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Items: 1 to 50 of 107

1.

Image-based Characterization of 3D Collagen Networks and the Effect of Embedded Cells.

Olivares V, Cóndor M, Del Amo C, Asín J, Borau C, García-Aznar JM.

Microsc Microanal. 2019 Aug;25(4):971-981. doi: 10.1017/S1431927619014570. Epub 2019 Jun 18.

PMID:
31210124
2.

Nonlinear elasticity of the lung extracellular microenvironment is regulated by macroscale tissue strain.

Jorba I, Beltrán G, Falcones B, Suki B, Farré R, García-Aznar JM, Navajas D.

Acta Biomater. 2019 Jul 1;92:265-276. doi: 10.1016/j.actbio.2019.05.023. Epub 2019 May 11.

PMID:
31085362
3.

Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation.

Escribano J, Chen MB, Moeendarbary E, Cao X, Shenoy V, Garcia-Aznar JM, Kamm RD, Spill F.

PLoS Comput Biol. 2019 May 2;15(5):e1006395. doi: 10.1371/journal.pcbi.1006395. eCollection 2019 May.

4.

Breast Cancer Cells Adapt Contractile Forces to Overcome Steric Hindrance.

Cóndor M, Mark C, Gerum RC, Grummel NC, Bauer A, García-Aznar JM, Fabry B.

Biophys J. 2019 Apr 2;116(7):1305-1312. doi: 10.1016/j.bpj.2019.02.029. Epub 2019 Mar 7.

PMID:
30902366
5.

Modelling actin polymerization: the effect on confined cell migration.

Hervas-Raluy S, Garcia-Aznar JM, Gomez-Benito MJ.

Biomech Model Mechanobiol. 2019 Aug;18(4):1177-1187. doi: 10.1007/s10237-019-01136-2. Epub 2019 Mar 1.

6.

Integration of in vitro and in silico Models Using Bayesian Optimization With an Application to Stochastic Modeling of Mesenchymal 3D Cell Migration.

Merino-Casallo F, Gomez-Benito MJ, Juste-Lanas Y, Martinez-Cantin R, Garcia-Aznar JM.

Front Physiol. 2018 Sep 11;9:1246. doi: 10.3389/fphys.2018.01246. eCollection 2018.

7.

From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β.

Plou J, Juste-Lanas Y, Olivares V, Del Amo C, Borau C, García-Aznar JM.

Sci Rep. 2018 Aug 24;8(1):12723. doi: 10.1038/s41598-018-30683-4.

8.

3D Cell Migration Studies for Chemotaxis on Microfluidic-Based Chips: A Comparison between Cardiac and Dermal Fibroblasts.

Pérez-Rodríguez S, Tomás-González E, García-Aznar JM.

Bioengineering (Basel). 2018 Jun 12;5(2). pii: E45. doi: 10.3390/bioengineering5020045.

9.

Matrix architecture plays a pivotal role in 3D osteoblast migration: The effect of interstitial fluid flow.

Del Amo C, Olivares V, Cóndor M, Blanco A, Santolaria J, Asín J, Borau C, García-Aznar JM.

J Mech Behav Biomed Mater. 2018 Jul;83:52-62. doi: 10.1016/j.jmbbm.2018.04.007. Epub 2018 Apr 10.

PMID:
29677555
10.

Combined experimental and computational characterization of crosslinked collagen-based hydrogels.

Valero C, Amaveda H, Mora M, García-Aznar JM.

PLoS One. 2018 Apr 17;13(4):e0195820. doi: 10.1371/journal.pone.0195820. eCollection 2018.

11.

A hybrid computational model for collective cell durotaxis.

Escribano J, Sunyer R, Sánchez MT, Trepat X, Roca-Cusachs P, García-Aznar JM.

Biomech Model Mechanobiol. 2018 Aug;17(4):1037-1052. doi: 10.1007/s10237-018-1010-2. Epub 2018 Mar 2.

PMID:
29500553
12.

A web-based application for automated quantification of chemical gradients induced in microfluidic devices.

Cóndor M, Rüberg T, Borau C, Piles J, García-Aznar JM.

Comput Biol Med. 2018 Apr 1;95:118-128. doi: 10.1016/j.compbiomed.2018.02.001. Epub 2018 Feb 6.

PMID:
29494849
13.

Biallelic inactivating variants in the GTPBP2 gene cause a neurodevelopmental disorder with severe intellectual disability.

Bertoli-Avella AM, Garcia-Aznar JM, Brandau O, Al-Hakami F, Yüksel Z, Marais A, Grüning NM, Abbasi Moheb L, Paknia O, Alshaikh N, Alameer S, Marafi MJ, Al-Mulla F, Al-Sannaa N, Rolfs A, Bauer P.

