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Items: 1 to 50 of 111

1.

Otilonium and pinaverium trigger mitochondrial-mediated apoptosis in rat embryo cortical neurons in vitro.

García-Alvarado F, Govoni G, de Pascual R, Ruiz-Ruiz C, Muñoz-Montero A, Gandía L, de Diego AMG, García AG.

Neurotoxicology. 2019 Jan;70:99-111. doi: 10.1016/j.neuro.2018.11.003. Epub 2018 Nov 15.

PMID:
30448301
2.

Altered excitability and exocytosis in chromaffin cells from the R6/1 mouse model of Huntington's disease is linked to over-expression of mutated huntingtin.

Martínez-Ramírez C, Baraibar AM, Nanclares C, Méndez-López I, Gómez A, Muñoz MP, de Diego AMG, Gandía L, Casarejos MJ, García AG.

J Neurochem. 2018 Nov;147(4):454-476. doi: 10.1111/jnc.14585. Epub 2018 Nov 12.

3.

Design and synthesis of multipotent 3-aminomethylindoles and 7-azaindoles with enhanced protein phosphatase 2A-activating profile and neuroprotection.

Lajarín-Cuesta R, Arribas RL, Nanclares C, García-Frutos EM, Gandía L, de Los Ríos C.

Eur J Med Chem. 2018 Sep 5;157:294-309. doi: 10.1016/j.ejmech.2018.07.030. Epub 2018 Jul 29.

PMID:
30099252
4.

Dual Antidepressant Duloxetine Blocks Nicotinic Receptor Currents, Calcium Signals and Exocytosis in Chromaffin Cells Stimulated with Acetylcholine.

Nanclares C, Gameiro-Ros I, Méndez-López I, Martínez-Ramírez C, Padín-Nogueira JF, Colmena I, Baraibar AM, Gandía L, García AG.

J Pharmacol Exp Ther. 2018 Oct;367(1):28-39. doi: 10.1124/jpet.118.250969. Epub 2018 Jul 13.

PMID:
30006476
5.

Distinct patterns of exocytosis elicited by Ca2+, Sr2+ and Ba2+ in bovine chromaffin cells.

Baraibar AM, de Pascual R, Camacho M, Domínguez N, David Machado J, Gandía L, Borges R.

Pflugers Arch. 2018 Oct;470(10):1459-1471. doi: 10.1007/s00424-018-2166-4. Epub 2018 Jun 21.

PMID:
29926228
6.

Hydrogen sulphide facilitates exocytosis by regulating the handling of intracellular calcium by chromaffin cells.

de Pascual R, Baraibar AM, Méndez-López I, Pérez-Ciria M, Polo-Vaquero I, Gandía L, Ohia SE, García AG, de Diego AMG.

Pflugers Arch. 2018 Aug;470(8):1255-1270. doi: 10.1007/s00424-018-2147-7. Epub 2018 May 2.

PMID:
29721607
7.

Oak wood extracts applied to the grapevine. An alternative to obtain quality Garnacha wines.

Jiménez-Moreno N, Moler JA, Urmeneta H, Suberviola-Ripa J, Cibriain-Sabalza F, Gandía LM, Ancín-Azpilicueta C.

Food Res Int. 2018 Mar;105:628-636. doi: 10.1016/j.foodres.2017.11.070. Epub 2017 Nov 28.

PMID:
29433256
8.

Old and emerging concepts on adrenal chromaffin cell stimulus-secretion coupling.

Borges R, Gandía L, Carbone E.

Pflugers Arch. 2018 Jan;470(1):1-6. doi: 10.1007/s00424-017-2082-z. Epub 2017 Nov 6.

9.

L-type calcium channels in exocytosis and endocytosis of chromaffin cells.

Nanclares C, Baraibar AM, Gandía L.

Pflugers Arch. 2018 Jan;470(1):53-60. doi: 10.1007/s00424-017-2064-1. Epub 2017 Sep 2. Review.

PMID:
28866764
10.

