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Items: 1 to 50 of 59

1.

Prevention of the anti-factor VIII memory B-cell response by inhibition of Bruton tyrosine kinase in experimental hemophilia A.

Delignat S, Russick J, Gangadharan B, Rayes J, Ing M, Voorberg J, Kaveri SV, Lacroix-Desmazes S.

Haematologica. 2019 May;104(5):1046-1054. doi: 10.3324/haematol.2018.200279. Epub 2018 Dec 13.

2.

Iron-Insensitive Quantitative Assessment of Subcortical Gray Matter Demyelination in Multiple Sclerosis Using the Macromolecular Proton Fraction.

Yarnykh VL, Krutenkova EP, Aitmagambetova G, Repovic P, Mayadev A, Qian P, Jung Henson LK, Gangadharan B, Bowen JD.

AJNR Am J Neuroradiol. 2018 Apr;39(4):618-625. doi: 10.3174/ajnr.A5542. Epub 2018 Feb 8.

3.

Oxidation of factor VIII increases its immunogenicity in mice with severe hemophilia A.

Peyron I, Dimitrov JD, Delignat S, Gangadharan B, Srivastava A, Kaveri SV, Lacroix-Desmazes S.

Cell Immunol. 2018 Mar;325:64-68. doi: 10.1016/j.cellimm.2018.01.008. Epub 2018 Jan 31.

PMID:
29395036
4.

Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region.

Gangadharan B, Sunitha MS, Mukherjee S, Chowdhury RR, Haque F, Sekar N, Sowdhamini R, Spudich JA, Mercer JA.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11115-11120. doi: 10.1073/pnas.1710354114. Epub 2017 Oct 2.

5.

Absolute quantitation of disease protein biomarkers in a single LC-MS acquisition using apolipoprotein F as an example.

Kumar A, Gangadharan B, Cobbold J, Thursz M, Zitzmann N.

Sci Rep. 2017 Sep 21;7(1):12072. doi: 10.1038/s41598-017-12229-2.

6.

The ADAMTS131239-1253 peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope.

Gilardin L, Delignat S, Peyron I, Ing M, Lone YC, Gangadharan B, Michard B, Kherabi Y, Sharma M, Pashov A, Latouche JB, Hamieh M, Toutirais O, Loiseau P, Galicier L, Veyradier A, Kaveri S, Maillère B, Coppo P, Lacroix-Desmazes S.

Haematologica. 2017 Nov;102(11):1833-1841. doi: 10.3324/haematol.2015.136671. Epub 2017 Jul 27.

7.

The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells.

Gangadharan B, Ing M, Delignat S, Peyron I, Teyssandier M, Kaveri SV, Lacroix-Desmazes S.

Haematologica. 2017 Feb;102(2):271-281. doi: 10.3324/haematol.2016.148502. Epub 2016 Oct 6.

8.

Multiple reaction monitoring and multiple reaction monitoring cubed based assays for the quantitation of apolipoprotein F.

Kumar A, Gangadharan B, Zitzmann N.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:278-286. doi: 10.1016/j.jchromb.2016.08.038. Epub 2016 Aug 27.

PMID:
27592286
9.

Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance.

Gupta N, Culina S, Meslier Y, Dimitrov J, Arnoult C, Delignat S, Gangadharan B, Lecerf M, Justesen S, Gouilleux-Gruart V, Salomon BL, Scott DW, Kaveri SV, Mallone R, Lacroix-Desmazes S.

Sci Transl Med. 2015 Feb 18;7(275):275ra21. doi: 10.1126/scitranslmed.aaa1957.

PMID:
25696000
10.

Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies.

Gupte TM, Haque F, Gangadharan B, Sunitha MS, Mukherjee S, Anandhan S, Rani DS, Mukundan N, Jambekar A, Thangaraj K, Sowdhamini R, Sommese RF, Nag S, Spudich JA, Mercer JA.

J Biol Chem. 2015 Mar 13;290(11):7003-15. doi: 10.1074/jbc.M114.596676. Epub 2014 Dec 29.

11.

Haemarthrosis and arthropathy do not favour the development of factor VIII inhibitors in severe haemophilia A mice.

Peyron I, Dimitrov JD, Delignat S, Gangadharan B, Planchais C, Kaveri SV, Lacroix-Desmazes S.

