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Diesel exhaust particle and dust mite induced airway inflammation is modified by cerium dioxide nanoparticles.

Meldrum K, Robertson S, Römer I, Marczylo T, Gant TW, Smith R, Tetley TD, Leonard MO.

Environ Toxicol Pharmacol. 2019 Oct 11;73:103273. doi: 10.1016/j.etap.2019.103273. [Epub ahead of print]


Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma.

Whittle E, Leonard MO, Gant TW, Tonge DP.

Sci Rep. 2019 Jun 20;9(1):8912. doi: 10.1038/s41598-019-45257-1.


Multi-Method Characterization of the Human Circulating Microbiome.

Whittle E, Leonard MO, Harrison R, Gant TW, Tonge DP.

Front Microbiol. 2019 Jan 17;9:3266. doi: 10.3389/fmicb.2018.03266. eCollection 2018.


Pulmonary toxicity of inhaled nano-sized cerium oxide aerosols in Sprague-Dawley rats.

Guo C, Robertson S, Weber RJM, Buckley A, Warren J, Hodgson A, Rappoport JZ, Ignatyev K, Meldrum K, Römer I, Macchiarulo S, Chipman JK, Marczylo T, Leonard MO, Gant TW, Viant MR, Smith R.

Nanotoxicology. 2019 Aug;13(6):733-750. doi: 10.1080/17435390.2018.1554751. Epub 2019 Feb 1.


PBTK model for assessment of operator exposure to haloxyfop using human biomonitoring and toxicokinetic data.

Cooper AB, Aggarwal M, Bartels MJ, Morriss A, Terry C, Lord GA, Gant TW.

Regul Toxicol Pharmacol. 2019 Mar;102:1-12. doi: 10.1016/j.yrtph.2018.12.004. Epub 2018 Dec 10.


Perturbation of microRNA signalling by doxorubicin in spermatogonial, Leydig and Sertoli cell lines in vitro.

Akinjo OO, Gant TW, Marczylo EL.

Toxicol Res (Camb). 2018 May 16;7(5):760-770. doi: 10.1039/c7tx00314e. eCollection 2018 Sep 1.


Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation.

Meldrum K, Robertson SB, Römer I, Marczylo T, Dean LSN, Rogers A, Gant TW, Smith R, Tetley TD, Leonard MO.

Part Fibre Toxicol. 2018 May 23;15(1):24. doi: 10.1186/s12989-018-0261-5.


The small airway epithelium as a target for the adverse pulmonary effects of silver nanoparticle inhalation.

Guo C, Buckley A, Marczylo T, Seiffert J, Römer I, Warren J, Hodgson A, Chung KF, Gant TW, Smith R, Leonard MO.

Nanotoxicology. 2018 Aug;12(6):539-553. doi: 10.1080/17435390.2018.1465140. Epub 2018 May 11.


Mechanistic insight into the impact of nanomaterials on asthma and allergic airway disease.

Meldrum K, Guo C, Marczylo EL, Gant TW, Smith R, Leonard MO.

Part Fibre Toxicol. 2017 Nov 21;14(1):45. doi: 10.1186/s12989-017-0228-y. Review.


A systematic review of the public health risks of bioaerosols from intensive farming.

Douglas P, Robertson S, Gay R, Hansell AL, Gant TW.

Int J Hyg Environ Health. 2018 Mar;221(2):134-173. doi: 10.1016/j.ijheh.2017.10.019. Epub 2017 Nov 7. Review.


A generic Transcriptomics Reporting Framework (TRF) for 'omics data processing and analysis.

Gant TW, Sauer UG, Zhang SD, Chorley BN, Hackermüller J, Perdichizzi S, Tollefsen KE, van Ravenzwaay B, Yauk C, Tong W, Poole A.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S36-S45. doi: 10.1016/j.yrtph.2017.11.001. Epub 2017 Nov 4. Review.


Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

Buesen R, Chorley BN, da Silva Lima B, Daston G, Deferme L, Ebbels T, Gant TW, Goetz A, Greally J, Gribaldo L, Hackermüller J, Hubesch B, Jennen D, Johnson K, Kanno J, Kauffmann HM, Laffont M, McMullen P, Meehan R, Pemberton M, Perdichizzi S, Piersma AH, Sauer UG, Schmidt K, Seitz H, Sumida K, Tollefsen KE, Tong W, Tralau T, van Ravenzwaay B, Weber RJM, Worth A, Yauk C, Poole A.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S3-S13. doi: 10.1016/j.yrtph.2017.09.002. Epub 2017 Sep 25. Review.


The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook.

Sauer UG, Deferme L, Gribaldo L, Hackermüller J, Tralau T, van Ravenzwaay B, Yauk C, Poole A, Tong W, Gant TW.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S14-S26. doi: 10.1016/j.yrtph.2017.09.020. Epub 2017 Sep 18. Review.


Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.

Kamola PJ, Maratou K, Wilson PA, Rush K, Mullaney T, McKevitt T, Evans P, Ridings J, Chowdhury P, Roulois A, Fairchild A, McCawley S, Cartwright K, Gooderham NJ, Gant TW, Moores K, Hughes SA, Edbrooke MR, Clark K, Parry JD.

