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Items: 1 to 50 of 86

1.

Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules.

Krovi SH, Kappler JW, Marrack P, Gapin L.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22252-22261. doi: 10.1073/pnas.1909504116. Epub 2019 Sep 30.

2.

How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S.

Sci Immunol. 2019 Apr 5;4(34). pii: eaav7517. doi: 10.1126/sciimmunol.aav7517.

PMID:
30952805
3.

Development of T cell lines sensitive to antigen stimulation.

Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M.

J Immunol Methods. 2018 Nov;462:65-73. doi: 10.1016/j.jim.2018.08.011. Epub 2018 Aug 28.

PMID:
30165064
4.

TCR signal strength controls thymic differentiation of iNKT cell subsets.

Tuttle KD, Krovi SH, Zhang J, Bedel R, Harmacek L, Peterson LK, Dragone LL, Lefferts A, Halluszczak C, Riemondy K, Hesselberth JR, Rao A, O'Connor BP, Marrack P, Scott-Browne J, Gapin L.

Nat Commun. 2018 Jul 9;9(1):2650. doi: 10.1038/s41467-018-05026-6.

5.

Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates.

Krovi SH, Gapin L.

Front Immunol. 2018 Jun 20;9:1393. doi: 10.3389/fimmu.2018.01393. eCollection 2018. Review.

6.

Characterization of Thymic Development of Natural Killer T Cell Subsets by Multiparameter Flow Cytometry.

Tuttle KD, Gapin L.

Methods Mol Biol. 2018;1799:121-133. doi: 10.1007/978-1-4939-7896-0_11.

PMID:
29956149
7.

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function.

Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1204-E1213. doi: 10.1073/pnas.1716669115. Epub 2018 Jan 19.

8.

The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.

Marrack P, Krovi SH, Silberman D, White J, Kushnir E, Nakayama M, Crooks J, Danhorn T, Leach S, Anselment R, Scott-Browne J, Gapin L, Kappler J.

Elife. 2017 Nov 17;6. pii: e30918. doi: 10.7554/eLife.30918.

9.

CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails.

Van Rhijn I, Iwany SK, Fodran P, Cheng TY, Gapin L, Minnaard AJ, Moody DB.

Eur J Immunol. 2017 Sep;47(9):1525-1534. doi: 10.1002/eji.201747062. Epub 2017 Jul 31.

10.

iNKT cells need UTX-tra demethylation.

Krovi SH, Gapin L.

Nat Immunol. 2017 Jan 19;18(2):148-150. doi: 10.1038/ni.3663. No abstract available.

PMID:
28102220
11.

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.

Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J.

Nat Commun. 2016 Oct 27;7:13257. doi: 10.1038/ncomms13257.

12.

Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors.

Silberman D, Krovi SH, Tuttle KD, Crooks J, Reisdorph R, White J, Gross J, Matsuda JL, Gapin L, Marrack P, Kappler JW.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5608-17. doi: 10.1073/pnas.1609717113. Epub 2016 Sep 1.

13.

Structure and function of the non-classical major histocompatibility complex molecule MR1.

Krovi SH, Gapin L.

Immunogenetics. 2016 Aug;68(8):549-59. doi: 10.1007/s00251-016-0939-5. Epub 2016 Jul 22. Review.

14.

Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice.

Zhang J, Bedel R, Krovi SH, Tuttle KD, Zhang B, Gross J, Gapin L, Matsuda JL.

Sci Rep. 2016 Jun 3;6:27375. doi: 10.1038/srep27375.

15.

Revealing the TCR bias for MHC molecules.

Krovi SH, Gapin L.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2809-11. doi: 10.1073/pnas.1601511113. Epub 2016 Mar 1. No abstract available.

16.

Development of invariant natural killer T cells.

Gapin L.

Curr Opin Immunol. 2016 Apr;39:68-74. doi: 10.1016/j.coi.2016.01.001. Epub 2016 Jan 21. Review.

17.

It is time to beelieve the CD1a hype!

Krovi SH, Gapin L.

Eur J Immunol. 2016 Jan;46(1):56-9. doi: 10.1002/eji.201546157.

18.

IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization.

Pennock ND, Gapin L, Kedl RM.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16472-7. doi: 10.1073/pnas.1407393111. Epub 2014 Sep 29.

19.

Check MAIT.

Gapin L.

J Immunol. 2014 May 15;192(10):4475-80. doi: 10.4049/jimmunol.1400119. Review.

20.

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity.

Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. doi: 10.1073/pnas.1320777110. Epub 2013 Dec 16.

21.

Natural Killer T cell obsession with self-antigens.

Gapin L, Godfrey DI, Rossjohn J.

