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Items: 25


Identification of the kinase STK25 as an upstream activator of LATS signaling.

Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ.

Nat Commun. 2019 Apr 4;10(1):1547. doi: 10.1038/s41467-019-09597-w.


CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels.

Quinton RJ, Ganem NJ.

Methods Mol Biol. 2019;1893:203-214. doi: 10.1007/978-1-4939-8910-2_16.


Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel.

Bolgioni AF, Vittoria MA, Ganem NJ.

J Vis Exp. 2018 May 14;(135). doi: 10.3791/57383.


A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation.

Vittoria MA, Shenk EM, O'Rourke KP, Bolgioni AF, Lim S, Kacprzak V, Quinton RJ, Ganem NJ.

Mol Biol Cell. 2018 Jul 15;29(13):1682-1692. doi: 10.1091/mbc.E18-02-0141. Epub 2018 May 23.


STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines.

Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A.

Oncotarget. 2017 Sep 11;8(45):78556-78572. doi: 10.18632/oncotarget.20833. eCollection 2017 Oct 3.


Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.

Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaam9078. doi: 10.1126/scitranslmed.aam9078.


Nuclear envelope rupture drives genome instability in cancer.

Lim S, Quinton RJ, Ganem NJ.

Mol Biol Cell. 2016 Nov 1;27(21):3210-3213.


Generation and Purification of Tetraploid Cells.

Shenk EM, Ganem NJ.

Methods Mol Biol. 2016;1413:393-401. doi: 10.1007/978-1-4939-3542-0_24.


The interplay between centrosomes and the Hippo tumor suppressor pathway.

Bolgioni AF, Ganem NJ.

Chromosome Res. 2016 Jan;24(1):93-104. doi: 10.1007/s10577-015-9502-8. Review.


Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes.

Russo A, Pacchierotti F, Cimini D, Ganem NJ, Genescà A, Natarajan AT, Pavanello S, Valle G, Degrassi F.

Environ Mol Mutagen. 2015 Aug;56(7):563-80. doi: 10.1002/em.21945. Epub 2015 Mar 18. Review.


Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.

Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L.

Science. 2015 Jan 16;347(6219):273-7. doi: 10.1126/science.1257216.


Tetraploidy and tumor development.

Lim S, Ganem NJ.

Oncotarget. 2014 Nov 30;5(22):10959-60. No abstract available.


Cytokinesis failure triggers hippo tumor suppressor pathway activation.

Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D.

Cell. 2014 Aug 14;158(4):833-848. doi: 10.1016/j.cell.2014.06.029.


Linking abnormal mitosis to the acquisition of DNA damage.

Ganem NJ, Pellman D.

J Cell Biol. 2012 Dec 10;199(6):871-81. doi: 10.1083/jcb.201210040. Review.


DNA breaks and chromosome pulverization from errors in mitosis.

Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D.

Nature. 2012 Jan 18;482(7383):53-8. doi: 10.1038/nature10802.


Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT.

Mol Cell Biol. 2009 Nov;29(21):5911-22. doi: 10.1128/MCB.00558-09. Epub 2009 Aug 24.


A mechanism linking extra centrosomes to chromosomal instability.

Ganem NJ, Godinho SA, Pellman D.

Nature. 2009 Jul 9;460(7252):278-82. doi: 10.1038/nature08136. Epub 2009 Jun 7.


Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D.

Genes Dev. 2008 Aug 15;22(16):2189-203. doi: 10.1101/gad.1700908. Epub 2008 Jul 28.


Limiting the proliferation of polyploid cells.

Ganem NJ, Pellman D.

Cell. 2007 Nov 2;131(3):437-40. Review.


The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.

Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA.

Mol Biol Cell. 2007 Aug;18(8):2970-9. Epub 2007 May 30.


Tetraploidy, aneuploidy and cancer.

Ganem NJ, Storchova Z, Pellman D.

Curr Opin Genet Dev. 2007 Apr;17(2):157-62. Epub 2007 Feb 26. Review.


Functional roles of poleward microtubule flux during mitosis.

Ganem NJ, Compton DA.

Cell Cycle. 2006 Mar;5(5):481-5. Epub 2006 Mar 1. Review.


2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis.

Couch RD, Ganem NJ, Zhou M, Popov VM, Honda T, Veenstra TD, Sporn MB, Anderson AC.

Mol Pharmacol. 2006 Apr;69(4):1158-65. Epub 2006 Jan 11.


Efficient mitosis in human cells lacking poleward microtubule flux.

Ganem NJ, Upton K, Compton DA.

Curr Biol. 2005 Oct 25;15(20):1827-32.


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