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Search for a Light Charged Higgs Boson Decaying to a W Boson and a CP-Odd Higgs Boson in Final States with eμμ or μμμ in Proton-Proton Collisions at sqrt[s]=13  TeV.

Sirunyan AM, Tumasyan A, Adam W, Ambrogi F, Bergauer T, Brandstetter J, Dragicevic M, Erö J, Escalante Del Valle A, Flechl M, Frühwirth R, Jeitler M, Krammer N, Krätschmer I, Liko D, Madlener T, Mikulec I, Rad N, Schieck J, Schöfbeck R, Spanring M, Spitzbart D, Waltenberger W, Wittmann J, Wulz CE, Zarucki M, Drugakov V, Mossolov V, Suarez Gonzalez J, Darwish MR, De Wolf EA, Di Croce D, Janssen X, Lauwers J, Lelek A, Pieters M, Van Haevermaet H, Van Mechelen P, Van Putte S, Van Remortel N, Blekman F, Bols ES, Chhibra SS, D'Hondt J, De Clercq J, Flouris G, Lontkovskyi D, Lowette S, Marchesini I, Moortgat S, Moreels L, Python Q, Skovpen K, Tavernier S, Van Doninck W, Van Mulders P, Van Parijs I, Beghin D, Bilin B, Brun H, Clerbaux B, De Lentdecker G, Delannoy H, Dorney B, Favart L, Grebenyuk A, Kalsi AK, Luetic J, Popov A, Postiau N, Starling E, Thomas L, Vander Velde C, Vanlaer P, Vannerom D, Wang Q, Cornelis T, Dobur D, Khvastunov I, Roskas C, Trocino D, Tytgat M, Verbeke W, Vermassen B, Vit M, Zaganidis N, Bondu O, Bruno G, Caputo C, David P, Delaere C, Delcourt M, Giammanco A, Krintiras G, Lemaitre V, Magitteri A, Piotrzkowski K, Prisciandaro J, Saggio A, Vidal Marono M, Vischia P, Zobec J, Alves FL, Alves GA, Correia Silva G, Hensel C, Moraes A, Rebello Teles P, Belchior Batista Das Chagas E, Carvalho W, Chinellato J, Coelho E, Da Costa EM, Da Silveira GG, De Jesus Damiao D, De Oliveira Martins C, Fonseca De Souza S, Huertas Guativa LM, Malbouisson H, Martins J, Matos Figueiredo D, Medina Jaime M, Melo De Almeida M, Mora Herrera C, Mundim L, Nogima H, Prado Da Silva WL, Sanchez Rosas LJ, Santoro A, Sznajder A, Thiel M, Tonelli Manganote EJ, Torres Da Silva De Araujo F, Vilela Pereira A, Ahuja S, Bernardes CA, Calligaris L, De Souza Lemos D, Tomei TRFP, Gregores EM, Mercadante PG, Novaes SF, Padula SS, Aleksandrov A, Antchev G, Hadjiiska R, Iaydjiev P, Marinov A, Misheva M, Rodozov M, Shopova M, Sultanov G, Dimitrov A, Litov L, Pavlov B, Petkov P, Fang W, Gao X, Yuan L, Ahmad M, Chen GM, Chen HS, Chen M, Jiang CH, Leggat D, Liao H, Liu Z, Shaheen SM, Spiezia A, Tao J, Yazgan E, Zhang H, Zhang S, Zhao J, Agapitos A, Ban Y, Chen G, Levin A, Li J, Li L, Li Q, Mao Y, Qian SJ, Wang D, Wang Y, Avila C, Cabrera A, Chaparro Sierra LF, Florez C, González Hernández CF, Segura Delgado MA, Ruiz Alvarez JD, Giljanović D, Godinovic N, Lelas D, Puljak I, Sculac T, Antunovic Z, Kovac M, Brigljevic V, Ceci S, Ferencek D, Kadija K, Mesic B, Roguljic M, Starodumov A, Susa T, Ather MW, Attikis A, Erodotou E, Ioannou A, Kolosova M, Konstantinou