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Items: 1 to 50 of 79

1.

Influenza hemagglutinin membrane anchor.

Benton DJ, Nans A, Calder LJ, Turner J, Neu U, Lin YP, Ketelaars E, Kallewaard NL, Corti D, Lanzavecchia A, Gamblin SJ, Rosenthal PB, Skehel JJ.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10112-10117. doi: 10.1073/pnas.1810927115. Epub 2018 Sep 17.

2.

The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites.

Mittal A, Hobor F, Zhang Y, Martin SR, Gamblin SJ, Ramos A, Wilson JR.

Nucleic Acids Res. 2018 Apr 20;46(7):3802-3812. doi: 10.1093/nar/gky199.

3.

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells.

Willows R, Sanders MJ, Xiao B, Patel BR, Martin SR, Read J, Wilson JR, Hubbard J, Gamblin SJ, Carling D.

Biochem J. 2017 Aug 22;474(17):3059-3073. doi: 10.1042/BCJ20170458.

4.

Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".

Zhang Y, Justin N, Wilson JR, Gamblin SJ.

Science. 2016 Dec 23;354(6319):1543. doi: 10.1126/science.aaf6236.

PMID:
28008037
5.

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.

Vaswani RG, Gehling VS, Dakin LA, Cook AS, Nasveschuk CG, Duplessis M, Iyer P, Balasubramanian S, Zhao F, Good AC, Campbell R, Lee C, Cantone N, Cummings RT, Normant E, Bellon SF, Albrecht BK, Harmange JC, Trojer P, Audia JE, Zhang Y, Justin N, Chen S, Wilson JR, Gamblin SJ.

J Med Chem. 2016 Nov 10;59(21):9928-9941. Epub 2016 Oct 28.

6.

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.

Kallewaard NL, Corti D, Collins PJ, Neu U, McAuliffe JM, Benjamin E, Wachter-Rosati L, Palmer-Hill FJ, Yuan AQ, Walker PA, Vorlaender MK, Bianchi S, Guarino B, De Marco A, Vanzetta F, Agatic G, Foglierini M, Pinna D, Fernandez-Rodriguez B, Fruehwirth A, Silacci C, Ogrodowicz RW, Martin SR, Sallusto F, Suzich JA, Lanzavecchia A, Zhu Q, Gamblin SJ, Skehel JJ.

Cell. 2016 Jul 28;166(3):596-608. doi: 10.1016/j.cell.2016.05.073. Epub 2016 Jul 21.

7.

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.

Justin N, Zhang Y, Tarricone C, Martin SR, Chen S, Underwood E, De Marco V, Haire LF, Walker PA, Reinberg D, Wilson JR, Gamblin SJ.

Nat Commun. 2016 Apr 28;7:11316. doi: 10.1038/ncomms11316.

8.

Evolving Catalytic Properties of the MLL Family SET Domain.

Zhang Y, Mittal A, Reid J, Reich S, Gamblin SJ, Wilson JR.

Structure. 2015 Oct 6;23(10):1921-1933. doi: 10.1016/j.str.2015.07.018. Epub 2015 Aug 27.

9.

Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody.

Xiong X, Corti D, Liu J, Pinna D, Foglierini M, Calder LJ, Martin SR, Lin YP, Walker PA, Collins PJ, Monne I, Suguitan AL Jr, Santos C, Temperton NJ, Subbarao K, Lanzavecchia A, Gamblin SJ, Skehel JJ.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9430-5. doi: 10.1073/pnas.1510816112. Epub 2015 Jul 13.

10.

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.

Sanulli S, Justin N, Teissandier A, Ancelin K, Portoso M, Caron M, Michaud A, Lombard B, da Rocha ST, Offer J, Loew D, Servant N, Wassef M, Burlina F, Gamblin SJ, Heard E, Margueron R.

Mol Cell. 2015 Mar 5;57(5):769-783. doi: 10.1016/j.molcel.2014.12.020. Epub 2015 Jan 22.

11.

Recent evolution of equine influenza and the origin of canine influenza.

