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The role of DUBs in the post-translational control of cell migration.

Lambies G, García de Herreros A, Díaz VM.

Essays Biochem. 2019 Oct 31;63(5):579-594. doi: 10.1042/EBC20190022.


Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization.

García de Herreros A, Duñach M.

Cells. 2019 Sep 25;8(10). pii: E1148. doi: 10.3390/cells8101148. Review.


Src and Fyn define a new signaling cascade activated by canonical and non-canonical Wnt ligands and required for gene transcription and cell invasion.

Villarroel A, Del Valle-Pérez B, Fuertes G, Curto J, Ontiveros N, Garcia de Herreros A, Duñach M.

Cell Mol Life Sci. 2019 Jul 16. doi: 10.1007/s00018-019-03221-2. [Epub ahead of print]


Abrogation of myofibroblast activities in metastasis and fibrosis by methyltransferase inhibition.

Sala L, Franco-Valls H, Stanisavljevic J, Curto J, Vergés J, Peña R, Duch P, Alcaraz J, García de Herreros A, Baulida J.

Int J Cancer. 2019 Dec 1;145(11):3064-3077. doi: 10.1002/ijc.32376. Epub 2019 May 14.


TGFβ-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1.

Lambies G, Miceli M, Martínez-Guillamon C, Olivera-Salguero R, Peña R, Frías CP, Calderón I, Atanassov BS, Dent SYR, Arribas J, García de Herreros A, Díaz VM.

Cancer Res. 2019 Jan 1;79(1):33-46. doi: 10.1158/0008-5472.CAN-18-0753. Epub 2018 Oct 19.


Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1.

Herrera A, Herrera M, Guerra-Perez N, Galindo-Pumariño C, Larriba MJ, García-Barberán V, Gil B, Giménez-Moyano S, Ferreiro-Monteagudo R, Veguillas P, Candia A, Peña R, Pinto J, García-Bermejo ML, Muñoz A, García de Herreros A, Bonilla F, Carrato A, Peña C.

Oncogenesis. 2018 Sep 24;7(9):76. doi: 10.1038/s41389-018-0085-z.


CK1ε and p120-catenin control Ror2 function in noncanonical Wnt signaling.

Curto J, Del Valle-Pérez B, Villarroel A, Fuertes G, Vinyoles M, Peña R, García de Herreros A, Duñach M.

Mol Oncol. 2018 May;12(5):611-629. doi: 10.1002/1878-0261.12184. Epub 2018 Mar 14.


Snail1 transcription factor controls telomere transcription and integrity.

Mazzolini R, Gonzàlez N, Garcia-Garijo A, Millanes-Romero A, Peiró S, Smith S, García de Herreros A, Canudas S.

Nucleic Acids Res. 2018 Jan 9;46(1):146-158. doi: 10.1093/nar/gkx958.


p120-catenin in canonical Wnt signaling.

Duñach M, Del Valle-Pérez B, García de Herreros A.

Crit Rev Biochem Mol Biol. 2017 Jun;52(3):327-339. doi: 10.1080/10409238.2017.1295920. Epub 2017 Mar 3. Review.


β-Catenin and plakoglobin N- and C-tails determine ligand specificity.

Solanas G, Miravet S, Casagolda D, Castaño J, Raurell I, Corrionero A, García de Herreros A, Duñach M.

J Biol Chem. 2016 Nov 11;291(46):23925-23927. No abstract available.


Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis.

Alba-Castellón L, Olivera-Salguero R, Mestre-Farrera A, Peña R, Herrera M, Bonilla F, Casal JI, Baulida J, Peña C, García de Herreros A.

Cancer Res. 2016 Nov 1;76(21):6205-6217. Epub 2016 Aug 8.


Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.

Herranz N, Dave N, Millanes-Romero A, Pascual-Reguant L, Morey L, Díaz VM, Lórenz-Fonfría V, Gutierrez-Gallego R, Jerónimo C, Iturbide A, Di Croce L, García de Herreros A, Peiró S.

FEBS J. 2016 Dec;283(23):4263-4273. doi: 10.1111/febs.13922. Epub 2016 Oct 30.


The transcriptional factor Tcf-4 contains different binding sites for β-catenin and plakoglobin.

Miravet S, Piedra J, Miró F, Itarte E, García de Herreros A, Duñach M.

J Biol Chem. 2016 Sep 2;291(36):18854. doi: 10.1074/jbc.A116.110248. No abstract available.