S, Mavromanolakis G, Mousa J, Nicolaou C, Ptochos F, Razis PA, Rykaczewski H, Tsiakkouri D, Finger M, Finger M, Kveton A, Tomsa J, Ayala E, Carrera Jarrin E, Assran Y, Elgammal S, Bhowmik S, Carvalho Antunes De Oliveira A, Dewanjee RK, Ehataht K, Kadastik M, Raidal M, Veelken C, Eerola P, Forthomme L, Kirschenmann H, Osterberg K, Pekkanen J, Voutilainen M, Garcia F, Havukainen J, Heikkilä JK, Järvinen T, Karimäki V, Kinnunen R, Lampén T, Lassila-Perini K, Laurila S, Lehti S, Lindén T, Luukka P, Mäenpää T, Siikonen H, Tuominen E, Tuominiemi J, Tuuva T, Besancon M, Couderc F, Dejardin M, Denegri D, Fabbro B, Faure JL, Ferri F, Ganjour S, Givernaud A, Gras P, Hamel de Monchenault G, Jarry P, Leloup C, Locci E, Malcles J, Rander J, Rosowsky A, Sahin MÖ, Savoy-Navarro A, Titov M, Amendola C, Beaudette F, Busson P, Charlot C, Diab B, Granier de Cassagnac R, Kucher I, Lobanov A, Martin Perez C, Nguyen M, Ochando C, Paganini P, Rembser J, Salerno R, Sauvan JB, Sirois Y, Zabi A, Zghiche A, Agram JL, Andrea J, Bloch D, Bourgatte G, Brom JM, Chabert EC, Collard C, Conte E, Fontaine JC, Gelé D, Goerlach U, Jansová M, Le Bihan AC, Tonon N, Van Hove P, Gadrat S, Beauceron S, Bernet C, Boudoul G, Camen C, Chanon N, Chierici R, Contardo D, Depasse P, El Mamouni H, Fay J, Gascon S, Gouzevitch M, Ille B, Jain S, Lagarde F, Laktineh IB, Lattaud H, Lethuillier M, Mirabito L, Perries S, Sordini V, Touquet G, Vander Donckt M, Viret S, Khvedelidze A, Tsamalaidze Z, Autermann C, Feld L, Kiesel MK, Klein K, Lipinski M, Meuser D, Pauls A, Preuten M, Rauch MP, Schomakers C, Schulz J, Teroerde M, Wittmer B, Albert A, Erdmann M, Erdweg S, Esch T, Fischer B, Fischer R, Ghosh S, Hebbeker T, Hoepfner K, Keller H, Mastrolorenzo L, Merschmeyer M, Meyer A, Millet P, Mocellin G, Mondal S, Mukherjee S, Noll D, Novak A, Pook T, Pozdnyakov A, Quast T, Radziej M, Rath Y, Reithler H, Rieger M, Schmidt A, Schuler SC, Sharma A, Thüer S, Wiedenbeck S, Flügge G, Hlushchenko O, Kress T, Müller T, Nehrkorn A, Nowack A, Pistone C, Pooth O, Roy D, Sert H, Stahl A, Aldaya Martin M, Asawatangtrakuldee C, Asmuss P, Babounikau I, Bakhshiansohi H, Beernaert K, Behnke O, Behrens U, Bermúdez Martínez A, Bertsche D, Bin Anuar AA, Borras K, Botta V, Campbell A, Cardini A, Connor P, Consuegra Rodríguez S, Contreras-Campana C, Danilov V, De Wit A, Defranchis MM, Diez Pardos C, Domínguez Damiani D, Eckerlin G, Eckstein D, Eichhorn T, Elwood A, Eren E, Gallo E, Geiser A, Grados Luyando JM, Grohsjean A, Guthoff M, Haranko M, Harb A, Jomhari NZ, Jung H, Kasem A, Kasemann M, Keaveney J, Kleinwort C, Knolle J, Krücker D, Lange W, Lenz T, Leonard J, Lidrych J, Lipka K, Lohmann W, Mankel R, Melzer-Pellmann IA, Meyer AB, Meyer M, Missiroli M, Mittag G, Mnich J, Mussgiller A, Myronenko V, Pérez Adán D, Pflitsch