Eur J Hum Genet. 2018 Apr;26(4):592-598. doi: 10.1038/s41431-018-0097-3. Epub 2018 Feb 15.

14.

Force loading explains spatial sensing of ligands by cells.

Oria R, Wiegand T, Escribano J, Elosegui-Artola A, Uriarte JJ, Moreno-Pulido C, Platzman I, Delcanale P, Albertazzi L, Navajas D, Trepat X, García-Aznar JM, Cavalcanti-Adam EA, Roca-Cusachs P.

Nature. 2017 Dec 14;552(7684):219-224. doi: 10.1038/nature24662. Epub 2017 Dec 6.

PMID:
29211717
15.

Degradation of extracellular matrix regulates osteoblast migration: A microfluidic-based study.

Movilla N, Borau C, Valero C, García-Aznar JM.

Bone. 2018 Feb;107:10-17. doi: 10.1016/j.bone.2017.10.025. Epub 2017 Oct 26.

PMID:
29107125
16.

The role of nuclear mechanics in cell deformation under creeping flows.

Serrano-Alcalde F, García-Aznar JM, Gómez-Benito MJ.

J Theor Biol. 2017 Nov 7;432:25-32. doi: 10.1016/j.jtbi.2017.07.028. Epub 2017 Aug 9.

PMID:
28802825
17.

Traction Force Microscopy in 3-Dimensional Extracellular Matrix Networks.

Cóndor M, Steinwachs J, Mark C, García-Aznar JM, Fabry B.

Curr Protoc Cell Biol. 2017 Jun 19;75:10.22.1-10.22.20. doi: 10.1002/cpcb.24.

PMID:
28627753
18.

Erratum to: Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons.

Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, García-Aznar JM, Vila M, Samitier J, Torrents E, Ferrer I, Gavín R, Hagesawa M, Del Río JA.

Mol Neurobiol. 2018 Mar;55(3):1861. doi: 10.1007/s12035-017-0553-z. No abstract available.

PMID:
28477141
19.

Localized tissue mineralization regulated by bone remodelling: A computational approach.

Berli M, Borau C, Decco O, Adams G, Cook RB, García Aznar JM, Zioupos P.

PLoS One. 2017 Mar 17;12(3):e0173228. doi: 10.1371/journal.pone.0173228. eCollection 2017.

20.

Quantifying 3D chemotaxis in microfluidic-based chips with step gradients of collagen hydrogel concentrations.

Del Amo C, Borau C, Movilla N, Asín J, García-Aznar JM.

Integr Biol (Camb). 2017 Apr 18;9(4):339-349. doi: 10.1039/c7ib00022g.

PMID:
28300261
21.

A hybrid computational model to explore the topological characteristics of epithelial tissues.

González-Valverde I, García-Aznar JM.

Int J Numer Method Biomed Eng. 2017 Nov;33(11). doi: 10.1002/cnm.2877. Epub 2017 Apr 11.

PMID:
28249103
22.

Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons.

Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, García-Aznar JM, Vila M, Samitier J, Torrents E, Ferrer I, Gavín R, Hagesawa M, Del Río JA.

Mol Neurobiol. 2018 Mar;55(3):1847-1860. doi: 10.1007/s12035-017-0451-4. Epub 2017 Feb 22. Erratum in: Mol Neurobiol. 2017 May 5;:.

23.

A phenomenological cohesive model for the macroscopic simulation of cell-matrix adhesions.

Cóndor M, García-Aznar JM.

Biomech Model Mechanobiol. 2017 Aug;16(4):1207-1224. doi: 10.1007/s10237-017-0883-9. Epub 2017 Feb 17.

PMID:
28213831
24.

Characterization of three-dimensional cancer cell migration in mixed collagen-Matrigel scaffolds using microfluidics and image analysis.

Anguiano M, Castilla C, Maška M, Ederra C, Peláez R, Morales X, Muñoz-Arrieta G, Mujika M, Kozubek M, Muñoz-Barrutia A, Rouzaut A, Arana S, Garcia-Aznar JM, Ortiz-de-Solorzano C.

PLoS One. 2017 Feb 6;12(2):e0171417. doi: 10.1371/journal.pone.0171417. eCollection 2017.

25.

Clinical exome sequencing: results from 2819 samples reflecting 1000 families.

Trujillano D, Bertoli-Avella AM, Kumar Kandaswamy K, Weiss ME, Köster J, Marais A, Paknia O, Schröder R, Garcia-Aznar JM, Werber M, Brandau O, Calvo Del Castillo M, Baldi C, Wessel K, Kishore S, Nahavandi N, Eyaid W, Al Rifai MT, Al-Rumayyan A, Al-Twaijri W, Alothaim A, Alhashem A, Al-Sannaa N, Al-Balwi M, Alfadhel M, Rolfs A, Abou Jamra R.