Haemophilia. 2015 Jan;21(1):e94-8. doi: 10.1111/hae.12579. Epub 2014 Dec 4. No abstract available.

PMID:
25471131
12.

Role of coagulation-associated processes on factor VIII immunogenicity in a mouse model of severe hemophilia A.

Gangadharan B, Delignat S, Ollivier V, Gupta N, Mackman N, Kaveri SV, Lacroix-Desmazes S.

J Thromb Haemost. 2014 Dec;12(12):2065-9. doi: 10.1111/jth.12740. Epub 2014 Oct 25.

13.

Fast whole-brain three-dimensional macromolecular proton fraction mapping in multiple sclerosis.

Yarnykh VL, Bowen JD, Samsonov A, Repovic P, Mayadev A, Qian P, Gangadharan B, Keogh BP, Maravilla KR, Jung Henson LK.

Radiology. 2015 Jan;274(1):210-20. doi: 10.1148/radiol.14140528. Epub 2014 Sep 10.

14.

Cryptic polyreactivity of IgG expressed by splenic marginal zone B-cell lymphoma.

Mahendra A, Gangadharan B, André S, Boudjoghra M, Davi F, Lecerf M, Planchais C, Kaveri SV, Lacroix-Desmazes S, Dimitrov JD.

Mol Immunol. 2014 Jul;60(1):54-61. doi: 10.1016/j.molimm.2014.03.009. Epub 2014 Apr 24.

PMID:
24769492
15.

Development and characterization of recombinant ovine coagulation factor VIII.

Zakas PM, Gangadharan B, Almeida-Porada G, Porada CD, Spencer HT, Doering CB.

PLoS One. 2012;7(11):e49481. doi: 10.1371/journal.pone.0049481. Epub 2012 Nov 9.

16.

Potentiation of thrombin generation in hemophilia A plasma by coagulation factor VIII and characterization of antibody-specific inhibition.

Doshi BS, Gangadharan B, Doering CB, Meeks SL.

PLoS One. 2012;7(10):e48172. doi: 10.1371/journal.pone.0048172. Epub 2012 Oct 29.

17.

Preclinical toxicity evaluation of erythrocyte-encapsulated thymidine phosphorylase in BALB/c mice and beagle dogs: an enzyme-replacement therapy for mitochondrial neurogastrointestinal encephalomyopathy.

Levene M, Coleman DG, Kilpatrick HC, Fairbanks LD, Gangadharan B, Gasson C, Bax BE.

Toxicol Sci. 2013 Jan;131(1):311-24. doi: 10.1093/toxsci/kfs278. Epub 2012 Sep 12.

PMID:
22977166
18.

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function.

Meeks SL, Cox CL, Healey JF, Parker ET, Doshi BS, Gangadharan B, Barrow RT, Lollar P.

Blood. 2012 Sep 20;120(12):2512-20. Epub 2012 Jul 31.

19.

Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.

Gangadharan B, Bapat M, Rossa J, Antrobus R, Chittenden D, Kampa B, Barnes E, Klenerman P, Dwek RA, Zitzmann N.

PLoS One. 2012;7(6):e39603. doi: 10.1371/journal.pone.0039603. Epub 2012 Jun 26.

20.

Hematopoietic stem cell function in a murine model of sickle cell disease.

Javazon EH, Radhi M, Gangadharan B, Perry J, Archer DR.

Anemia. 2012;2012:387385. doi: 10.1155/2012/387385. Epub 2012 Jun 4.

21.

Image quality improvement in megavoltage cone beam CT using an imaging beam line and a sintered pixelated array system.

Breitbach EK, Maltz JS, Gangadharan B, Bani-Hashemi A, Anderson CM, Bhatia SK, Stiles J, Edwards DS, Flynn RT.

Med Phys. 2011 Nov;38(11):5969-79. doi: 10.1118/1.3651470.

PMID:
22047361
22.

Enhanced biosynthesis of coagulation factor VIII through diminished engagement of the unfolded protein response.

Brown HC, Gangadharan B, Doering CB.

J Biol Chem. 2011 Jul 8;286(27):24451-7. doi: 10.1074/jbc.M111.238758. Epub 2011 May 23.

23.

New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients.

Gangadharan B, Antrobus R, Chittenden D, Rossa J, Bapat M, Klenerman P, Barnes E, Dwek RA, Zitzmann N.

