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Combined Ibrutinib and Venetoclax for First-Line Treatment for Patients with Chronic Lymphocytic Leukemia (CLL).

Jain N, Keating MJ, Thompson PA, Ferrajoli A, Burger JA, Borthakur GM, Takahashi K, Estrov ZE, Fowler NH, Kadia TM, Konopleva MY, Alvarado Y, Yilmaz M, DiNardo CD, Bose P, Ohanian M, Pemmaraju N, Jabbour E, Sasaki K, Kanagal-Shamanna R, Patel K, Jorgensen JL, Wang SA, Garg N, Wang X, Sondermann K, Cruz N, Wei C, Ayala A, Plunkett W, Kantarjian HM, Gandhi V, Wierda WG.

Blood. 2019 Nov 13;134(Supplement_1):34. doi: 10.1182/blood-2019-131847.


Physiotherapy rehabilitation for osteoporotic vertebral fracture-a randomised controlled trial and economic evaluation (PROVE trial).

Barker KL, Newman M, Stallard N, Leal J, Lowe CM, Javaid MK, Noufaily A, Hughes T, Smith D, Gandhi V, Cooper C, Lamb SE; PROVE trial group.

Osteoporos Int. 2019 Nov 12. doi: 10.1007/s00198-019-05133-0. [Epub ahead of print]


Drugs, discovery, and dermatology: Renbök, research and repurposing.

Sonthalia S, Agrawal M, Sehgal VN, Gandhi V, Gupta KS.

Drug Discov Today. 2019 Oct 31. pii: S1359-6446(19)30415-5. doi: 10.1016/j.drudis.2019.10.011. [Epub ahead of print] No abstract available.


Successful nonsurgical treatment of penile Buschke-Löwenstein tumor with 12 weeks of 5% imiquimod alone.

Sonthalia S, Gandhi V, Agrawal M, Sharma P.

Int J STD AIDS. 2019 Oct;30(11):1136-1139. doi: 10.1177/0956462419855505. Epub 2019 Sep 24. No abstract available.


Trabectedin Reveals a Strategy of Immunomodulation in Chronic Lymphocytic Leukemia.

Banerjee P, Zhang R, Ivan C, Galletti G, Clise-Dwyer K, Barbaglio F, Scarfò L, Aracil M, Klein C, Wierda W, Plunkett W, Caligaris-Cappio F, Gandhi V, Keating MJ, Bertilaccio MTS.

Cancer Immunol Res. 2019 Sep 17. doi: 10.1158/2326-6066.CIR-19-0152. [Epub ahead of print]


Oral administration of 3,3'-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis.

Gandhi KA, Goda JS, Gandhi VV, Sadanpurwala A, Jain VK, Joshi K, Epari S, Rane S, Mohanty B, Chaudhari P, Kembhavi S, Kunwar A, Gota V, Priyadarsini KI.

Free Radic Biol Med. 2019 Dec;145:8-19. doi: 10.1016/j.freeradbiomed.2019.09.009. Epub 2019 Sep 12.


Passive and Active Drug Targeting: Role of Nanocarriers in Rational Design of Anticancer Formulations.

Das RP, Gandhi VV, Singh BG, Kunwar A.

Curr Pharm Des. 2019;25(28):3034-3056. doi: 10.2174/1381612825666190830155319.


Exercise or manual physiotherapy compared with a single session of physiotherapy for osteoporotic vertebral fracture: three-arm PROVE RCT.

Barker KL, Newman M, Stallard N, Leal J, Minns Lowe C, Javaid MK, Noufaily A, Adhikari A, Hughes T, Smith DJ, Gandhi V, Cooper C, Lamb SE.

Health Technol Assess. 2019 Aug;23(44):1-318. doi: 10.3310/hta23440.


Ibrutinib and Venetoclax for First-Line Treatment of CLL. Reply.

Jain N, Gandhi V, Wierda W.

N Engl J Med. 2019 Aug 22;381(8):789. doi: 10.1056/NEJMc1908754. No abstract available.


Adult with intestinal malrotation and colocolic intussusception: an unusual combo.