Eur J Hum Genet. 2017 Feb;25(2):176-182. doi: 10.1038/ejhg.2016.146. Epub 2016 Nov 16.

26.

Subject-specific musculoskeletal loading of the tibia: Computational load estimation.

Garijo N, Verdonschot N, Engelborghs K, García-Aznar JM, Pérez MA.

J Mech Behav Biomed Mater. 2017 Jan;65:334-343. doi: 10.1016/j.jmbbm.2016.08.026. Epub 2016 Aug 26.

PMID:
27631171
27.

Phenomenological modelling and simulation of cell clusters in 3D cultures.

González-Valverde I, Semino C, García-Aznar JM.

Comput Biol Med. 2016 Oct 1;77:249-60. doi: 10.1016/j.compbiomed.2016.08.019. Epub 2016 Sep 3.

PMID:
27615191
28.

Collective cell durotaxis emerges from long-range intercellular force transmission.

Sunyer R, Conte V, Escribano J, Elosegui-Artola A, Labernadie A, Valon L, Navajas D, García-Aznar JM, Muñoz JJ, Roca-Cusachs P, Trepat X.

Science. 2016 Sep 9;353(6304):1157-61. doi: 10.1126/science.aaf7119.

29.

Computational model of mesenchymal migration in 3D under chemotaxis.

Ribeiro FO, Gómez-Benito MJ, Folgado J, Fernandes PR, García-Aznar JM.

Comput Methods Biomech Biomed Engin. 2017 Jan;20(1):59-74. Epub 2016 Jun 23.

30.

Finite element simulation for the mechanical characterization of soft biological materials by atomic force microscopy.

Valero C, Navarro B, Navajas D, García-Aznar JM.

J Mech Behav Biomed Mater. 2016 Sep;62:222-235. doi: 10.1016/j.jmbbm.2016.05.006. Epub 2016 May 11.

PMID:
27214690
31.

Biomechanical assessment and clinical analysis of different intramedullary nailing systems for oblique fractures.

Alierta JA, Pérez MA, Seral B, García-Aznar JM.

Comput Methods Biomech Biomed Engin. 2016 Sep;19(12):1266-77. doi: 10.1080/10255842.2015.1125473. Epub 2015 Dec 29.

PMID:
26712100
32.

Free Form Deformation-Based Image Registration Improves Accuracy of Traction Force Microscopy.

Jorge-Peñas A, Izquierdo-Alvarez A, Aguilar-Cuenca R, Vicente-Manzanares M, Garcia-Aznar JM, Van Oosterwyck H, de-Juan-Pardo EM, Ortiz-de-Solorzano C, Muñoz-Barrutia A.

PLoS One. 2015 Dec 7;10(12):e0144184. doi: 10.1371/journal.pone.0144184. eCollection 2015.

33.

Quantification of angiogenic sprouting under different growth factors in a microfluidic platform.

Del Amo C, Borau C, Gutiérrez R, Asín J, García-Aznar JM.

J Biomech. 2016 May 24;49(8):1340-1346. doi: 10.1016/j.jbiomech.2015.10.026. Epub 2015 Oct 27.

PMID:
26556715
34.

Probabilistic Voxel-Fe model for single cell motility in 3D.

Borau C, Polacheck WJ, Kamm RD, García-Aznar JM.

In Silico Cell Tissue Sci. 2014 Oct 1;1:2.

35.

Characterization of Fibrin and Collagen Gels for Engineering Wound Healing Models.

Moreno-Arotzena O, Meier JG, Del Amo C, García-Aznar JM.

Materials (Basel). 2015 Apr 1;8(4):1636-1651.

36.

Modeling the formation of cell-matrix adhesions on a single 3D matrix fiber.

Escribano J, Sánchez MT, García-Aznar JM.

J Theor Biol. 2015 Nov 7;384:84-94. doi: 10.1016/j.jtbi.2015.07.015. Epub 2015 Jul 31.

PMID:
26235289
37.

In silico Mechano-Chemical Model of Bone Healing for the Regeneration of Critical Defects: The Effect of BMP-2.

Ribeiro FO, Gómez-Benito MJ, Folgado J, Fernandes PR, García-Aznar JM.

PLoS One. 2015 Jun 4;10(6):e0127722. doi: 10.1371/journal.pone.0127722. eCollection 2015.

38.

Fibroblast Migration in 3D is Controlled by Haptotaxis in a Non-muscle Myosin II-Dependent Manner.

