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Items: 33


Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice.

Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, Zink EM, Casey CP, Taylor BC, Lane CJ, Bramer LM, Isern NG, Hoyt DW, Noecker C, Sweredoski MJ, Moradian A, Borenstein E, Jansson JK, Knight R, Metz TO, Lois C, Geschwind DH, Krajmalnik-Brown R, Mazmanian SK.

Cell. 2019 May 30;177(6):1600-1618.e17. doi: 10.1016/j.cell.2019.05.004.


Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia.

Fan CC, McGrath JJ, Appadurai V, Buil A, Gandal MJ, Schork AJ, Mortensen PB, Agerbo E, Geschwind SA, Geschwind D, Werge T, Thompson WK, Pedersen CB.

Nat Commun. 2018 Dec 13;9(1):5296. doi: 10.1038/s41467-018-07708-7.


Comprehensive functional genomic resource and integrative model for the human brain.

Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümüş ZH, Crawford GE; PsychENCODE Consortium, Roussos P, Akbarian S, Jaffe AE, White KP, Weng Z, Sestan N, Geschwind DH, Knowles JA, Gerstein MB.

Science. 2018 Dec 14;362(6420). pii: eaat8464. doi: 10.1126/science.aat8464.


Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.

Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE; PsychENCODE Consortium, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH.

Science. 2018 Dec 14;362(6420). pii: eaat8127. doi: 10.1126/science.aat8127.


Integrative network analysis reveals biological pathways associated with Williams syndrome.

Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, Geschwind DH, Hagiwara M.

J Child Psychol Psychiatry. 2019 May;60(5):585-598. doi: 10.1111/jcpp.12999. Epub 2018 Oct 25.


Banking on Polygenicity to Disentangle Psychiatric Comorbidity.

Haney JR, Parhami S, Gandal MJ.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jul;3(7):577-578. doi: 10.1016/j.bpsc.2018.05.006. No abstract available.


Author Correction: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism.

Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, de la Torre Ubieta L, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH.

Nature. 2018 Aug;560(7718):E30. doi: 10.1038/s41586-018-0295-8.


Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex.

Schwede M, Nagpal S, Gandal MJ, Parikshak NN, Mirnics K, Geschwind DH, Morrow EM.

J Neurodev Disord. 2018 Jun 1;10(1):18. doi: 10.1186/s11689-018-9237-x.


Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.

Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP; CommonMind Consortium; PsychENCODE Consortium; iPSYCH-BROAD Working Group, Horvath S, Geschwind DH.

Science. 2018 Feb 9;359(6376):693-697. doi: 10.1126/science.aad6469.


Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism.

Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, Ubieta LT, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH.

Nature. 2016 Dec 15;540(7633):423-427. doi: 10.1038/nature20612. Epub 2016 Dec 5. Erratum in: Nature. 2018 Aug;560(7718):E30.


The road to precision psychiatry: translating genetics into disease mechanisms.

Gandal MJ, Leppa V, Won H, Parikshak NN, Geschwind DH.

Nat Neurosci. 2016 Oct 26;19(11):1397-1407. doi: 10.1038/nn.4409. Review.


Chromosome conformation elucidates regulatory relationships in developing human brain.

Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH.

Nature. 2016 Oct 27;538(7626):523-527. doi: 10.1038/nature19847. Epub 2016 Oct 19.


The Genetics-Driven Revival in Neuropsychiatric Drug Development.

Gandal MJ, Geschwind DH.

Biol Psychiatry. 2016 Apr 15;79(8):628-30. doi: 10.1016/j.biopsych.2016.02.024. No abstract available.


Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders.

Parikshak NN, Gandal MJ, Geschwind DH.

Nat Rev Genet. 2015 Aug;16(8):441-58. doi: 10.1038/nrg3934. Epub 2015 Jul 7. Review.


Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology.

Port RG, Gandal MJ, Roberts TP, Siegel SJ, Carlson GC.

Front Cell Neurosci. 2014 Dec 8;8:414. doi: 10.3389/fncel.2014.00414. eCollection 2014. Review.


Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability.

Tatard-Leitman VM, Jutzeler CR, Suh J, Saunders JA, Billingslea EN, Morita S, White R, Featherstone RE, Ray R, Ortinski PI, Banerjee A, Gandal MJ, Lin R, Alexandrescu A, Liang Y, Gur RE, Borgmann-Winter KE, Carlson GC, Hahn CG, Siegel SJ.

Biol Psychiatry. 2015 Mar 15;77(6):556-68. doi: 10.1016/j.biopsych.2014.06.026. Epub 2014 Jul 18.


Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits.

Billingslea EN, Tatard-Leitman VM, Anguiano J, Jutzeler CR, Suh J, Saunders JA, Morita S, Featherstone RE, Ortinski PI, Gandal MJ, Lin R, Liang Y, Gur RE, Carlson GC, Hahn CG, Siegel SJ.

Neuropsychopharmacology. 2014 Jun;39(7):1603-13. doi: 10.1038/npp.2014.7. Epub 2014 Feb 14.