SK, Pitzl D, Raspereza A, Saibel A, Savitskyi M, Scheurer V, Schütze P, Schwanenberger C, Shevchenko R, Singh A, Tholen H, Turkot O, Vagnerini A, Van De Klundert M, Van Onsem GP, Walsh R, Wen Y, Wichmann K, Wissing C, Zenaiev O, Zlebcik R, Aggleton R, Bein S, Benato L, Benecke A, Blobel V, Dreyer T, Ebrahimi A, Fröhlich A, Garbers C, Garutti E, Gonzalez D, Gunnellini P, Haller J, Hinzmann A, Karavdina A, Kasieczka G, Klanner R, Kogler R, Kovalchuk N, Kurz S, Kutzner V, Lange J, Lange T, Malara A, Marconi D, Multhaup J, Niedziela M, Niemeyer CEN, Nowatschin D, Perieanu A, Reimers A, Rieger O, Scharf C, Schleper P, Schumann S, Schwandt J, Sonneveld J, Stadie H, Steinbrück G, Stober FM, Stöver M, Vormwald B, Zoi I, Akbiyik M, Barth C, Baselga M, Baur S, Berger T, Butz E, Caspart R, Chwalek T, De Boer W, Dierlamm A, El Morabit K, Faltermann N, Giffels M, Goldenzweig P, Harrendorf MA, Hartmann F, Husemann U, Kudella S, Mitra S, Mozer MU, Müller T, Musich M, Nürnberg A, Quast G, Rabbertz K, Schröder M, Shvetsov I, Simonis HJ, Ulrich R, Weber M, Wöhrmann C, Wolf R, Anagnostou G, Asenov P, Daskalakis G, Geralis T, Kyriakis A, Loukas D, Paspalaki G, Diamantopoulou M, Karathanasis G, Kontaxakis P, Panagiotou A, Papavergou I, Saoulidou N, Theofilatos K, Vellidis K, Bakas G, Kousouris K, Papakrivopoulos I, Tsipolitis G, Evangelou I, Foudas C, Gianneios P, Katsoulis P, Kokkas P, Mallios S, Manitara K, Manthos N, Papadopoulos I, Paradas E, Strologas J, Triantis FA, Tsitsonis D, Bartók M, Csanad M, Major P, Mandal K, Mehta A, Nagy MI, Pasztor G, Surányi O, Veres GI, Bencze G, Hajdu C, Horvath D, Hunyadi Á, 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C, Cappati A, Cartiglia N, Cenna F, Cometti S, Costa M, Covarelli R, Demaria N, Kiani B, Mariotti C, Maselli S, Migliore E, Monaco V, Monteil E, Monteno M, Obertino MM, Pacher L, Pastrone N, Pelliccioni M, Pinna Angioni GL, Romero A, Ruspa M, Sacchi R, Salvatico R, Shchelina K, Sola V, Solano A, Soldi D, Staiano A, Belforte S, Candelise V, Casarsa M, Cossutti F, Da Rold A, Della Ricca G, Vazzoler F, Zanetti A, Kim B, Kim DH, Kim GN, Kim MS, Lee J, Lee SW, Moon CS, Oh YD, Pak SI, Sekmen S, Son DC, Yang YC, Kim H, Moon DH, Oh G, Francois B, Kim TJ, Park J, Cho S, Choi S, Go Y, Gyun D, Ha S, Hong B, Jo Y, Lee K, Lee KS, Lee S, Lim J, Park J, Park SK, Roh Y, Goh J, Kim HS, Almond J, Bhyun JH, Choi J, Jeon S, Kim J, Kim JS, Lee H, Lee K, Lee S, Nam K, Oh SB, Radburn-Smith BC, Seo SH, Yang UK, Yoo HD, Yoon I, Yu GB, Jeon D, Kim H, Kim JH, Lee JSH, Park IC, Watson I, Choi Y, Hwang C, Jeong Y, Lee J, Lee Y, Yu I, Veckalns V, Dudenas V, Juodagalvis A, Vaitkus J, Ibrahim ZA, Mohamad Idris F, Wan 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Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma.

