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Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.

Flores RR, Carbo L, Kim E, Van Meter M, De Padilla CML, Zhao J, Colangelo D, Yousefzadeh MJ, Angelini LA, Zhang L, Pola E, Vo N, Evans CH, Gambotto A, Niedernhofer LJ, Robbins PD.

FASEB J. 2019 Aug;33(8):9505-9515. doi: 10.1096/fj.201900420R. Epub 2019 Jun 6.


Multiple antigen-engineered DC vaccines with or without IFNα to promote antitumor immunity in melanoma.

Butterfield LH, Vujanovic L, Santos PM, Maurer DM, Gambotto A, Lohr J, Li C, Waldman J, Chandran U, Lin Y, Lin H, Tawbi HA, Tarhini AA, Kirkwood JM.

J Immunother Cancer. 2019 Apr 24;7(1):113. doi: 10.1186/s40425-019-0552-x.


Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions.

Garcia-Bates TM, Palma ML, Shen C, Gambotto A, Macatangay BJC, Ferris RL, Rinaldo CR, Mailliard RB.

J Virol. 2019 Feb 19;93(5). pii: e02035-18. doi: 10.1128/JVI.02035-18. Print 2019 Mar 1.


Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles.

Grabosch S, Bulatovic M, Zeng F, Ma T, Zhang L, Ross M, Brozick J, Fang Y, Tseng G, Kim E, Gambotto A, Elishaev E, P Edwards R, Vlad AM.

Oncogene. 2019 Mar;38(13):2380-2393. doi: 10.1038/s41388-018-0581-9. Epub 2018 Dec 5.


Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus.

Guo ZS, Liu Z, Sathaiah M, Wang J, Ravindranathan R, Kim E, Huang S, Kenniston TW, Bell JC, Zeh HJ 3rd, Butterfield LH, Gambotto A, Bartlett DL.

Mol Ther Methods Clin Dev. 2017 Sep 30;7:112-122. doi: 10.1016/j.omtm.2017.09.007. eCollection 2017 Dec 15.


IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage.

Vicetti Miguel RD, Quispe Calla NE, Dixon D, Foster RA, Gambotto A, Pavelko SD, Hall-Stoodley L, Cherpes TL.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6892-E6901. doi: 10.1073/pnas.1621253114. Epub 2017 Aug 1.


Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation.

Kim E, Erdos G, Huang S, Kenniston T, Falo LD Jr, Gambotto A.

EBioMedicine. 2016 Nov;13:315-320. doi: 10.1016/j.ebiom.2016.09.028. Epub 2016 Oct 3.


Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1.

Garcia-Bates TM, Kim E, Concha-Benavente F, Trivedi S, Mailliard RB, Gambotto A, Ferris RL.

J Immunol. 2016 Mar 15;196(6):2870-8. doi: 10.4049/jimmunol.1502027. Epub 2016 Feb 5.


IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice.

Flores RR, Kim E, Zhou L, Yang C, Zhao J, Gambotto A, Robbins PD.

Eur J Immunol. 2015 Nov;45(11):3114-25. doi: 10.1002/eji.201445403. Epub 2015 Sep 1.


Correction for Kim et al., development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model.

Kim E, Okada K, Beeler JA, Crim RL, Steitz J, Piedra PA, Gilbert BE, Gambotto A.

J Virol. 2015 May;89(9):5193. doi: 10.1128/JVI.03669-14. No abstract available.


Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice.

Kim E, Okada K, Kenniston T, Raj VS, AlHajri MM, Farag EA, AlHajri F, Osterhaus AD, Haagmans BL, Gambotto A.

Vaccine. 2014 Oct 14;32(45):5975-82. doi: 10.1016/j.vaccine.2014.08.058. Epub 2014 Sep 3.


Development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model.

Kim E, Okada K, Beeler JA, Crim RL, Piedra PA, Gilbert BE, Gambotto A.