Retraction Notice to: Lysyl Oxidase-like 2 Deaminates Lysine 4 in Histone H3.

Herranz N, Dave N, Millanes-Romero A, Morey L, Díaz VM, Lórenz-Fonfría V, Gutierrez-Gallego R, Jerónimo C, Di Croce L, García de Herreros A, Peiró S.

Mol Cell. 2016 Jul 7;63(1):180. doi: 10.1016/j.molcel.2016.06.013. No abstract available.


Antisense non-coding RNAs and regulation of gene transcription.

Beltran M, García de Herreros A.

Transcription. 2016 Mar 14;7(2):39-43. doi: 10.1080/21541264.2016.1148804. Epub 2016 Mar 17.


Wnt controls the transcriptional activity of Kaiso through CK1ε-dependent phosphorylation of p120-catenin.

del Valle-Pérez B, Casagolda D, Lugilde E, Valls G, Codina M, Dave N, García de Herreros A, Duñach M.

J Cell Sci. 2016 Feb 15;129(4):873. doi: 10.1242/jcs.186288. No abstract available.


Vitamin D and the Epithelial to Mesenchymal Transition.

Larriba MJ, García de Herreros A, Muñoz A.

Stem Cells Int. 2016;2016:6213872. doi: 10.1155/2016/6213872. Epub 2016 Jan 6. Review.


Snail1 is required for the maintenance of the pancreatic acinar phenotype.

Loubat-Casanovas J, Peña R, Gonzàlez N, Alba-Castellón L, Rosell S, Francí C, Navarro P, García de Herreros A.

Oncotarget. 2016 Jan 26;7(4):4468-82. doi: 10.18632/oncotarget.6785.


A Switch in Akt Isoforms Is Required for Notch-Induced Snail1 Expression and Protection from Cell Death.

Frías A, Lambies G, Viñas-Castells R, Martínez-Guillamon C, Dave N, García de Herreros A, Díaz VM.

Mol Cell Biol. 2015 Dec 28;36(6):923-40. doi: 10.1128/MCB.01074-15.


Data from proteomic characterization of the role of Snail1 in murine mesenchymal stem cells and 3T3-L1 fibroblasts differentiation.

Peláez-García A, Barderas R, Mendes M, Lopez-Lucendo M, Sanchez JC, García de Herreros A, Casal JI.

Data Brief. 2015 Jul 31;4:606-13. doi: 10.1016/j.dib.2015.07.027. eCollection 2015 Sep.


LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival.

Torres S, Garcia-Palmero I, Herrera M, Bartolomé RA, Peña C, Fernandez-Aceñero MJ, Padilla G, Peláez-García A, Lopez-Lucendo M, Rodriguez-Merlo R, García de Herreros A, Bonilla F, Casal JI.

Clin Cancer Res. 2015 Nov 1;21(21):4892-902. doi: 10.1158/1078-0432.CCR-14-3096. Epub 2015 Jul 23.


Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.

Baulida J, García de Herreros A.

Biochim Biophys Acta. 2015 Aug;1856(1):55-61. doi: 10.1016/j.bbcan.2015.05.005. Epub 2015 Jun 4. Review.


LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation.

Iturbide A, Pascual-Reguant L, Fargas L, Cebrià JP, Alsina B, García de Herreros A, Peiró S.

Mol Cell. 2015 Jun 4;58(5):755-66. doi: 10.1016/j.molcel.2015.04.012. Epub 2015 May 7.


Epithelial to mesenchymal transition in tumor cells as consequence of phenotypic instability.

García de Herreros A.

Front Cell Dev Biol. 2014 Dec 12;2:71. doi: 10.3389/fcell.2014.00071. eCollection 2014.


A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and interleukin 17 (IL-17) to inhibit adipocyte differentiation.

Peláez-García A, Barderas R, Batlle R, Viñas-Castells R, Bartolomé RA, Torres S, Mendes M, Lopez-Lucendo M, Mazzolini R, Bonilla F, García de Herreros A, Casal JI.

Mol Cell Proteomics. 2015 Feb;14(2):303-15. doi: 10.1074/mcp.M114.045328. Epub 2014 Dec 10.


Snail1-expressing fibroblasts in the tumor microenvironment display mechanical properties that support metastasis.

Stanisavljevic J, Loubat-Casanovas J, Herrera M, Luque T, Peña R, Lluch A, Albanell J, Bonilla F, Rovira A, Peña C, Navajas D, Rojo F, García de Herreros A, Baulida J.

