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Items: 1 to 50 of 60

1.

Linagliptin and telmisartan induced effects on renal and urinary exosomal miRNA expression in rats with 5/6 nephrectomy.

Delić D, Wiech F, Urquhart R, Gabrielyan O, Rieber K, Rolser M, Tsuprykov O, Hasan AA, Krämer BK, Baum P, Köhler A, Gantner F, Mark M, Hocher B, Klein T.

Sci Rep. 2020 Feb 25;10(1):3373. doi: 10.1038/s41598-020-60336-4.

PMID:
32099009
2.

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Krebs A, Waldmann T, Wilks MF, Van Vugt-Lussenburg BMA, Van der Burg B, Terron A, Steger-Hartmann T, Ruegg J, Rovida C, Pedersen E, Pallocca G, Luijten M, Leite SB, Kustermann S, Kamp H, Hoeng J, Hewitt P, Herzler M, Hengstler JG, Heinonen T, Hartung T, Hardy B, Gantner F, Fritsche E, Fant K, Ezendam J, Exner T, Dunkern T, Dietrich DR, Coecke S, Busquet F, Braeuning A, Bondarenko O, Bennekou SH, Beilmann M, Leist M.

ALTEX. 2020;37(1):164. doi: 10.14573/altex.1909271e.

3.

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Krebs A, Waldmann T, Wilks MF, Van Vugt-Lussenburg BMA, Van der Burg B, Terron A, Steger-Hartmann T, Ruegg J, Rovida C, Pedersen E, Pallocca G, Luijten M, Leite SB, Kustermann S, Kamp H, Hoeng J, Hewitt P, Herzler M, Hengstler JG, Heinonen T, Hartung T, Hardy B, Gantner F, Fritsche E, Fant K, Ezendam J, Exner T, Dunkern T, Dietrich DR, Coecke S, Busquet F, Braeuning A, Bondarenko O, Bennekou SH, Beilmann M, Leist M.

ALTEX. 2019;36(4):682-699. doi: 10.14573/altex.1909271. Erratum in: ALTEX. 2020;37(1):164.

4.

DMSO cryopreservation is the method of choice to preserve cells for droplet-based single-cell RNA sequencing.

Wohnhaas CT, Leparc GG, Fernandez-Albert F, Kind D, Gantner F, Viollet C, Hildebrandt T, Baum P.

Sci Rep. 2019 Jul 23;9(1):10699. doi: 10.1038/s41598-019-46932-z.

5.

Differentiation of hiPS Cells into Definitive Endoderm for High-Throughput Screening.

Bluhmki T, Traub S, Schruf E, Garnett J, Gantner F, Bischoff D, Heilker R.

Methods Mol Biol. 2019;1994:101-115. doi: 10.1007/978-1-4939-9477-9_9.

PMID:
31124108
6.

Opposing effects of in vitro differentiated macrophages sub-type on epithelial wound healing.

Gindele JA, Mang S, Pairet N, Christ I, Gantner F, Schymeinsky J, Lamb DJ.

PLoS One. 2017 Sep 1;12(9):e0184386. doi: 10.1371/journal.pone.0184386. eCollection 2017.

7.

Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis.

Herrmann FE, Wollin L, Wirth J, Gantner F, Lämmle B, Wex E.

Br J Pharmacol. 2017 Nov;174(21):3848-3864. doi: 10.1111/bph.13982. Epub 2017 Sep 20.

8.

Clinical imaging in anti-atherosclerosis drug development.

Ehlgen A, Bylock A, Kreuzer J, Koslowski M, Gantner F, Niessen HG.

Drug Discov Today. 2015 Nov;20(11):1317-27. doi: 10.1016/j.drudis.2015.06.014. Epub 2015 Jul 4. Review.

PMID:
26151479
9.

Riboswitch-mediated Attenuation of Transgene Cytotoxicity Increases Adeno-associated Virus Vector Yields in HEK-293 Cells.

Strobel B, Klauser B, Hartig JS, Lamla T, Gantner F, Kreuz S.

Mol Ther. 2015 Oct;23(10):1582-91. doi: 10.1038/mt.2015.123. Epub 2015 Jul 3.

10.

Modeling Pulmonary Disease Pathways Using Recombinant Adeno-Associated Virus 6.2.

Strobel B, Duechs MJ, Schmid R, Stierstorfer BE, Bucher H, Quast K, Stiller D, Hildebrandt T, Mennerich D, Gantner F, Erb KJ, Kreuz S.

Am J Respir Cell Mol Biol. 2015 Sep;53(3):291-302. doi: 10.1165/rcmb.2014-0338MA.

PMID:
25845025
11.

Nuclear imaging to support anti-inflammatory drug discovery and development.

Wunder A, Thiele A, Koslowski M, Gantner F, Niessen H.

Q J Nucl Med Mol Imaging. 2014 Sep;58(3):290-8. Review.

