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Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?

Li F, Liu J, Liu N, Kuhn LA, Garavito RM, Ferguson-Miller S.

Biochemistry. 2016 May 24;55(20):2821-31. doi: 10.1021/acs.biochem.6b00142. Epub 2016 May 9.


Response to Comment on "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism".

Li F, Liu J, Zheng Y, Garavito RM, Ferguson-Miller S.

Science. 2015 Oct 30;350(6260):519. doi: 10.1126/science.aab2595. Epub 2015 Oct 29.


Evolving understanding of translocator protein 18 kDa (TSPO).

Li F, Liu J, Garavito RM, Ferguson-Miller S.

Pharmacol Res. 2015 Sep;99:404-9. doi: 10.1016/j.phrs.2015.03.022. Epub 2015 Apr 13. Review.


Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism.

Li F, Liu J, Zheng Y, Garavito RM, Ferguson-Miller S.

Science. 2015 Jan 30;347(6221):555-8. doi: 10.1126/science.1260590.


Structural characterization of a β-hydroxyacid dehydrogenase from Geobacter sulfurreducens and Geobacter metallireducens with succinic semialdehyde reductase activity.

Zhang Y, Zheng Y, Qin L, Wang S, Buchko GW, Garavito RM.

Biochimie. 2014 Sep;104:61-9. doi: 10.1016/j.biochi.2014.05.002. Epub 2014 May 27.


Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.

Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ.

J Biol Chem. 2014 Mar 7;289(10):6799-808. doi: 10.1074/jbc.M113.517987. Epub 2014 Jan 14.


Gene transfer from bacteria and archaea facilitated evolution of an extremophilic eukaryote.

Schönknecht G, Chen WH, Ternes CM, Barbier GG, Shrestha RP, Stanke M, Bräutigam A, Baker BJ, Banfield JF, Garavito RM, Carr K, Wilkerson C, Rensing SA, Gagneul D, Dickenson NE, Oesterhelt C, Lercher MJ, Weber AP.

Science. 2013 Mar 8;339(6124):1207-10. doi: 10.1126/science.1231707.


Voltage dependent closure of PorB class II porin from Neisseria meningitidis investigated using impedance spectroscopy in a tethered bilayer lipid membrane interface.

Jadhav SR, Rao KS, Zheng Y, Garavito RM, Worden RM.

J Colloid Interface Sci. 2013 Jan 15;390(1):211-6. doi: 10.1016/j.jcis.2012.09.031. Epub 2012 Sep 26.


Limited proteolysis via millisecond digestions in protease-modified membranes.

Tan YJ, Wang WH, Zheng Y, Dong J, Stefano G, Brandizzi F, Garavito RM, Reid GE, Bruening ML.

Anal Chem. 2012 Oct 2;84(19):8357-63. doi: 10.1021/ac3019153. Epub 2012 Sep 21.


Identification of succinic semialdehyde reductases from Geobacter: expression, purification, crystallization, preliminary functional, and crystallographic analysis.

Zhang Y, Gao X, Zheng Y, Garavito RM.

Acta Biochim Biophys Sin (Shanghai). 2011 Dec;43(12):996-1002. doi: 10.1093/abbs/gmr097. Epub 2011 Oct 27.


The structure of sucrose synthase-1 from Arabidopsis thaliana and its functional implications.

Zheng Y, Anderson S, Zhang Y, Garavito RM.

J Biol Chem. 2011 Oct 14;286(41):36108-18. doi: 10.1074/jbc.M111.275974. Epub 2011 Aug 24.


Biochemical characterization of human dynamin-like protein 1.

Zhang Y, Gao X, Garavito RM.

J Biochem. 2011 Dec;150(6):627-33. doi: 10.1093/jb/mvr102. Epub 2011 Aug 12.


Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.

Tippin BL, Levine AJ, Materi AM, Song WL, Keku TO, Goodman JE, Sansbury LB, Das S, Dai A, Kwong AM, Lin AM, Lin JM, Park JM, Patterson RE, Chlebowski RT, Garavito RM, Inoue T, Cho W, Lawson JA, Kapoor S, Kolonel LN, Le Marchand L, Haile RW, Sandler RS, Lin HJ.

Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):22-8. doi: 10.1016/j.prostaglandins.2011.07.006. Epub 2011 Jul 28.


