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Items: 42

1.

Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 Copy Number Variant-Mediated Risk for Neuropsychiatric Disorders.

Forsyth JK, Nachun D, Gandal MJ, Geschwind DH, Anderson AE, Coppola G, Bearden CE.

Biol Psychiatry. 2019 Jul 11. pii: S0006-3223(19)31514-8. doi: 10.1016/j.biopsych.2019.06.029. [Epub ahead of print]

2.

Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage.

Lee C, Kang EY, Gandal MJ, Eskin E, Geschwind DH.

Nat Neurosci. 2019 Sep;22(9):1521-1532. doi: 10.1038/s41593-019-0461-9. Epub 2019 Aug 26.

PMID:
31455884
3.

Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks.

Ruzzo EK, Pérez-Cano L, Jung JY, Wang LK, Kashef-Haghighi D, Hartl C, Singh C, Xu J, Hoekstra JN, Leventhal O, Leppä VM, Gandal MJ, Paskov K, Stockham N, Polioudakis D, Lowe JK, Prober DA, Geschwind DH, Wall DP.

Cell. 2019 Aug 8;178(4):850-866.e26. doi: 10.1016/j.cell.2019.07.015.

4.

Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice.

Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, Zink EM, Casey CP, Taylor BC, Lane CJ, Bramer LM, Isern NG, Hoyt DW, Noecker C, Sweredoski MJ, Moradian A, Borenstein E, Jansson JK, Knight R, Metz TO, Lois C, Geschwind DH, Krajmalnik-Brown R, Mazmanian SK.

Cell. 2019 May 30;177(6):1600-1618.e17. doi: 10.1016/j.cell.2019.05.004.

5.

A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment.

Schork AJ, Won H, Appadurai V, Nudel R, Gandal M, Delaneau O, Revsbech Christiansen M, Hougaard DM, Bækved-Hansen M, Bybjerg-Grauholm J, Giørtz Pedersen M, Agerbo E, Bøcker Pedersen C, Neale BM, Daly MJ, Wray NR, Nordentoft M, Mors O, Børglum AD, Bo Mortensen P, Buil A, Thompson WK, Geschwind DH, Werge T.

Nat Neurosci. 2019 Mar;22(3):353-361. doi: 10.1038/s41593-018-0320-0. Epub 2019 Jan 28.

6.

Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia.

Fan CC, McGrath JJ, Appadurai V, Buil A, Gandal MJ, Schork AJ, Mortensen PB, Agerbo E, Geschwind SA, Geschwind D, Werge T, Thompson WK, Pedersen CB.

Nat Commun. 2018 Dec 13;9(1):5296. doi: 10.1038/s41467-018-07708-7.

7.

Comprehensive functional genomic resource and integrative model for the human brain.

Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümüş ZH, Crawford GE; PsychENCODE Consortium, Roussos P, Akbarian S, Jaffe AE, White KP, Weng Z, Sestan N, Geschwind DH, Knowles JA, Gerstein MB.

Science. 2018 Dec 14;362(6420). pii: eaat8464. doi: 10.1126/science.aat8464.

8.

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.

Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE; PsychENCODE Consortium, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH.

Science. 2018 Dec 14;362(6420). pii: eaat8127. doi: 10.1126/science.aat8127.

9.

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.

Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, Baldursson G, Belliveau R, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Churchhouse C, Dumont A, Eriksson N, Gandal M, Goldstein JI, Grasby KL, Grove J, Gudmundsson OO, Hansen CS, Hauberg ME, Hollegaard MV, Howrigan DP, Huang H, Maller JB, Martin AR, Martin NG, Moran J, Pallesen J, Palmer DS, Pedersen CB, Pedersen MG, Poterba T, Poulsen JB, Ripke S, Robinson EB, Satterstrom FK, Stefansson H, Stevens C, Turley P, Walters GB, Won H, Wright MJ; ADHD Working Group of the Psychiatric Genomics Consortium (PGC); Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium; 23andMe Research Team, Andreassen OA, Asherson P, Burton CL, Boomsma DI, Cormand B, Dalsgaard S, Franke B, Gelernter J, Geschwind D, Hakonarson H, Haavik J, Kranzler HR, Kuntsi J, Langley K, Lesch KP, Middeldorp C, Reif A, Rohde LA, Roussos P, Schachar R, Sklar P, Sonuga-Barke EJS, Sullivan PF, Thapar A, Tung JY, Waldman ID, Medland SE, Stefansson K, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Daly MJ, Faraone SV, Børglum AD, Neale BM.

Nat Genet. 2019 Jan;51(1):63-75. doi: 10.1038/s41588-018-0269-7. Epub 2018 Nov 26.

10.

Integrative network analysis reveals biological pathways associated with Williams syndrome.

Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, Geschwind DH, Hagiwara M.

J Child Psychol Psychiatry. 2019 May;60(5):585-598. doi: 10.1111/jcpp.12999. Epub 2018 Oct 25.

11.

Banking on Polygenicity to Disentangle Psychiatric Comorbidity.