Curr Opin Immunol. 2013 Apr;25(2):168-73. doi: 10.1016/j.coi.2013.01.002. Epub 2013 Feb 4. Review.

22.

CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function.

Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM.

J Immunol. 2013 Mar 1;190(5):1936-47. doi: 10.4049/jimmunol.1203149. Epub 2013 Jan 25.

23.

MAIT cell recognition of MR1 on bacterially infected and uninfected cells.

Young MH, U'Ren L, Huang S, Mallevaey T, Scott-Browne J, Crawford F, Lantz O, Hansen TH, Kappler J, Marrack P, Gapin L.

PLoS One. 2013;8(1):e53789. doi: 10.1371/journal.pone.0053789. Epub 2013 Jan 14.

24.

Mucosal associated invariant T cells: don't forget your vitamins.

Young MH, Gapin L.

Cell Res. 2013 Apr;23(4):460-2. doi: 10.1038/cr.2012.168. Epub 2012 Dec 4.

25.

Recognition of CD1d-restricted antigens by natural killer T cells.

Rossjohn J, Pellicci DG, Patel O, Gapin L, Godfrey DI.

Nat Rev Immunol. 2012 Dec;12(12):845-57. doi: 10.1038/nri3328. Epub 2012 Nov 16. Review.

26.

T cells and their eons-old obsession with MHC.

Yin L, Scott-Browne J, Kappler JW, Gapin L, Marrack P.

Immunol Rev. 2012 Nov;250(1):49-60. doi: 10.1111/imr.12004. Review.

27.

iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma.

Bjordahl RL, Gapin L, Marrack P, Refaeli Y.

PLoS One. 2012;7(8):e42635. doi: 10.1371/journal.pone.0042635. Epub 2012 Aug 7.

28.

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor.

Patel O, Pellicci DG, Gras S, Sandoval-Romero ML, Uldrich AP, Mallevaey T, Clarke AJ, Le Nours J, Theodossis A, Cardell SL, Gapin L, Godfrey DI, Rossjohn J.

Nat Immunol. 2012 Sep;13(9):857-63. doi: 10.1038/ni.2372. Epub 2012 Jul 22.

PMID:
22820603
29.

Lower TCR repertoire diversity in Traj18-deficient mice.

Bedel R, Matsuda JL, Brigl M, White J, Kappler J, Marrack P, Gapin L.

Nat Immunol. 2012 Jul 19;13(8):705-6. doi: 10.1038/ni.2347. No abstract available.

30.

A closer look at TCR germline recognition.

Garcia KC, Gapin L, Adams JJ, Birnbaum ME, Scott-Browne JP, Kappler JW, Marrack P.

Immunity. 2012 Jun 29;36(6):887-8. doi: 10.1016/j.immuni.2012.05.018. Epub 2012 Jun 14. No abstract available.

31.

T cells interact with T cells via CD40-CD154 to promote autoimmunity in type 1 diabetes.

Baker RL, Mallevaey T, Gapin L, Haskins K.

Eur J Immunol. 2012 Mar;42(3):672-80. doi: 10.1002/eji.201142071.

32.

Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice.

Nakayama M, Castoe T, Sosinowski T, He X, Johnson K, Haskins K, Vignali DA, Gapin L, Pollock D, Eisenbarth GS.

Diabetes. 2012 Apr;61(4):857-65. doi: 10.2337/db11-1113. Epub 2012 Feb 7.

33.

Vβ2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen.

Patel O, Pellicci DG, Uldrich AP, Sullivan LC, Bhati M, McKnight M, Richardson SK, Howell AR, Mallevaey T, Zhang J, Bedel R, Besra GS, Brooks AG, Kjer-Nielsen L, McCluskey J, Porcelli SA, Gapin L, Rossjohn J, Godfrey DI.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19007-12. doi: 10.1073/pnas.1109066108. Epub 2011 Nov 7.

34.

Evolutionarily conserved features contribute to αβ T cell receptor specificity.

Scott-Browne JP, Crawford F, Young MH, Kappler JW, Marrack P, Gapin L.

Immunity. 2011 Oct 28;35(4):526-35. doi: 10.1016/j.immuni.2011.09.005. Epub 2011 Sep 29.

35.

Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors.

Pellicci DG, Clarke AJ, Patel O, Mallevaey T, Beddoe T, Le Nours J, Uldrich AP, McCluskey J, Besra GS, Porcelli SA, Gapin L, Godfrey DI, Rossjohn J.

Nat Immunol. 2011 Jul 31;12(9):827-33. doi: 10.1038/ni.2076.

36.

A molecular basis for NKT cell recognition of CD1d-self-antigen.

