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Items: 1 to 50 of 80

1.
2.

A Simple, General Synthesis of Carbonimidic Dichlorides.

Gober CM, Le HV, Ganem B.

Tetrahedron Lett. 2012 Aug 22;53(34):4536-4537. Epub 2012 Jun 15.

3.

Studies on the synthesis of amidoximes from nitroalkanes.

Sanguineti G, Le HV, Ganem B.

Tetrahedron. 2011 Dec 30;67(52):10208-10211.

4.

Trifluoroacetic anhydride-catalyzed oxidation of isonitriles by DMSO: a rapid, convenient synthesis of isocyanates.

Le HV, Ganem B.

Org Lett. 2011 May 20;13(10):2584-5. doi: 10.1021/ol200695y. Epub 2011 Apr 14.

5.

Use of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function.

Lewis RW, Hess GP, Ganem B.

Future Med Chem. 2011 Feb;3(2):243-50. doi: 10.4155/fmc.10.302. Review.

6.

Dihydropyrimidinone positive modulation of delta-subunit-containing gamma-aminobutyric acid type A receptors, including an epilepsy-linked mutant variant.

Lewis RW, Mabry J, Polisar JG, Eagen KP, Ganem B, Hess GP.

Biochemistry. 2010 Jun 15;49(23):4841-51. doi: 10.1021/bi100119t.

7.

A new synthesis of caged GABA compounds for studying GABAA receptors.

Fan L, Lewis RW, Hess GP, Ganem B.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3932-3. doi: 10.1016/j.bmcl.2009.03.065. Epub 2009 Mar 21.

PMID:
19364648
8.

Strategies for innovation in multicomponent reaction design.

Ganem B.

Acc Chem Res. 2009 Mar 17;42(3):463-72. doi: 10.1021/ar800214s.

9.

Studies on the chemistry and reactivity of alpha-substituted ketones in isonitrile-based multicomponent reactions.

Fan L, Adams AM, Polisar JG, Ganem B.

J Org Chem. 2008 Dec 19;73(24):9720-6. doi: 10.1021/jo8019708.

10.

A three-component Fischer indole synthesis.

Simoneau CA, Ganem B.

Nat Protoc. 2008;3(8):1249-52. doi: 10.1038/nprot.2008.94.

PMID:
18714292
11.

One-pot synthesis of polysubstituted indoles from aliphatic nitro compounds under mild conditions.

Simoneau CA, Strohl AM, Ganem B.

Tetrahedron Lett. 2007 Mar 5;48(10):1809-1811.

12.

Bioactive 2-oxazolines: a new approach via one-pot, four-component reaction.

Fan L, Lobkovsky E, Ganem B.

Org Lett. 2007 May 10;9(10):2015-7. Epub 2007 Apr 12.

PMID:
17428065
13.

Paclitaxel from primary taxanes: a perspective on creative invention in organozirconium chemistry.

Ganem B, Franke RR.

J Org Chem. 2007 May 25;72(11):3981-7. Epub 2007 Mar 24. Review.

PMID:
17381159
14.

Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase.

Allan AL, Gladstone PL, Price ML, Hopkins SA, Juarez JC, DoƱate F, Ternansky RJ, Shaw DE, Ganem B, Li Y, Wang W, Ealick S.

J Med Chem. 2006 Dec 28;49(26):7807-15.

PMID:
17181163
15.

Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase.

Toms AV, Wang W, Li Y, Ganem B, Ealick SE.

Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1449-58. Epub 2005 Oct 19.

PMID:
16239721
16.

Selective inhibition of MCF-7(piGST) breast tumors using glutathione transferase-derived 2-methylene-cycloalkenones.

Joseph E, Ganem B, Eiseman JL, Creighton DJ.

J Med Chem. 2005 Oct 20;48(21):6549-52.

PMID:
16220971
17.

Three-component condensation leading to beta-amino acid diamides: convergent assembly of beta-peptide analogues.

Oaksmith JM, Peters U, Ganem B.

J Am Chem Soc. 2004 Oct 27;126(42):13606-7.

PMID:
15493904
18.

Mechanism of the glutathione transferase-catalyzed conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones to GSH adducts.

Hamilton DS, Zhang X, Ding Z, Hubatsch I, Mannervik B, Houk KN, Ganem B, Creighton DJ.

J Am Chem Soc. 2003 Dec 10;125(49):15049-58.

PMID:
14653739
19.

An engineered chorismate mutase with allosteric regulation.

Zhang S, Wilson DB, Ganem B.

Bioorg Med Chem. 2003 Jul 17;11(14):3109-14.

PMID:
12818673
20.

Reversing the action of noncompetitive inhibitors (MK-801 and cocaine) on a protein (nicotinic acetylcholine receptor)-mediated reaction.

Hess GP, Gameiro AM, Schoenfeld RC, Chen Y, Ulrich H, Nye JA, Sit B, Carroll FI, Ganem B.

Biochemistry. 2003 May 27;42(20):6106-14.

PMID:
12755612
21.

Mapping of chorismate mutase and prephenate dehydrogenase domains in the Escherichia coli T-protein.