Intramembrane proteolytic cleavage of a membrane-tethered transcription factor by a metalloprotease depends on ATP.

Zhou R, Cusumano C, Sui D, Garavito RM, Kroos L.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16174-9. doi: 10.1073/pnas.0901455106. Epub 2009 Sep 2.


The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway.

King JD, Poon KKH, Webb NA, Anderson EM, McNally DJ, Brisson JR, Messner P, Garavito RM, Lam JS.

FEBS J. 2009 May;276(10):2686-2700. doi: 10.1111/j.1742-4658.2009.06993.x.


Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication.

Gao F, Sui D, Garavito RM, Worden RM, Wang DH.

Hypertension. 2009 Feb;53(2):228-35. doi: 10.1161/HYPERTENSIONAHA.108.117499. Epub 2008 Dec 15.


Fabrication of highly insulating tethered bilayer lipid membrane using yeast cell membrane fractions for measuring ion channel activity.

Jadhav SR, Sui D, Garavito RM, Worden RM.

J Colloid Interface Sci. 2008 Jun 15;322(2):465-72. doi: 10.1016/j.jcis.2008.02.064. Epub 2008 Mar 6.


Conserved lipid-binding sites in membrane proteins: a focus on cytochrome c oxidase.

Qin L, Sharpe MA, Garavito RM, Ferguson-Miller S.

Curr Opin Struct Biol. 2007 Aug;17(4):444-50. Epub 2007 Aug 23. Review.


Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.

Harman CA, Turman MV, Kozak KR, Marnett LJ, Smith WL, Garavito RM.

J Biol Chem. 2007 Sep 21;282(38):28096-105. Epub 2007 Jul 26.


Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products.

Wada M, DeLong CJ, Hong YH, Rieke CJ, Song I, Sidhu RS, Yuan C, Warnock M, Schmaier AH, Yokoyama C, Smyth EM, Wilson SJ, FitzGerald GA, Garavito RM, Sui de X, Regan JW, Smith WL.

J Biol Chem. 2007 Aug 3;282(31):22254-66. Epub 2007 May 22.


Crystallographic location and mutational analysis of Zn and Cd inhibitory sites and role of lipidic carboxylates in rescuing proton path mutants in cytochrome c oxidase.

Qin L, Mills DA, Hiser C, Murphree A, Garavito RM, Ferguson-Miller S, Hosler J.

Biochemistry. 2007 May 29;46(21):6239-48. Epub 2007 May 4.


Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidase.

Qin L, Hiser C, Mulichak A, Garavito RM, Ferguson-Miller S.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16117-22. Epub 2006 Oct 18.


Structure determination and analysis of acyl-CoA oxidase (ACX1) from tomato.

Powers RA, Rife CL, Schilmiller AL, Howe GA, Garavito RM.

Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):683-6. Epub 2006 May 12.


Ferredoxin-dependent glutamate synthase moonlights in plant sulfolipid biosynthesis by forming a complex with SQD1.

Shimojima M, Hoffmann-Benning S, Garavito RM, Benning C.

Arch Biochem Biophys. 2005 Apr 1;436(1):206-14.


EST-analysis of the thermo-acidophilic red microalga Galdieria sulphuraria reveals potential for lipid A biosynthesis and unveils the pathway of carbon export from rhodoplasts.

Weber AP, Oesterhelt C, Gross W, Bräutigam A, Imboden LA, Krassovskaya I, Linka N, Truchina J, Schneidereit J, Voll H, Voll LM, Zimmermann M, Jamai A, Riekhof WR, Yu B, Garavito RM, Benning C.

Plant Mol Biol. 2004 May;55(1):17-32.


Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands.

Mulichak AM, Lu W, Losey HC, Walsh CT, Garavito RM.

Biochemistry. 2004 May 11;43(18):5170-80.


Crystal structure of a tetrameric GDP-D-mannose 4,6-dehydratase from a bacterial GDP-D-rhamnose biosynthetic pathway.

Webb NA, Mulichak AM, Lam JS, Rocchetta HL, Garavito RM.

Protein Sci. 2004 Feb;13(2):529-39.


Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway.

Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9238-43. Epub 2003 Jul 21.


The structure of mammalian cyclooxygenases.

Garavito RM, Mulichak AM.

Annu Rev Biophys Biomol Struct. 2003;32:183-206. Epub 2003 Feb 5. Review.


