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Items: 24


The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening.

Kim J, Sun C, Tran AD, Chin PJ, Ruiz PD, Wang K, Gibbons RJ, Gamble MJ, Liu Y, Oberdoerffer P.

Nat Struct Mol Biol. 2019 Mar;26(3):213-219. doi: 10.1038/s41594-019-0192-3. Epub 2019 Mar 4.


MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20.

Ruiz PD, Gamble MJ.

Nat Commun. 2018 Dec 3;9(1):5143. doi: 10.1038/s41467-018-07189-8.


Histone Variant MacroH2A1 Plays an Isoform-Specific Role in Suppressing Epithelial-Mesenchymal Transition.

Hodge DQ, Cui J, Gamble MJ, Guo W.

Sci Rep. 2018 Jan 16;8(1):841. doi: 10.1038/s41598-018-19364-4.


S100A4 regulates macrophage invasion by distinct myosin-dependent and myosin-independent mechanisms.

Dulyaninova NG, Ruiz PD, Gamble MJ, Backer JM, Bresnick AR.

Mol Biol Cell. 2018 Mar 1;29(5):632-642. doi: 10.1091/mbc.E17-07-0460. Epub 2017 Dec 27.


MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype.

Chen H, Ruiz PD, McKimpson WM, Novikov L, Kitsis RN, Gamble MJ.

Mol Cell. 2015 Sep 3;59(5):719-31. doi: 10.1016/j.molcel.2015.07.011. Epub 2015 Aug 20.


MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation.

Chen H, Ruiz PD, Novikov L, Casill AD, Park JW, Gamble MJ.

Nat Struct Mol Biol. 2014 Nov;21(11):981-9. doi: 10.1038/nsmb.2903. Epub 2014 Oct 12.


Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development.

Wang WL, Anderson LC, Nicklay JJ, Chen H, Gamble MJ, Shabanowitz J, Hunt DF, Shechter D.

Epigenetics Chromatin. 2014 Sep 6;7:22. doi: 10.1186/1756-8935-7-22. eCollection 2014.


The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1.

Hussey KM, Chen H, Yang C, Park E, Hah N, Erdjument-Bromage H, Tempst P, Gamble MJ, Kraus WL.

Mol Cell Biol. 2014 Jul;34(13):2437-49. doi: 10.1128/MCB.01315-13. Epub 2014 Apr 21.


Expanding the functional repertoire of macrodomains.

Gamble MJ.

Nat Struct Mol Biol. 2013 Apr;20(4):407-8. doi: 10.1038/nsmb.2552. No abstract available.


Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase.

Zhang T, Berrocal JG, Yao J, DuMond ME, Krishnakumar R, Ruhl DD, Ryu KW, Gamble MJ, Kraus WL.

J Biol Chem. 2012 Apr 6;287(15):12405-16. doi: 10.1074/jbc.M111.304469. Epub 2012 Feb 13.


QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation.

Novikov L, Park JW, Chen H, Klerman H, Jalloh AS, Gamble MJ.

Mol Cell Biol. 2011 Oct;31(20):4244-55. doi: 10.1128/MCB.05244-11. Epub 2011 Aug 15.


Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.

Zhang X, Gamble MJ, Stadler S, Cherrington BD, Causey CP, Thompson PR, Roberson MS, Kraus WL, Coonrod SA.

PLoS Genet. 2011 Jun;7(6):e1002112. doi: 10.1371/journal.pgen.1002112. Epub 2011 Jun 2.


Multiple facets of the unique histone variant macroH2A: from genomics to cell biology.

Gamble MJ, Kraus WL.

Cell Cycle. 2010 Jul 1;9(13):2568-74. Review.


The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing.

Gamble MJ, Frizzell KM, Yang C, Krishnakumar R, Kraus WL.

Genes Dev. 2010 Jan 1;24(1):21-32. doi: 10.1101/gad.1876110. Epub 2009 Dec 15.


Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells.

Frizzell KM, Gamble MJ, Berrocal JG, Zhang T, Krishnakumar R, Cen Y, Sauve AA, Kraus WL.

J Biol Chem. 2009 Dec 4;284(49):33926-38. doi: 10.1074/jbc.M109.023879. Epub 2009 Oct 7.


Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters.

Zhang T, Berrocal JG, Frizzell KM, Gamble MJ, DuMond ME, Krishnakumar R, Yang T, Sauve AA, Kraus WL.

J Biol Chem. 2009 Jul 24;284(30):20408-17. doi: 10.1074/jbc.M109.016469. Epub 2009 May 28.


Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes.

Krishnakumar R, Gamble MJ, Frizzell KM, Berrocal JG, Kininis M, Kraus WL.

Science. 2008 Feb 8;319(5864):819-21. doi: 10.1126/science.1149250.


SET and PARP1 remove DEK from chromatin to permit access by the transcription machinery.

Gamble MJ, Fisher RP.

Nat Struct Mol Biol. 2007 Jun;14(6):548-55. Epub 2007 May 27.


Visualizing the histone code on LSD1.

Gamble MJ, Kraus WL.

Cell. 2007 Feb 9;128(3):433-4.


Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.

Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, Blethrow JD, Shokat KM, Fisher RP.

Nat Struct Mol Biol. 2006 Jan;13(1):55-62. Epub 2005 Dec 4.


Using the matron's charter to improve hospital cleaning.

Gamble MJ.

Nurs Times. 2005 Apr 12-18;101(15):26-7.


The histone chaperone TAF-I/SET/INHAT is required for transcription in vitro of chromatin templates.

Gamble MJ, Erdjument-Bromage H, Tempst P, Freedman LP, Fisher RP.

Mol Cell Biol. 2005 Jan;25(2):797-807.


A coactivator code for transcription.

Gamble MJ, Freedman LP.

Trends Biochem Sci. 2002 Apr;27(4):165-7. No abstract available.


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