Lokau J, Schoeder V, Haybaeck J, Garbers C.

Cancers (Basel). 2019 Nov 1;11(11). pii: E1704. doi: 10.3390/cancers11111704. Review.

3.

Treatment of type 2 diabetes with the designer cytokine IC7Fc.

Findeisen M, Allen TL, Henstridge DC, Kammoun H, Brandon AE, Baggio LL, Watt KI, Pal M, Cron L, Estevez E, Yang C, Kowalski GM, O'Reilly L, Egan C, Sun E, Thai LM, Krippner G, Adams TE, Lee RS, Grötzinger J, Garbers C, Risis S, Kraakman MJ, Mellet NA, Sligar J, Kimber ET, Young RL, Cowley MA, Bruce CR, Meikle PJ, Baldock PA, Gregorevic P, Biden TJ, Cooney GJ, Keating DJ, Drucker DJ, Rose-John S, Febbraio MA.

Nature. 2019 Oct;574(7776):63-68. doi: 10.1038/s41586-019-1601-9. Epub 2019 Sep 25.

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The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients.

Dos Santos Guilherme M, Stoye NM, Rose-John S, Garbers C, Fellgiebel A, Endres K.

Front Aging Neurosci. 2019 Jul 23;11:182. doi: 10.3389/fnagi.2019.00182. eCollection 2019.

5.

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.

Sammel M, Peters F, Lokau J, Scharfenberg F, Werny L, Linder S, Garbers C, Rose-John S, Becker-Pauly C.

Int J Mol Sci. 2019 Jul 26;20(15). pii: E3677. doi: 10.3390/ijms20153677.

6.

The IL-6-neutralizing sIL-6R-sgp130 buffer system is disturbed in patients with type 2 diabetes.

Aparicio-Siegmund S, Garbers Y, Flynn CM, Waetzig GH, Gouni-Berthold I, Krone W, Berthold HK, Laudes M, Rose-John S, Garbers C.

Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E411-E420. doi: 10.1152/ajpendo.00166.2019. Epub 2019 Jun 25.

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31237452
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Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling.

Flynn CM, Garbers Y, Lokau J, Wesch D, Schulte DM, Laudes M, Lieb W, Aparicio-Siegmund S, Garbers C.

Sci Rep. 2019 May 13;9(1):7306. doi: 10.1038/s41598-019-43617-5.

8.

Activating mutations of the gp130/JAK/STAT pathway in human diseases.

Lokau J, Garbers C.

Adv Protein Chem Struct Biol. 2019;116:283-309. doi: 10.1016/bs.apcsb.2018.11.007. Epub 2018 Dec 27.

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Observation of Two Excited B_{c}^{+} States and Measurement of the B_{c}^{+}(2S) Mass in pp Collisions at sqrt[s]=13  TeV.

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Cooperstein S, Dezoort G, Elmer P, Haubrich N, Higginbotham S, Kalogeropoulos A, Kwan S, Lange D, Lucchini MT, Luo J, Marlow D, Mei K, Ojalvo I, Olsen J, Palmer C, Piroué P, Salfeld-Nebgen J, Stickland D, Tully C, Wang Z, Malik S, Norberg S, Barker A, Barnes VE, Das S, Gutay L, Jones M, Jung AW, Khatiwada A, Mahakud B, Miller DH, Negro G, Neumeister N, Peng CC, Piperov S, Qiu H, Schulte JF, Sun J, Wang F, Xiao R, Xie W, Cheng T, Dolen J, Parashar N, Ecklund KM, Freed S, Geurts FJM, Kilpatrick M, Kumar A, Li W, Padley BP, Redjimi R, Roberts J, Rorie J, Shi W, Stahl Leiton AG, Tu Z, Zhang A, Bodek A, de Barbaro P, Demina R, Duh YT, Dulemba JL, Fallon C, Ferbel T, Galanti M, Garcia-Bellido A, Han J, Hindrichs O, Khukhunaishvili A, Ranken E, Tan P, Taus R, Chiarito B, Chou JP, Gershtein Y, Halkiadakis E, Hart A, Heindl M, Hughes E, Kaplan S, Kyriacou S, Laflotte I, Lath A, Montalvo R, Nash K, Osherson M, Saka H, Salur S, Schnetzer S, Sheffield D, Somalwar S, Stone R, Thomas S, Thomassen P, Acharya H, Delannoy AG, Heideman J, Riley G, Spanier S, Bouhali O, Celik A, Dalchenko M, De Mattia M, Delgado A, Dildick S, Eusebi R, Gilmore J, Huang T, Kamon T, Luo S, Marley D, Mueller R, Overton D, Perniè L, Rathjens D, Safonov A, Akchurin N, Damgov J, De Guio F, Kunori S, Lamichhane K, Lee SW, Mengke T, Muthumuni S, Peltola T, Undleeb S, Volobouev I, Wang Z, Whitbeck A, Greene S, Gurrola A, Janjam R, Johns W, Maguire C, Ni H, Romeo F, Sheldon P, Tuo S, Velkovska J, Verweij M, Arenton MW, Barria P, Cox B, Cummings G, Hirosky R, Joyce M, Ledovskoy A, Neu C, Tannenwald B, Wang Y, Wolfe E, Xia F, Harr R, Karchin PE, Poudyal N, Sturdy J, Thapa P, Zaleski S, Buchanan J, Caillol C, Carlsmith D, Dasu S, De Bruyn I, Dodd L, Gomber B, Grothe M, Herndon M, Hervé A, Hussain U, Klabbers P, Lanaro A, Long K, Loveless R, Ruggles T, Savin A, Sharma V, Smith WH, Woods N; CMS Collaboration.

