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Items: 45

1.

De novo design approaches targeting an envelope protein pocket to identify small molecules against dengue virus.

Leal ES, Adler NS, Fernández GA, Gebhard LG, Battini L, Aucar MG, Videla M, Monge ME, Hernández de Los Ríos A, Acosta Dávila JA, Morell ML, Cordo SM, García CC, Gamarnik AV, Cavasotto CN, Bollini M.

Eur J Med Chem. 2019 Aug 15;182:111628. doi: 10.1016/j.ejmech.2019.111628. [Epub ahead of print]

PMID:
31472473
2.

Thermodynamic study of the effect of ions on the interaction between dengue virus NS3 helicase and single stranded RNA.

Cababie LA, Incicco JJ, González-Lebrero RM, Roman EA, Gebhard LG, Gamarnik AV, Kaufman SB.

Sci Rep. 2019 Jul 22;9(1):10569. doi: 10.1038/s41598-019-46741-4.

3.

RNA Structure Duplication in the Dengue Virus 3' UTR: Redundancy or Host Specificity?

de Borba L, Villordo SM, Marsico FL, Carballeda JM, Filomatori CV, Gebhard LG, Pallarés HM, Lequime S, Lambrechts L, Sánchez Vargas I, Blair CD, Gamarnik AV.

MBio. 2019 Jan 8;10(1). pii: e02506-18. doi: 10.1128/mBio.02506-18.

4.

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ.

Cell. 2018 Dec 13;175(7):1931-1945.e18. doi: 10.1016/j.cell.2018.11.028.

PMID:
30550790
5.

Discovery of novel dengue virus entry inhibitors via a structure-based approach.

Leal ES, Aucar MG, Gebhard LG, Iglesias NG, Pascual MJ, Casal JJ, Gamarnik AV, Cavasotto CN, Bollini M.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3851-3855. doi: 10.1016/j.bmcl.2017.06.049. Epub 2017 Jun 23.

PMID:
28668194
6.

Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells.

Filomatori CV, Carballeda JM, Villordo SM, Aguirre S, Pallarés HM, Maestre AM, Sánchez-Vargas I, Blair CD, Fabri C, Morales MA, Fernandez-Sesma A, Gamarnik AV.

PLoS Pathog. 2017 Mar 6;13(3):e1006265. doi: 10.1371/journal.ppat.1006265. eCollection 2017 Mar.

7.

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing.

De Maio FA, Risso G, Iglesias NG, Shah P, Pozzi B, Gebhard LG, Mammi P, Mancini E, Yanovsky MJ, Andino R, Krogan N, Srebrow A, Gamarnik AV.

PLoS Pathog. 2016 Aug 30;12(8):e1005841. doi: 10.1371/journal.ppat.1005841. eCollection 2016 Aug.

8.

Properties and Functions of the Dengue Virus Capsid Protein.

Byk LA, Gamarnik AV.

Annu Rev Virol. 2016 Sep 29;3(1):263-281. Epub 2016 Aug 3. Review.

9.

Dengue Virus Genome Uncoating Requires Ubiquitination.

Byk LA, Iglesias NG, De Maio FA, Gebhard LG, Rossi M, Gamarnik AV.

MBio. 2016 Jun 28;7(3). pii: e00804-16. doi: 10.1128/mBio.00804-16.

10.

A Proline-Rich N-Terminal Region of the Dengue Virus NS3 Is Crucial for Infectious Particle Production.

Gebhard LG, Iglesias NG, Byk LA, Filomatori CV, De Maio FA, Gamarnik AV.

J Virol. 2016 May 12;90(11):5451-61. doi: 10.1128/JVI.00206-16. Print 2016 Jun 1.

11.

RNA Structure Duplications and Flavivirus Host Adaptation.

Villordo SM, Carballeda JM, Filomatori CV, Gamarnik AV.

Trends Microbiol. 2016 Apr;24(4):270-283. doi: 10.1016/j.tim.2016.01.002. Epub 2016 Feb 3. Review.

12.

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.

Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I.

Immunity. 2016 Jan 19;44(1):46-58. doi: 10.1016/j.immuni.2015.12.017. Erratum in: Immunity. 2016 Feb 16;44(2):438. Sachs, David H [corrected to Sachs, David].

13.

Dengue Virus Uses a Non-Canonical Function of the Host GBF1-Arf-COPI System for Capsid Protein Accumulation on Lipid Droplets.

