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Genome Sequences of Four Cluster P Mycobacteriophages.

Doyle EL, Fillman CL, Reyna NS, Tobiason DM, Westholm DE, Askins JL, Backus BP, Baker AC, Ballard HS, Bisesi PJ, Bond L, Byrnes D, Carlstedt H, Dodson KS, Fallert MJ, Foster KJ, Games DN, Grams TR, Guild NA, Hurd A, Iwata N, Kepler CR, Krenzke LR, Luekens K, Lewis J, McEntee C, McGee JC, Nalley N, Plymale RC, Prochaska J, Rogers RG, Schipper JB, Snyder K, Uhrich K, Vermillion CD, Vickers SK, Wenta MD, Yates TZ, Young CF, Stoner TH, Pope WH, Jacobs-Sera D, Garlena RA, Russell DA, Cresawn SG, Hatfull GF.

Genome Announc. 2018 Jan 11;6(2). pii: e01101-17. doi: 10.1128/genomeA.01101-17.


Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy.

Spencer B, Valera E, Rockenstein E, Overk C, Mante M, Adame A, Zago W, Seubert P, Barbour R, Schenk D, Games D, Rissman RA, Masliah E.

Acta Neuropathol Commun. 2017 Jan 13;5(1):7. doi: 10.1186/s40478-016-0410-8.


Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.

Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, Patrick C, Ubhi K, Nuber S, Sacayon P, Zago W, Seubert P, Barbour R, Schenk D, Masliah E.

J Neurosci. 2014 Jul 9;34(28):9441-54. doi: 10.1523/JNEUROSCI.5314-13.2014.


Vascular alterations in PDAPP mice after anti-Aβ immunotherapy: Implications for amyloid-related imaging abnormalities.

Zago W, Schroeter S, Guido T, Khan K, Seubert P, Yednock T, Schenk D, Gregg KM, Games D, Bard F, Kinney GG.

Alzheimers Dement. 2013 Oct;9(5 Suppl):S105-15. doi: 10.1016/j.jalz.2012.11.010. Epub 2013 Apr 11.


Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.

Games D, Seubert P, Rockenstein E, Patrick C, Trejo M, Ubhi K, Ettle B, Ghassemiam M, Barbour R, Schenk D, Nuber S, Masliah E.

Am J Pathol. 2013 Mar;182(3):940-53. doi: 10.1016/j.ajpath.2012.11.018. Epub 2013 Jan 9.


Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.

Zago W, Buttini M, Comery TA, Nishioka C, Gardai SJ, Seubert P, Games D, Bard F, Schenk D, Kinney GG.

J Neurosci. 2012 Feb 22;32(8):2696-702. doi: 10.1523/JNEUROSCI.1676-11.2012.


Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.

Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D.

PLoS One. 2011 Apr 29;6(4):e19338. doi: 10.1371/journal.pone.0019338.


The role of animal models in advancing amyloid-beta immunotherapy to the clinic.

Games D, Seubert P.

Alzheimers Res Ther. 2010 Jul 29;2(4):22. doi: 10.1186/alzrt46.


Faster forgetting contributes to impaired spatial memory in the PDAPP mouse: deficit in memory retrieval associated with increased sensitivity to interference?

Daumas S, Sandin J, Chen KS, Kobayashi D, Tulloch J, Martin SJ, Games D, Morris RG.

Learn Mem. 2008 Aug 26;15(9):625-32. doi: 10.1101/lm.990208. Print 2008 Sep.


Immunotherapy reduces vascular amyloid-beta in PDAPP mice.

Schroeter S, Khan K, Barbour R, Doan M, Chen M, Guido T, Gill D, Basi G, Schenk D, Seubert P, Games D.

J Neurosci. 2008 Jul 2;28(27):6787-93. doi: 10.1523/JNEUROSCI.2377-07.2008.


Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse.

Seubert P, Barbour R, Khan K, Motter R, Tang P, Kholodenko D, Kling K, Schenk D, Johnson-Wood K, Schroeter S, Gill D, Jacobsen JS, Pangalos M, Basi G, Games D.