J Proteome Res. 2011 May 6;10(5):2643-50. doi: 10.1021/pr101077c. Epub 2011 Mar 30.

24.

Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII.

Spencer HT, Denning G, Gautney RE, Dropulic B, Roy AJ, Baranyi L, Gangadharan B, Parker ET, Lollar P, Doering CB.

Mol Ther. 2011 Feb;19(2):302-9. doi: 10.1038/mt.2010.239. Epub 2010 Nov 16.

25.

Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro.

Woodhouse SD, Narayan R, Latham S, Lee S, Antrobus R, Gangadharan B, Luo S, Schroth GP, Klenerman P, Zitzmann N.

Hepatology. 2010 Aug;52(2):443-53. doi: 10.1002/hep.23733.

26.

Comparison of patient megavoltage cone beam CT images acquired with an unflattened beam from a carbon target and a flattened treatment beam.

Faddegon BA, Aubin M, Bani-Hashemi A, Gangadharan B, Gottschalk AR, Morin O, Sawkey D, Wu V, Yom SS.

Med Phys. 2010 Apr;37(4):1737-41.

PMID:
20443494
27.

Functional aspects of factor VIII expression after transplantation of genetically-modified hematopoietic stem cells for hemophilia A.

Ide LM, Iwakoshi NN, Gangadharan B, Jobe S, Moot R, McCarty D, Doering CB, Spencer HT.

J Gene Med. 2010 Apr;12(4):333-44. doi: 10.1002/jgm.1442.

PMID:
20209485
28.

Image quality & dosimetric property of an investigational imaging beam line MV-CBCT.

Beltran C, Lukose R, Gangadharan B, Bani-Hashemi A, Faddegon BA.

J Appl Clin Med Phys. 2009 Jun 17;10(3):3023.

29.

Proteomic analysis of cells in the early stages of herpes simplex virus type-1 infection reveals widespread changes in the host cell proteome.

Antrobus R, Grant K, Gangadharan B, Chittenden D, Everett RD, Zitzmann N, Boutell C.

Proteomics. 2009 Aug;9(15):3913-27. doi: 10.1002/pmic.200900207.

PMID:
19670248
30.

Directed engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A.

Doering CB, Denning G, Dooriss K, Gangadharan B, Johnston JM, Kerstann KW, McCarty DA, Spencer HT.

Mol Ther. 2009 Jul;17(7):1145-54. doi: 10.1038/mt.2009.35. Epub 2009 Mar 3.

31.

Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A.

Dooriss KL, Denning G, Gangadharan B, Javazon EH, McCarty DA, Spencer HT, Doering CB.

Hum Gene Ther. 2009 May;20(5):465-78. doi: 10.1089/hum.2008.150.

32.

Murid herpesvirus-4 induces chronic inflammation of intrahepatic bile ducts in mice deficient in gamma-interferon signalling.

Gangadharan B, Dutia BM, Rhind SM, Nash AA.

Hepatol Res. 2009 Feb;39(2):187-94. doi: 10.1111/j.1872-034X.2008.00440.x.

PMID:
19208039
33.

Low dose megavoltage cone beam computed tomography with an unflattened 4 MV beam from a carbon target.

Faddegon BA, Wu V, Pouliot J, Gangadharan B, Bani-Hashemi A.

Med Phys. 2008 Dec;35(12):5777-86.

PMID:
19175135
34.

Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection.

Narayan R, Gangadharan B, Hantz O, Antrobus R, García A, Dwek RA, Zitzmann N.

J Proteome Res. 2009 Jan;8(1):118-22. doi: 10.1021/pr800562j.

PMID:
19053806
35.

Algorithm for X-ray scatter, beam-hardening, and beam profile correction in diagnostic (kilovoltage) and treatment (megavoltage) cone beam CT.

Maltz JS, Gangadharan B, Bose S, Hristov DH, Faddegon BA, Paidi A, Bani-Hashemi AR.

IEEE Trans Med Imaging. 2008 Dec;27(12):1791-810. doi: 10.1109/TMI.2008.928922.

PMID:
19033095
36.

Automatic coregistration of volumetric images based on implanted fiducial markers.

Koch M, Maltz JS, Belongie SJ, Gangadharan B, Bose S, Shukla H, Bani-Hashemi AR.