Haney JR, Parhami S, Gandal MJ.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jul;3(7):577-578. doi: 10.1016/j.bpsc.2018.05.006. No abstract available.

PMID:
30047475
12.

Author Correction: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism.

Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, de la Torre Ubieta L, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH.

Nature. 2018 Aug;560(7718):E30. doi: 10.1038/s41586-018-0295-8.

13.

Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex.

Schwede M, Nagpal S, Gandal MJ, Parikshak NN, Mirnics K, Geschwind DH, Morrow EM.

J Neurodev Disord. 2018 Jun 1;10(1):18. doi: 10.1186/s11689-018-9237-x.

14.

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.

Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP; CommonMind Consortium; PsychENCODE Consortium; iPSYCH-BROAD Working Group, Horvath S, Geschwind DH.

Science. 2018 Feb 9;359(6376):693-697. doi: 10.1126/science.aad6469.

15.

The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability.

Singh T, Walters JTR, Johnstone M, Curtis D, Suvisaari J, Torniainen M, Rees E, Iyegbe C, Blackwood D, McIntosh AM, Kirov G, Geschwind D, Murray RM, Di Forti M, Bramon E, Gandal M, Hultman CM, Sklar P; INTERVAL Study; UK10K Consortium, Palotie A, Sullivan PF, O'Donovan MC, Owen MJ, Barrett JC.

Nat Genet. 2017 Aug;49(8):1167-1173. doi: 10.1038/ng.3903. Epub 2017 Jun 26.

16.

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism.

Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, Ubieta LT, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH.

Nature. 2016 Dec 15;540(7633):423-427. doi: 10.1038/nature20612. Epub 2016 Dec 5. Erratum in: Nature. 2018 Aug;560(7718):E30.

17.

The road to precision psychiatry: translating genetics into disease mechanisms.

Gandal MJ, Leppa V, Won H, Parikshak NN, Geschwind DH.

Nat Neurosci. 2016 Oct 26;19(11):1397-1407. doi: 10.1038/nn.4409. Review.

18.

Chromosome conformation elucidates regulatory relationships in developing human brain.

Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH.

Nature. 2016 Oct 27;538(7626):523-527. doi: 10.1038/nature19847. Epub 2016 Oct 19.

19.

The Genetics-Driven Revival in Neuropsychiatric Drug Development.

Gandal MJ, Geschwind DH.

Biol Psychiatry. 2016 Apr 15;79(8):628-30. doi: 10.1016/j.biopsych.2016.02.024. No abstract available.

20.

Cannabis-induced psychosis associated with high potency "wax dabs".

Pierre JM, Gandal M, Son M.

Schizophr Res. 2016 Apr;172(1-3):211-2. doi: 10.1016/j.schres.2016.01.056. Epub 2016 Feb 11.

PMID:
26876313
21.

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders.

Parikshak NN, Gandal MJ, Geschwind DH.

Nat Rev Genet. 2015 Aug;16(8):441-58. doi: 10.1038/nrg3934. Epub 2015 Jul 7. Review.

22.

Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology.

Port RG, Gandal MJ, Roberts TP, Siegel SJ, Carlson GC.

Front Cell Neurosci. 2014 Dec 8;8:414. doi: 10.3389/fncel.2014.00414. eCollection 2014. Review.

23.

Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability.

Tatard-Leitman VM, Jutzeler CR, Suh J, Saunders JA, Billingslea EN, Morita S, White R, Featherstone RE, Ray R, Ortinski PI, Banerjee A, Gandal MJ, Lin R, Alexandrescu A, Liang Y, Gur RE, Borgmann-Winter KE, Carlson GC, Hahn CG, Siegel SJ.

Biol Psychiatry. 2015 Mar 15;77(6):556-68. doi: 10.1016/j.biopsych.2014.06.026. Epub 2014 Jul 18.

24.

Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits.

Billingslea EN, Tatard-Leitman VM, Anguiano J, Jutzeler CR, Suh J, Saunders JA, Morita S, Featherstone RE, Ortinski PI, Gandal MJ, Lin R, Liang Y, Gur RE, Carlson GC, Hahn CG, Siegel SJ.

Neuropsychopharmacology. 2014 Jun;39(7):1603-13. doi: 10.1038/npp.2014.7. Epub 2014 Feb 14.

25.

Measuring the maturity of the fast-spiking interneuron transcriptional program in autism, schizophrenia, and bipolar disorder.

Gandal MJ, Nesbitt AM, McCurdy RM, Alter MD.

PLoS One. 2012;7(8):e41215. doi: 10.1371/journal.pone.0041215. Epub 2012 Aug 24.

26.

GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.

Gandal MJ, Sisti J, Klook K, Ortinski PI, Leitman V, Liang Y, Thieu T, Anderson R, Pierce RC, Jonak G, Gur RE, Carlson G, Siegel SJ.

Transl Psychiatry. 2012 Jul 17;2:e142. doi: 10.1038/tp.2012.69.

27.

NMDA antagonist MK801 recreates auditory electrophysiology disruption present in autism and other neurodevelopmental disorders.