Phys Rev Lett. 2019 Apr 5;122(13):132001. doi: 10.1103/PhysRevLett.122.132001.

PMID:
31012626
10.

The metalloprotease ADAM17 in inflammation and cancer.

Düsterhöft S, Lokau J, Garbers C.

Pathol Res Pract. 2019 Jun;215(6):152410. doi: 10.1016/j.prp.2019.04.002. Epub 2019 Apr 6. Review.

PMID:
30992230
11.

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.

Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.

EMBO Mol Med. 2019 Apr;11(4). pii: e9976. doi: 10.15252/emmm.201809976.

12.

Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage.

Prenissl N, Lokau J, Rose-John S, Haybaeck J, Garbers C.

Cytokine. 2019 Feb;114:1-5. doi: 10.1016/j.cyto.2018.11.023. Epub 2018 Dec 14.

13.

Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival.

Kleinegger F, Hofer E, Wodlej C, Golob-Schwarzl N, Birkl-Toeglhofer AM, Stallinger A, Petzold J, Orlova A, Krassnig S, Reihs R, Niedrist T, Mangge H, Park YN, Thalhammer M, Aigelsreiter A, Lax S, Garbers C, Fickert P, Rose-John S, Moriggl R, Rinner B, Haybaeck J.

Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):308-321. doi: 10.1016/j.bbadis.2018.11.006. Epub 2018 Nov 9.

14.

Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.

Agthe M, Brügge J, Garbers Y, Wandel M, Kespohl B, Arnold P, Flynn CM, Lokau J, Aparicio-Siegmund S, Bretscher C, Rose-John S, Waetzig GH, Putoczki T, Grötzinger J, Garbers C.

Cell Rep. 2018 Oct 2;25(1):10-18.e5. doi: 10.1016/j.celrep.2018.09.005.

15.

Interleukin-6: designing specific therapeutics for a complex cytokine.

Garbers C, Heink S, Korn T, Rose-John S.

Nat Rev Drug Discov. 2018 Jun;17(6):395-412. doi: 10.1038/nrd.2018.45. Epub 2018 May 4. Review.

PMID:
29725131
16.

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment.

Wunderlich CM, Ackermann PJ, Ostermann AL, Adams-Quack P, Vogt MC, Tran ML, Nikolajev A, Waisman A, Garbers C, Theurich S, Mauer J, Hövelmeyer N, Wunderlich FT.

Nat Commun. 2018 Apr 25;9(1):1646. doi: 10.1038/s41467-018-03773-0.

17.

Two N-Linked Glycans Differentially Control Maturation, Trafficking and Proteolysis, but not Activity of the IL-11 Receptor.

Agthe M, Garbers Y, Grötzinger J, Garbers C.

Cell Physiol Biochem. 2018;45(5):2071-2085. doi: 10.1159/000488044. Epub 2018 Mar 7.

18.

The length of the interleukin-11 receptor stalk determines its capacity for classic signaling.

Lokau J, Garbers C.

J Biol Chem. 2018 Apr 27;293(17):6398-6409. doi: 10.1074/jbc.RA118.001879. Epub 2018 Mar 9.

19.

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.

Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.

J Exp Med. 2018 Apr 2;215(4):1205-1225. doi: 10.1084/jem.20171696. Epub 2018 Feb 22.

20.

Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer.

Garbers C, Rose-John S.

Methods Mol Biol. 2018;1725:127-140. doi: 10.1007/978-1-4939-7568-6_11.

PMID:
29322414
21.

Measurement of the top quark mass with lepton+jets final states using p p collisions at s = 13 TeV.

