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Items: 45


Effect of the BTK inhibitor ibrutinib on macrophage- and γδ T cell-mediated response against Mycobacterium tuberculosis.

Colado A, Genoula M, Cougoule C, Marín Franco JL, Almejún MB, Risnik D, Kviatcovsky D, Podaza E, Elías EE, Fuentes F, Maridonneau-Parini I, Bezares FR, Fernandez Grecco H, Cabrejo M, Jancic C, Sasiain MDC, Giordano M, Gamberale R, Balboa L, Borge M.

Blood Cancer J. 2018 Nov 5;8(11):100. doi: 10.1038/s41408-018-0136-x. No abstract available.


Chronic lymphocytic leukemia cells increase neutrophils survival and promote their differentiation into CD16high CD62Ldim immunosuppressive subset.

Podaza E, Risnik D, Colado A, Elías E, Almejún MB, Fernandez Grecco H, Bezares RF, Borge M, Gamberale R, Giordano M.

Int J Cancer. 2019 Mar 1;144(5):1128-1134. doi: 10.1002/ijc.31762. Epub 2018 Sep 29.


Autologous T-cell activation fosters ABT-199 resistance in chronic lymphocytic leukemia: rationale for a combined therapy with SYK inhibitors and anti-CD20 monoclonal antibodies.

Elías EE, Almejún MB, Colado A, Cordini G, Vergara-Rubio M, Podaza E, Risnik D, Cabrejo M, Fernández-Grecco H, Bezares RF, Custidiano MDR, Sánchez-Ávalos JC, Vicente Á, Garate GM, Borge M, Giordano M, Gamberale R.

Haematologica. 2018 Oct;103(10):e458-e461. doi: 10.3324/haematol.2018.188680. Epub 2018 May 10. No abstract available.


Revisiting the role of interleukin-8 in chronic lymphocytic leukemia.

Risnik D, Podaza E, Almejún MB, Colado A, Elías EE, Bezares RF, Fernández-Grecco H, Cranco S, Sánchez-Ávalos JC, Borge M, Gamberale R, Giordano M.

Sci Rep. 2017 Nov 16;7(1):15714. doi: 10.1038/s41598-017-15953-x.


Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells.

Almejún MB, Borge M, Colado A, Elías EE, Podaza E, Risnik D, De Brasi CD, Stanganelli C, Slavutsky I, Cabrejo M, Fernández-Grecco H, Bezares RF, Cranco S, Burgos RÁ, Sánchez-Ávalos JC, Oppezzo P, Giordano M, Gamberale R.

Haematologica. 2017 Jul;102(7):e257-e260. doi: 10.3324/haematol.2017.167353. Epub 2017 Mar 30. No abstract available.


The kinase inhibitors R406 and GS-9973 impair T cell functions and macrophage-mediated anti-tumor activity of rituximab in chronic lymphocytic leukemia patients.

Colado A, Almejún MB, Podaza E, Risnik D, Stanganelli C, Elías EE, Dos Santos P, Slavutsky I, Fernández Grecco H, Cabrejo M, Bezares RF, Giordano M, Gamberale R, Borge M.

Cancer Immunol Immunother. 2017 Apr;66(4):461-473. doi: 10.1007/s00262-016-1946-y. Epub 2016 Dec 23.


Neutrophils from chronic lymphocytic leukemia patients exhibit an increased capacity to release extracellular traps (NETs).

Podaza E, Sabbione F, Risnik D, Borge M, Almejún MB, Colado A, Fernández-Grecco H, Cabrejo M, Bezares RF, Trevani A, Gamberale R, Giordano M.

Cancer Immunol Immunother. 2017 Jan;66(1):77-89. doi: 10.1007/s00262-016-1921-7. Epub 2016 Oct 28.


Soluble RANKL production by leukemic cells in a case of chronic lymphocytic leukemia with bone destruction.

Borge M, Delpino MV, Podaza E, Stanganelli C, Palau-Nagore V, Roisman A, Slavutsky I, Palacios MF, Ledesma I, Arra A, Díaz A, Giordano M, Gamberale R, Bezares RF.