The Differential Organization of F-Actin Alters the Distribution of Organelles in Cultured When Compared to Native Chromaffin Cells.

Gimenez-Molina Y, Villanueva J, Nanclares C, Lopez-Font I, Viniegra S, Francés MDM, Gandia L, Gil A, Gutiérrez LM.

Front Cell Neurosci. 2017 May 4;11:135. doi: 10.3389/fncel.2017.00135. eCollection 2017.

11.

Choline induces opposite changes in pyramidal neuron excitability and synaptic transmission through a nicotinic receptor-independent process in hippocampal slices.

Albiñana E, Luengo JG, Baraibar AM, Muñoz MD, Gandía L, Solís JM, Hernández-Guijo JM.

Pflugers Arch. 2017 Jun;469(5-6):779-795. doi: 10.1007/s00424-017-1939-5. Epub 2017 Feb 8.

PMID:
28176016
12.

Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices.

Punzón E, García-Alvarado F, Maroto M, Fernández-Mendívil C, Michalska P, García-Álvarez I, Arranz-Tagarro JA, Buendia I, López MG, León R, Gandía L, Fernández-Mayoralas A, García AG.

Neuropharmacology. 2017 Apr;116:110-121. doi: 10.1016/j.neuropharm.2016.12.016. Epub 2016 Dec 20.

13.

The quantal catecholamine release from mouse chromaffin cells challenged with repeated ACh pulses is regulated by the mitochondrial Na+ /Ca2+ exchanger.

López-Gil A, Nanclares C, Méndez-López I, Martínez-Ramírez C, de Los Rios C, Padín-Nogueira JF, Montero M, Gandía L, García AG.

J Physiol. 2017 Mar 15;595(6):2129-2146. doi: 10.1113/JP273339. Epub 2017 Feb 7.

14.

Regulation by L channels of Ca(2+)-evoked secretory responses in ouabain-treated chromaffin cells.

De Pascual R, Colmena I, Ruiz-Pascual L, Baraibar AM, Egea J, Gandía L, García AG.

Pflugers Arch. 2016 Oct;468(10):1779-92. doi: 10.1007/s00424-016-1866-x. Epub 2016 Aug 24.

PMID:
27558258
15.

Gramine Derivatives Targeting Ca(2+) Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases.

Lajarín-Cuesta R, Nanclares C, Arranz-Tagarro JA, González-Lafuente L, Arribas RL, Araujo de Brito M, Gandía L, de Los Ríos C.

J Med Chem. 2016 Jul 14;59(13):6265-80. doi: 10.1021/acs.jmedchem.6b00478. Epub 2016 Jun 24.

16.

N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists.

Criado M, Mulet J, Sala F, Sala S, Colmena I, Gandía L, Bautista-Aguilera OM, Samadi A, Chioua M, Marco-Contelles J.

ACS Chem Neurosci. 2016 Aug 17;7(8):1157-65. doi: 10.1021/acschemneuro.6b00122. Epub 2016 Jun 10.

17.

Novel synthetic sulfoglycolipid IG20 facilitates exocytosis in chromaffin cells through the regulation of sodium channels.

Crespo-Castrillo A, Punzón E, de Pascual R, Maroto M, Padín JF, García-Álvarez I, Nanclares C, Ruiz-Pascual L, Gandía L, Fernández-Mayoralas A, García AG.

J Neurochem. 2015 Dec;135(5):880-96. doi: 10.1111/jnc.13357. Epub 2015 Oct 14.

18.

Depressed excitability and ion currents linked to slow exocytotic fusion pore in chromaffin cells of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Calvo-Gallardo E, de Pascual R, Fernández-Morales JC, Arranz-Tagarro JA, Maroto M, Nanclares C, Gandía L, de Diego AM, Padín JF, García AG.

Am J Physiol Cell Physiol. 2015 Jan 1;308(1):C1-19. doi: 10.1152/ajpcell.00272.2014. Epub 2014 Nov 5.