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F, Harr R, Karchin PE, Poudyal N, Sturdy J, Thapa P, Zaleski S, Brodski M, Buchanan J, Caillol C, Carlsmith D, Dasu S, Dodd L, Duric S, Gomber B, Grothe M, Herndon M, Hervé A, Hussain U, Klabbers P, Lanaro A, Levine A, Long K, Loveless R, Rekovic V, Ruggles T, Savin A, Smith N, Smith WH, Woods N; CMS Collaboration.

Eur Phys J C Part Fields. 2018;78(11):891. doi: 10.1140/epjc/s10052-018-6332-9. Epub 2018 Nov 2.

22.

The SNP rs4252548 (R112H) which is associated with reduced human height compromises the stability of IL-11.

Lokau J, Göttert S, Arnold P, Düsterhöft S, Massa López D, Grötzinger J, Garbers C.

Biochim Biophys Acta Mol Cell Res. 2018 Mar;1865(3):496-506. doi: 10.1016/j.bbamcr.2017.12.003. Epub 2017 Dec 10.

23.

Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors.

Moll JM, Wehmöller M, Frank NC, Homey L, Baran P, Garbers C, Lamertz L, Axelrod JH, Galun E, Mootz HD, Scheller J.

ACS Synth Biol. 2017 Dec 15;6(12):2260-2272. doi: 10.1021/acssynbio.7b00208. Epub 2017 Nov 29.

PMID:
29136368
24.

Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling.

Dixit A, Bottek J, Beerlage AL, Schuettpelz J, Thiebes S, Brenzel A, Garbers C, Rose-John S, Mittrücker HW, Squire A, Engel DR.

J Leukoc Biol. 2018 Jan;103(1):13-22. doi: 10.1189/jlb.3HI0517-198R. Epub 2017 Dec 28.

PMID:
28882904
25.

Interleukin-11 classic but not trans-signaling is essential for fertility in mice.

Agthe M, Garbers Y, Putoczki T, Garbers C.

Placenta. 2017 Sep;57:13-16. doi: 10.1016/j.placenta.2017.05.015. Epub 2017 May 28.

PMID:
28864002
26.

Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.

Lokau J, Flynn CM, Garbers C.

Biochem Biophys Res Commun. 2017 Sep 16;491(2):296-302. doi: 10.1016/j.bbrc.2017.07.106. Epub 2017 Jul 20.

PMID:
28735867
27.

Proteolytic control of Interleukin-11 and Interleukin-6 biology.

Lokau J, Agthe M, Flynn CM, Garbers C.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2105-2117. doi: 10.1016/j.bbamcr.2017.06.008. Epub 2017 Jun 16. Review.

28.

The balance between Treg and TH17 cells: CD11b and interleukin-6.

Garbers C, Rose-John S.

Eur J Immunol. 2017 Apr;47(4):629-632. doi: 10.1002/eji.201746988.

29.

Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.

Nat Immunol. 2017 Mar 22;18(4):474. doi: 10.1038/ni0417-474b. No abstract available.

PMID:
28323263
30.

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.

Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.

31.

Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice.

Tode J, Richert E, Koinzer S, Klettner A, Pickhinke U, Garbers C, Rose-John S, Nölle B, Roider J.

Cytokine. 2017 Aug;96:8-15. doi: 10.1016/j.cyto.2017.02.023. Epub 2017 Mar 6.

PMID:
28267649
32.

Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.

Balic JJ, Garbers C, Rose-John S, Yu L, Jenkins BJ.

Cytokine. 2017 Apr;92:118-123. doi: 10.1016/j.cyto.2017.01.015. Epub 2017 Feb 1.

PMID:
28160627
33.

Trans-signaling of interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by soluble CD5.

Aparicio-Siegmund S, Deseke M, Lickert A, Garbers C.

Biochem Biophys Res Commun. 2017 Mar 18;484(4):808-812. doi: 10.1016/j.bbrc.2017.01.174. Epub 2017 Jan 31.

PMID:
28159554
34.

Enhancing Interleukin-6 and Interleukin-11 receptor cleavage.

Lokau J, Wandel M, Garbers C.

Int J Biochem Cell Biol. 2017 Apr;85:6-14. doi: 10.1016/j.biocel.2017.01.014. Epub 2017 Jan 29.