Leuk Lymphoma. 2016 Oct;57(10):2468-71. doi: 10.3109/10428194.2016.1151506. Epub 2016 Feb 25. No abstract available.


Ibrutinib impairs the phagocytosis of rituximab-coated leukemic cells from chronic lymphocytic leukemia patients by human macrophages.

Borge M, Belén Almejún M, Podaza E, Colado A, Fernández Grecco H, Cabrejo M, Bezares RF, Giordano M, Gamberale R.

Haematologica. 2015 Apr;100(4):e140-2. doi: 10.3324/haematol.2014.119669. Epub 2015 Jan 23. No abstract available.


Surface localization of high-mobility group nucleosome-binding protein 2 on leukemic B cells from patients with chronic lymphocytic leukemia is related to secondary autoimmune hemolytic anemia.

Morande PE, Borge M, Abreu C, Galletti J, Zanetti SR, Nannini P, Bezares RF, Pantano S, Dighiero G, Oppezzo P, Gamberale R, Giordano M.

Leuk Lymphoma. 2015 Apr;56(4):1115-22. doi: 10.3109/10428194.2014.957205. Epub 2015 Jan 21.


The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406.

Borge M, Remes Lenicov F, Nannini PR, de los Ríos Alicandú MM, Podaza E, Ceballos A, Fernández Grecco H, Cabrejo M, Bezares RF, Morande PE, Oppezzo P, Giordano M, Gamberale R.

J Immunol. 2014 Sep 15;193(6):3165-74. doi: 10.4049/jimmunol.1400547. Epub 2014 Aug 15.


Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia.

Abreu C, Moreno P, Palacios F, Borge M, Morande P, Landoni AI, Gabus R, Dighiero G, Giordano M, Gamberale R, Oppezzo P.

Leuk Lymphoma. 2013 Aug;54(8):1844-8. doi: 10.3109/10428194.2013.796057. Epub 2013 Jun 21.


Nurse-like cells control the activity of chronic lymphocytic leukemia B cells via galectin-1.

Croci DO, Morande PE, Dergan-Dylon S, Borge M, Toscano MA, Stupirski JC, Bezares RF, Avalos JS, Narbaitz M, Gamberale R, Rabinovich GA, Giordano M.

Leukemia. 2013 Jun;27(6):1413-6. doi: 10.1038/leu.2012.315. Epub 2012 Nov 7. No abstract available.


CXCL12 is a costimulator for CD4+ T cell activation and proliferation in chronic lymphocytic leukemia patients.

Borge M, Nannini PR, Morande PE, Jancic C, Bistmans A, Bezares RF, Giordano M, Gamberale R.

Cancer Immunol Immunother. 2013 Jan;62(1):113-24. doi: 10.1007/s00262-012-1320-7. Epub 2012 Jul 29.


Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment.

Moreno P, Abreu C, Borge M, Palacios F, Morande P, Pegazzano M, Bianchi S, Landoni AI, Agrelo R, Giordano M, Dighiero G, Gamberale R, Oppezzo P.

Leukemia. 2013 Mar;27(3):721-5. doi: 10.1038/leu.2012.212. Epub 2012 Jul 25. No abstract available.


The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells.

Morande PE, Zanetti SR, Borge M, Nannini P, Jancic C, Bezares RF, Bitsmans A, González M, Rodríguez AL, Galmarini CM, Gamberale R, Giordano M.

Invest New Drugs. 2012 Oct;30(5):1830-40. doi: 10.1007/s10637-011-9740-3. Epub 2011 Sep 2.


CCR4 expression in a case of cutaneous Richter's transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma (DLBCL) and in CLL patients with no skin manifestations.

Nannini PR, Borge M, Mikolaitis VC, Abreu C, Morande PE, Zanetti SR, Oppezzo P, Palacios F, Ledesma I, Bezares RF, Giordano M, Gamberale R.

Eur J Haematol. 2011 Jul;87(1):80-6. doi: 10.1111/j.1600-0609.2011.01613.x.


CXCL12-induced chemotaxis is impaired in T cells from patients with ZAP-70-negative chronic lymphocytic leukemia.

Borge M, Nannini PR, Galletti JG, Morande PE, Avalos JS, Bezares RF, Giordano M, Gamberale R.