Gandhi V, Pai N, Kashiva R, Mane D.

BMJ Case Rep. 2019 Jul 22;12(7). pii: e226398. doi: 10.1136/bcr-2018-226398.


Stability of peripheral blood immune markers in patients with asthma.

Shrestha Palikhe N, Bosonea AM, Laratta C, Gandhi VD, Nahirney D, Hillaby A, Bowen M, Bhutani M, Mayers I, Cameron L, Vliagoftis H.

Allergy Asthma Clin Immunol. 2019 Apr 29;15:30. doi: 10.1186/s13223-019-0343-4. eCollection 2019.


Recurrent acute pancreatitis and the reverse 'S'-shaped pancreatic duct.

Gandhi V, Gautam P, Pai N.

BMJ Case Rep. 2019 Jun 3;12(6). pii: e226492. doi: 10.1136/bcr-2018-226492. No abstract available.


Recurrent gastrointestinal bleeding in a patient with type 1 neurofibromatosis.

Gandhi V, Gautam P, Chharchhodawala T, Pai N.

BMJ Case Rep. 2019 Jun 3;12(6). pii: e226303. doi: 10.1136/bcr-2018-226303.


Induction of apoptosis by MCL-1 inhibitors in chronic lymphocytic leukemia cells.

Chen LS, Keating MJ, Wierda WG, Gandhi V.

Leuk Lymphoma. 2019 Dec;60(12):3063-3066. doi: 10.1080/10428194.2019.1622098. Epub 2019 Jun 4. No abstract available.


Ibrutinib and Venetoclax for First-Line Treatment of CLL.

Jain N, Keating M, Thompson P, Ferrajoli A, Burger J, Borthakur G, Takahashi K, Estrov Z, Fowler N, Kadia T, Konopleva M, Alvarado Y, Yilmaz M, DiNardo C, Bose P, Ohanian M, Pemmaraju N, Jabbour E, Sasaki K, Kanagal-Shamanna R, Patel K, Jorgensen J, Garg N, Wang X, Sondermann K, Cruz N, Wei C, Ayala A, Plunkett W, Kantarjian H, Gandhi V, Wierda W.

N Engl J Med. 2019 May 30;380(22):2095-2103. doi: 10.1056/NEJMoa1900574.


PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells.

Cervantes-Gomez F, Stellrecht CM, Ayres ML, Keating MJ, Wierda WG, Gandhi V.

Oncotarget. 2019 Apr 19;10(29):2793-2809. doi: 10.18632/oncotarget.26876. eCollection 2019 Apr 19.


Long-Term Treatment and Prevention of PE: Part 3.

Rali P, Gandhi V, Sockrider M.

Am J Respir Crit Care Med. 2019 May 1;199(9):P17-P18. doi: 10.1164/rccm.1999P17. No abstract available.


LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma.

Galan-Cobo A, Sitthideatphaiboon P, Qu X, Poteete A, Pisegna MA, Tong P, Chen PH, Boroughs LK, Rodriguez MLM, Zhang W, Parlati F, Wang J, Gandhi V, Skoulidis F, DeBerardinis RJ, Minna JD, Heymach JV.

Cancer Res. 2019 Jul 1;79(13):3251-3267. doi: 10.1158/0008-5472.CAN-18-3527. Epub 2019 Apr 30.


Acute Treatment of Pulmonary Embolism: Part 2.

Rali P, Gandhi V, Sockrider M.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):P15-P16. doi: 10.1164/rccm.1998P15. No abstract available.


8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia.

Buettner R, Nguyen LXT, Kumar B, Morales C, Liu C, Chen LS, Pemovska T, Synold TW, Palmer J, Thompson R, Li L, Hoang DH, Zhang B, Ghoda L, Kowolik C, Kontro M, Leitch C, Wennerberg K, Yu X, Chen CC, Horne D, Gandhi V, Pullarkat V, Marcucci G, Rosen ST.

J Cell Physiol. 2019 Feb 15. doi: 10.1002/jcp.28294. [Epub ahead of print]


Ibrutinib dose and clinical outcome in chronic lymphocytic leukemia - learning from the 'real world'.