J Virol. 2014 May;88(9):5100-8. doi: 10.1128/JVI.03194-13. Epub 2014 Feb 26. Erratum in: J Virol. 2015 May;89(9):5193.


Lim mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through Kruppel-like factor-4 downregulation and further bone-specific gene expression.

Barba M, Pirozzi F, Saulnier N, Vitali T, Natale MT, Logroscino G, Robbins PD, Gambotto A, Neri G, Michetti F, Pola E, Lattanzi W.

J Biomed Biotechnol. 2012;2012:813894. doi: 10.1155/2012/813894. Epub 2012 Oct 2.


Intranasal vaccination with replication-defective adenovirus type 5 encoding influenza virus hemagglutinin elicits protective immunity to homologous challenge and partial protection to heterologous challenge in pigs.

Braucher DR, Henningson JN, Loving CL, Vincent AL, Kim E, Steitz J, Gambotto AA, Kehrli ME Jr.

Clin Vaccine Immunol. 2012 Nov;19(11):1722-9. doi: 10.1128/CVI.00315-12. Epub 2012 Aug 29.


The antitumor effects of adenoviral-mediated, intratumoral delivery of interleukin 23 require endogenous IL-12.

Reay J, Gambotto A, Robbins PD.

Cancer Gene Ther. 2012 Feb;19(2):135-43. doi: 10.1038/cgt.2011.78. Epub 2011 Dec 9.


Early transcriptional events during osteogenic differentiation of human bone marrow stromal cells induced by Lim mineralization protein 3.

Bernardini C, Saulnier N, Parrilla C, Pola E, Gambotto A, Michetti F, Robbins PD, Lattanzi W.

Gene Expr. 2010;15(1):27-42.


Assessment of route of administration and dose escalation for an adenovirus-based influenza A Virus (H5N1) vaccine in chickens.

Steitz J, Wagner RA, Bristol T, Gao W, Donis RO, Gambotto A.

Clin Vaccine Immunol. 2010 Sep;17(9):1467-72. doi: 10.1128/CVI.00180-10. Epub 2010 Jul 21.


A candidate H1N1 pandemic influenza vaccine elicits protective immunity in mice.

Steitz J, Barlow PG, Hossain J, Kim E, Okada K, Kenniston T, Rea S, Donis RO, Gambotto A.

PLoS One. 2010 May 5;5(5):e10492. doi: 10.1371/journal.pone.0010492.


Balb/c EGFP mice are tolerant against immunization utilizing recombinant adenoviral-based vectors encoding EGFP: a novel model for the study of tolerance mechanisms and vaccine efficacy.

Steitz J, Soloff AC, Barratt-Boyes SM, Alber SM, Watkins SC, Okada H, Gambotto A.

Mol Immunol. 2010 Feb;47(5):1149-53. doi: 10.1016/j.molimm.2009.11.018. Epub 2009 Dec 21.


Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment.

Gao W, Kang JH, Liao Y, Ding WX, Gambotto AA, Watkins SC, Liu YJ, Stolz DB, Yin XM.

J Biol Chem. 2010 Jan 8;285(2):1371-83. doi: 10.1074/jbc.M109.054197. Epub 2009 Nov 12.


Adenovirus 5- and 35-based immunotherapy enhances the strength but not breadth or quality of immunity during chronic SIV infection.

Soloff AC, Liu X, Gao W, Day RD, Gambotto A, Barratt-Boyes SM.

Eur J Immunol. 2009 Sep;39(9):2437-49. doi: 10.1002/eji.200839130.


Identification of a 17beta-hydroxysteroid dehydrogenase type 12 pseudogene as the source of a highly restricted BALB/c Meth A tumor rejection peptide.

Hendrickson RC, Cicinnati VR, Albers A, Dworacki G, Gambotto A, Pagliano O, Tüting T, Mayordomo JI, Visus C, Appella E, Shabanowitz J, Hunt DF, DeLeo AB.

Cancer Immunol Immunother. 2010 Jan;59(1):113-24. doi: 10.1007/s00262-009-0730-7. Epub 2009 Jun 27.