Measuring the maturity of the fast-spiking interneuron transcriptional program in autism, schizophrenia, and bipolar disorder.

Gandal MJ, Nesbitt AM, McCurdy RM, Alter MD.

PLoS One. 2012;7(8):e41215. doi: 10.1371/journal.pone.0041215. Epub 2012 Aug 24.


GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.

Gandal MJ, Sisti J, Klook K, Ortinski PI, Leitman V, Liang Y, Thieu T, Anderson R, Pierce RC, Jonak G, Gur RE, Carlson G, Siegel SJ.

Transl Psychiatry. 2012 Jul 17;2:e142. doi: 10.1038/tp.2012.69.


NMDA antagonist MK801 recreates auditory electrophysiology disruption present in autism and other neurodevelopmental disorders.

Saunders JA, Gandal MJ, Roberts TP, Siegel SJ.

Behav Brain Res. 2012 Oct 1;234(2):233-7. doi: 10.1016/j.bbr.2012.06.032. Epub 2012 Jul 5.


Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia?

Gandal MJ, Anderson RL, Billingslea EN, Carlson GC, Roberts TP, Siegel SJ.

Genes Brain Behav. 2012 Aug;11(6):740-50. doi: 10.1111/j.1601-183X.2012.00816.x.


Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density.

Cao YA, Featherstone RE, Gandal MJ, Liang Y, Jutzeler C, Saunders J, Tatard-Leitman V, Chen J, Weinberger DR, Lerman C, Siegel SJ.

Behav Neurosci. 2012 Apr;126(2):332-43. doi: 10.1037/a0027047. Epub 2012 Feb 6.


MeCP2+/- mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder.

Liao W, Gandal MJ, Ehrlichman RS, Siegel SJ, Carlson GC.

Neurobiol Dis. 2012 Apr;46(1):88-92. doi: 10.1016/j.nbd.2011.12.048. Epub 2012 Jan 9.


NMDA antagonists recreate signal-to-noise ratio and timing perturbations present in schizophrenia.

Saunders JA, Gandal MJ, Siegel SJ.

Neurobiol Dis. 2012 Apr;46(1):93-100. doi: 10.1016/j.nbd.2011.12.049. Epub 2012 Jan 9.


mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism.

Mehta MV, Gandal MJ, Siegel SJ.

PLoS One. 2011;6(10):e26077. doi: 10.1371/journal.pone.0026077. Epub 2011 Oct 7.


Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia.

Carlson GC, Talbot K, Halene TB, Gandal MJ, Kazi HA, Schlosser L, Phung QH, Gur RE, Arnold SE, Siegel SJ.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E962-70. doi: 10.1073/pnas.1109625108. Epub 2011 Oct 3.


Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia.

Gandal MJ, Edgar JC, Klook K, Siegel SJ.

Neuropharmacology. 2012 Mar;62(3):1504-18. doi: 10.1016/j.neuropharm.2011.02.007. Epub 2011 Feb 22. Review.


Validating γ oscillations and delayed auditory responses as translational biomarkers of autism.

Gandal MJ, Edgar JC, Ehrlichman RS, Mehta M, Roberts TP, Siegel SJ.

Biol Psychiatry. 2010 Dec 15;68(12):1100-6. doi: 10.1016/j.biopsych.2010.09.031.


Mouse behavioral endophenotypes for schizophrenia.

Amann LC, Gandal MJ, Halene TB, Ehrlichman RS, White SL, McCarren HS, Siegel SJ.

Brain Res Bull. 2010 Sep 30;83(3-4):147-61. doi: 10.1016/j.brainresbull.2010.04.008. Epub 2010 Apr 28. Review.


In vitro-in vivo correlations of scalable PLGA-risperidone implants for the treatment of schizophrenia.

Amann LC, Gandal MJ, Lin R, Liang Y, Siegel SJ.

Pharm Res. 2010 Aug;27(8):1730-7. doi: 10.1007/s11095-010-0152-4. Epub 2010 Apr 27.


Ketamine modulates theta and gamma oscillations.

Lazarewicz MT, Ehrlichman RS, Maxwell CR, Gandal MJ, Finkel LH, Siegel SJ.

J Cogn Neurosci. 2010 Jul;22(7):1452-64. doi: 10.1162/jocn.2009.21305.


N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia.

Ehrlichman RS, Gandal MJ, Maxwell CR, Lazarewicz MT, Finkel LH, Contreras D, Turetsky BI, Siegel SJ.

Neuroscience. 2009 Jan 23;158(2):705-12. doi: 10.1016/j.neuroscience.2008.10.031. Epub 2008 Oct 28.


A novel electrophysiological model of chemotherapy-induced cognitive impairments in mice.

Gandal MJ, Ehrlichman RS, Rudnick ND, Siegel SJ.

Neuroscience. 2008 Nov 11;157(1):95-104. doi: 10.1016/j.neuroscience.2008.08.060. Epub 2008 Sep 9.

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