Collins PJ, Vachieri SG, Haire LF, Ogrodowicz RW, Martin SR, Walker PA, Xiong X, Gamblin SJ, Skehel JJ.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11175-80. doi: 10.1073/pnas.1406606111. Epub 2014 Jul 14.

12.

Enhanced human receptor binding by H5 haemagglutinins.

Xiong X, Xiao H, Martin SR, Coombs PJ, Liu J, Collins PJ, Vachieri SG, Walker PA, Lin YP, McCauley JW, Gamblin SJ, Skehel JJ.

Virology. 2014 May;456-457:179-87. doi: 10.1016/j.virol.2014.03.008. Epub 2014 Apr 12.

13.

Receptor binding by H10 influenza viruses.

Vachieri SG, Xiong X, Collins PJ, Walker PA, Martin SR, Haire LF, Zhang Y, McCauley JW, Gamblin SJ, Skehel JJ.

Nature. 2014 Jul 24;511(7510):475-7. doi: 10.1038/nature13443.

PMID:
24870229
14.

Structural basis of AMPK regulation by small molecule activators.

Xiao B, Sanders MJ, Carmena D, Bright NJ, Haire LF, Underwood E, Patel BR, Heath RB, Walker PA, Hallen S, Giordanetto F, Martin SR, Carling D, Gamblin SJ.

Nat Commun. 2013;4:3017. doi: 10.1038/ncomms4017.

15.

Changes in the hemagglutinin of H5N1 viruses during human infection--influence on receptor binding.

Crusat M, Liu J, Palma AS, Childs RA, Liu Y, Wharton SA, Lin YP, Coombs PJ, Martin SR, Matrosovich M, Chen Z, Stevens DJ, Hien VM, Thanh TT, Nhu le NT, Nguyet LA, Ha do Q, van Doorn HR, Hien TT, Conradt HS, Kiso M, Gamblin SJ, Chai W, Skehel JJ, Hay AJ, Farrar J, de Jong MD, Feizi T.

Virology. 2013 Dec;447(1-2):326-37. doi: 10.1016/j.virol.2013.08.010. Epub 2013 Sep 17.

16.

Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus.

Xiong X, Tuzikov A, Coombs PJ, Martin SR, Walker PA, Gamblin SJ, Bovin N, Skehel JJ.

Virus Res. 2013 Dec 5;178(1):12-4. doi: 10.1016/j.virusres.2013.08.007. Epub 2013 Sep 10. No abstract available.

PMID:
24036174
17.

Receptor binding by an H7N9 influenza virus from humans.

Xiong X, Martin SR, Haire LF, Wharton SA, Daniels RS, Bennett MS, McCauley JW, Collins PJ, Walker PA, Skehel JJ, Gamblin SJ.

Nature. 2013 Jul 25;499(7459):496-9. doi: 10.1038/nature12372.

PMID:
23787694
18.

Receptor binding by a ferret-transmissible H5 avian influenza virus.

Xiong X, Coombs PJ, Martin SR, Liu J, Xiao H, McCauley JW, Locher K, Walker PA, Collins PJ, Kawaoka Y, Skehel JJ, Gamblin SJ.

Nature. 2013 May 16;497(7449):392-6. doi: 10.1038/nature12144. Epub 2013 Apr 24.

PMID:
23615615
19.

Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin.

Lin YP, Xiong X, Wharton SA, Martin SR, Coombs PJ, Vachieri SG, Christodoulou E, Walker PA, Liu J, Skehel JJ, Gamblin SJ, Hay AJ, Daniels RS, McCauley JW.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21474-9. doi: 10.1073/pnas.1218841110. Epub 2012 Dec 10. Erratum in: Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2677.

20.

H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis.

van der Vries E, Collins PJ, Vachieri SG, Xiong X, Liu J, Walker PA, Haire LF, Hay AJ, Schutten M, Osterhaus AD, Martin SR, Boucher CA, Skehel JJ, Gamblin SJ.

PLoS Pathog. 2012 Sep;8(9):e1002914. doi: 10.1371/journal.ppat.1002914. Epub 2012 Sep 20.

21.

A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses.

Hu H, Voss J, Zhang G, Buchy P, Zuo T, Wang L, Wang F, Zhou F, Wang G, Tsai C, Calder L, Gamblin SJ, Zhang L, Deubel V, Zhou B, Skehel JJ, Zhou P.