Neurodegener Dis. 2008;5(2):65-71. doi: 10.1159/000112834. Epub 2008 Jan 4.


Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.

McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S.

J Biol Chem. 2007 Sep 7;282(36):26326-34. Epub 2007 Jul 6.


Quantitative determination of acetyl glucoside isoflavones and their metabolites in human urine using combined liquid chromatography-mass spectrometry.

Chen L, Zhao X, Fang L, Games DE.

J Chromatogr A. 2007 Jun 22;1154(1-2):103-10. Epub 2007 Mar 15.


Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid.

Chen G, Chen KS, Kobayashi D, Barbour R, Motter R, Games D, Martin SJ, Morris RG.

J Neurosci. 2007 Mar 7;27(10):2654-62.


Abeta species removal after abeta42 immunization.

Nicoll JA, Barton E, Boche D, Neal JW, Ferrer I, Thompson P, Vlachouli C, Wilkinson D, Bayer A, Games D, Seubert P, Schenk D, Holmes C.

J Neuropathol Exp Neurol. 2006 Nov;65(11):1040-8.


Increased T cell recruitment to the CNS after amyloid beta 1-42 immunization in Alzheimer's mice overproducing transforming growth factor-beta 1.

Buckwalter MS, Coleman BS, Buttini M, Barbour R, Schenk D, Games D, Seubert P, Wyss-Coray T.

J Neurosci. 2006 Nov 1;26(44):11437-41.


Mice as models: transgenic approaches and Alzheimer's disease.

Games D, Buttini M, Kobayashi D, Schenk D, Seubert P.

J Alzheimers Dis. 2006;9(3 Suppl):133-49. Review.


Assessment of ovarian failure and osteoporosis in premenopausal breast cancer survivors.

McCune JS, Games DM, Espirito JL.

J Oncol Pharm Pract. 2005 Jun;11(2):37-43.


Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease.

Donovan MH, Yazdani U, Norris RD, Games D, German DC, Eisch AJ.

J Comp Neurol. 2006 Mar 1;495(1):70-83.


Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides.

Esh C, Patton L, Kalback W, Kokjohn TA, Lopez J, Brune D, Newell AJ, Beach T, Schenk D, Games D, Paul S, Bales K, Ghetti B, Castaño EM, Roher AE.

Biochemistry. 2005 Oct 25;44(42):13807-19.


The PDAPP mouse model of Alzheimer's disease: locus coeruleus neuronal shrinkage.

German DC, Nelson O, Liang F, Liang CL, Games D.

J Comp Neurol. 2005 Nov 28;492(4):469-76.


Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.

Buttini M, Masliah E, Barbour R, Grajeda H, Motter R, Johnson-Wood K, Khan K, Seubert P, Freedman S, Schenk D, Games D.

J Neurosci. 2005 Oct 5;25(40):9096-101.


Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease.

Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Seubert P, Lee M, Goldstein J, Chilcote T, Games D, Schenk D.

Neuron. 2005 Jun 16;46(6):857-68.


Comparison of high-speed counter-current chromatography instruments for the separation of the extracts of the seeds of Oroxylum indicum.

Chen LJ, Song H, Lan XQ, Games DE, Sutherland IA.

J Chromatogr A. 2005 Jan 21;1063(1-2):241-5.


Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease.

Masliah E, Hansen L, Adame A, Crews L, Bard F, Lee C, Seubert P, Games D, Kirby L, Schenk D.

Neurology. 2005 Jan 11;64(1):129-31.


Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.

Bussière T, Bard F, Barbour R, Grajeda H, Guido T, Khan K, Schenk D, Games D, Seubert P, Buttini M.

Am J Pathol. 2004 Sep;165(3):987-95.


Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses.

Wu CC, Chawla F, Games D, Rydel RE, Freedman S, Schenk D, Young WG, Morrison JH, Bloom FE.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):7141-6. Epub 2004 Apr 26.


