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Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.

Chen J, Qi Y, Zhao Y, Kaczorowski D, Couttas TA, Coleman PR, Don AS, Bertolino P, Gamble JR, Vadas MA, Xia P, McCaughan GW.

Oncotarget. 2018 Feb 26;9(21):15635-15649. doi: 10.18632/oncotarget.24583. eCollection 2018 Mar 20.


ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype.

Liu R, Lo L, Lay AJ, Zhao Y, Ting KK, Robertson EN, Sherrah AG, Jarrah S, Li H, Zhou Z, Hambly BD, Richmond DR, Jeremy RW, Bannon PG, Vadas MA, Gamble JR.

Circ Res. 2017 Aug 18;121(5):512-524. doi: 10.1161/CIRCRESAHA.117.310692. Epub 2017 Jul 12.


Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell-Mediated Immunotherapy.

Zhao Y, Ting KK, Li J, Cogger VC, Chen J, Johansson-Percival A, Ngiow SF, Holst J, Grau G, Goel S, Muller T, Dejana E, McCaughan G, Smyth MJ, Ganss R, Vadas MA, Gamble JR.

Cancer Res. 2017 Aug 15;77(16):4434-4447. doi: 10.1158/0008-5472.CAN-16-3129. Epub 2017 Jun 27.


Targeting the vasculature in hepatocellular carcinoma treatment: Starving versus normalizing blood supply.

Liu K, Zhang X, Xu W, Chen J, Yu J, Gamble JR, McCaughan GW.

Clin Transl Gastroenterol. 2017 Jun 15;8(6):e98. doi: 10.1038/ctg.2017.28.


Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence.

McRobb LS, McKay MJ, Gamble JR, Grace M, Moutrie V, Santos ED, Lee VS, Zhao Z, Molloy MP, Stoodley MA.

Aging (Albany NY). 2017 Apr;9(4):1248-1268. doi: 10.18632/aging.101225.


The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.

Lovelace MD, Powter EE, Coleman PR, Zhao Y, Parker A, Chang GH, Lay AJ, Hunter J, McGrath AP, Jormakka M, Bertolino P, McCaughan G, Kavallaris M, Vadas MA, Gamble JR.

Mol Biol Cell. 2017 Apr 15;28(8):1066-1078. doi: 10.1091/mbc.E16-05-0285. Epub 2017 Mar 1.


Contextual effects of noise on vocalization encoding in primary auditory cortex.

Ni R, Bender DA, Shanechi AM, Gamble JR, Barbour DL.

J Neurophysiol. 2017 Feb 1;117(2):713-727. doi: 10.1152/jn.00476.2016. Epub 2016 Nov 23.


The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b.

Li J, Zhao Y, Lu Y, Ritchie W, Grau G, Vadas MA, Gamble JR.

Mol Ther Nucleic Acids. 2016 Aug 23;5(8):e354. doi: 10.1038/mtna.2016.62.


Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers.

Zhang X, Gee H, Rose B, Lee CS, Clark J, Elliott M, Gamble JR, Cairns MJ, Harris A, Khoury S, Tran N.

BMC Cancer. 2016 Feb 11;16:86. doi: 10.1186/s12885-016-2109-4.


Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.

Chen J, Wang W, Qi Y, Kaczorowski D, McCaughan GW, Gamble JR, Don AS, Gao X, Vadas MA, Xia P.

Biochim Biophys Acta. 2016 Feb;1861(2):138-147. doi: 10.1016/j.bbalip.2015.11.006. Epub 2015 Nov 23.


ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.

Chang GH, Lay AJ, Ting KK, Zhao Y, Coleman PR, Powter EE, Formaz-Preston A, Jolly CJ, Bower NI, Hogan BM, Rinkwitz S, Becker TS, Vadas MA, Gamble JR.

Small GTPases. 2014;5(3):1-15. doi: 10.4161/21541248.2014.975002.


Caveolae control the anti-inflammatory phenotype of senescent endothelial cells.

Powter EE, Coleman PR, Tran MH, Lay AJ, Bertolino P, Parton RG, Vadas MA, Gamble JR.

Aging Cell. 2015 Feb;14(1):102-11. doi: 10.1111/acel.12270. Epub 2014 Nov 19.


Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells.

Tay SS, Wong YC, Roediger B, Sierro F, Lu B, McDonald DM, McGuffog CM, Meyer NJ, Alexander IE, Parish IA, Heath WR, Weninger W, Bishop GA, Gamble JR, McCaughan GW, Bertolino P, Bowen DG.

J Immunol. 2014 Sep 1;193(5):2087-95. doi: 10.4049/jimmunol.1400037. Epub 2014 Jul 28.


Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses.