19.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.

PMID:
25127677
20.

Selective activation of α7 nicotinic acetylcholine receptor (nAChRα7) inhibits muscular degeneration in mdx dystrophic mice.

Leite PE, Gandía L, de Pascual R, Nanclares C, Colmena I, Santos WC, Lagrota-Candido J, Quirico-Santos T.

Brain Res. 2014 Jul 21;1573:27-36. doi: 10.1016/j.brainres.2014.05.004. Epub 2014 May 14.

21.

Plasmalemmal sodium-calcium exchanger shapes the calcium and exocytotic signals of chromaffin cells at physiological temperature.

Padín JF, Fernández-Morales JC, Olivares R, Vestring S, Arranz-Tagarro JA, Calvo-Gallardo E, de Pascual R, Gandía L, García AG.

Am J Physiol Cell Physiol. 2013 Jul 15;305(2):C160-72. doi: 10.1152/ajpcell.00016.2013. Epub 2013 Apr 17.

22.

Lower density of L-type and higher density of P/Q-type of calcium channels in chromaffin cells of hypertensive, compared with normotensive rats.

de Pascual R, Miranda-Ferreira R, Galvão KM, Lameu C, Ulrich H, Smaili SS, Jurkiewicz A, García AG, Gandía L.

Eur J Pharmacol. 2013 Apr 15;706(1-3):25-35. doi: 10.1016/j.ejphar.2013.02.046. Epub 2013 Mar 13.

PMID:
23499685
23.

Regulation by L-type calcium channels of endocytosis: an overview.

Rosa JM, Nanclares C, Orozco A, Colmena I, de Pascual R, García AG, Gandía L.

J Mol Neurosci. 2012 Oct;48(2):360-7. Epub 2012 May 12. Review.

PMID:
22581437
24.

Paradoxical facilitation of exocytosis by inhibition of L-type calcium channels of bovine chromaffin cells.

Rosa JM, Conde M, Nanclares C, Orozco A, Colmena I, de Pascual R, García AG, Gandía L.

Biochem Biophys Res Commun. 2011 Jul 1;410(2):307-11. doi: 10.1016/j.bbrc.2011.05.138. Epub 2011 May 31.

PMID:
21663733
25.

Multiple response optimization of vegetable oils fatty acid composition to improve biodiesel physical properties.

Pinzi S, Leiva D, Arzamendi G, Gandia LM, Dorado MP.

Bioresour Technol. 2011 Aug;102(15):7280-8. doi: 10.1016/j.biortech.2011.05.005. Epub 2011 May 25.

PMID:
21612917
26.

Calcium entry through slow-inactivating L-type calcium channels preferentially triggers endocytosis rather than exocytosis in bovine chromaffin cells.

Rosa JM, Torregrosa-Hetland CJ, Colmena I, Gutiérrez LM, García AG, Gandía L.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C86-98. doi: 10.1152/ajpcell.00440.2010. Epub 2011 Mar 30.

27.

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.

Samadi A, Valderas C, de los Ríos C, Bastida A, Chioua M, González-Lafuente L, Colmena I, Gandía L, Romero A, Del Barrio L, Martín-de-Saavedra MD, López MG, Villarroya M, Marco-Contelles J.

Bioorg Med Chem. 2011 Jan 1;19(1):122-33. doi: 10.1016/j.bmc.2010.11.040. Epub 2010 Nov 26.

PMID:
21163662
28.

Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.

Tomassoli I, Ismaili L, Pudlo M, de Los Ríos C, Soriano E, Colmena I, Gandía L, Rivas L, Samadi A, Marco-Contelles J, Refouvelet B.

Eur J Med Chem. 2011 Jan;46(1):1-10. doi: 10.1016/j.ejmech.2010.08.054. Epub 2010 Dec 15.

PMID:
21111515
29.

Influence of vegetable oils fatty acid composition on reaction temperature and glycerides conversion to biodiesel during transesterification.