Iglesias NG, Mondotte JA, Byk LA, De Maio FA, Samsa MM, Alvarez C, Gamarnik AV.

Traffic. 2015 Sep;16(9):962-77. doi: 10.1111/tra.12305. Epub 2015 Jun 29.

14.

Dengue virus RNA structure specialization facilitates host adaptation.

Villordo SM, Filomatori CV, Sánchez-Vargas I, Blair CD, Gamarnik AV.

PLoS Pathog. 2015 Jan 30;11(1):e1004604. doi: 10.1371/journal.ppat.1004604. eCollection 2015 Jan.

15.

Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication.

de Borba L, Villordo SM, Iglesias NG, Filomatori CV, Gebhard LG, Gamarnik AV.

J Virol. 2015 Mar;89(6):3430-7. doi: 10.1128/JVI.02677-14. Epub 2015 Jan 14.

16.

Monomeric nature of dengue virus NS3 helicase and thermodynamic analysis of the interaction with single-stranded RNA.

Gebhard LG, Incicco JJ, Smal C, Gallo M, Gamarnik AV, Kaufman SB.

Nucleic Acids Res. 2014 Oct;42(18):11668-86. doi: 10.1093/nar/gku812. Epub 2014 Sep 15.

17.

Differential RNA sequence requirement for dengue virus replication in mosquito and mammalian cells.

Villordo SM, Gamarnik AV.

J Virol. 2013 Aug;87(16):9365-72. doi: 10.1128/JVI.00567-13. Epub 2013 Jun 12.

18.

Steady-state NTPase activity of Dengue virus NS3: number of catalytic sites, nucleotide specificity and activation by ssRNA.

Incicco JJ, Gebhard LG, González-Lebrero RM, Gamarnik AV, Kaufman SB.

PLoS One. 2013;8(3):e58508. doi: 10.1371/journal.pone.0058508. Epub 2013 Mar 19.

19.

An analogue of the antibiotic teicoplanin prevents flavivirus entry in vitro.

De Burghgraeve T, Kaptein SJ, Ayala-Nunez NV, Mondotte JA, Pastorino B, Printsevskaya SS, de Lamballerie X, Jacobs M, Preobrazhenskaya M, Gamarnik AV, Smit JM, Neyts J.

PLoS One. 2012;7(5):e37244. doi: 10.1371/journal.pone.0037244. Epub 2012 May 18.

20.

Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase.

Gebhard LG, Kaufman SB, Gamarnik AV.

PLoS One. 2012;7(4):e36244. doi: 10.1371/journal.pone.0036244. Epub 2012 Apr 30.

21.

Uncoupling cis-Acting RNA elements from coding sequences revealed a requirement of the N-terminal region of dengue virus capsid protein in virus particle formation.

Samsa MM, Mondotte JA, Caramelo JJ, Gamarnik AV.

J Virol. 2012 Jan;86(2):1046-58. doi: 10.1128/JVI.05431-11. Epub 2011 Nov 9.

22.

Functional RNA elements in the dengue virus genome.

Gebhard LG, Filomatori CV, Gamarnik AV.

Viruses. 2011 Sep;3(9):1739-56. doi: 10.3390/v3091739. Epub 2011 Sep 15. Review.

23.

Dynamic RNA structures in the dengue virus genome.

Iglesias NG, Gamarnik AV.

RNA Biol. 2011 Mar-Apr;8(2):249-57. Epub 2011 Mar 1. Review.

PMID:
21593583
24.

The F1 motif of dengue virus polymerase NS5 is involved in promoter-dependent RNA synthesis.

Iglesias NG, Filomatori CV, Gamarnik AV.

J Virol. 2011 Jun;85(12):5745-56. doi: 10.1128/JVI.02343-10. Epub 2011 Apr 6.

25.

RNA sequences and structures required for the recruitment and activity of the dengue virus polymerase.

Filomatori CV, Iglesias NG, Villordo SM, Alvarez DE, Gamarnik AV.

J Biol Chem. 2011 Mar 4;286(9):6929-39. doi: 10.1074/jbc.M110.162289. Epub 2010 Dec 23.

26.

A balance between circular and linear forms of the dengue virus genome is crucial for viral replication.

Villordo SM, Alvarez DE, Gamarnik AV.

RNA. 2010 Dec;16(12):2325-35. doi: 10.1261/rna.2120410. Epub 2010 Oct 27.