Transduction of liver metastases after intravenous injection of Ad5/35 or Ad35 vectors with and without factor X-binding protein pretreatment.

Liu Y, Wang H, Yumul R, Gao W, Gambotto A, Morita T, Baker A, Shayakhmetov D, Lieber A.

Hum Gene Ther. 2009 Jun;20(6):621-9. doi: 10.1089/hum.2008.142.


Lentiviral vectors encoding human MUC1-specific, MHC-unrestricted single-chain TCR and a fusion suicide gene: potential for universal and safe cancer immunotherapy.

Chen X, Gao W, Gambotto A, Finn OJ.

Cancer Immunol Immunother. 2009 Jun;58(6):977-87. doi: 10.1007/s00262-008-0624-0. Epub 2008 Nov 21.


Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence.

Shi YH, Ding WX, Zhou J, He JY, Xu Y, Gambotto AA, Rabinowich H, Fan J, Yin XM.

Hepatology. 2008 Aug;48(2):497-507. doi: 10.1002/hep.22393.


Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models.

Lattanzi W, Parrilla C, Fetoni A, Logroscino G, Straface G, Pecorini G, Stigliano E, Tampieri A, Bedini R, Pecci R, Michetti F, Gambotto A, Robbins PD, Pola E.

Gene Ther. 2008 Oct;15(19):1330-43. doi: 10.1038/gt.2008.116. Epub 2008 Jul 17.


Human infection with highly pathogenic H5N1 influenza virus.

Gambotto A, Barratt-Boyes SM, de Jong MD, Neumann G, Kawaoka Y.

Lancet. 2008 Apr 26;371(9622):1464-75. doi: 10.1016/S0140-6736(08)60627-3. Review.


Efficacy of topical immunoglobulins against experimental adenoviral ocular infection.

Nwanegbo EC, Romanowski EG, Gordon YJ, Gambotto A.

Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4171-6.


Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation.

Rehman KK, Bertera S, Trucco M, Gambotto A, Robbins PD.

Transplantation. 2007 Aug 15;84(3):301-7.


Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk.

Xu J, Chakrabarti AK, Tan JL, Ge L, Gambotto A, Vujanovic NL.

Blood. 2007 Apr 15;109(8):3333-41. Epub 2006 Dec 12.


Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury.

Chen X, Ding WX, Ni HM, Gao W, Shi YH, Gambotto AA, Fan J, Beg AA, Yin XM.

Mol Cell Biol. 2007 Jan;27(2):541-53. Epub 2006 Nov 13.


Adoptive transfer of type 1 CTL mediates effective anti-central nervous system tumor response: critical roles of IFN-inducible protein-10.

Nishimura F, Dusak JE, Eguchi J, Zhu X, Gambotto A, Storkus WJ, Okada H.

Cancer Res. 2006 Apr 15;66(8):4478-87.


Evidence of the capability of the CMV enhancer to activate in trans gene expression in mammalian cells.

D'Aiuto L, De Marco R, Edward N, Rizzo A, Chaillet JR, Montecalvo A, Lotze MT, Gambotto A.

DNA Cell Biol. 2006 Mar;25(3):171-80.


Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization.

Gao W, Soloff AC, Lu X, Montecalvo A, Nguyen DC, Matsuoka Y, Robbins PD, Swayne DE, Donis RO, Katz JM, Barratt-Boyes SM, Gambotto A.

J Virol. 2006 Feb;80(4):1959-64.


Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors.

Barratt-Boyes SM, Soloff AC, Gao W, Nwanegbo E, Liu X, Rajakumar PA, Brown KN, Robbins PD, Murphey-Corb M, Day RD, Gambotto A.

J Gen Virol. 2006 Jan;87(Pt 1):139-49.


Delivery of dendritic cells engineered to secrete IFN-alpha into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on apoptotic pathways.

