

26.
27.

Yeast cell-free nuclear protein import requires ATP hydrolysis.

Garcia-Bustos JF, Wagner P, Hall MN.

Exp Cell Res. 1991 Jan;192(1):213-9.

PMID:
1984412
28.

Production of interleukin-1 but not tumor necrosis factor by human monocytes stimulated with pneumococcal cell surface components.

Riesenfeld-Orn I, Wolpe S, Garcia-Bustos JF, Hoffmann MK, Tuomanen E.

Infect Immun. 1989 Jul;57(7):1890-3.

29.

Altered peptidoglycan structure in a pneumococcal transformant resistant to penicillin.

Garcia-Bustos JF, Chait BT, Tomasz A.

J Bacteriol. 1988 May;170(5):2143-7.

30.

Structure of the peptide network of pneumococcal peptidoglycan.

Garcia-Bustos JF, Chait BT, Tomasz A.

J Biol Chem. 1987 Nov 15;262(32):15400-5.

31.

Alterations in peptidoglycan of Neisseria gonorrhoeae induced by sub-MICs of beta-lactam antibiotics.

Garcia-Bustos JF, Dougherty TJ.

Antimicrob Agents Chemother. 1987 Feb;31(2):178-82.

32.
33.

Structure and mode of action of microcin 7, an antibacterial peptide produced by Escherichia coli.

Garcia-Bustos JF, Pezzi N, Mendez E.

Antimicrob Agents Chemother. 1985 May;27(5):791-7.

34.

Microcin 7: purification and properties.

García-Bustos JF, Pezzi N, Asensio C.

Biochem Biophys Res Commun. 1984 Mar 15;119(2):779-85.

PMID:
6370248

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