Cancer Res. 2015 Jan 15;75(2):284-95. doi: 10.1158/0008-5472.CAN-14-1903. Epub 2014 Dec 8.


Invasive cells follow Snail's slow and persistent pace.

García de Herreros A, Moustakas A.

Cell Cycle. 2014;13(15):2320-1. doi: 10.4161/cc.29831. No abstract available.


Regulation of the protein stability of EMT transcription factors.

Díaz VM, Viñas-Castells R, García de Herreros A.

Cell Adh Migr. 2014;8(4):418-28. doi: 10.4161/19336918.2014.969998. Review.


A new role for LOX and LOXL2 proteins in transcription regulation.

Iturbide A, García de Herreros A, Peiró S.

FEBS J. 2015 May;282(9):1768-73. doi: 10.1111/febs.12961. Epub 2014 Sep 6. Review.


Epithelial-to-mesenchymal transition in penile squamous cell carcinoma.

Masferrer E, Ferrándiz-Pulido C, Masferrer-Niubò M, Rodríguez-Rodríguez A, Gil I, Pont A, Servitje O, García de Herreros A, Lloveras B, García-Patos V, Pujol RM, Toll A, Hernández-Muñoz I.

J Urol. 2015 Feb;193(2):699-705. doi: 10.1016/j.juro.2014.07.083. Epub 2014 Jul 22.


Snail1 expression is required for sarcomagenesis.

Alba-Castellón L, Batlle R, Francí C, Fernández-Aceñero MJ, Mazzolini R, Peña R, Loubat J, Alameda F, Rodríguez R, Curto J, Albanell J, Muñoz A, Bonilla F, Ignacio Casal J, Rojo F, García de Herreros A.

Neoplasia. 2014 May;16(5):413-21. doi: 10.1016/j.neo.2014.05.002. Epub 2014 Jun 16.


Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.

Vinyoles M, Del Valle-Pérez B, Curto J, Viñas-Castells R, Alba-Castellón L, García de Herreros A, Duñach M.

Mol Cell. 2014 Feb 6;53(3):444-57. doi: 10.1016/j.molcel.2013.12.010. Epub 2014 Jan 9.


Targeting epithelial-to-mesenchymal transition with Met inhibitors reverts chemoresistance in small cell lung cancer.

Cañadas I, Rojo F, Taus Á, Arpí O, Arumí-Uría M, Pijuan L, Menéndez S, Zazo S, Dómine M, Salido M, Mojal S, García de Herreros A, Rovira A, Albanell J, Arriola E.

Clin Cancer Res. 2014 Feb 15;20(4):938-50. doi: 10.1158/1078-0432.CCR-13-1330. Epub 2013 Nov 27.


Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition.

Millanes-Romero A, Herranz N, Perrera V, Iturbide A, Loubat-Casanovas J, Gil J, Jenuwein T, García de Herreros A, Peiró S.

Mol Cell. 2013 Dec 12;52(5):746-57. doi: 10.1016/j.molcel.2013.10.015. Epub 2013 Nov 14.


Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability.

Viñas-Castells R, Frías Á, Robles-Lanuza E, Zhang K, Longmore GD, García de Herreros A, Díaz VM.

Nucleic Acids Res. 2014 Jan;42(2):1079-94. doi: 10.1093/nar/gkt935. Epub 2013 Oct 23.


Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients.

Herrera M, Herrera A, Domínguez G, Silva J, García V, García JM, Gómez I, Soldevilla B, Muñoz C, Provencio M, Campos-Martin Y, García de Herreros A, Casal I, Bonilla F, Peña C.

Cancer Sci. 2013 Apr;104(4):437-44. doi: 10.1111/cas.12096. Epub 2013 Feb 21.


Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin.

Valls G, Codina M, Miller RK, Del Valle-Pérez B, Vinyoles M, Caelles C, McCrea PD, García de Herreros A, Duñach M.

J Cell Sci. 2012 Nov 15;125(Pt 22):5288-301. doi: 10.1242/jcs.101030. Epub 2012 Sep 3. Erratum in: J Cell Sci. 2016 May 15;129(10 ):2120-3.


Snail1 controls TGF-β responsiveness and differentiation of mesenchymal stem cells.