Pinzi S, Gandía LM, Arzamendi G, Ruiz JJ, Dorado MP.

Bioresour Technol. 2011 Jan;102(2):1044-50. doi: 10.1016/j.biortech.2010.08.029. Epub 2010 Aug 10.

PMID:
20801017
30.

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.

Samadi A, Marco-Contelles J, Soriano E, Alvarez-Pérez M, Chioua M, Romero A, González-Lafuente L, Gandía L, Roda JM, López MG, Villarroya M, García AG, Ríos Cde L.

Bioorg Med Chem. 2010 Aug 15;18(16):5861-72. doi: 10.1016/j.bmc.2010.06.095. Epub 2010 Jul 3.

PMID:
20656495
31.

Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells.

Rosa JM, Gandía L, García AG.

Pflugers Arch. 2010 Oct;460(5):901-14. doi: 10.1007/s00424-010-0861-x. Epub 2010 Jul 17.

PMID:
20640579
32.

Greater cytosolic and mitochondrial calcium transients in adrenal medullary slices of hypertensive, compared with normotensive rats.

Miranda-Ferreira R, de Pascual R, Smaili SS, Caricati-Neto A, Gandía L, García AG, Jurkiewicz A.

Eur J Pharmacol. 2010 Jun 25;636(1-3):126-36. doi: 10.1016/j.ejphar.2010.03.044. Epub 2010 Mar 31.

PMID:
20361955
33.

The effects of 3,4-methylenedioxymethamphetamine (MDMA) on nicotinic receptors: intracellular calcium increase, calpain/caspase 3 activation, and functional upregulation.

Garcia-Ratés S, Camarasa J, Sánchez-García AI, Gandía L, Escubedo E, Pubill D.

Toxicol Appl Pharmacol. 2010 May 1;244(3):344-53. doi: 10.1016/j.taap.2010.01.014. Epub 2010 Feb 2.

PMID:
20132834
34.

Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis.

Darios F, Wasser C, Shakirzyanova A, Giniatullin A, Goodman K, Munoz-Bravo JL, Raingo J, Jorgacevski J, Kreft M, Zorec R, Rosa JM, Gandia L, Gutiérrez LM, Binz T, Giniatullin R, Kavalali ET, Davletov B.

Neuron. 2009 Jun 11;62(5):683-94. doi: 10.1016/j.neuron.2009.04.024.

35.

Computational analysis of the binding ability of heterocyclic and conformationally constrained epibatidine analogs in the neuronal nicotinic acetylcholine receptor.

Soriano E, Marco-Contelles J, Colmena I, Gandía L.

Mol Divers. 2010 May;14(2):201-11. doi: 10.1007/s11030-009-9161-9. Epub 2009 May 29. Erratum in: Mol Divers.2010 May;14(2):213.

PMID:
19479336
36.

Use of transgenic (knockout) mice reveals a site distinct from the alpha2A-adrenoceptors for agmatine in the vas deferens.

Santos WC, Garcez-do-Carmo L, da Silva EC, de Pascual R, Jurkiewicz NH, Jurkiewicz A, Gandía L.

Pharmacol Rep. 2009 Mar-Apr;61(2):325-9.

37.

Inhibition of N and PQ calcium channels by calcium entry through L channels in chromaffin cells.

Rosa JM, Gandía L, García AG.

Pflugers Arch. 2009 Aug;458(4):795-807. doi: 10.1007/s00424-009-0662-2. Epub 2009 Apr 4.

PMID:
19347353
38.

Preconditioning stimuli that augment chromaffin cell secretion.

Tapia L, García-Eguiagaray J, García AG, Gandía L.

Am J Physiol Cell Physiol. 2009 Apr;296(4):C792-800. doi: 10.1152/ajpcell.00600.2008. Epub 2009 Feb 11.

39.

Role of the endoplasmic reticulum and mitochondria on quantal catecholamine release from chromaffin cells of control and hypertensive rats.

Miranda-Ferreira R, de Pascual R, Caricati-Neto A, Gandía L, Jurkiewicz A, García AG.