Haematologica. 2010 May;95(5):768-75. doi: 10.3324/haematol.2009.013995. Epub 2010 Feb 9.


Chronic lymphocytic leukemia cells bind and present the erythrocyte protein band 3: possible role as initiators of autoimmune hemolytic anemia.

Galletti J, Cañones C, Morande P, Borge M, Oppezzo P, Geffner J, Bezares R, Gamberale R, Giordano M.

J Immunol. 2008 Sep 1;181(5):3674-83.


Modulation of the human equilibrative nucleoside transporter1 (hENT1) activity by IL-4 and PMA in B cells from chronic lymphocytic leukemia.

Fernández Calotti P, Galmarini CM, Cañones C, Gamberale R, Saénz D, Avalos JS, Chianelli M, Rosenstein R, Giordano M.

Biochem Pharmacol. 2008 Feb 15;75(4):857-65. Epub 2007 Oct 22.


SHIP-1 protein level and phosphorylation status differs between CLL cells segregated by ZAP-70 expression.

Gabelloni ML, Borge M, Galletti J, Cañones C, Fernández Calotti P, Bezares RF, Avalos JS, Giordano M, Gamberale R.

Br J Haematol. 2008 Jan;140(1):117-9. Epub 2007 Nov 12. No abstract available.


Neutrophil signaling pathways activated by bacterial DNA stimulation.

Alvarez ME, Fuxman Bass JI, Geffner JR, Fernández Calotti PX, Costas M, Coso OA, Gamberale R, Vermeulen ME, Salamone G, Martinez D, Tanos T, Trevani AS.

J Immunol. 2006 Sep 15;177(6):4037-46.


Fludarabine induces pro-inflammatory activation of human monocytic cells through a MAPK/ERK pathway.

Fernández-Calotti P, Gamberale R, Costas M, Sánchez Avalos J, Geffner J, Giordano M.

Int Immunopharmacol. 2006 May;6(5):715-23. Epub 2005 Sep 22.


The effect of fludarabine on interferon-gamma production by lymphoid cells from healthy donors and patients with B-cell chronic lymphocytic leukemia.

Gamberale R, Fernández-Calotti P, Sánchez-Avalos J, Alberto MF, Geffner J, Giordano M.

Haematologica. 2006 Apr;91(4):574-6. Epub 2006 Mar 1.


Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways.

Martínez D, Vermeulen M, Trevani A, Ceballos A, Sabatté J, Gamberale R, Alvarez ME, Salamone G, Tanos T, Coso OA, Geffner J.

J Immunol. 2006 Jan 15;176(2):1163-71.


Signaling capacity of FcgammaRII isoforms in B-CLL cells.

Gamberale R, Fernández-Calotti P, Sanjurjo J, Arrossagaray G, Avalos JS, Geffner J, Giordano M.

Leuk Res. 2005 Nov;29(11):1277-84.


The impact of extracellular acidosis on dendritic cell function.

Vermeulen ME, Gamberale R, Trevani AS, Martínez D, Ceballos A, Sabatte J, Giordano M, Geffner JR.

Crit Rev Immunol. 2004;24(5):363-84. Review.


Analysis of the mechanisms involved in the stimulation of neutrophil apoptosis by tumour necrosis factor-alpha.

Salamone G, Trevani A, Martínez D, Vermeulen M, Gamberale R, Fernández-Calotti P, Raiden S, Giordano M, Geffner J.

Immunology. 2004 Nov;113(3):355-62.


Acidosis improves uptake of antigens and MHC class I-restricted presentation by dendritic cells.

Vermeulen M, Giordano M, Trevani AS, Sedlik C, Gamberale R, Fernández-Calotti P, Salamone G, Raiden S, Sanjurjo J, Geffner JR.

J Immunol. 2004 Mar 1;172(5):3196-204.


In vitro susceptibility of CD4+ and CD8+ T cell subsets to fludarabine.

Gamberale R, Galmarini CM, Fernández-Calotti P, Jordheim L, Sánchez-Avalos J, Dumontet C, Geffner J, Giordano M.

Biochem Pharmacol. 2003 Dec 1;66(11):2185-91.