Batlle R, Alba-Castellón L, Loubat-Casanovas J, Armenteros E, Francí C, Stanisavljevic J, Banderas R, Martin-Caballero J, Bonilla F, Baulida J, Casal JI, Gridley T, García de Herreros A.

Oncogene. 2013 Jul 11;32(28):3381-9. doi: 10.1038/onc.2012.342. Epub 2012 Aug 6.


Lysyl oxidase-like 2 deaminates lysine 4 in histone H3.

Herranz N, Dave N, Millanes-Romero A, Morey L, Díaz VM, Lórenz-Fonfría V, Gutierrez-Gallego R, Jerónimo C, Di Croce L, García de Herreros A, Peiró S.

Mol Cell. 2012 May 11;46(3):369-76. doi: 10.1016/j.molcel.2012.03.002. Epub 2012 Apr 5. Retraction in: Mol Cell. 2016 Jul 7;63(1):180.


Cooperation, amplification, and feed-back in epithelial-mesenchymal transition.

García de Herreros A, Baulida J.

Biochim Biophys Acta. 2012 Apr;1825(2):223-8. doi: 10.1016/j.bbcan.2012.01.003. Epub 2012 Jan 28. Review.


Akt2 interacts with Snail1 in the E-cadherin promoter.

Villagrasa P, Díaz VM, Viñas-Castells R, Peiró S, Del Valle-Pérez B, Dave N, Rodríguez-Asiain A, Casal JI, Lizcano JM, Duñach M, García de Herreros A.

Oncogene. 2012 Sep 6;31(36):4022-33. doi: 10.1038/onc.2011.562. Epub 2011 Dec 12.


TWIST1 is expressed in colorectal carcinomas and predicts patient survival.

Gomez I, Peña C, Herrera M, Muñoz C, Larriba MJ, Garcia V, Dominguez G, Silva J, Rodriguez R, Garcia de Herreros A, Bonilla F, Garcia JM.

PLoS One. 2011 Mar 28;6(3):e18023. doi: 10.1371/journal.pone.0018023.


TFCP2c/LSF/LBP-1c is required for Snail1-induced fibronectin gene expression.

Porta-de-la-Riva M, Stanisavljevic J, Curto J, Francí C, Díaz VM, García de Herreros A, Baulida J.

Biochem J. 2011 May 1;435(3):563-8. doi: 10.1042/BJ20102057.


Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes.

Fuxe J, Vincent T, Garcia de Herreros A.

Cell Cycle. 2010 Jun 15;9(12):2363-74. Epub 2010 Jun 15. Review.


Novel snail1 target proteins in human colon cancer identified by proteomic analysis.

Larriba MJ, Casado-Vela J, Pendás-Franco N, Peña R, García de Herreros A, Berciano MT, Lafarga M, Casal JI, Muñoz A.

PLoS One. 2010 Apr 20;5(4):e10221. doi: 10.1371/journal.pone.0010221.


Snail1 protein in the stroma as a new putative prognosis marker for colon tumours.

Francí C, Gallén M, Alameda F, Baró T, Iglesias M, Virtanen I, García de Herreros A.

PLoS One. 2009;4(5):e5595. doi: 10.1371/journal.pone.0005595. Epub 2009 May 18.


Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs.

Rowe RG, Li XY, Hu Y, Saunders TL, Virtanen I, Garcia de Herreros A, Becker KF, Ingvarsen S, Engelholm LH, Bommer GT, Fearon ER, Weiss SJ.

J Cell Biol. 2009 Feb 9;184(3):399-408. doi: 10.1083/jcb.200810113. Epub 2009 Feb 2.


Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression.

Wanami LS, Chen HY, Peiró S, García de Herreros A, Bachelder RE.

Exp Cell Res. 2008 Aug 1;314(13):2448-53. doi: 10.1016/j.yexcr.2008.05.004. Epub 2008 May 17.


Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.

Herranz N, Pasini D, Díaz VM, Francí C, Gutierrez A, Dave N, Escrivà M, Hernandez-Muñoz I, Di Croce L, Helin K, García de Herreros A, Peiró S.

Mol Cell Biol. 2008 Aug;28(15):4772-81. doi: 10.1128/MCB.00323-08. Epub 2008 Jun 2.


Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.

Takkunen M, Ainola M, Vainionpää N, Grenman R, Patarroyo M, García de Herreros A, Konttinen YT, Virtanen I.

Histochem Cell Biol. 2008 Sep;130(3):509-25. doi: 10.1007/s00418-008-0443-6. Epub 2008 May 22.


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