PMID:
28143719
35.

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.

PLoS Biol. 2017 Jan 6;15(1):e2000080. doi: 10.1371/journal.pbio.2000080. eCollection 2017 Jan.

36.

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose John S, Knolle PA, Wohlleber D.

J Hepatol. 2017 May;66(5):978-986. doi: 10.1016/j.jhep.2016.12.015. Epub 2016 Dec 23.

PMID:
28025060
37.

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.

Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28. Erratum in: Nat Immunol. 2017 Mar 22;18(4):474.

38.

Erratum: Control of ADAM17 activity by regulation of its cellular localisation.

Lorenzen I, Lokau J, Korpys Y, Oldefest M, Flynn CM, Künzel U, Garbers C, Freeman M, Grötzinger J, Düsterhöft S.

Sci Rep. 2016 Nov 21;6:37364. doi: 10.1038/srep37364. No abstract available.

39.

Control of ADAM17 activity by regulation of its cellular localisation.

Lorenzen I, Lokau J, Korpys Y, Oldefest M, Flynn CM, Künzel U, Garbers C, Freeman M, Grötzinger J, Düsterhöft S.

Sci Rep. 2016 Oct 12;6:35067. doi: 10.1038/srep35067. Erratum in: Sci Rep. 2016 Nov 21;6:37364.

40.

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.

Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C, Chalaris A, Rose-John S, Rabe B.

J Immunol. 2016 Nov 1;197(9):3705-3715. Epub 2016 Oct 3.

41.

Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation.

Lokau J, Agthe M, Garbers C.

Mediators Inflamm. 2016;2016:1785021. doi: 10.1155/2016/1785021. Epub 2016 Jul 14. Review.

42.

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor.

Monhasery N, Moll J, Cuman C, Franke M, Lamertz L, Nitz R, Görg B, Häussinger D, Lokau J, Floss DM, Piekorz R, Dimitriadis E, Garbers C, Scheller J.

Cell Rep. 2016 Jul 26;16(4):1067-1081. doi: 10.1016/j.celrep.2016.06.062. Epub 2016 Jul 14.

43.

Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.

Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, Alhayyani S, Tate MD, Deswaerte V, Brooks GD, Bozinovski S, MacDonald M, Garbers C, King PT, Bardin PG, Vlahos R, Rose-John S, Anderson GP, Jenkins BJ.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1494-1505.

PMID:
27373892
44.

Wavelength Discrimination in Drosophila Suggests a Role of Rhodopsin 1 in Color Vision.

Garbers C, Wachtler T.

PLoS One. 2016 Jun 3;11(6):e0155728. doi: 10.1371/journal.pone.0155728. eCollection 2016.

45.

Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling.

Wolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S, Garbers C.

J Biol Chem. 2016 Jul 29;291(31):16186-96. doi: 10.1074/jbc.M116.718551. Epub 2016 May 23.

46.

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

Riethmueller S, Ehlers JC, Lokau J, Düsterhöft S, Knittler K, Dombrowsky G, Grötzinger J, Rabe B, Rose-John S, Garbers C.

Sci Rep. 2016 May 6;6:25550. doi: 10.1038/srep25550.

47.

Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.

Franke M, Schröder J, Monhasery N, Ackfeld T, Hummel TM, Rabe B, Garbers C, Becker-Pauly C, Floss DM, Scheller J.

J Biol Chem. 2016 May 13;291(20):10551-61. doi: 10.1074/jbc.M115.710541. Epub 2016 Mar 9.

48.

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C.

Cell Rep. 2016 Feb 23;14(7):1761-1773. doi: 10.1016/j.celrep.2016.01.053. Epub 2016 Feb 11.

49.

A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.

Wolf J, Waetzig GH, Reinheimer TM, Scheller J, Rose-John S, Garbers C.

Biochem Biophys Res Commun. 2016 Feb 19;470(4):870-6. doi: 10.1016/j.bbrc.2016.01.127. Epub 2016 Jan 22.

PMID:
26809098
50.

Modular organization of Interleukin-6 and Interleukin-11 α-receptors.

Nitz R, Lokau J, Aparicio-Siegmund S, Scheller J, Garbers C.

Biochimie. 2015 Dec;119:175-82. doi: 10.1016/j.biochi.2015.11.005. Epub 2015 Nov 10.

PMID:
26551279

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