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Hemoglobin deoxygenation and methemoglobinemia prevent regulatory volume decrease in crucian carp (Carassius carassius) red blood cells.

Andreyeva AY, Soldatov AA, Krivchenko AI, Mindukshev IV, Gambaryan S.

Fish Physiol Biochem. 2019 Aug 8. doi: 10.1007/s10695-019-00689-4. [Epub ahead of print]


Mechanisms of increased mitochondria-dependent necrosis in Wiskott-Aldrich syndrome platelets.

Obydennyi SI, Artemenko EO, Sveshnikova AN, Ignatova AA, Varlamova TV, Gambaryan S, Lomakina GY, Ugarova NN, Kireev II, Ataullakhanov FI, Novichkova GA, Maschan AA, Shcherbina A, Panteleev M.

Haematologica. 2019 Jul 5. pii: haematol.2018.214460. doi: 10.3324/haematol.2018.214460. [Epub ahead of print]


The Direct Thrombin Inhibitors Dabigatran and Lepirudin Inhibit GPIbα-Mediated Platelet Aggregation.

Trabold K, Makhoul S, Gambaryan S, van Ryn J, Walter U, Jurk K.

Thromb Haemost. 2019 Jun;119(6):916-929. doi: 10.1055/s-0039-1685139. Epub 2019 Apr 20.


NAD Metabolome Analysis in Human Cells Using ¹H NMR Spectroscopy.

Shabalin K, Nerinovski K, Yakimov A, Kulikova V, Svetlova M, Solovjeva L, Khodorkovskiy M, Gambaryan S, Cunningham R, Migaud ME, Ziegler M, Nikiforov A.

Int J Mol Sci. 2018 Dec 6;19(12). pii: E3906. doi: 10.3390/ijms19123906.


Multifaceted effects of arachidonic acid and interaction with cyclic nucleotides in human platelets.

Rukoyatkina N, Shpakova V, Panteleev M, Kharazova A, Gambaryan S, Geiger J.

Thromb Res. 2018 Nov;171:22-30. doi: 10.1016/j.thromres.2018.09.047. Epub 2018 Sep 13.


Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets.

Makhoul S, Walter E, Pagel O, Walter U, Sickmann A, Gambaryan S, Smolenski A, Zahedi RP, Jurk K.

Nitric Oxide. 2018 Jun 1;76:71-80. doi: 10.1016/j.niox.2018.03.008. Epub 2018 Mar 14. Review.


Hypoxia inhibits the regulatory volume decrease in red blood cells of common frog (Rana temporaria).

Andreyeva AY, Skverchinskaya EA, Gambaryan S, Soldatov AA, Mindukshev IV.

Comp Biochem Physiol A Mol Integr Physiol. 2018 May;219-220:44-47. doi: 10.1016/j.cbpa.2018.02.016. Epub 2018 Mar 1.


Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation.

Kiouptsi K, Gambaryan S, Walter E, Walter U, Jurk K, Reinhardt C.

Sci Rep. 2017 Aug 8;7(1):7621. doi: 10.1038/s41598-017-07988-x.


Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis.

Rukoyatkina N, Butt E, Subramanian H, Nikolaev VO, Mindukshev I, Walter U, Gambaryan S, Benz PM.

Cell Death Dis. 2017 Jun 29;8(6):e2898. doi: 10.1038/cddis.2017.290.


Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B.

Loroch S, Trabold K, Gambaryan S, Reiß C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U, Jurk K.

Thromb Haemost. 2017 Feb 28;117(3):556-569. doi: 10.1160/TH16-07-0515. Epub 2017 Jan 12.


Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition.

Beck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Pötz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP, Sickmann A.

Blood. 2017 Jan 12;129(2):e1-e12. doi: 10.1182/blood-2016-05-714048. Epub 2016 Nov 9.


PTH1R Mutants Found in Patients with Primary Failure of Tooth Eruption Disrupt G-Protein Signaling.

Subramanian H, Döring F, Kollert S, Rukoyatkina N, Sturm J, Gambaryan S, Stellzig-Eisenhauer A, Meyer-Marcotty P, Eigenthaler M, Wischmeyer E.