J Virol. 2012 Mar;86(6):2978-89. doi: 10.1128/JVI.06665-11. Epub 2012 Jan 11.

22.

ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.

Mayer FV, Heath R, Underwood E, Sanders MJ, Carmena D, McCartney RR, Leiper FC, Xiao B, Jing C, Walker PA, Haire LF, Ogrodowicz R, Martin SR, Schmidt MC, Gamblin SJ, Carling D.

Cell Metab. 2011 Nov 2;14(5):707-14. doi: 10.1016/j.cmet.2011.09.009. Epub 2011 Oct 20.

23.

A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins.

Corti D, Voss J, Gamblin SJ, Codoni G, Macagno A, Jarrossay D, Vachieri SG, Pinna D, Minola A, Vanzetta F, Silacci C, Fernandez-Rodriguez BM, Agatic G, Bianchi S, Giacchetto-Sasselli I, Calder L, Sallusto F, Collins P, Haire LF, Temperton N, Langedijk JP, Skehel JJ, Lanzavecchia A.

Science. 2011 Aug 12;333(6044):850-6. doi: 10.1126/science.1205669. Epub 2011 Jul 28.

24.

AMP-activated protein kinase: also regulated by ADP?

Hardie DG, Carling D, Gamblin SJ.

Trends Biochem Sci. 2011 Sep;36(9):470-7. doi: 10.1016/j.tibs.2011.06.004. Epub 2011 Jul 23. Review.

PMID:
21782450
25.

AMP-activated protein kinase: nature's energy sensor.

Carling D, Mayer FV, Sanders MJ, Gamblin SJ.

Nat Chem Biol. 2011 Jul 18;7(8):512-8. doi: 10.1038/nchembio.610. Review.

PMID:
21769098
26.

Structure of mammalian AMPK and its regulation by ADP.

Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, Gamblin SJ.

Nature. 2011 Apr 14;472(7342):230-3. doi: 10.1038/nature09932. Epub 2011 Mar 13.

27.

Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies.

Justin N, De Marco V, Aasland R, Gamblin SJ.

Curr Opin Struct Biol. 2010 Dec;20(6):730-8. doi: 10.1016/j.sbi.2010.09.012. Epub 2010 Oct 16. Review.

PMID:
20956082
28.

Influenza hemagglutinin and neuraminidase membrane glycoproteins.

Gamblin SJ, Skehel JJ.

J Biol Chem. 2010 Sep 10;285(37):28403-9. doi: 10.1074/jbc.R110.129809. Epub 2010 Jun 10. Review.

29.

Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: substrate specificity and mechanism of M23 metallopeptidases.

Spencer J, Murphy LM, Conners R, Sessions RB, Gamblin SJ.

J Mol Biol. 2010 Mar 5;396(4):908-23. doi: 10.1016/j.jmb.2009.12.021. Epub 2009 Dec 21.

PMID:
20026068
30.

Structural basis for oseltamivir resistance of influenza viruses.

Collins PJ, Haire LF, Lin YP, Liu J, Russell RJ, Walker PA, Martin SR, Daniels RS, Gregory V, Skehel JJ, Gamblin SJ, Hay AJ.

Vaccine. 2009 Oct 23;27(45):6317-23. doi: 10.1016/j.vaccine.2009.07.017.

PMID:
19840667
31.

Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957.

Liu J, Stevens DJ, Haire LF, Walker PA, Coombs PJ, Russell RJ, Gamblin SJ, Skehel JJ.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17175-80. doi: 10.1073/pnas.0906849106. Epub 2009 Sep 28.

32.

Role of the polycomb protein EED in the propagation of repressive histone marks.

Margueron R, Justin N, Ohno K, Sharpe ML, Son J, Drury WJ 3rd, Voigt P, Martin SR, Taylor WR, De Marco V, Pirrotta V, Reinberg D, Gamblin SJ.

Nature. 2009 Oct 8;461(7265):762-7. doi: 10.1038/nature08398. Epub 2009 Sep 20.

33.

Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion.