PMID:
25265250
12.

Nuclear imaging to support anti-inflammatory drug discovery and development.

Wunder A, Thiele A, Koslowski M, Gantner F, Niessen H.

Q J Nucl Med Mol Imaging. 2014 May 15. [Epub ahead of print]

PMID:
24829127
13.

Development of a novel severe triple allergen asthma model in mice which is resistant to dexamethasone and partially resistant to TLR7 and TLR9 agonist treatment.

Duechs MJ, Tilp C, Tomsic C, Gantner F, Erb KJ.

PLoS One. 2014 Mar 11;9(3):e91223. doi: 10.1371/journal.pone.0091223. eCollection 2014.

14.

Molecular basis for the long duration of action and kinetic selectivity of tiotropium for the muscarinic M3 receptor.

Tautermann CS, Kiechle T, Seeliger D, Diehl S, Wex E, Banholzer R, Gantner F, Pieper MP, Casarosa P.

J Med Chem. 2013 Nov 14;56(21):8746-56. doi: 10.1021/jm401219y. Epub 2013 Oct 25.

PMID:
24088171
15.

The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge.

Schymeinsky J, Mayer H, Tomsic C, Tilp C, Schuetz JD, Cui Y, Wollin L, Gantner F, Erb KJ.

PLoS One. 2013 Apr 22;8(4):e61193. doi: 10.1371/journal.pone.0061193. Print 2013.

16.

Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo.

Wex E, Bouyssou T, Duechs MJ, Erb KJ, Gantner F, Sanderson MP, Schnapp A, Stierstorfer BE, Wollin L.

Eur J Immunol. 2011 Nov;41(11):3208-18. doi: 10.1002/eji.201141502. Epub 2011 Sep 26.

17.

Functional and biochemical rationales for the 24-hour-long duration of action of olodaterol.

Casarosa P, Kollak I, Kiechle T, Ostermann A, Schnapp A, Kiesling R, Pieper M, Sieger P, Gantner F.

J Pharmacol Exp Ther. 2011 Jun;337(3):600-9. doi: 10.1124/jpet.111.179259. Epub 2011 Feb 28.

PMID:
21357659
18.

TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways.

Duechs MJ, Hahn C, Benediktus E, Werner-Klein M, Braun A, Hoymann HG, Gantner F, Erb KJ.

Pulm Pharmacol Ther. 2011 Apr;24(2):203-14. doi: 10.1016/j.pupt.2010.12.009. Epub 2010 Dec 31.

PMID:
21195789
19.

Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.

Baum P, Schmid R, Ittrich C, Rust W, Fundel-Clemens K, Siewert S, Baur M, Mara L, Gruenbaum L, Heckel A, Eils R, Kontermann RE, Roth GJ, Gantner F, Schnapp A, Park JE, Weith A, Quast K, Mennerich D.

PLoS One. 2010 Dec 10;5(12):e14272. doi: 10.1371/journal.pone.0014272.

20.

The constitutive activity of the human muscarinic M3 receptor unmasks differences in the pharmacology of anticholinergics.

Casarosa P, Kiechle T, Sieger P, Pieper M, Gantner F.

J Pharmacol Exp Ther. 2010 Apr;333(1):201-9. doi: 10.1124/jpet.109.163188. Epub 2009 Dec 24.

PMID:
20035022
21.

Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs.

Casarosa P, Bouyssou T, Germeyer S, Schnapp A, Gantner F, Pieper M.

J Pharmacol Exp Ther. 2009 Aug;330(2):660-8. doi: 10.1124/jpet.109.152470. Epub 2009 May 28.

PMID:
19478135
22.

Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete.

Stadler M, Bitzer J, Mayer-Bartschmid A, Müller H, Benet-Buchholz J, Gantner F, Tichy HV, Reinemer P, Bacon KB.

J Nat Prod. 2007 Feb;70(2):246-52. Epub 2007 Jan 24.

PMID:
17249727
23.

PAR-2 deficient CD4+ T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice.

Shichijo M, Kondo S, Ishimori M, Watanabe S, Helin H, Yamasaki T, Stevens ME, Gantner F, Bacon KB.

Allergol Int. 2006 Sep;55(3):271-8.

24.

Endogenous cortisol determines the circadian rhythm of lipopolysaccharide-- but not lipoteichoic acid--inducible cytokine release.

Hermann C, von Aulock S, Dehus O, Keller M, Okigami H, Gantner F, Wendel A, Hartung T.

Eur J Immunol. 2006 Feb;36(2):371-9.

25.

A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.

Ziegelbauer K, Gantner F, Lukacs NW, Berlin A, Fuchikami K, Niki T, Sakai K, Inbe H, Takeshita K, Ishimori M, Komura H, Murata T, Lowinger T, Bacon KB.

Br J Pharmacol. 2005 May;145(2):178-92.

26.

CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation.