J Pharmacol Exp Ther. 2009 Apr;329(1):231-40. doi: 10.1124/jpet.108.147413. Epub 2009 Jan 8.

PMID:
19131584
40.

A low nicotine concentration augments vesicle motion and exocytosis triggered by K(+) depolarisation of chromaffin cells.

de Diego AM, Tapia L, Alvarez RM, Mosquera M, Cortés L, López I, Gutiérrez LM, Gandía L, García AG.

Eur J Pharmacol. 2008 Nov 19;598(1-3):81-6. doi: 10.1016/j.ejphar.2008.09.003. Epub 2008 Sep 16.

PMID:
18831972
41.

Differential variations in Ca2+ entry, cytosolic Ca2+ and membrane capacitance upon steady or action potential depolarizing stimulation of bovine chromaffin cells.

de Diego AM, Arnáiz-Cot JJ, Hernández-Guijo JM, Gandía L, García AG.

Acta Physiol (Oxf). 2008 Oct;194(2):97-109. doi: 10.1111/j.1748-1716.2008.01871.x. Epub 2008 Jun 28.

PMID:
18485124
42.

Allosteric modulation of alpha 7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission.

Arnaiz-Cot JJ, González JC, Sobrado M, Baldelli P, Carbone E, Gandía L, García AG, Hernández-Guijo JM.

Eur J Neurosci. 2008 Mar;27(5):1097-110. doi: 10.1111/j.1460-9568.2008.06077.x. Epub 2008 Feb 29.

PMID:
18312591
43.

A physiological view of the central and peripheral mechanisms that regulate the release of catecholamines at the adrenal medulla.

de Diego AM, Gandía L, García AG.

Acta Physiol (Oxf). 2008 Feb;192(2):287-301. Epub 2007 Nov 15. Review.

PMID:
18005392
44.

Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca(2+) signalling in hippocampal neurons.

González JC, Egea J, Del Carmen Godino M, Fernandez-Gomez FJ, Sánchez-Prieto J, Gandía L, García AG, Jordán J, Hernández-Guijo JM.

Eur J Neurosci. 2007 Nov;26(9):2481-95.

PMID:
17986028
45.

A two-step model for acetylcholine control of exocytosis via nicotinic receptors.

Arnáiz-Cot JJ, de Diego AM, Hernández-Guijo JM, Gandía L, García AG.

Biochem Biophys Res Commun. 2008 Jan 18;365(3):413-9. Epub 2007 Nov 5.

PMID:
17981151
46.

Single-vesicle catecholamine release has greater quantal content and faster kinetics in chromaffin cells from hypertensive, as compared with normotensive, rats.

Miranda-Ferreira R, de Pascual R, de Diego AM, Caricati-Neto A, Gandía L, Jurkiewicz A, García AG.

J Pharmacol Exp Ther. 2008 Feb;324(2):685-93. Epub 2007 Oct 25.

PMID:
17962518
47.

L-type calcium channels are preferentially coupled to endocytosis in bovine chromaffin cells.

Rosa JM, de Diego AM, Gandía L, García AG.

Biochem Biophys Res Commun. 2007 Jun 15;357(4):834-9. Epub 2007 Apr 16.

PMID:
17451644
48.

Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.

Egea J, Rosa AO, Sobrado M, Gandía L, López MG, García AG.

Neuroscience. 2007 Mar 30;145(3):866-72. Epub 2007 Feb 8.

PMID:
17291692
49.

Enhancement of secretion by threshold nicotinic stimulation in bovine chromaffin cells.

Tapia L, Eguiagaray JG, Egea J, García AG, Gandía L.

J Mol Neurosci. 2006;30(1-2):81-2.

PMID:
17192638
50.

Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: involvement of the alpha7 nAChR subtype.

Rosa AO, Egea J, Gandía L, López MG, García AG.

J Mol Neurosci. 2006;30(1-2):61-2.

PMID:
17192628

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