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Items: 16

1.

Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs.

Harris HM, Eans SO, Ganno ML, Davis JC, Dooley CT, McLaughlin JP, Nefzi A.

Org Biomol Chem. 2019 Jun 7;17(21):5305-5315. doi: 10.1039/c9ob00882a. Epub 2019 May 16.

PMID:
31094391
2.

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation.

Shao J, Houghten RA, Dooley CT, Cazares M, McLaughlin JP, Eans SO, Ganno ML, Hoot MR, Giulianotti MA, Yu Y.

Org Biomol Chem. 2017 Sep 26;15(37):7796-7801. doi: 10.1039/c7ob01924f.

PMID:
28875208
3.

Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice.

Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP.

Br J Pharmacol. 2017 Aug;174(15):2444-2456. doi: 10.1111/bph.13854. Epub 2017 Jun 27.

4.

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.

Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L.

ACS Comb Sci. 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5.

5.

Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior.

Váradi A, Marrone GF, Eans SO, Ganno ML, Subrath JJ, Le Rouzic V, Hunkele A, Pasternak GW, McLaughlin JP, Majumdar S.

ACS Chem Neurosci. 2015 Nov 18;6(11):1813-24. doi: 10.1021/acschemneuro.5b00153. Epub 2015 Sep 14.

6.

Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.

Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A.

J Med Chem. 2015 Jun 25;58(12):4905-17. doi: 10.1021/jm501637c. Epub 2015 Jun 4.

PMID:
25996309
7.

HIV-1 Tat protein exposure potentiates ethanol reward and reinstates extinguished ethanol-conditioned place preference.

McLaughlin JP, Ganno ML, Eans SO, Mizrachi E, Paris JJ.

Curr HIV Res. 2014;12(6):415-23.

PMID:
25760047
8.

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.

Hu M, Giulianotti MA, McLaughlin JP, Shao J, Debevec G, Maida LE, Geer P, Cazares M, Misler J, Li L, Dooley C, Ganno ML, Eans SO, Mizrachi E, Santos RG, Yongye AB, Houghten RA, Yu Y.

Eur J Med Chem. 2015 Mar 6;92:270-81. doi: 10.1016/j.ejmech.2014.12.049. Epub 2014 Dec 29.

PMID:
25559207
9.

Alanine analogues of [D-Trp]CJ-15,208: novel opioid activity profiles and prevention of drug- and stress-induced reinstatement of cocaine-seeking behaviour.

Aldrich JV, Senadheera SN, Ross NC, Reilley KA, Ganno ML, Eans SE, Murray TF, McLaughlin JP.

Br J Pharmacol. 2014 Jul;171(13):3212-22. doi: 10.1111/bph.12664.

10.

Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat.

Paris JJ, Singh HD, Ganno ML, Jackson P, McLaughlin JP.

Psychopharmacology (Berl). 2014 Jun;231(11):2349-60. doi: 10.1007/s00213-013-3385-1. Epub 2013 Dec 19.

11.

Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors.

Patkar KA, Wu J, Ganno ML, Singh HD, Ross NC, Rasakham K, Toll L, McLaughlin JP.

J Pharmacol Exp Ther. 2013 Sep;346(3):545-54. doi: 10.1124/jpet.113.206086. Epub 2013 Jul 12.

PMID:
23853171
12.

The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration.

Eans SO, Ganno ML, Reilley KJ, Patkar KA, Senadheera SN, Aldrich JV, McLaughlin JP.

Br J Pharmacol. 2013 May;169(2):426-36. doi: 10.1111/bph.12132.

13.

Central administration of angiotensin IV rapidly enhances novel object recognition among mice.

Paris JJ, Eans SO, Mizrachi E, Reilley KJ, Ganno ML, McLaughlin JP.

Neuropharmacology. 2013 Jul;70:247-53. doi: 10.1016/j.neuropharm.2013.01.025. Epub 2013 Feb 14.

14.

Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library.

Armishaw CJ, Banerjee J, Ganno ML, Reilley KJ, Eans SO, Mizrachi E, Gyanda R, Hoot MR, Houghten RA, McLaughlin JP.

ACS Comb Sci. 2013 Mar 11;15(3):153-61. doi: 10.1021/co300152x. Epub 2013 Feb 27.

PMID:
23414173
15.

The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior.

Aldrich JV, Senadheera SN, Ross NC, Ganno ML, Eans SO, McLaughlin JP.

J Nat Prod. 2013 Mar 22;76(3):433-8. doi: 10.1021/np300697k. Epub 2013 Jan 17.

16.

Unexpected opioid activity profiles of analogues of the novel peptide kappa opioid receptor ligand CJ-15,208.

Aldrich JV, Kulkarni SS, Senadheera SN, Ross NC, Reilley KJ, Eans SO, Ganno ML, Murray TF, McLaughlin JP.

ChemMedChem. 2011 Sep 5;6(9):1739-45. doi: 10.1002/cmdc.201100113. Epub 2011 Jul 14.

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