Kuwashima N, Nishimura F, Eguchi J, Sato H, Hatano M, Tsugawa T, Sakaida T, Dusak JE, Fellows-Mayle WK, Papworth GD, Watkins SC, Gambotto A, Pollack IF, Storkus WJ, Okada H.

J Immunol. 2005 Aug 15;175(4):2730-40.


Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis.

Kim SH, Lechman ER, Bianco N, Menon R, Keravala A, Nash J, Mi Z, Watkins SC, Gambotto A, Robbins PD.

J Immunol. 2005 May 15;174(10):6440-8.


Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumors.

Sato H, Kuwashima N, Sakaida T, Hatano M, Dusak JE, Fellows-Mayle WK, Papworth GD, Watkins SC, Gambotto A, Pollack IF, Okada H.

Cancer Gene Ther. 2005 Sep;12(9):757-68.


Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.

Hui H, Khoury N, Zhao X, Balkir L, D'Amico E, Bullotta A, Nguyen ED, Gambotto A, Perfetti R.

Diabetes. 2005 Feb;54(2):424-33.


Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin.

Pizzoferrato E, Liu Y, Gambotto A, Armstrong MJ, Stang MT, Gooding WE, Alber SM, Shand SH, Watkins SC, Storkus WJ, Yim JH.

Cancer Res. 2004 Nov 15;64(22):8381-8.


Sequential delivery of interferon-alpha gene and DCs to intracranial gliomas promotes an effective antitumor response.

Tsugawa T, Kuwashima N, Sato H, Fellows-Mayle WK, Dusak JE, Okada K, Papworth GD, Watkins SC, Gambotto A, Yoshida J, Pollack IF, Okada H.

Gene Ther. 2004 Nov;11(21):1551-8.


Delivery of interferon-alpha transfected dendritic cells into central nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccines.

Okada H, Tsugawa T, Sato H, Kuwashima N, Gambotto A, Okada K, Dusak JE, Fellows-Mayle WK, Papworth GD, Watkins SC, Chambers WH, Potter DM, Storkus WJ, Pollack IF.

Cancer Res. 2004 Aug 15;64(16):5830-8.


UpGene: Application of a web-based DNA codon optimization algorithm.

Gao W, Rzewski A, Sun H, Robbins PD, Gambotto A.

Biotechnol Prog. 2004 Mar-Apr;20(2):443-8.


Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa, and the United States.

Nwanegbo E, Vardas E, Gao W, Whittle H, Sun H, Rowe D, Robbins PD, Gambotto A.

Clin Diagn Lab Immunol. 2004 Mar;11(2):351-7.


IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo.

Kim PK, Armstrong M, Liu Y, Yan P, Bucher B, Zuckerbraun BS, Gambotto A, Billiar TR, Yim JH.

Oncogene. 2004 Feb 5;23(5):1125-35.


Efficient bone formation by gene transfer of human LIM mineralization protein-3.

Pola E, Gao W, Zhou Y, Pola R, Lattanzi W, Sfeir C, Gambotto A, Robbins PD.

Gene Ther. 2004 Apr;11(8):683-93.


Effects of a SARS-associated coronavirus vaccine in monkeys.

Gao W, Tamin A, Soloff A, D'Aiuto L, Nwanegbo E, Robbins PD, Bellini WJ, Barratt-Boyes S, Gambotto A.

Lancet. 2003 Dec 6;362(9399):1895-6.


Adenovirus-transduced dendritic cells injected into skin or lymph node prime potent simian immunodeficiency virus-specific T cell immunity in monkeys.

Brown K, Gao W, Alber S, Trichel A, Murphey-Corb M, Watkins SC, Gambotto A, Barratt-Boyes SM.

J Immunol. 2003 Dec 15;171(12):6875-82.


Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity.

Tatsumi T, Huang J, Gooding WE, Gambotto A, Robbins PD, Vujanovic NL, Alber SM, Watkins SC, Okada H, Storkus WJ.

Cancer Res. 2003 Oct 1;63(19):6378-86.

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