Moreno-Arotzena O, Borau C, Movilla N, Vicente-Manzanares M, García-Aznar JM.

Ann Biomed Eng. 2015 Dec;43(12):3025-39. doi: 10.1007/s10439-015-1343-2. Epub 2015 May 27.

39.

Erratum: Publisher's Note: "Inducing chemotactic and haptotactic cues in microfluidicdevices for three-dimensional in vitro assays" [Biomicrofluidics 8, 064122 (2014)].

Moreno-Arotzena O, Mendoza G, Cóndor M, Rüberg T, García-Aznar JM.

Biomicrofluidics. 2014 Dec 30;8(6):069901. doi: 10.1063/1.4905312. eCollection 2014 Nov. No abstract available.

40.

Inducing chemotactic and haptotactic cues in microfluidic devices for three-dimensional in vitro assays.

Moreno-Arotzena O, Mendoza G, Cóndor M, Rüberg T, García-Aznar JM.

Biomicrofluidics. 2014 Dec 11;8(6):064122. doi: 10.1063/1.4903948. eCollection 2014 Nov. Erratum in: Biomicrofluidics. 2014 Nov;8(6):069901.

41.

Challenges in the Modeling of Wound Healing Mechanisms in Soft Biological Tissues.

Valero C, Javierre E, García-Aznar JM, Menzel A, Gómez-Benito MJ.

Ann Biomed Eng. 2015 Jul;43(7):1654-65. doi: 10.1007/s10439-014-1200-8. Epub 2014 Dec 2. Review.

PMID:
25449152
42.

Image analysis for the quantitative comparison of stress fibers and focal adhesions.

Elosegui-Artola A, Jorge-Peñas A, Moreno-Arotzena O, Oregi A, Lasa M, García-Aznar JM, De Juan-Pardo EM, Aldabe R.

PLoS One. 2014 Sep 30;9(9):e107393. doi: 10.1371/journal.pone.0107393. eCollection 2014.

43.

Is the callus shape an optimal response to a mechanobiological stimulus?

Ribeiro FO, Folgado J, Garcia-Aznar JM, Gómez-Benito MJ, Fernandes PR.

Med Eng Phys. 2014 Nov;36(11):1508-14. doi: 10.1016/j.medengphy.2014.07.015. Epub 2014 Aug 27.

PMID:
25171991
44.

A cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.

Valero C, Javierre E, García-Aznar JM, Gómez-Benito MJ.

PLoS One. 2014 Mar 28;9(3):e92774. doi: 10.1371/journal.pone.0092774. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e101714.

45.

A bone remodelling model including the effect of damage on the steering of BMUs.

Martínez-Reina J, Reina I, Domínguez J, García-Aznar JM.

J Mech Behav Biomed Mater. 2014 Apr;32:99-112. doi: 10.1016/j.jmbbm.2013.12.025. Epub 2014 Jan 4.

PMID:
24445006
46.

Nonlinear finite element simulations of injuries with free boundaries: application to surgical wounds.

Valero C, Javierre E, García-Aznar JM, Gómez-Benito MJ.

Int J Numer Method Biomed Eng. 2014 Jun;30(6):616-33. doi: 10.1002/cnm.2621. Epub 2014 Jan 17.

47.

Role of subject-specific musculoskeletal loading on the prediction of bone density distribution in the proximal femur.

Vahdati A, Walscharts S, Jonkers I, Garcia-Aznar JM, Vander Sloten J, van Lenthe GH.

J Mech Behav Biomed Mater. 2014 Feb;30:244-52. doi: 10.1016/j.jmbbm.2013.11.015. Epub 2013 Dec 1.

PMID:
24342624
48.

A coupled mechano-biochemical model for bone adaptation.

Klika V, Pérez MA, García-Aznar JM, Maršík F, Doblaré M.

J Math Biol. 2014 Dec;69(6-7):1383-429. doi: 10.1007/s00285-013-0736-9. Epub 2013 Nov 12.

PMID:
24212399
49.

An interface finite element model can be used to predict healing outcome of bone fractures.

Alierta JA, Pérez MA, García-Aznar JM.

J Mech Behav Biomed Mater. 2014 Jan;29:328-38. doi: 10.1016/j.jmbbm.2013.09.023. Epub 2013 Oct 8.

PMID:
24145150
50.

Computational methodology to determine fluid related parameters of non regular three-dimensional scaffolds.

Acosta Santamaría VA, Malvè M, Duizabo A, Mena Tobar A, Gallego Ferrer G, García Aznar JM, Doblaré M, Ochoa I.

Ann Biomed Eng. 2013 Nov;41(11):2367-80. doi: 10.1007/s10439-013-0849-8. Epub 2013 Jun 27.

PMID:
23807712

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