Bose P, Chen LS, Gandhi V.

Leuk Lymphoma. 2019 Jul;60(7):1603-1605. doi: 10.1080/10428194.2019.1571207. Epub 2019 Feb 6. No abstract available.


Development and pilot testing of an mHealth behavioral cancer pain protocol for medically underserved communities.

Dorfman CS, Kelleher SA, Winger JG, Shelby RA, Thorn BE, Sutton LM, Keefe FJ, Gandhi V, Manohar P, Somers TJ.

J Psychosoc Oncol. 2019 May-Jun;37(3):335-349. doi: 10.1080/07347332.2018.1479327. Epub 2018 Dec 26.


Extracellular Flux Assays to Determine Oxidative Phosphorylation and Glycolysis in Chronic Lymphocytic Leukemia Cells.

Vangapandu HV, Gandhi V.

Methods Mol Biol. 2019;1881:121-128. doi: 10.1007/978-1-4939-8876-1_10.


In Vitro Assay to Study CLL and Monocyte Interactions.

Bertilaccio MTS, Zhang R, Banerjee P, Gandhi V.

Methods Mol Biol. 2019;1881:113-119. doi: 10.1007/978-1-4939-8876-1_9.


Ex Vivo Pharmacological Profiling in Chronic Lymphocytic Leukemia Cells.

Aslan B, Ayres ML, Gandhi V.

Methods Mol Biol. 2019;1881:19-25. doi: 10.1007/978-1-4939-8876-1_2.


Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol.

Williamson E, Ward L, Vadher K, Dutton SJ, Parker B, Petrou S, Hutchinson CE, Gagen R, Arden NK, Barker K, Boniface G, Bruce J, Collins G, Fairbank J, Fitch J, French DP, Garrett A, Gandhi V, Griffiths F, Hansen Z, Mallen C, Morris A, Lamb SE.

BMJ Open. 2018 Oct 18;8(10):e022205. doi: 10.1136/bmjopen-2018-022205.


A pilot study of lower doses of ibrutinib in patients with chronic lymphocytic leukemia.

Chen LS, Bose P, Cruz ND, Jiang Y, Wu Q, Thompson PA, Feng S, Kroll MH, Qiao W, Huang X, Jain N, Wierda WG, Keating MJ, Gandhi V.

Blood. 2018 Nov 22;132(21):2249-2259. doi: 10.1182/blood-2018-06-860593. Epub 2018 Sep 25.


Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents.

Chen W, Fan H, Balakrishnan K, Wang Y, Sun H, Fan Y, Gandhi V, Arnold LA, Peng X.

J Med Chem. 2018 Oct 25;61(20):9132-9145. doi: 10.1021/acs.jmedchem.8b00559. Epub 2018 Oct 10.


What evidence is used to underpin the design of strength-based exercise interventions evaluated in randomised controlled trials for rheumatoid arthritis? A systematic review protocol.

Boniface G, Norris M, Williamson E, Gandhi V, Kirtley S, O'Connell N.

BMJ Open. 2018 Sep 10;8(9):e024127. doi: 10.1136/bmjopen-2018-024127.


Comprehensive Ara-C SNP score predicts leukemic cell intracellular ara-CTP levels in pediatric acute myeloid leukemia patients.

Elsayed AH, Cao X, Crews KR, Gandhi V, Plunkett W, Rubnitz JE, Ribeiro RC, Pounds SB, Lamba JK.

Pharmacogenomics. 2018 Sep 1;19(14):1101-1110. doi: 10.2217/pgs-2018-0086. Epub 2018 Aug 8.


A Pilot Phase II Study of Erlotinib for the Treatment of Patients with Relapsed/Refractory Acute Myeloid Leukemia.

Abou Dalle I, Cortes JE, Pinnamaneni P, Lamothe B, Diaz Duque A, Randhawa J, Pemmaraju N, Jabbour E, Ferrajoli A, Wierda WG, Estrov Z, Konopleva M, Ravandi F, Alvarado Y, Borthakur G, Gandhi V, Kantarjian HM.

