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Items: 1 to 50 of 85

1.

Lipopolysaccharide Reverses Hepatic Stellate Cell Activation via Modulation of cMyb, SMADs and C/EBP Transcription Factors.

Sharma A, Verma AK, Kofron M, Kudira R, Miethke A, Wu T, Wang J, Gandhi CR.

Hepatology. 2020 Feb 16. doi: 10.1002/hep.31188. [Epub ahead of print]

PMID:
32064648
2.

Hepatic deficiency of augmenter of liver regeneration predisposes to nonalcoholic steatohepatitis and fibrosis.

Kumar S, Verma AK, Rani R, Sharma A, Wang J, Shah SA, Behari J, Salazar Gonzalez R, Kohli R, Gandhi CR.

Hepatology. 2020 Feb 7. doi: 10.1002/hep.31167. [Epub ahead of print]

PMID:
32031683
3.

YAP in Kupffer cells enhances the production of pro-inflammatory cytokines and promotes the development of non-alcoholic steatohepatitis.

Song K, Kwon H, Han C, Chen W, Zhang J, Ma W, Dash S, Gandhi CR, Wu T.

Hepatology. 2019 Oct 14. doi: 10.1002/hep.30990. [Epub ahead of print]

PMID:
31610032
4.

The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis.

Flood HM, Bolte C, Dasgupta N, Sharma A, Zhang Y, Gandhi CR, Kalin TV, Kalinichenko VV.

Biol Open. 2019 Feb 11;8(2). pii: bio039800. doi: 10.1242/bio.039800.

5.

Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.

Kumar S, Rani R, Karns R, Gandhi CR.

FASEB J. 2019 Mar;33(3):3825-3840. doi: 10.1096/fj.201802015R. Epub 2018 Dec 12.

PMID:
30540918
6.

Mechanisms of concanavalin A-induced cytokine synthesis by hepatic stellate cells: Distinct roles of interferon regulatory factor-1 in liver injury.

Rani R, Kumar S, Sharma A, Mohanty SK, Donnelly B, Tiao GM, Gandhi CR.

J Biol Chem. 2018 Nov 30;293(48):18466-18476. doi: 10.1074/jbc.RA118.005583. Epub 2018 Oct 22.

7.

"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress.

Vodovotz Y, Simmons RL, Gandhi CR, Barclay D, Jefferson BS, Huang C, Namas R, El-Dehaibi F, Mi Q, Billiar TR, Zamora R.

Front Physiol. 2017 Dec 22;8:1104. doi: 10.3389/fphys.2017.01104. eCollection 2017.

8.

"CHOP"ing intestinal stem cells on way to cholestatic liver injury.

Sharma A, Gandhi CR.

Hepatology. 2018 Apr;67(4):1216-1218. doi: 10.1002/hep.29656. Epub 2018 Feb 20. No abstract available.

PMID:
29144555
9.

Hepatic stellate cell activation and pro-fibrogenic signals.

Gandhi CR.

J Hepatol. 2017 Nov;67(5):1104-1105. doi: 10.1016/j.jhep.2017.06.001. Epub 2017 Sep 20. No abstract available.

10.

Stellate Cells Orchestrate Concanavalin A-Induced Acute Liver Damage.

Rani R, Tandon A, Wang J, Kumar S, Gandhi CR.

Am J Pathol. 2017 Sep;187(9):2008-2019. doi: 10.1016/j.ajpath.2017.05.015. Epub 2017 Jul 13.

11.

15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury.

Yao L, Chen W, Song K, Han C, Gandhi CR, Lim K, Wu T.

PLoS One. 2017 Apr 19;12(4):e0176106. doi: 10.1371/journal.pone.0176106. eCollection 2017.

12.

Toll-Like Receptor 4-Independent Carbon Tetrachloride-Induced Fibrosis and Lipopolysaccharide-Induced Acute Liver Injury in Mice: Role of Hepatic Stellate Cells.

Kumar S, Wang J, Shanmukhappa SK, Gandhi CR.

Am J Pathol. 2017 Jun;187(6):1356-1367. doi: 10.1016/j.ajpath.2017.01.021. Epub 2017 Apr 13.

13.

Augmenter of liver regeneration: A fundamental life protein.

Nalesnik MA, Gandhi CR, Starzl TE.

Hepatology. 2017 Jul;66(1):266-270. doi: 10.1002/hep.29047. Epub 2017 May 22. Review. No abstract available.

14.

Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation.

Kumar S, Wang J, Thomson AW, Gandhi CR.

J Leukoc Biol. 2017 Feb;101(2):429-438. doi: 10.1189/jlb.2A0516-239R. Epub 2016 Aug 31.

15.

Functional Immune Anatomy of the Liver-As an Allograft.

Demetris AJ, Bellamy CO, Gandhi CR, Prost S, Nakanuma Y, Stolz DB.

Am J Transplant. 2016 Jun;16(6):1653-80. doi: 10.1111/ajt.13749. Epub 2016 Mar 21. Review.

16.

Hepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice.

Kumar S, Wang J, Rani R, Gandhi CR.

PLoS One. 2016 Jan 25;11(1):e0147864. doi: 10.1371/journal.pone.0147864. eCollection 2016.

17.

A novel role for hepatic stellate cells in pathogenesis of visceral leishmaniasis.

Shoukry NH, Fabre T, Gandhi CR.

Hepatology. 2016 Feb;63(2):375-6. doi: 10.1002/hep.28247. Epub 2015 Nov 30. No abstract available.

PMID:
26403215
18.

Endotoxin-stimulated Rat Hepatic Stellate Cells Induce Autophagy in Hepatocytes as a Survival Mechanism.

Dangi A, Huang C, Tandon A, Stolz D, Wu T, Gandhi CR.

J Cell Physiol. 2016 Jan;231(1):94-105. doi: 10.1002/jcp.25055.

19.

Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.

Gandhi CR, Chaillet JR, Nalesnik MA, Kumar S, Dangi A, Demetris AJ, Ferrell R, Wu T, Divanovic S, Stankeiwicz T, Shaffer B, Stolz DB, Harvey SA, Wang J, Starzl TE.

Gastroenterology. 2015 Feb;148(2):379-391.e4. doi: 10.1053/j.gastro.2014.10.008. Epub 2014 Oct 13.

20.

Reply to: "depletion of hepatic stellate cells: have Kupffer cells lost their bad neighbor?".

Dangi A, Gandhi CR.

J Hepatol. 2014 Sep;61(3):715-6. doi: 10.1016/j.jhep.2014.05.038. Epub 2014 Jun 2. No abstract available.

21.

Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice.

Quillin RC 3rd, Wilson GC, Nojima H, Freeman CM, Wang J, Schuster RM, Blanchard JA, Edwards MJ, Gandhi CR, Gulbins E, Lentsch AB.

Hepatol Res. 2015 Mar;45(3):305-14. doi: 10.1111/hepr.12352. Epub 2014 Jun 4.

22.

The transcriptomic response of rat hepatic stellate cells to endotoxin: implications for hepatic inflammation and immune regulation.

Harvey SA, Dangi A, Tandon A, Gandhi CR.

PLoS One. 2013 Dec 9;8(12):e82159. doi: 10.1371/journal.pone.0082159. eCollection 2013.

23.

A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury.

Stewart RK, Dangi A, Huang C, Murase N, Kimura S, Stolz DB, Wilson GC, Lentsch AB, Gandhi CR.

J Hepatol. 2014 Feb;60(2):298-305. doi: 10.1016/j.jhep.2013.09.013. Epub 2013 Sep 20.

24.

miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression.

Li J, Ghazwani M, Zhang Y, Lu J, Li J, Fan J, Gandhi CR, Li S.

J Hepatol. 2013 Mar;58(3):522-8. doi: 10.1016/j.jhep.2012.11.011. Epub 2012 Nov 21.

25.

Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies.

Vodovotz Y, Prelich J, Lagoa C, Barclay D, Zamora R, Murase N, Gandhi CR.

Mol Med. 2013 Jan 22;18:1421-9. doi: 10.2119/molmed.2012.00183.

26.

Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO.

Sumpter TL, Dangi A, Matta BM, Huang C, Stolz DB, Vodovotz Y, Thomson AW, Gandhi CR.

J Immunol. 2012 Oct 15;189(8):3848-58. doi: 10.4049/jimmunol.1200819. Epub 2012 Sep 7.

27.

Augmenter of liver regeneration.

Gandhi CR.

Fibrogenesis Tissue Repair. 2012 Jul 9;5(1):10. doi: 10.1186/1755-1536-5-10.

28.

Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance.

Dangi A, Sumpter TL, Kimura S, Stolz DB, Murase N, Raimondi G, Vodovotz Y, Huang C, Thomson AW, Gandhi CR.