Chen S, Vincent S, Wilson DB, Ganem B.

Eur J Biochem. 2003 Feb;270(4):757-63.

22.

Going gently into flight: analyzing noncovalent interactions by mass spectrometry.

Ganem B, Henion JD.

Bioorg Med Chem. 2003 Feb 6;11(3):311-4. No abstract available.

PMID:
12517426
23.

Molecular basis of the antitumor activities of 2-crotonyloxymethyl-2-cycloalkenones.

Joseph E, Eiseman JL, Hamilton DS, Wang H, Tak H, Ding Z, Ganem B, Creighton DJ.

J Med Chem. 2003 Jan 2;46(1):194-6.

PMID:
12502374
24.
25.

Alkylation of nucleic acids by the antitumor agent COMC.

Zhang Q, Ding Z, Creighton DJ, Ganem B, Fabris D.

Org Lett. 2002 May 2;4(9):1459-62.

PMID:
11975603
26.
27.

Glutathionyl transferase catalyzed addition of glutathione to COMC: a new hypothesis for antitumor activity.

Hamilton DS, Ding Z, Ganem B, Creighton DJ.

Org Lett. 2002 Apr 4;4(7):1209-12. Erratum in: Org Lett 2002 May 16;4(10):1817.

PMID:
11922820
28.

Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues.

Schoenfeld RC, Conova S, Rittschof D, Ganem B.

Bioorg Med Chem Lett. 2002 Mar 11;12(5):823-5.

PMID:
11859011
29.

A theoretical study of the chorismate synthase reaction.

Dmitrenko O, Wood HB Jr, Bach RD, Ganem B.

Org Lett. 2001 Dec 27;3(26):4137-40.

PMID:
11784161
30.

Amidrazone and Amidoxime Inhibitors of Squalene Hopene Cyclase.

Ganem B, Dong Y, Zheng YF, Prestwich GD.

J Org Chem. 1999 Jul 23;64(15):5441-5446.

PMID:
11674605
31.

An Enantioselective Synthesis of (-)-Allosamidin by Asymmetric Desymmetrization of a Highly Functionalized meso-Epoxide.

Kassab DJ, Ganem B.

J Org Chem. 1999 Mar 19;64(6):1782-1783. No abstract available.

PMID:
11674264
32.

The photochemistry of pyrylium salts: new photohydrations and photoamidations of heterocycles leading to bicyclic oxazolines and functionalized cyclopentenes.

Clark MA, Schoenfeld RC, Ganem B.

J Am Chem Soc. 2001 Oct 24;123(42):10425-6. No abstract available.

PMID:
11604009
33.

Studies on 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase using chorismate mutase inhibitors.

Birck MR, Husain A, Sheflyan GY, Ganem B, Woodard RW.

Bioorg Med Chem Lett. 2001 Nov 5;11(21):2795-8.

PMID:
11597402
34.

A selective inhibitor of Escherichia coli prephenate dehydratase.

Husain A, Chen S, Wilson DB, Ganem B.

Bioorg Med Chem Lett. 2001 Sep 17;11(18):2485-8.

PMID:
11549452
35.
36.
37.

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.

Li Z, Fennie MW, Ganem B, Hancock MT, Kobaslija M, Rattendi D, Bacchi CJ, O'Sullivan MC.

Bioorg Med Chem Lett. 2001 Jan 22;11(2):251-4.

PMID:
11206471
38.

Total synthesis of mololipids: a new series of anti-HIV Moloka'iamine derivatives.

Schoenfeld RC, Lumb JP, Fantini J, Ganem B.

Bioorg Med Chem Lett. 2000 Dec 4;10(23):2679-81.

PMID:
11128650
39.

Reaction of COTC with glutathione: structure of the putative glyoxalase I inhibitor.

Huntley CF, Hamilton DS, Creighton DJ, Ganem B.

Org Lett. 2000 Oct 5;2(20):3143-4.

PMID:
11009366
40.
41.

Synthesis of glycolipid analogues that disrupt binding of HIV-1 gp120 to galactosylceramide.

Weber KT, Hammache D, Fantini J, Ganem B.

Bioorg Med Chem Lett. 2000 May 15;10(10):1011-4.

PMID:
10843204
42.
43.

A pharmacokinetic-pharmacodynamic modelling of the antihistaminic (H1) effects of cetirizine.

Urien S, Tillement JP, Ganem B, Kuch MD.

Int J Clin Pharmacol Ther. 1999 Oct;37(10):499-502.

PMID:
10543317
44.
45.
46.

Chorismate mutase-prephenate dehydratase from Escherichia coli. Study of catalytic and regulatory domains using genetically engineered proteins.

Zhang S, Pohnert G, Kongsaeree P, Wilson DB, Clardy J, Ganem B.

J Biol Chem. 1998 Mar 13;273(11):6248-53.

47.
48.
50.

Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors.

Faerman CH, Savvides SN, Strickland C, Breidenbach MA, Ponasik JA, Ganem B, Ripoll D, Krauth-Siegel RL, Karplus PA.

Bioorg Med Chem. 1996 Aug;4(8):1247-53.

PMID:
8879546

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