Urinary modified nucleosides as tumor markers.

Dudley E, Lemiere F, Van Dongen W, Esmans E, El-Sharkawi AM, Games DE, Brenton AG, Newton RP.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):987-9.


Cholinergic neuropathology in a mouse model of Alzheimer's disease.

German DC, Yazdani U, Speciale SG, Pasbakhsh P, Games D, Liang CL.

J Comp Neurol. 2003 Aug 4;462(4):371-81.


Analysis of urinary nucleosides. III. Identification of 5'-deoxycytidine in urine of a patient with head and neck cancer.

Dudley E, Lemiere F, Van Dongen W, Langridge JI, El-Sharkawi S, Games DE, Esmans EL, Newton RP.

Rapid Commun Mass Spectrom. 2003;17(11):1132-6.


Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.

Reilly JF, Games D, Rydel RE, Freedman S, Schenk D, Young WG, Morrison JH, Bloom FE.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4837-42.


Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.

Bard F, Barbour R, Cannon C, Carretto R, Fox M, Games D, Guido T, Hoenow K, Hu K, Johnson-Wood K, Khan K, Kholodenko D, Lee C, Lee M, Motter R, Nguyen M, Reed A, Schenk D, Tang P, Vasquez N, Seubert P, Yednock T.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2023-8. Epub 2003 Feb 3. Erratum in: Proc Natl Acad Sci U S A. 2004 Aug 3;101(3):11526.


Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis.

Redwine JM, Kosofsky B, Jacobs RE, Games D, Reilly JF, Morrison JH, Young WG, Bloom FE.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1381-6. Epub 2003 Jan 24.


Cyclic nucleotide content of tobacco BY-2 cells.

Richards H, Das S, Smith CJ, Pereira L, Geisbrecht A, Devitt NJ, Games DE, van Geyschem J, Gareth Brenton A, Newton RP.

Phytochemistry. 2002 Nov;61(5):531-7.


Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT.

J Neurosci. 2002 Sep 15;22(18):7873-8.


Loss of medial septal modulation of dentate gyrus physiology in young mice overexpressing human beta-amyloid precursor protein.

Sánchez-Alavez M, Gallegos RA, Kalafut MA, Games D, Henriksen SJ, Criado JR.

Neurosci Lett. 2002 Sep 13;330(1):45-8.


Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice.

Huitrón-Reséndiz S, Sánchez-Alavez M, Gallegos R, Berg G, Crawford E, Giacchino JL, Games D, Henriksen SJ, Criado JR.

Brain Res. 2002 Feb 22;928(1-2):126-37.


Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization.

Schenk D, Games D, Seubert P.

J Mol Neurosci. 2001 Oct;17(2):259-67. Review.


Apolipoprotein D mRNA expression is elevated in PDAPP transgenic mice.

Thomas EA, Sautkulis LN, Criado JR, Games D, Sutcliffe JG.

J Neurochem. 2001 Dec;79(5):1059-64.


Analysis of urinary nucleosides. II. Comparison of mass spectrometric methods for the analysis of urinary nucleosides.

Dudley E, Lemiere F, Van Dongen W, Langridge JI, El-Sharkawi S, Games DE, Esmans EL, Newton RP.

Rapid Commun Mass Spectrom. 2001;15(18):1701-7.


Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease.

Gonzalez-Lima F, Berndt JD, Valla JE, Games D, Reiman EM.

Neuroreport. 2001 Aug 8;12(11):2375-9.


BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.

Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L.

Hum Mol Genet. 2001 Jun 1;10(12):1317-24.


Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain.

Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y.

Am J Pathol. 2001 Jun;158(6):2209-18.


Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.

Masliah E, Sisk A, Mallory M, Games D.

J Neuropathol Exp Neurol. 2001 Apr;60(4):357-68.


Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.

Bacskai BJ, Kajdasz ST, Christie RH, Carter C, Games D, Seubert P, Schenk D, Hyman BT.

Nat Med. 2001 Mar;7(3):369-72. No abstract available.


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