Mol Ther Nucleic Acids. 2017 Sep 15;8:383-394. doi: 10.1016/j.omtn.2017.07.003. Epub 2017 Jul 8.


Diesel exhaust particulate associated chemicals attenuate expression of CXCL10 in human primary bronchial epithelial cells.

Meldrum K, Gant TW, Leonard MO.

Toxicol In Vitro. 2017 Dec;45(Pt 3):409-416. doi: 10.1016/j.tiv.2017.06.023. Epub 2017 Jun 24.


Environmentally induced epigenetic toxicity: potential public health concerns.

Marczylo EL, Jacobs MN, Gant TW.

Crit Rev Toxicol. 2016 Sep;46(8):676-700. doi: 10.1080/10408444.2016.1175417. Epub 2016 Jun 9. Review.


Perturbation of epigenetic processes by doxorubicin in the mouse testis.

Akinjo OO, Gant TW, Marczylo EL.

Toxicol Res (Camb). 2016 Jun 1;5(4):1229-1243. doi: 10.1039/c6tx00078a. eCollection 2016 Jul 1.


What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme.

Tonge DP, Gant TW.

BMC Mol Biol. 2016 Feb 9;17:4. doi: 10.1186/s12867-016-0057-9.


Bronchial epithelial innate and adaptive immunity signals are induced by polycyclic aromatic hydrocarbons.

Meldrum K, Gant TW, Macchiarulo S, Leonard MO.

Toxicol Res (Camb). 2016 Feb 9;5(3):816-827. doi: 10.1039/c5tx00389j. eCollection 2016 May 1.


Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington's disease models.

Smalley JL, Breda C, Mason RP, Kooner G, Luthi-Carter R, Gant TW, Giorgini F.

J Mol Med (Berl). 2016 Feb;94(2):235-45. doi: 10.1007/s00109-015-1344-5. Epub 2015 Oct 2.


Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo.

Broom AJ, Ambroso J, Brunori G, Burns AK, Armitage JR, Francis I, Gandhi M, Peterson RA, Gant TW, Boobis AR, Lyon JJ.

Toxicol Res (Camb). 2015 Sep 17;5(1):136-150. doi: 10.1039/c5tx00197h. eCollection 2016 Jan 1.


In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.

Kamola PJ, Kitson JD, Turner G, Maratou K, Eriksson S, Panjwani A, Warnock LC, Douillard Guilloux GA, Moores K, Koppe EL, Wixted WE, Wilson PA, Gooderham NJ, Gant TW, Clark KL, Hughes SA, Edbrooke MR, Parry JD.

Nucleic Acids Res. 2015 Oct 15;43(18):8638-50. doi: 10.1093/nar/gkv857. Epub 2015 Sep 3.


Exposures and health outcomes in relation to bioaerosol emissions from composting facilities: a systematic review of occupational and community studies.

Pearson C, Littlewood E, Douglas P, Robertson S, Gant TW, Hansell AL.

J Toxicol Environ Health B Crit Rev. 2015;18(1):43-69. doi: 10.1080/10937404.2015.1009961. Review.


Amplicon-based metagenomic analysis of mixed fungal samples using proton release amplicon sequencing.

Tonge DP, Pashley CH, Gant TW.

PLoS One. 2014 Apr 11;9(4):e93849. doi: 10.1371/journal.pone.0093849. eCollection 2014.


The role of microRNAs in the pathogenesis of MMPi-induced skin fibrodysplasia.

Tonge DP, Tugwood JD, Kelsall J, Gant TW.

BMC Genomics. 2013 May 20;14:338. doi: 10.1186/1471-2164-14-338.


Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity.

Dudek KM, Suter L, Darras VM, Marczylo EL, Gant TW.

Biochem J. 2013 Jul 1;453(1):71-82. doi: 10.1042/BJ20130049.


A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, Dinsdale D, Cohen GM.

Cell Death Differ. 2012 Dec;19(12):1896-907. doi: 10.1038/cdd.2012.108. Epub 2012 Sep 7.


Smoking induces differential miRNA expression in human spermatozoa: a potential transgenerational epigenetic concern?

Marczylo EL, Amoako AA, Konje JC, Gant TW, Marczylo TH.

Epigenetics. 2012 May;7(5):432-9. doi: 10.4161/epi.19794. Epub 2012 May 1.


Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.

Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE.

Cell Death Differ. 2012 Jun;19(6):1003-12. doi: 10.1038/cdd.2011.183. Epub 2012 Jan 6.


MicroRNA expression profiling in patients with lamin A/C-associated muscular dystrophy.

Sylvius N, Bonne G, Straatman K, Reddy T, Gant TW, Shackleton S.

FASEB J. 2011 Nov;25(11):3966-78. doi: 10.1096/fj.11-182915. Epub 2011 Aug 12.


Skills and training for the 21st century chemical toxicologist.

Gant TW.