J Immunol. 2012 Apr 15;188(8):3667-77. doi: 10.4049/jimmunol.1102460. Epub 2012 Mar 16.

29.
30.

Involvement of cytosolic phospholipase A2 alpha signalling pathway in spontaneous and transforming growth factor-beta-induced activation of rat hepatic stellate cells.

Zhao L, Gandhi CR, Gao ZH.

Liver Int. 2011 Nov;31(10):1565-73. doi: 10.1111/j.1478-3231.2011.02632.x. Epub 2011 Aug 31.

PMID:
22093332
31.

Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells.

Li J, Zhang Y, Kuruba R, Gao X, Gandhi CR, Xie W, Li S.

Mol Pharmacol. 2011 Jul;80(1):191-200. doi: 10.1124/mol.110.068247. Epub 2011 Apr 21. Erratum in: Mol Pharmacol. 2012 Aug;82(2):360.

32.

Constitutive release of powerful antioxidant-scavenging activity by hepatic stellate cells: protection of hepatocytes from ischemia/reperfusion injury.

Jameel NM, Thirunavukkarasu C, Murase N, Cascio M, Prelich J, Yang S, Harvey SA, Gandhi CR.

Liver Transpl. 2010 Dec;16(12):1400-9. doi: 10.1002/lt.22172.

33.
34.

Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure.

Han C, Li G, Lim K, DeFrances MC, Gandhi CR, Wu T.

J Immunol. 2008 Dec 1;181(11):8027-35.

35.

p38-MAPK- and caspase-3-mediated superoxide-induced apoptosis of rat hepatic stellate cells: reversal by retinoic acid.

Jameel NM, Thirunavukkarasu C, Wu T, Watkins SC, Friedman SL, Gandhi CR.

J Cell Physiol. 2009 Jan;218(1):157-66. doi: 10.1002/jcp.21581.

36.

Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes.

Thirunavukkarasu C, Wang LF, Harvey SA, Watkins SC, Chaillet JR, Prelich J, Starzl TE, Gandhi CR.

J Hepatol. 2008 Apr;48(4):578-88. doi: 10.1016/j.jhep.2007.12.010. Epub 2008 Jan 28.

37.
38.
39.

Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes.

Thirunavukkarasu C, Uemura T, Wang LF, Watkins SC, Gandhi CR.

J Cell Physiol. 2005 Aug;204(2):654-65.

PMID:
15828022
40.

Inhibition of T-cell responses by hepatic stellate cells via B7-H1-mediated T-cell apoptosis in mice.

Yu MC, Chen CH, Liang X, Wang L, Gandhi CR, Fung JJ, Lu L, Qian S.

Hepatology. 2004 Dec;40(6):1312-21.

PMID:
15565659
41.

Superoxide-induced apoptosis of activated rat hepatic stellate cells.

Thirunavukkarasu C, Watkins S, Harvey SA, Gandhi CR.

J Hepatol. 2004 Oct;41(4):567-75.

PMID:
15464236
42.

Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats.

Thirunavukkarasu C, Yang Y, Subbotin VM, Harvey SA, Fung J, Gandhi CR.

Gut. 2004 Jul;53(7):1010-9.

43.
44.

Some morphological, growth, and genomic properties of human cells chronically infected with porcine endogenous retrovirus (PERV).

Kuddus RH, Gandhi CR, Rehman KK, Guo F, Watkins SC, Valdivia LA, Fung JJ.

Genome. 2003 Oct;46(5):858-69.

PMID:
14608403
45.
46.
47.

Portacaval shunt causes apoptosis and liver atrophy in rats despite increases in endogenous levels of major hepatic growth factors.

Gandhi CR, Murase N, Subbotin VM, Uemura T, Nalesnik M, Demetris AJ, Fung JJ, Starzl TE.

J Hepatol. 2002 Sep;37(3):340-8.

48.

Accelerated reversal of carbon tetrachloride-induced cirrhosis in rats by the endothelin receptor antagonist TAK-044.

Anselmi K, Subbotin VM, Nemoto E, Gandhi CR.

J Gastroenterol Hepatol. 2002 May;17(5):589-97.

PMID:
12084034
49.

Down-regulation and recovery of endothelin-1 binding and signaling in rat cardiomyocytes.

Harvey SA, Gandhi CR, Behal RH, Olson MS.

Biochem Biophys Res Commun. 2001 Nov 2;288(3):558-63.

PMID:
11676479

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