Takeshita K, Yamasaki T, Nagao K, Sugimoto H, Shichijo M, Gantner F, Bacon KB.

Int Immunol. 2004 Jul;16(7):947-59. Epub 2004 Jun 1.

PMID:
15173122
27.

Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.

Takeshita K, Yamasaki T, Akira S, Gantner F, Bacon KB.

Int Immunol. 2004 May;16(5):685-95. Epub 2004 Mar 29.

PMID:
15096484
28.

Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan.

Takeshita K, Bacon KB, Gantner F.

J Pharmacol Exp Ther. 2004 Jul;310(1):272-80. Epub 2004 Mar 2.

PMID:
14996947
29.

A versatile high-throughput screen for inhibitors of lipid kinase activity: development of an immobilized phospholipid plate assay for phosphoinositide 3-kinase gamma.

Fuchikami K, Togame H, Sagara A, Satoh T, Gantner F, Bacon KB, Reinemer P.

J Biomol Screen. 2002 Oct;7(5):441-50.

PMID:
14599360
30.

Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo.

Takeshita K, Sakai K, Bacon KB, Gantner F.

J Pharmacol Exp Ther. 2003 Dec;307(3):1072-8. Epub 2003 Oct 9.

PMID:
14551291
31.

Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats.

Shichijo M, Sugimoto H, Nagao K, Inbe H, Encinas JA, Takeshita K, Bacon KB, Gantner F.

J Pharmacol Exp Ther. 2003 Nov;307(2):518-25. Epub 2003 Sep 15.

PMID:
12975488
32.

CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides.

Gantner F, Hermann P, Nakashima K, Matsukawa S, Sakai K, Bacon KB.

Eur J Immunol. 2003 Jun;33(6):1576-85.

33.

An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro.

Sugimoto H, Shichijo M, Iino T, Manabe Y, Watanabe A, Shimazaki M, Gantner F, Bacon KB.

J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.

PMID:
12649388
34.

Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells.

Gantner F, Sakai K, Tusche MW, Cruikshank WW, Center DM, Bacon KB.

J Pharmacol Exp Ther. 2002 Oct;303(1):300-7.

PMID:
12235264
35.
36.
37.

Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms.

Hirt UA, Gantner F, Leist M.

J Immunol. 2000 Jun 15;164(12):6520-9.

38.
39.
40.

Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions.

Hartung T, Doecke WD, Bundschuh D, Foote MA, Gantner F, Hermann C, Lenz A, Milwee S, Rich B, Simon B, Volk HD, von Aulock S, Wendel A.

Clin Pharmacol Ther. 1999 Oct;66(4):415-24.

PMID:
10546926
41.

Therapeutic potential of selective PDE inhibitors in asthma.

Schudt C, Gantner F, Tenors H, Hatzelmann A.

Pulm Pharmacol Ther. 1999;12(2):123-9. Review. No abstract available.

PMID:
10373395
42.

Cytokine-mediated hepatic apoptosis.

Leist M, Gantner F, Künstle G, Wendel A.

Rev Physiol Biochem Pharmacol. 1998;133:109-55. Review. No abstract available.

PMID:
9600012
43.

Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation.

Gantner F, Götz C, Gekeler V, Schudt C, Wendel A, Hatzelmann A.

Br J Pharmacol. 1998 Mar;123(6):1031-8.

44.

Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: a comparative study.

Gantner F, Tenor H, Gekeler V, Schudt C, Wendel A, Hatzelmann A.

J Allergy Clin Immunol. 1997 Oct;100(4):527-35.

PMID:
9338548
46.

Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins.

Leist M, Gantner F, Naumann H, Bluethmann H, Vogt K, Brigelius-Flohé R, Nicotera P, Volk HD, Wendel A.

Gastroenterology. 1997 Mar;112(3):923-34.

PMID:
9041255
47.

Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors.

Gantner F, Küsters S, Wendel A, Hatzelmann A, Schudt C, Tiegs G.

J Pharmacol Exp Ther. 1997 Jan;280(1):53-60.

PMID:
8996181
48.

T cell stimulus-induced crosstalk between lymphocytes and liver macrophages results in augmented cytokine release.

Gantner F, Leist M, Küsters S, Vogt K, Volk HD, Tiegs G.

Exp Cell Res. 1996 Nov 25;229(1):137-46.

PMID:
8940257
49.

DNA fragmentation in mouse organs during endotoxic shock.

Bohlinger I, Leist M, Gantner F, Angermüller S, Tiegs G, Wendel A.

Am J Pathol. 1996 Oct;149(4):1381-93.

50.

Role of sinusoidal endothelial cells of the liver in concanavalin A-induced hepatic injury in mice.

Knolle PA, Gerken G, Loser E, Dienes HP, Gantner F, Tiegs G, Meyer zum Buschenfelde KH, Lohse AW.

Hepatology. 1996 Oct;24(4):824-9.

PMID:
8855184

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