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Items: 16


Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear.

Gant JC, Kadish I, Chen KC, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Alzheimers Dis. 2018;66(4):1371-1378. doi: 10.3233/JAD-180618.


FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2+], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats.

Gant JC, Blalock EM, Chen KC, Kadish I, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2018 Jan 24;38(4):1030-1041. doi: 10.1523/JNEUROSCI.2234-17.2017. Epub 2017 Dec 18.


In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome.

Berkowitz BA, Lenning J, Khetarpal N, Tran C, Wu JY, Berri AM, Dernay K, Haacke EM, Shafie-Khorassani F, Podolsky RH, Gant JC, Maimaiti S, Thibault O, Murphy GG, Bennett BM, Roberts R.

FASEB J. 2017 Sep;31(9):4179-4186. doi: 10.1096/fj.201700229R. Epub 2017 Jun 7.


Calcium's role as nuanced modulator of cellular physiology in the brain.

Frazier HN, Maimaiti S, Anderson KL, Brewer LD, Gant JC, Porter NM, Thibault O.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):981-987. doi: 10.1016/j.bbrc.2016.08.105. Epub 2016 Aug 20. Review.


Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.

Gant JC, Chen KC, Kadish I, Blalock EM, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2015 Jul 29;35(30):10878-87. doi: 10.1523/JNEUROSCI.1248-15.2015.


Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging.

Maimaiti S, Anderson KL, DeMoll C, Brewer LD, Rauh BA, Gant JC, Blalock EM, Porter NM, Thibault O.

J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):30-9. doi: 10.1093/gerona/glu314. Epub 2015 Feb 6.


FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?

Gant JC, Blalock EM, Chen KC, Kadish I, Porter NM, Norris CM, Thibault O, Landfield PW.

Eur J Pharmacol. 2014 Sep 15;739:74-82. doi: 10.1016/j.ejphar.2013.10.070. Epub 2013 Nov 28. Review.


Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM.

J Neurosci. 2012 Nov 14;32(46):16129-40. doi: 10.1523/JNEUROSCI.2323-12.2012.


Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.

Gant JC, Chen KC, Norris CM, Kadish I, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Neurosci. 2011 Feb 2;31(5):1693-703. doi: 10.1523/JNEUROSCI.4805-10.2011.


Effects of long-term pioglitazone treatment on peripheral and central markers of aging.

Blalock EM, Phelps JT, Pancani T, Searcy JL, Anderson KL, Gant JC, Popovic J, Avdiushko MG, Cohen DA, Chen KC, Porter NM, Thibault O.

PLoS One. 2010 Apr 29;5(4):e10405. doi: 10.1371/journal.pone.0010405.


Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment.

Kadish I, Thibault O, Blalock EM, Chen KC, Gant JC, Porter NM, Landfield PW.

J Neurosci. 2009 Feb 11;29(6):1805-16. doi: 10.1523/JNEUROSCI.4599-08.2009.


Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy.

Gant JC, Thibault O, Blalock EM, Yang J, Bachstetter A, Kotick J, Schauwecker PE, Hauser KF, Smith GM, Mervis R, Li Y, Barnes GN.

Epilepsia. 2009 Apr;50(4):629-45. doi: 10.1111/j.1528-1167.2008.01725.x. Epub 2008 Jul 24.


Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization.

Gant JC, Thibault O.

Neurobiol Aging. 2009 Dec;30(12):2053-64. doi: 10.1016/j.neurobiolaging.2008.02.006. Epub 2008 Mar 25.


Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store.

Thibault O, Gant JC, Landfield PW.

Aging Cell. 2007 Jun;6(3):307-17. Epub 2007 Apr 26. Review.


Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release.

Gant JC, Sama MM, Landfield PW, Thibault O.

J Neurosci. 2006 Mar 29;26(13):3482-90.


Palliative treatment of benign prostatic hypertrophy; value of glycine-alanine-glutamic acid combination.


J Maine Med Assoc. 1958 Mar;49(3):99-101 passim. No abstract available.


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