Bacterial DNA activates human neutrophils by a CpG-independent pathway.

Trevani AS, Chorny A, Salamone G, Vermeulen M, Gamberale R, Schettini J, Raiden S, Geffner J.

Eur J Immunol. 2003 Nov;33(11):3164-74.


Expression of Fcgamma receptors type II (FcgammaRII) in chronic lymphocytic leukemia B cells.

Gamberale R, Geffner JR, Sanjurjo J, Fernandez-Calotti PX, Arrosagaray G, Sanchez Avalos J, Giordano M.

Blood. 2003 Oct 1;102(7):2698-9. No abstract available.


Human platelets produce granulocyte-macrophage colony-stimulating factor and delay eosinophil apoptosis.

Raiden S, Schettini J, Salamone G, Trevani A, Vermeulen M, Gamberale R, Giordano M, Geffner J.

Lab Invest. 2003 Apr;83(4):589-98.


Downregulation of mac-1 expression in monocytes by surface-bound IgG.

Fernández-Calotti PX, Salamone G, Gamberale R, Trevani A, Vermeulen M, Geffner J, Giordano M.

Scand J Immunol. 2003 Jan;57(1):35-44.


A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation.

Sedlik C, Orbach D, Veron P, Schweighoffer E, Colucci F, Gamberale R, Ioan-Facsinay A, Verbeek S, Ricciardi-Castagnoli P, Bonnerot C, Tybulewicz VL, Di Santo J, Amigorena S.

J Immunol. 2003 Jan 15;170(2):846-52.


Control of dendritic cell differentiation by angiotensin II.

Nahmod KA, Vermeulen ME, Raiden S, Salamone G, Gamberale R, Fernández-Calotti P, Alvarez A, Nahmod V, Giordano M, Geffner JR.

FASEB J. 2003 Mar;17(3):491-3. Epub 2003 Jan 2.


Stimulation of neutrophil apoptosis by immobilized IgA.

Schettini J, Salamone G, Trevani A, Raiden S, Gamberale R, Vermeulen M, Giordano M, Geffner JR.

J Leukoc Biol. 2002 Oct;72(4):685-91.


Immune complexes and apoptosis in B-cell chronic lymphocytic leukemia.

Gamberale R, Geffner JR, Giordano M.

Leuk Lymphoma. 2002 Feb;43(2):251-5. Review.


Non-malignant leukocytes delay spontaneous B-CLL cell apoptosis.

Gamberale R, Geffner J, Arrosagaray G, Scolnik M, Salamone G, Trevani A, Vermeulen M, Giordano M.

Leukemia. 2001 Dec;15(12):1860-7.


Medroxyprogesterone acetate enhances in vivo and in vitro antibody production.

Vermeulen M, Pazos P, Lanari C, Molinolo A, Gamberale R, Geffner JR, Giordano M.

Immunology. 2001 Sep;104(1):80-6.


Promotion of neutrophil apoptosis by TNF-alpha.

Salamone G, Giordano M, Trevani AS, Gamberale R, Vermeulen M, Schettinni J, Geffner JR.

J Immunol. 2001 Mar 1;166(5):3476-83.


Immune complexes inhibit apoptosis of chronic lymphocytic leukaemia B cells.

Gamberale R, Geffner JR, Trevani A, Cherñavsky A, Scolnik M, Arrosagaray G, Sarmiento M, Giordano M.

Br J Haematol. 1999 Dec;107(4):870-6.


Extracellular acidification induces human neutrophil activation.

Trevani AS, Andonegui G, Giordano M, López DH, Gamberale R, Minucci F, Geffner JR.

J Immunol. 1999 Apr 15;162(8):4849-57.


Effect of nitric oxide donors on oxygen-dependent cytotoxic responses mediated by neutrophils.

Andonegui G, Trevani AS, Gamberale R, Carreras MC, Poderoso JJ, Giordano M, Geffner JR.

J Immunol. 1999 Mar 1;162(5):2922-30.


Modulation of human neutrophil apoptosis by immune complexes.

Gamberale R, Giordano M, Trevani AS, Andonegui G, Geffner JR.

J Immunol. 1998 Oct 1;161(7):3666-74.

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