PLoS One. 2016 Nov 29;11(11):e0167033. doi: 10.1371/journal.pone.0167033. eCollection 2016.


Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets.

Benz PM, Laban H, Zink J, Günther L, Walter U, Gambaryan S, Dib K.

Cell Commun Signal. 2016 Sep 13;14(1):21. doi: 10.1186/s12964-016-0144-z.


Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis.

Gambaryan S, Subramanian H, Kehrer L, Mindukshev I, Sudnitsyna J, Reiss C, Rukoyatkina N, Friebe A, Sharina I, Martin E, Walter U.

Cell Commun Signal. 2016 Aug 11;14(1):16. doi: 10.1186/s12964-016-0139-9.


Carbonic anhydrases are producers of S-nitrosothiols from inorganic nitrite and modulators of soluble guanylyl cyclase in human platelets.

Hanff E, Böhmer A, Zinke M, Gambaryan S, Schwarz A, Supuran CT, Tsikas D.

Amino Acids. 2016 Jul;48(7):1695-706. doi: 10.1007/s00726-016-2234-z. Epub 2016 Apr 29.


Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.

Nagy Z, Wynne K, von Kriegsheim A, Gambaryan S, Smolenski A.

J Biol Chem. 2015 Dec 11;290(50):29974-83. doi: 10.1074/jbc.M115.678003. Epub 2015 Oct 27.


The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood.

Reiss C, Mindukshev I, Bischoff V, Subramanian H, Kehrer L, Friebe A, Stasch JP, Gambaryan S, Walter U.

Br J Pharmacol. 2015 Nov;172(21):5199-210. doi: 10.1111/bph.13286. Epub 2015 Oct 18.


A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from L-arginine or nitrite?

Gambaryan S, Tsikas D.

Amino Acids. 2015 Sep;47(9):1779-93. doi: 10.1007/s00726-015-1986-1. Epub 2015 May 1. Review.


The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.

Sharina IG, Sobolevsky M, Papakyriakou A, Rukoyatkina N, Spyroulias GA, Gambaryan S, Martin E.

Br J Pharmacol. 2015 May;172(9):2316-29. doi: 10.1111/bph.13055. Epub 2015 Feb 10.


Human blood platelets lack nitric oxide synthase activity.

Böhmer A, Gambaryan S, Tsikas D.

Platelets. 2015;26(6):583-8. doi: 10.3109/09537104.2014.974024. Epub 2014 Oct 31.


[Ureido-¹⁵N]citrulline UPLC-MS/MS nitric oxide synthase (NOS) activity assay: development, validation, and applications to assess NOS uncoupling and human platelets NOS activity.

Böhmer A, Gambaryan S, Flentje M, Jordan J, Tsikas D.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15;965:173-82. doi: 10.1016/j.jchromb.2014.06.025. Epub 2014 Jun 28.


A comparative analysis of the bistability switch for platelet aggregation by logic ODE based dynamical modeling.

Mischnik M, Gambaryan S, Subramanian H, Geiger J, Schütz C, Timmer J, Dandekar T.

Mol Biosyst. 2014 Aug;10(8):2082-9. doi: 10.1039/c4mb00170b.


Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation.

Navdaev A, Subramanian H, Petunin A, Clemetson KJ, Gambaryan S, Walter U.

PLoS One. 2014 Apr 4;9(4):e93569. doi: 10.1371/journal.pone.0093569. eCollection 2014.


What can proteomics tell us about platelets?

Burkhart JM, Gambaryan S, Watson SP, Jurk K, Walter U, Sickmann A, Heemskerk JW, Zahedi RP.

Circ Res. 2014 Mar 28;114(7):1204-19. doi: 10.1161/CIRCRESAHA.114.301598. Review.


Orai1-induced store-operated Ca(2+) entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets.

Chen W, Thielmann I, Gupta S, Subramanian H, Stegner D, van Kruchten R, Dietrich A, Gambaryan S, Heemskerk JW, Hermanns HM, Nieswandt B, Braun A.

J Thromb Haemost. 2014 Apr;12(4):528-39. doi: 10.1111/jth.12525.


Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways.

Beck F, Geiger J, Gambaryan S, Veit J, Vaudel M, Nollau P, Kohlbacher O, Martens L, Walter U, Sickmann A, Zahedi RP.

Blood. 2014 Jan 30;123(5):e1-e10. doi: 10.1182/blood-2013-07-512384. Epub 2013 Dec 9.


Dual role of the p38 MAPK/cPLA2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists.

Rukoyatkina N, Mindukshev I, Walter U, Gambaryan S.

Cell Death Dis. 2013 Nov 21;4:e931. doi: 10.1038/cddis.2013.459.


Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.

Benz PM, Merkel CJ, Offner K, Abeßer M, Ullrich M, Fischer T, Bayer B, Wagner H, Gambaryan S, Ursitti JA, Adham IM, Linke WA, Feller SM, Fleming I, Renné T, Frantz S, Unger A, Schuh K.

Cell Commun Signal. 2013 Aug 12;11:56. doi: 10.1186/1478-811X-11-56.


Response: platelet transcriptome and proteome--relation rather than correlation.

Geiger J, Burkhart JM, Gambaryan S, Walter U, Sickmann A, Zahedi RP.

Blood. 2013 Jun 27;121(26):5257-8. doi: 10.1182/blood-2013-04-493403. No abstract available.


Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase.

Lies B, Groneberg D, Gambaryan S, Friebe A.

Br J Pharmacol. 2013 Sep;170(2):317-27. doi: 10.1111/bph.12275.


Determination of ATP and ADP Secretion from Human and Mouse Platelets by an HPLC Assay.

von Papen M, Gambaryan S, Schütz C, Geiger J.

Transfus Med Hemother. 2013 Apr;40(2):109-16. doi: 10.1159/000350294. Epub 2013 Mar 15.


Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.

Subramanian H, Zahedi RP, Sickmann A, Walter U, Gambaryan S.

J Thromb Haemost. 2013 Aug;11(8):1574-82. doi: 10.1111/jth.12271.


Immune escape of AKT overexpressing ovarian cancer cells.

Hahne JC, Meyer SR, Gambaryan S, Walter U, Dietl J, Engel JB, Honig A.

Int J Oncol. 2013 May;42(5):1630-5. doi: 10.3892/ijo.2013.1846. Epub 2013 Mar 4.


Soluble guanylyl cyclase is the only enzyme responsible for cyclic guanosine monophosphate synthesis in human platelets.

Gambaryan S, Subramanian H, Rukoyatkina N, Herterich S, Walter U.

Thromb Haemost. 2013 May;109(5):973-5. doi: 10.1160/TH12-12-0916. Epub 2013 Mar 7. No abstract available.


Frog urinary bladder epithelial cells express TLR4 and respond to bacterial LPS by increase of iNOS expression and L-arginine uptake.

Nikolaeva S, Bachteeva V, Fock E, Herterich S, Lavrova E, Borodkina A, Gambaryan S, Parnova R.

Am J Physiol Regul Integr Comp Physiol. 2012 Nov 15;303(10):R1042-52. doi: 10.1152/ajpregu.00045.2012. Epub 2012 Sep 26.


The Thr715Pro variant impairs terminal glycosylation of P-selectin.

Subramanian H, Gambaryan S, Panzer S, Gremmel T, Walter U, Mannhalter C.

Thromb Haemost. 2012 Nov;108(5):963-72. doi: 10.1160/TH12-01-0047. Epub 2012 Sep 26.


Potential pitfalls with the use of acetoxy (CH(3)COO) drugs in studies on nitric oxide synthase in platelets.

Böhmer A, Niemann J, Schwedhelm KS, Meyer HH, Gambaryan S, Tsikas D.

Nitric Oxide. 2013 Jan 15;28:14-6. doi: 10.1016/j.niox.2012.09.002. Epub 2012 Sep 18. No abstract available.


Downregulation of AKT reverses platinum resistance of human ovarian cancers in vitro.

Hahne JC, Honig A, Meyer SR, Gambaryan S, Walter U, Wischhusen J, Häussler SF, Segerer SE, Fujita N, Dietl J, Engel JB.