Russell RJ, Kerry PS, Stevens DJ, Steinhauer DA, Martin SR, Gamblin SJ, Skehel JJ.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17736-41. doi: 10.1073/pnas.0807142105. Epub 2008 Nov 12.

34.

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.

Collins PJ, Haire LF, Lin YP, Liu J, Russell RJ, Walker PA, Skehel JJ, Martin SR, Hay AJ, Gamblin SJ.

Nature. 2008 Jun 26;453(7199):1258-61. doi: 10.1038/nature06956. Epub 2008 May 14.

PMID:
18480754
35.

Structural basis for AMP binding to mammalian AMP-activated protein kinase.

Xiao B, Heath R, Saiu P, Leiper FC, Leone P, Jing C, Walker PA, Haire L, Eccleston JF, Davis CT, Martin SR, Carling D, Gamblin SJ.

Nature. 2007 Sep 27;449(7161):496-500. Epub 2007 Sep 12.

PMID:
17851531
36.

Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.

Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso M, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y.

Nature. 2006 Nov 16;444(7117):378-82.

PMID:
17108965
37.

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.

Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ.

Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16.

PMID:
16915235
38.

Avian and human receptor binding by hemagglutinins of influenza A viruses.

Russell RJ, Stevens DJ, Haire LF, Gamblin SJ, Skehel JJ.

Glycoconj J. 2006 Feb;23(1-2):85-92.

PMID:
16575525
39.

6 Structure of SET domain protein lysine methyltransferases.

Xiao B, Gamblin SJ, Wilson JR.

Enzymes. 2006;24:155-78. doi: 10.1016/S1874-6047(06)80008-9. Epub 2007 Jun 4.

PMID:
26718040
40.

Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography.

Spencer J, Read J, Sessions RB, Howell S, Blackburn GM, Gamblin SJ.

J Am Chem Soc. 2005 Oct 19;127(41):14439-44.

PMID:
16218639
41.

Specificity and mechanism of the histone methyltransferase Pr-Set7.

Xiao B, Jing C, Kelly G, Walker PA, Muskett FW, Frenkiel TA, Martin SR, Sarma K, Reinberg D, Gamblin SJ, Wilson JR.

Genes Dev. 2005 Jun 15;19(12):1444-54. Epub 2005 Jun 2.

42.

Regulation of p53 activity through lysine methylation.

Chuikov S, Kurash JK, Wilson JR, Xiao B, Justin N, Ivanov GS, McKinney K, Tempst P, Prives C, Gamblin SJ, Barlev NA, Reinberg D.

Nature. 2004 Nov 18;432(7015):353-60. Epub 2004 Nov 3.

43.

H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes.

Russell RJ, Gamblin SJ, Haire LF, Stevens DJ, Xiao B, Ha Y, Skehel JJ.

Virology. 2004 Aug 1;325(2):287-96.

44.

The structure and receptor binding properties of the 1918 influenza hemagglutinin.

Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ.

Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5.

45.

SET domains and histone methylation.

Xiao B, Wilson JR, Gamblin SJ.

Curr Opin Struct Biol. 2003 Dec;13(6):699-705. Review.

PMID:
14675547
46.

Comment on "The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction".

Blackburn GM, Williams NH, Gamblin SJ, Smerdon SJ.

Science. 2003 Aug 29;301(5637):1184; author reply 1184. No abstract available.

47.

NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity.

Beinke S, Deka J, Lang V, Belich MP, Walker PA, Howell S, Smerdon SJ, Gamblin SJ, Ley SC.

Mol Cell Biol. 2003 Jul;23(14):4739-52.

48.

A knot or not a knot? SETting the record 'straight' on proteins.

Taylor WR, Xiao B, Gamblin SJ, Lin K.

Comput Biol Chem. 2003 Feb;27(1):11-5.

PMID:
12798035
49.

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.

Xiao B, Spencer J, Clements A, Ali-Khan N, Mittnacht S, Broceño C, Burghammer M, Perrakis A, Marmorstein R, Gamblin SJ.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2363-8. Epub 2003 Feb 21.

50.

Structure and catalytic mechanism of the human histone methyltransferase SET7/9.

Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ.

Nature. 2003 Feb 6;421(6923):652-6. Epub 2003 Jan 22.

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