Saunders JA, Gandal MJ, Roberts TP, Siegel SJ.

Behav Brain Res. 2012 Oct 1;234(2):233-7. doi: 10.1016/j.bbr.2012.06.032. Epub 2012 Jul 5.

28.

Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia?

Gandal MJ, Anderson RL, Billingslea EN, Carlson GC, Roberts TP, Siegel SJ.

Genes Brain Behav. 2012 Aug;11(6):740-50. doi: 10.1111/j.1601-183X.2012.00816.x.

29.

Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density.

Cao YA, Featherstone RE, Gandal MJ, Liang Y, Jutzeler C, Saunders J, Tatard-Leitman V, Chen J, Weinberger DR, Lerman C, Siegel SJ.

Behav Neurosci. 2012 Apr;126(2):332-43. doi: 10.1037/a0027047. Epub 2012 Feb 6.

PMID:
22309446
30.

MeCP2+/- mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder.

Liao W, Gandal MJ, Ehrlichman RS, Siegel SJ, Carlson GC.

Neurobiol Dis. 2012 Apr;46(1):88-92. doi: 10.1016/j.nbd.2011.12.048. Epub 2012 Jan 9.

31.

NMDA antagonists recreate signal-to-noise ratio and timing perturbations present in schizophrenia.

Saunders JA, Gandal MJ, Siegel SJ.

Neurobiol Dis. 2012 Apr;46(1):93-100. doi: 10.1016/j.nbd.2011.12.049. Epub 2012 Jan 9.

32.

mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism.

Mehta MV, Gandal MJ, Siegel SJ.

PLoS One. 2011;6(10):e26077. doi: 10.1371/journal.pone.0026077. Epub 2011 Oct 7.

33.

Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia.

Carlson GC, Talbot K, Halene TB, Gandal MJ, Kazi HA, Schlosser L, Phung QH, Gur RE, Arnold SE, Siegel SJ.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E962-70. doi: 10.1073/pnas.1109625108. Epub 2011 Oct 3.

34.

Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia.

Gandal MJ, Edgar JC, Klook K, Siegel SJ.

Neuropharmacology. 2012 Mar;62(3):1504-18. doi: 10.1016/j.neuropharm.2011.02.007. Epub 2011 Feb 22. Review.

35.

Validating γ oscillations and delayed auditory responses as translational biomarkers of autism.

Gandal MJ, Edgar JC, Ehrlichman RS, Mehta M, Roberts TP, Siegel SJ.

Biol Psychiatry. 2010 Dec 15;68(12):1100-6. doi: 10.1016/j.biopsych.2010.09.031.

36.

Mouse behavioral endophenotypes for schizophrenia.

Amann LC, Gandal MJ, Halene TB, Ehrlichman RS, White SL, McCarren HS, Siegel SJ.

Brain Res Bull. 2010 Sep 30;83(3-4):147-61. doi: 10.1016/j.brainresbull.2010.04.008. Epub 2010 Apr 28. Review.

PMID:
20433908
37.

In vitro-in vivo correlations of scalable PLGA-risperidone implants for the treatment of schizophrenia.

Amann LC, Gandal MJ, Lin R, Liang Y, Siegel SJ.

Pharm Res. 2010 Aug;27(8):1730-7. doi: 10.1007/s11095-010-0152-4. Epub 2010 Apr 27.

PMID:
20422263
38.

MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism.

Roberts TP, Khan SY, Rey M, Monroe JF, Cannon K, Blaskey L, Woldoff S, Qasmieh S, Gandal M, Schmidt GL, Zarnow DM, Levy SE, Edgar JC.

Autism Res. 2010 Feb;3(1):8-18. doi: 10.1002/aur.111.

39.

Ketamine modulates theta and gamma oscillations.

Lazarewicz MT, Ehrlichman RS, Maxwell CR, Gandal MJ, Finkel LH, Siegel SJ.

J Cogn Neurosci. 2010 Jul;22(7):1452-64. doi: 10.1162/jocn.2009.21305.

PMID:
19583475
40.

N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia.

Ehrlichman RS, Gandal MJ, Maxwell CR, Lazarewicz MT, Finkel LH, Contreras D, Turetsky BI, Siegel SJ.

Neuroscience. 2009 Jan 23;158(2):705-12. doi: 10.1016/j.neuroscience.2008.10.031. Epub 2008 Oct 28.

PMID:
19015010
41.

A novel electrophysiological model of chemotherapy-induced cognitive impairments in mice.

Gandal MJ, Ehrlichman RS, Rudnick ND, Siegel SJ.

Neuroscience. 2008 Nov 11;157(1):95-104. doi: 10.1016/j.neuroscience.2008.08.060. Epub 2008 Sep 9.

42.

Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control.

Karai L, Brown DC, Mannes AJ, Connelly ST, Brown J, Gandal M, Wellisch OM, Neubert JK, Olah Z, Iadarola MJ.

J Clin Invest. 2004 May;113(9):1344-52.

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