Oncol Rep. 2012 Dec;28(6):2023-8. doi: 10.3892/or.2012.2041. Epub 2012 Sep 18.


Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis.

Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE Jr, Hartwig JH, Walter U.

Exp Hematol. 2013 Jan;41(1):91-101.e4. doi: 10.1016/j.exphem.2012.09.001. Epub 2012 Sep 11.


The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways.

Burkhart JM, Vaudel M, Gambaryan S, Radau S, Walter U, Martens L, Geiger J, Sickmann A, Zahedi RP.

Blood. 2012 Oct 11;120(15):e73-82. doi: 10.1182/blood-2012-04-416594. Epub 2012 Aug 6.


Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets?

Gambaryan S, Friebe A, Walter U.

Blood. 2012 May 31;119(22):5335-6; author reply 5336-7. doi: 10.1182/blood-2011-12-396374. No abstract available.


The oligopeptide DT-2 is a specific PKG I inhibitor only in vitro, not in living cells.

Gambaryan S, Butt E, Kobsar A, Geiger J, Rukoyatkina N, Parnova R, Nikolaev VO, Walter U.

Br J Pharmacol. 2012 Oct;167(4):826-38. doi: 10.1111/j.1476-5381.2012.02044.x.


Functional hyper-IL-6 from vaccinia virus-colonized tumors triggers platelet formation and helps to alleviate toxicity of mitomycin C enhanced virus therapy.

Sturm JB, Hess M, Weibel S, Chen NG, Yu YA, Zhang Q, Donat U, Reiss C, Gambaryan S, Krohne G, Stritzker J, Szalay AA.

J Transl Med. 2012 Jan 11;10:9. doi: 10.1186/1479-5876-10-9.


The thrombin inhibitors hirudin and Refludan(®) activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets.

Kobsar A, Koessler J, Kehrer L, Gambaryan S, Walter U.

Thromb Haemost. 2012 Mar;107(3):521-9. doi: 10.1160/TH11-07-0461. Epub 2012 Jan 11.


Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors.

Mindukshev I, Gambaryan S, Kehrer L, Schuetz C, Kobsar A, Rukoyatkina N, Nikolaev VO, Krivchenko A, Watson SP, Walter U, Geiger J.

Clin Chem Lab Med. 2012 Jul;50(7):1253-62.


Neisseria meningitidis induces platelet inhibition and increases vascular endothelial permeability via nitric oxide regulated pathways.

Kobsar A, Siauw C, Gambaryan S, Hebling S, Speer C, Schubert-Unkmeir A, Eigenthaler M.

Thromb Haemost. 2011 Dec;106(6):1127-38. doi: 10.1160/TH11-07-0491. Epub 2011 Nov 10.


Differentiation of cGMP-dependent and -independent nitric oxide effects on platelet apoptosis and reactive oxygen species production using platelets lacking soluble guanylyl cyclase.

Rukoyatkina N, Walter U, Friebe A, Gambaryan S.

Thromb Haemost. 2011 Nov;106(5):922-33. doi: 10.1160/TH11-05-0319. Epub 2011 Jul 28.


Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice.

Grinevich V, Jezova D, Gambaryan S, Illarionova A, Kolleker A, Seeburg PH, Schwarz MK.

Horm Metab Res. 2011 Jul;43(8):551-6. doi: 10.1055/s-0031-1280828. Epub 2011 Jul 19.


Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases.

Polzin D, Kaminski HJ, Kastner C, Wang W, Krämer S, Gambaryan S, Russwurm M, Peters H, Wu Q, Vandewalle A, Bachmann S, Theilig F.

Kidney Int. 2010 Oct;78(7):650-9. doi: 10.1038/ki.2010.197. Epub 2010 Jul 7.


Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex.

Gambaryan S, Kobsar A, Rukoyatkina N, Herterich S, Geiger J, Smolenski A, Lohmann SM, Walter U.

J Biol Chem. 2010 Jun 11;285(24):18352-63. doi: 10.1074/jbc.M109.077602. Epub 2010 Mar 31.

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