Med Phys. 2008 Oct;35(10):4513-23.

PMID:
18975698
37.

Focused beam-stop array for the measurement of scatter in megavoltage portal and cone beam CT imaging.

Maltz JS, Gangadharan B, Vidal M, Paidi A, Bose S, Faddegon BA, Aubin M, Morin O, Pouliot J, Zheng Z, Svatos MM, Bani-Hashemi AR.

Med Phys. 2008 Jun;35(6):2452-62.

PMID:
18649478
38.

Murine gammaherpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages.

Gangadharan B, Hoeve MA, Allen JE, Ebrahimi B, Rhind SM, Dutia BM, Nash AA.

J Leukoc Biol. 2008 Jul;84(1):50-8. doi: 10.1189/jlb.0507270. Epub 2008 Apr 24.

PMID:
18436582
39.

Antioxidative potential of melatonin against mercury induced intoxication in spermatozoa in vitro.

Rao MV, Gangadharan B.

Toxicol In Vitro. 2008 Jun;22(4):935-42. doi: 10.1016/j.tiv.2008.01.014. Epub 2008 Feb 2.

PMID:
18329842
40.

Novel serum biomarker candidates for liver fibrosis in hepatitis C patients.

Gangadharan B, Antrobus R, Dwek RA, Zitzmann N.

Clin Chem. 2007 Oct;53(10):1792-9. Epub 2007 Aug 16.

41.

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens.

Ide LM, Gangadharan B, Chiang KY, Doering CB, Spencer HT.

Blood. 2007 Oct 15;110(8):2855-63. Epub 2007 Jun 14.

42.

Hematopoietic stem cells encoding porcine factor VIII induce pro-coagulant activity in hemophilia A mice with pre-existing factor VIII immunity.

Doering CB, Gangadharan B, Dukart HZ, Spencer HT.

Mol Ther. 2007 Jun;15(6):1093-9. Epub 2007 Mar 27.

43.

Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy.

McMillin DW, Hewes B, Gangadharan B, Archer DR, Mittler RS, Spencer HT.

Hum Gene Ther. 2006 Aug;17(8):798-806.

PMID:
16942440
44.

The M4 gene of murine gammaherpesvirus 68 modulates latent infection.

Geere HM, Ligertwood Y, Templeton KM, Bennet I, Gangadharan B, Rhind SM, Nash AA, Dutia BM.

J Gen Virol. 2006 Apr;87(Pt 4):803-7.

PMID:
16528028
45.

High-level expression of porcine factor VIII from genetically modified bone marrow-derived stem cells.

Gangadharan B, Parker ET, Ide LM, Spencer HT, Doering CB.

Blood. 2006 May 15;107(10):3859-64. Epub 2006 Jan 31.

46.

Enforced expression of cytosolic 5'-nucleotidase I confers resistance to nucleoside analogues in vitro but systemic chemotherapy toxicity precludes in vivo selection.

Gray T, Morrey EL, Gangadharan B, Sumter TF, Spychala J, Archer DR, Spencer HT.

Cancer Chemother Pharmacol. 2006 Jul;58(1):117-28. Epub 2005 Dec 15.

PMID:
16362297
47.

Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.

Simmons A, Gangadharan B, Hodges A, Sharrocks K, Prabhakar S, García A, Dwek R, Zitzmann N, McMichael A.

Immunity. 2005 Dec;23(6):621-34.

48.

Prevalence of antibodies to Toxoplasmagondii and Neosporacaninum in red foxes (Vulpesvulpes) from around the UK.

Hamilton CM, Gray R, Wright SE, Gangadharan B, Laurenson K, Innes EA.

Vet Parasitol. 2005 Jun 10;130(1-2):169-73. Epub 2005 Apr 15.

PMID:
15893084
49.

Highly efficient transduction of repopulating bone marrow cells using rapidly concentrated polymer-complexed retrovirus.

McMillin DW, Landázuri N, Gangadharan B, Hewes B, Archer DR, Spencer HT, Le Doux JM.

Biochem Biophys Res Commun. 2005 May 13;330(3):768-75.

PMID:
15809063
50.

Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo.

Jessani N, Humphrey M, McDonald WH, Niessen S, Masuda K, Gangadharan B, Yates JR 3rd, Mueller BM, Cravatt BF.

Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13756-61. Epub 2004 Sep 8.

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