Tay SS, Wong YC, McDonald DM, Wood NA, Roediger B, Sierro F, Mcguffog C, Alexander IE, Bishop GA, Gamble JR, Weninger W, McCaughan GW, Bertolino P, Bowen DG.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2540-9. doi: 10.1073/pnas.1406674111. Epub 2014 Jun 10.


Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction.

Wu LE, Meoli CC, Mangiafico SP, Fazakerley DJ, Cogger VC, Mohamad M, Pant H, Kang MJ, Powter E, Burchfield JG, Xirouchaki CE, Mikolaizak AS, Stöckli J, Kolumam G, van Bruggen N, Gamble JR, Le Couteur DG, Cooney GJ, Andrikopoulos S, James DE.

Diabetes. 2014 Aug;63(8):2656-67. doi: 10.2337/db13-1665. Epub 2014 Apr 2.


miR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer.

Brockhausen J, Tay SS, Grzelak CA, Bertolino P, Bowen DG, d'Avigdor WM, Teoh N, Pok S, Shackel N, Gamble JR, Vadas M, McCaughan GW.

Liver Int. 2015 Jan;35(1):240-53. doi: 10.1111/liv.12517. Epub 2014 Apr 30.


Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells.

Coleman PR, Chang G, Hutas G, Grimshaw M, Vadas MA, Gamble JR.

Aging (Albany NY). 2013 Dec;5(12):913-24.


Beyond liver fibrosis: hepatic stellate cell senescence links obesity to liver cancer by way of the microbiome.

Shackel NA, Vadas MA, Gamble JR, McCaughan GW.

Hepatology. 2014 Jun;59(6):2413-5. doi: 10.1002/hep.26932. Epub 2014 Apr 9. No abstract available.


Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27.

Young JA, Ting KK, Li J, Moller T, Dunn L, Lu Y, Moses J, Prado-Lourenço L, Khachigian LM, Ng M, Gregory PA, Goodall GJ, Tsykin A, Lichtenstein I, Hahn CN, Tran N, Shackel N, Kench JG, McCaughan G, Vadas MA, Gamble JR.

Blood. 2013 Oct 17;122(16):2911-9. doi: 10.1182/blood-2012-12-473017. Epub 2013 Sep 5. Erratum in: Blood. 2014 Nov 6;124(19):3034.


Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies.

Lichtenstein I, Charleston MA, Caetano TS, Gamble JR, Vadas MA.

BMC Bioinformatics. 2013 Feb 21;14:59. doi: 10.1186/1471-2105-14-59.


A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration.

Williams SL, Milne IR, Bagley CJ, Gamble JR, Vadas MA, Pitson SM, Khew-Goodall Y.

J Immunol. 2010 Sep 1;185(5):3057-63. doi: 10.4049/jimmunol.1000119. Epub 2010 Aug 2.


Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells.

Coleman PR, Hahn CN, Grimshaw M, Lu Y, Li X, Brautigan PJ, Beck K, Stocker R, Vadas MA, Gamble JR.

Blood. 2010 Nov 11;116(19):4016-24. doi: 10.1182/blood-2009-11-252700. Epub 2010 Jul 27.


Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival.

Gamble JR, Sun WY, Li X, Hahn CN, Pitson SM, Vadas MA, Bonder CS.

Am J Pathol. 2009 Nov;175(5):2217-25. doi: 10.2353/ajpath.2009.090076. Epub 2009 Oct 8.


Heme oxygenase-1 increases endothelial progenitor cells.

Wu BJ, Midwinter RG, Cassano C, Beck K, Wang Y, Changsiri D, Gamble JR, Stocker R.

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1537-42. doi: 10.1161/ATVBAHA.109.184713. Epub 2009 Jun 18.


JAM-C induces endothelial cell permeability through its association and regulation of {beta}3 integrins.

Li X, Stankovic M, Lee BP, Aurrand-Lions M, Hahn CN, Lu Y, Imhof BA, Vadas MA, Gamble JR.

Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1200-6. doi: 10.1161/ATVBAHA.109.189217. Epub 2009 May 21.


The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells.

Limaye V, Vadas MA, Pitson SM, Gamble JR.

Cell Mol Biol Lett. 2009;14(3):411-23. doi: 10.2478/s11658-009-0008-2. Epub 2009 Feb 23.


Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells.

Limaye V, Xia P, Hahn C, Smith M, Vadas MA, Pitson SM, Gamble JR.

Cell Mol Biol Lett. 2009;14(3):424-41. doi: 10.2478/s11658-009-0009-1. Epub 2009 Feb 23.


Insights into defibrotide as therapy for veno-occlusive disease.

Gamble JR, Vadas MA.

Hepatology. 2009 Feb;49(2):689-90. doi: 10.1002/hep.22770. No abstract available.


Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation.