Acta Haematol. 2018;140(1):30-39. doi: 10.1159/000490092. Epub 2018 Aug 2.


Toxicity and Antigenotoxic Effect of Hispolon Derivatives: Role of Structure in Modulating Cellular Redox State and Thioredoxin Reductase.

Chethna P, Iyer SS, Gandhi VV, Kunwar A, Singh BG, Barik A, Balaji NV, Ramani MV, Subbaraju GV, Priyadarsini KI.

ACS Omega. 2018 Jun 30;3(6):5958-5970. doi: 10.1021/acsomega.8b00415. Epub 2018 Jun 1.


SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium.

Perekatt AO, Shah PP, Cheung S, Jariwala N, Wu A, Gandhi V, Kumar N, Feng Q, Patel N, Chen L, Joshi S, Zhou A, Taketo MM, Xing J, White E, Gao N, Gatza ML, Verzi MP.

Cancer Res. 2018 Sep 1;78(17):4878-4890. doi: 10.1158/0008-5472.CAN-18-0043. Epub 2018 Jul 9.


Insulin decreases expression of the proinflammatory receptor proteinase-activated receptor-2 on human airway epithelial cells.

Gandhi VD, Shrestha Palikhe N, Hamza SM, Dyck JRB, Buteau J, Vliagoftis H.

J Allergy Clin Immunol. 2018 Sep;142(3):1003-1006.e8. doi: 10.1016/j.jaci.2018.04.040. Epub 2018 Jun 8. No abstract available.


Biological and metabolic effects of IACS-010759, an OxPhos inhibitor, on chronic lymphocytic leukemia cells.

Vangapandu HV, Alston B, Morse J, Ayres ML, Wierda WG, Keating MJ, Marszalek JR, Gandhi V.

Oncotarget. 2018 May 18;9(38):24980-24991. doi: 10.18632/oncotarget.25166. eCollection 2018 May 18.


Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers.

Cortes J, Tamura K, DeAngelo DJ, de Bono J, Lorente D, Minden M, Uy GL, Kantarjian H, Chen LS, Gandhi V, Godin R, Keating K, McEachern K, Vishwanathan K, Pease JE, Dean E.

Br J Cancer. 2018 May;118(11):1425-1433. doi: 10.1038/s41416-018-0082-1. Epub 2018 May 16.


Do preterm infants with a birth weight ≤1250 g born to single-parent families have poorer neurodevelopmental outcomes at age 3 than those born to two-parent families?

Lodha A, Lakhani J, Ediger K, Tang S, Lodha A, Gandhi V, Creighton D.

J Perinatol. 2018 Jul;38(7):900-907. doi: 10.1038/s41372-018-0118-7. Epub 2018 May 8.


Reminders of cancer risk and pain catastrophizing: relationships with cancer worry and perceived risk in women with a first-degree relative with breast cancer.

Whitney CA, Dorfman CS, Shelby RA, Keefe FJ, Gandhi V, Somers TJ.

Fam Cancer. 2019 Jan;18(1):9-18. doi: 10.1007/s10689-018-0082-6.


A new appliance for efficient molar distalization.

Gandhi V, Mehta F, Parekh H, Agrawal M.

J Clin Orthod. 2017 Nov;51(11):738-747. No abstract available.


Recent therapeutic advances in chronic lymphocytic leukemia.

Bose P, Gandhi V.

F1000Res. 2017 Oct 31;6:1924. doi: 10.12688/f1000research.11618.1. eCollection 2017. Review.


Pharmacodynamics and proteomic analysis of acalabrutinib therapy: similarity of on-target effects to ibrutinib and rationale for combination therapy.

Patel VK, Lamothe B, Ayres ML, Gay J, Cheung JP, Balakrishnan K, Ivan C, Morse J, Nelson M, Keating MJ, Wierda WG, Marszalek JR, Gandhi V.

Leukemia. 2018 Apr;32(4):920-930. doi: 10.1038/leu.2017.321. Epub 2017 Nov 3.