Structure of the MUR1 GDP-mannose 4,6-dehydratase from Arabidopsis thaliana: implications for ligand binding and specificity.

Mulichak AM, Bonin CP, Reiter WD, Garavito RM.

Biochemistry. 2002 Dec 31;41(52):15578-89.


Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.

Lin HJ, Lakkides KM, Keku TO, Reddy ST, Louie AD, Kau IH, Zhou H, Gim JS, Ma HL, Matthies CF, Dai A, Huang HF, Materi AM, Lin JH, Frankl HD, Lee ER, Hardy SI, Herschman HR, Henderson BE, Kolonel LN, Le Marchand L, Garavito RM, Sandler RS, Haile RW, Smith WL.

Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1305-15.


The structures of prostaglandin endoperoxide H synthases-1 and -2.

Garavito RM, Malkowski MG, DeWitt DL.

Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:129-52. Review.


Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.

Malkowski MG, Thuresson ED, Lakkides KM, Rieke CJ, Micielli R, Smith WL, Garavito RM.

J Biol Chem. 2001 Oct 5;276(40):37547-55. Epub 2001 Jul 27.


Membrane protein structural biology minireview series.

Smith WL, Garavito RM, Ferguson-Miller S.

J Biol Chem. 2001 Aug 31;276(35):32393-4. Epub 2001 Jun 29. No abstract available.


Detergents as tools in membrane biochemistry.

Garavito RM, Ferguson-Miller S.

J Biol Chem. 2001 Aug 31;276(35):32403-6. Epub 2001 Jun 29. Review.


Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases.

Thuresson ED, Malkowski MG, Lakkides KM, Rieke CJ, Mulichak AM, Ginell SL, Garavito RM, Smith WL.

J Biol Chem. 2001 Mar 30;276(13):10358-65. Epub 2000 Dec 19.


Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid.

Thuresson ED, Lakkides KM, Rieke CJ, Sun Y, Wingerd BA, Micielli R, Mulichak AM, Malkowski MG, Garavito RM, Smith WL.

J Biol Chem. 2001 Mar 30;276(13):10347-57. Epub 2000 Dec 19.


Recombinant Arabidopsis SQD1 converts udp-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro.

Sanda S, Leustek T, Theisen MJ, Garavito RM, Benning C.

J Biol Chem. 2001 Feb 9;276(6):3941-6. Epub 2000 Nov 9.


Atomic force microscopy of the three-dimensional crystal of membrane protein, OmpC porin.

Kim H, Garavito RM, Lal R.

Colloids Surf B Biointerfaces. 2000 Dec 30;19(4):347-355.


The productive conformation of arachidonic acid bound to prostaglandin synthase.

Malkowski MG, Ginell SL, Smith WL, Garavito RM.

Science. 2000 Sep 15;289(5486):1933-7.


Cyclooxygenases: structural, cellular, and molecular biology.

Smith WL, DeWitt DL, Garavito RM.

Annu Rev Biochem. 2000;69:145-82. Review.


Fatty-acid substrate interactions with cyclo-oxygenases.

Smith WL, Rieke CJ, Thuresson ED, Mulichak AM, Garavito RM.

Ernst Schering Res Found Workshop. 2000;(31):53-64. Review. No abstract available.


The formation of stable fatty acid substrate complexes in prostaglandin H(2) synthase-1.

Malkowski MG, Theisen MJ, Scharmen A, Garavito RM.

Arch Biochem Biophys. 2000 Aug 1;380(1):39-45.


Peroxidase activity in prostaglandin endoperoxide H synthase-1 occurs with a neutral histidine proximal heme ligand.

Seibold SA, Cerda JF, Mulichak AM, Song I, Garavito RM, Arakawa T, Smith WL, Babcock GT.

Biochemistry. 2000 Jun 6;39(22):6616-24.


The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins.

Garavito RM, DeWitt DL.

Biochim Biophys Acta. 1999 Nov 23;1441(2-3):278-87. Review.


Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose.

Mulichak AM, Theisen MJ, Essigmann B, Benning C, Garavito RM.

Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13097-102.


The membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis.

Spencer AG, Thuresson E, Otto JC, Song I, Smith T, DeWitt DL, Garavito RM, Smith WL.

J Biol Chem. 1999 Nov 12;274(46):32936-42.

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