Bonder CS, Sun WY, Matthews T, Cassano C, Li X, Ramshaw HS, Pitson SM, Lopez AF, Coates PT, Proia RL, Vadas MA, Gamble JR.

Blood. 2009 Feb 26;113(9):2108-17. doi: 10.1182/blood-2008-07-166942. Epub 2008 Dec 24.


Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1.

Li X, Stankovic M, Bonder CS, Hahn CN, Parsons M, Pitson SM, Xia P, Proia RL, Vadas MA, Gamble JR.

Blood. 2008 Apr 1;111(7):3489-97. doi: 10.1182/blood-2007-05-092148. Epub 2008 Jan 16.


Physician Assistant Program in North Carolina.

Gamble JR Jr.

N C Med J. 2007 Sep-Oct;68(5):379-80. No abstract available.


Endothelial cell COX-2 expression and activity in hypoxia.

Cook-Johnson RJ, Demasi M, Cleland LG, Gamble JR, Saint DA, James MJ.

Biochim Biophys Acta. 2006 Dec;1761(12):1443-9. Epub 2006 Sep 14.


Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development.

Young N, Hahn CN, Poh A, Dong C, Wilhelm D, Olsson J, Muscat GE, Parsons P, Gamble JR, Koopman P.

J Natl Cancer Inst. 2006 Aug 2;98(15):1060-7.


Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects.

Gamble JR, Xia P, Hahn CN, Drew JJ, Drogemuller CJ, Brown D, Vadas MA.

Int J Cancer. 2006 May 15;118(10):2412-20.


Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells.

Wang L, Xing XP, Holmes A, Wadham C, Gamble JR, Vadas MA, Xia P.

Circ Res. 2005 Oct 28;97(9):891-9. Epub 2005 Sep 22.


Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis.

Hahn CN, Su ZJ, Drogemuller CJ, Tsykin A, Waterman SR, Brautigan PJ, Yu S, Kremmidiotis G, Gardner A, Solomon PJ, Goodall GJ, Vadas MA, Gamble JR.

Physiol Genomics. 2005 Jun 16;22(1):57-69. Epub 2005 Apr 19.


Eliminating racial and ethnic health diparities.

Gamble JR Jr.

N C Med J. 2005 Jan-Feb;66(1):79. No abstract available.


Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members.

Limaye V, Li X, Hahn C, Xia P, Berndt MC, Vadas MA, Gamble JR.

Blood. 2005 Apr 15;105(8):3169-77. Epub 2005 Jan 4.


A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis.

Su ZJ, Hahn CN, Goodall GJ, Reck NM, Leske AF, Davy A, Kremmidiotis G, Vadas MA, Gamble JR.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12212-7. Epub 2004 Aug 9.


Role of protein kinase Czeta in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1.

Li X, Hahn CN, Parsons M, Drew J, Vadas MA, Gamble JR.

Blood. 2004 Sep 15;104(6):1716-24. Epub 2004 Jun 1.


PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase.

Verrier E, Wang L, Wadham C, Albanese N, Hahn C, Gamble JR, Chatterjee VK, Vadas MA, Xia P.

Circ Res. 2004 Jun 11;94(11):1515-22. Epub 2004 Apr 29.


High-density lipoproteins neutralize C-reactive protein proinflammatory activity.

Wadham C, Albanese N, Roberts J, Wang L, Bagley CJ, Gamble JR, Rye KA, Barter PJ, Vadas MA, Xia P.

Circulation. 2004 May 4;109(17):2116-22. Epub 2004 Apr 12.


Biofiltration of trichloroethylene-contaminated air: a pilot study.

Lackey LW, Gamble JR, Boles JL.

J Air Waste Manag Assoc. 2003 Oct;53(10):1248-55.


On primary care and access to care.

Gamble JR Jr.

N C Med J. 2002 Nov-Dec;63(6):315. No abstract available.


More consequences of wait times.

Gamble JR Jr.

Postgrad Med. 2003 Aug;114(2):2; author reply 2. No abstract available.


The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.

Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y.

Mol Biol Cell. 2003 Jun;14(6):2520-9. Epub 2003 Feb 6.


Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response.

Brand C, Grimbaldeston MA, Gamble JR, Drew J, Finlay-Jones JJ, Hart PH.

Inflamm Res. 2002 May;51(5):236-44.


Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.

Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D'Andrea RJ, Gamble JR, Vadas MA.

J Biol Chem. 2002 Mar 8;277(10):7996-8003. Epub 2002 Jan 2. Erratum in: J Biol Chem. 2011 Dec 9;286(49):42785. J Biol Chem. 2011 Mar 18;286(11):9894.


Rate of endothelial expansion is controlled by cell:cell adhesion.

Underwood PA, Bean PA, Gamble JR.

Int J Biochem Cell Biol. 2002 Jan;34(1):55-69.


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