27.

A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro.

Kaptein SJ, De Burghgraeve T, Froeyen M, Pastorino B, Alen MM, Mondotte JA, Herdewijn P, Jacobs M, de Lamballerie X, Schols D, Gamarnik AV, Sztaricskai F, Neyts J.

Antimicrob Agents Chemother. 2010 Dec;54(12):5269-80. doi: 10.1128/AAC.00686-10. Epub 2010 Sep 13.

28.

Dengue virus capsid protein usurps lipid droplets for viral particle formation.

Samsa MM, Mondotte JA, Iglesias NG, Assunção-Miranda I, Barbosa-Lima G, Da Poian AT, Bozza PT, Gamarnik AV.

PLoS Pathog. 2009 Oct;5(10):e1000632. doi: 10.1371/journal.ppat.1000632. Epub 2009 Oct 23.

29.

Structural and functional studies of the promoter element for dengue virus RNA replication.

Lodeiro MF, Filomatori CV, Gamarnik AV.

J Virol. 2009 Jan;83(2):993-1008. doi: 10.1128/JVI.01647-08. Epub 2008 Nov 12.

30.

Genome cyclization as strategy for flavivirus RNA replication.

Villordo SM, Gamarnik AV.

Virus Res. 2009 Feb;139(2):230-9. doi: 10.1016/j.virusres.2008.07.016. Epub 2008 Sep 9. Review.

31.

Functional analysis of dengue virus cyclization sequences located at the 5' and 3'UTRs.

Alvarez DE, Filomatori CV, Gamarnik AV.

Virology. 2008 May 25;375(1):223-35. doi: 10.1016/j.virol.2008.01.014. Epub 2008 Mar 4.

32.

Essential role of dengue virus envelope protein N glycosylation at asparagine-67 during viral propagation.

Mondotte JA, Lozach PY, Amara A, Gamarnik AV.

J Virol. 2007 Jul;81(13):7136-48. Epub 2007 Apr 25.

33.

Structural and functional analysis of dengue virus RNA.

Alvarez DE, Lodeiro MF, Filomatori CV, Fucito S, Mondotte JA, Gamarnik AV.

Novartis Found Symp. 2006;277:120-32; discussion 132-5, 251-3. Review.

PMID:
17319158
34.

A 5' RNA element promotes dengue virus RNA synthesis on a circular genome.

Filomatori CV, Lodeiro MF, Alvarez DE, Samsa MM, Pietrasanta L, Gamarnik AV.

Genes Dev. 2006 Aug 15;20(16):2238-49. Epub 2006 Aug 1.

35.

Exploring RNA virus replication in Xenopus oocytes.

Gamarnik AV, Andino R.

Methods Mol Biol. 2006;322:367-78. Review.

PMID:
16739737
36.

Characterization of internal ribosomal entry sites of Triatoma virus.

Czibener C, Alvarez D, Scodeller E, Gamarnik AV.

J Gen Virol. 2005 Aug;86(Pt 8):2275-80.

PMID:
16033975
37.

Role of RNA structures present at the 3'UTR of dengue virus on translation, RNA synthesis, and viral replication.

Alvarez DE, De Lella Ezcurra AL, Fucito S, Gamarnik AV.

Virology. 2005 Sep 1;339(2):200-12.

38.

Long-range RNA-RNA interactions circularize the dengue virus genome.

Alvarez DE, Lodeiro MF, Ludueña SJ, Pietrasanta LI, Gamarnik AV.

J Virol. 2005 Jun;79(11):6631-43.

39.

Translation and replication of human rhinovirus type 14 and mengovirus in Xenopus oocytes.

Gamarnik AV, Böddeker N, Andino R.

J Virol. 2000 Dec;74(24):11983-7.

42.

Intracellular determinants of picornavirus replication.

Andino R, Böddeker N, Silvera D, Gamarnik AV.

Trends Microbiol. 1999 Feb;7(2):76-82. Review.

PMID:
10081085
43.

Switch from translation to RNA replication in a positive-stranded RNA virus.

Gamarnik AV, Andino R.

Genes Dev. 1998 Aug 1;12(15):2293-304.

45.

Replication of poliovirus in Xenopus oocytes requires two human factors.

Gamarnik AV, Andino R.

EMBO J. 1996 Nov 1;15(21):5988-98.

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