Mallevaey T, Clarke AJ, Scott-Browne JP, Young MH, Roisman LC, Pellicci DG, Patel O, Vivian JP, Matsuda JL, McCluskey J, Godfrey DI, Marrack P, Rossjohn J, Gapin L.

Immunity. 2011 Mar 25;34(3):315-26. doi: 10.1016/j.immuni.2011.01.013. Epub 2011 Mar 3.

37.

A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells.

Wun KS, Cameron G, Patel O, Pang SS, Pellicci DG, Sullivan LC, Keshipeddy S, Young MH, Uldrich AP, Thakur MS, Richardson SK, Howell AR, Illarionov PA, Brooks AG, Besra GS, McCluskey J, Gapin L, Porcelli SA, Godfrey DI, Rossjohn J.

Immunity. 2011 Mar 25;34(3):327-39. doi: 10.1016/j.immuni.2011.02.001. Epub 2011 Mar 3.

38.

Group 1 CD1-restricted T cells take center stage.

Young MH, Gapin L.

Eur J Immunol. 2011 Mar;41(3):592-4. doi: 10.1002/eji.201141408. Epub 2011 Feb 11.

39.

Plasticity of invariant NKT cell regulation of allergic airway disease is dependent on IFN-gamma production.

Matsuda H, Takeda K, Koya T, Okamoto M, Shiraishi Y, Miyahara N, Dakhama A, Matsuda JL, Gapin L, Gelfand EW.

J Immunol. 2010 Jul 1;185(1):253-62. doi: 10.4049/jimmunol.0902301. Epub 2010 Jun 4.

40.

iNKT cell autoreactivity: what is 'self' and how is it recognized?

Gapin L.

Nat Rev Immunol. 2010 Apr;10(4):272-7. doi: 10.1038/nri2743. Epub 2010 Mar 12. Review.

41.

Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity.

McWilliams JA, Sanchez PJ, Haluszczak C, Gapin L, Kedl RM.

Vaccine. 2010 Feb 10;28(6):1468-76. doi: 10.1016/j.vaccine.2009.11.071. Epub 2009 Dec 6.

42.

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.

Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S.

EMBO J. 2009 Dec 2;28(23):3781. doi: 10.1038/emboj.2009.348. No abstract available.

43.

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.

Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S.

EMBO J. 2009 Nov 18;28(22):3579-90. doi: 10.1038/emboj.2009.286. Epub 2009 Oct 8. Erratum in: EMBO J. 2009 Dec 2;28(23):3781.

44.

Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors.

Pellicci DG, Patel O, Kjer-Nielsen L, Pang SS, Sullivan LC, Kyparissoudis K, Brooks AG, Reid HH, Gras S, Lucet IS, Koh R, Smyth MJ, Mallevaey T, Matsuda JL, Gapin L, McCluskey J, Godfrey DI, Rossjohn J.

Immunity. 2009 Jul 17;31(1):47-59. doi: 10.1016/j.immuni.2009.04.018.

45.

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.

Mallevaey T, Scott-Browne JP, Matsuda JL, Young MH, Pellicci DG, Patel O, Thakur M, Kjer-Nielsen L, Richardson SK, Cerundolo V, Howell AR, McCluskey J, Godfrey DI, Rossjohn J, Marrack P, Gapin L.

Immunity. 2009 Jul 17;31(1):60-71. doi: 10.1016/j.immuni.2009.05.010.

46.

Where do MAIT cells fit in the family of unconventional T cells?

Gapin L.

PLoS Biol. 2009 Mar 31;7(3):e70. doi: 10.1371/journal.pbio.1000070. Review. No abstract available.

47.

Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection.

Scott-Browne JP, White J, Kappler JW, Gapin L, Marrack P.

Nature. 2009 Apr 23;458(7241):1043-6. doi: 10.1038/nature07812. Epub 2009 Mar 4.

48.

The making of NKT cells.

Gapin L.

Nat Immunol. 2008 Sep;9(9):1009-11. doi: 10.1038/ni0908-1009. No abstract available.

49.

CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system.

Matsuda JL, Mallevaey T, Scott-Browne J, Gapin L.

Curr Opin Immunol. 2008 Jun;20(3):358-68. doi: 10.1016/j.coi.2008.03.018. Epub 2008 May 22. Review.

50.

A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.

Wun KS, Borg NA, Kjer-Nielsen L, Beddoe T, Koh R, Richardson SK, Thakur M, Howell AR, Scott-Browne JP, Gapin L, Godfrey DI, McCluskey J, Rossjohn J.

J Exp Med. 2008 Apr 14;205(4):939-49. doi: 10.1084/jem.20072141. Epub 2008 Mar 31.

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