Human Immunodeficiency Virus Medicine Association Pain Management Guidelines Needed to Curb Opioid Epidemic.

Gandhi V, Nurutdinova D, Milunka Kojic E, Aberg JA.

Clin Infect Dis. 2018 Mar 19;66(7):1152-1153. doi: 10.1093/cid/cix932. No abstract available.


The relationship between holding back from communicating about breast concerns and anxiety in the year following breast biopsy.

Dorfman CS, Lamb E, Van Denburg A, Wren AA, Soo MS, Faircloth K, Gandhi V, Shelby RA.

J Psychosoc Oncol. 2018 Mar-Apr;36(2):222-237. doi: 10.1080/07347332.2017.1395939. Epub 2018 Jan 11.


Proteomics profiling identifies induction of caveolin-1 in chronic lymphocytic leukemia cells by bone marrow stromal cells.

Vangapandu HV, Chen H, Wierda WG, Keating MJ, Korkut A, Gandhi V.

Leuk Lymphoma. 2018 Jun;59(6):1427-1438. doi: 10.1080/10428194.2017.1376747. Epub 2017 Oct 3.


Catheter pinch-off syndrome.

Gandhi VG, Rali P, Shah P, Cheema T.

Lung India. 2017 Sep-Oct;34(5):470-471. doi: 10.4103/lungindia.lungindia_14_17. No abstract available.


The Stromal Microenvironment Modulates Mitochondrial Oxidative Phosphorylation in Chronic Lymphocytic Leukemia Cells.

Vangapandu HV, Ayres ML, Bristow CA, Wierda WG, Keating MJ, Balakrishnan K, Stellrecht CM, Gandhi V.

Neoplasia. 2017 Oct;19(10):762-771. doi: 10.1016/j.neo.2017.07.004. Epub 2017 Aug 30.


B-cell Receptor Signaling Regulates Metabolism in Chronic Lymphocytic Leukemia.

Vangapandu HV, Havranek O, Ayres ML, Kaipparettu BA, Balakrishnan K, Wierda WG, Keating MJ, Davis RE, Stellrecht CM, Gandhi V.

Mol Cancer Res. 2017 Dec;15(12):1692-1703. doi: 10.1158/1541-7786.MCR-17-0026. Epub 2017 Aug 23.


Chlorinated adenosine analogue induces AMPK and autophagy in chronic lymphocytic leukaemia cells during therapy.

Stellrecht CM, Chen LS, Ayres ML, Dennison JB, Shentu S, Chen Y, Keating MJ, Wierda WG, Gandhi V.

Br J Haematol. 2017 Oct;179(2):266-271. doi: 10.1111/bjh.14859. Epub 2017 Jul 24.


A phase I/II randomized trial of clofarabine or fludarabine added to idarubicin and cytarabine for adults with relapsed or refractory acute myeloid leukemia.

Short NJ, Kantarjian H, Ravandi F, Huang X, Xiao L, Garcia-Manero G, Plunkett W, Gandhi V, Sasaki K, Pemmaraju N, Daver NG, Borthakur G, Jain N, Konopleva M, Estrov Z, Kadia TM, Wierda WG, DiNardo CD, Brandt M, O'Brien SM, Cortes JE, Jabbour E.

Leuk Lymphoma. 2018 Apr;59(4):813-820. doi: 10.1080/10428194.2017.1349907. Epub 2017 Jul 18.


A randomized phase 2 study of idarubicin and cytarabine with clofarabine or fludarabine in patients with newly diagnosed acute myeloid leukemia.

Jabbour E, Short NJ, Ravandi F, Huang X, Xiao L, Garcia-Manero G, Plunkett W, Gandhi V, Sasaki K, Pemmaraju N, Daver NG, Borthakur G, Jain N, Konopleva M, Estrov Z, Kadia TM, Wierda WG, DiNardo CD, Brandt M, O'Brien SM, Cortes JE, Kantarjian H.

Cancer. 2017 Nov 15;123(22):4430-4439. doi: 10.1002/cncr.30883. Epub 2017 Jul 14.

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