Chem Res Toxicol. 2011 Jul 18;24(7):985-7. doi: 10.1021/tx200204q. No abstract available.


Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.

Pointon AV, Walker TM, Phillips KM, Luo J, Riley J, Zhang SD, Parry JD, Lyon JJ, Marczylo EL, Gant TW.

PLoS One. 2010 Sep 15;5(9):e12733. doi: 10.1371/journal.pone.0012733. Erratum in: PLoS One. 2014;9(7):e102278.


Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability.

Foster CT, Dovey OM, Lezina L, Luo JL, Gant TW, Barlev N, Bradley A, Cowley SM.

Mol Cell Biol. 2010 Oct;30(20):4851-63. doi: 10.1128/MCB.00521-10. Epub 2010 Aug 16.


Upregulation of nuclear-encoded mitochondrial LON protease in HAART-treated HIV-positive patients with lipodystrophy: implications for the pathogenesis of the disease.

Pinti M, Gibellini L, Guaraldi G, Orlando G, Gant TW, Morselli E, Nasi M, Salomoni P, Mussini C, Cossarizza A.

AIDS. 2010 Mar 27;24(6):841-50. doi: 10.1097/QAD.0b013e32833779a3.


Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model.

Ridd K, Dhir S, Smith AG, Gant TW.

Toxicol In Vitro. 2010 Apr;24(3):910-5. doi: 10.1016/j.tiv.2009.11.017. Epub 2009 Nov 27.


Application of connectivity mapping in predictive toxicology based on gene-expression similarity.

Smalley JL, Gant TW, Zhang SD.

Toxicology. 2010 Feb 9;268(3):143-6. doi: 10.1016/j.tox.2009.09.014. Epub 2009 Sep 27. Review.


Twenty-first century approaches to toxicity testing, biomonitoring, and risk assessment: perspectives from the global chemical industry.

Phillips RD, Bahadori T, Barry BE, Bus JS, Gant TW, Mostowy JM, Smith C, Willuhn M, Zimmer U.

J Expo Sci Environ Epidemiol. 2009 Sep;19(6):536-43. doi: 10.1038/jes.2009.38.


sscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signatures.

Zhang SD, Gant TW.

BMC Bioinformatics. 2009 Jul 31;10:236. doi: 10.1186/1471-2105-10-236.


Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.

Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, Stoneley M, Kong YW, Cotes JA, Smith GC, Wek R, Hayes C, Gant TW, Spriggs KA, Bushell M, Willis AE.

Genes Dev. 2009 May 15;23(10):1207-20. doi: 10.1101/gad.516509.


Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.

Parry JD, Pointon AV, Lutz U, Teichert F, Charlwood JK, Chan PH, Athersuch TJ, Taylor EL, Singh R, Luo J, Phillips KM, Vetillard A, Lyon JJ, Keun HC, Lutz WK, Gant TW.

Chem Res Toxicol. 2009 Apr;22(4):717-25. doi: 10.1021/tx800472z.


Novel genomic methods for drug discovery and mechanism-based toxicological assessment.

Gant TW, Zhang SD, Taylor EL.

Curr Opin Drug Discov Devel. 2009 Jan;12(1):72-80. Review.


A simple and robust method for connecting small-molecule drugs using gene-expression signatures.

Zhang SD, Gant TW.

BMC Bioinformatics. 2008 Jun 2;9:258. doi: 10.1186/1471-2105-9-258.


Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.

Teichert F, Verschoyle RD, Greaves P, Edwards RE, Teahan O, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gant TW, Gescher AJ, Keun HC.

Prostate. 2008 Jul 1;68(10):1035-47. doi: 10.1002/pros.20761.


Emerging fundamental roles for non-coding RNA species in toxicology.

Taylor EL, Gant TW.

Toxicology. 2008 Apr 3;246(1):34-9. doi: 10.1016/j.tox.2007.12.030. Epub 2008 Jan 15. Review.


Essential role of the AH receptor in the dysfunction of heme metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Davies R, Clothier B, Robinson SW, Edwards RE, Greaves P, Luo J, Gant TW, Chernova T, Smith AG.

Chem Res Toxicol. 2008 Feb;21(2):330-40. doi: 10.1021/tx700176r. Epub 2007 Dec 29.


A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells.

Meijer HA, Bushell M, Hill K, Gant TW, Willis AE, Jones P, de Moor CH.

Nucleic Acids Res. 2007;35(19):e132. Epub 2007 Oct 11.


Novel and future applications of microarrays in toxicological research.

Gant TW.

Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):599-608. Review.


Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.

Inoue S, Riley J, Gant TW, Dyer MJ, Cohen GM.

Leukemia. 2007 Aug;21(8):1773-82. Epub 2007 May 24.


Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin.

Ridd K, Zhang SD, Edwards RE, Davies R, Greaves P, Wolfreys A, Smith AG, Gant TW.

Carcinogenesis. 2006 Aug;27(8):1556-66. Epub 2006 Mar 14.


Inflammatory genomics.

Gant TW.

Environ Health Perspect. 2005 Dec;113(12):A794-5. No abstract available.

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