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Items: 1 to 50 of 114

1.

The isolation of thyroxine (T4), the discovery of 3,5,3'-triiodothyronine (T3), and the identification of the deiodinases that generate T3 from T4: An historical review.

Morris JC, Galton VA.

Endocrine. 2019 Oct;66(1):3-9. doi: 10.1007/s12020-019-01990-1. Epub 2019 Jun 29. No abstract available.

PMID:
31256344
2.

De novo triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone.

Citterio CE, Veluswamy B, Morgan SJ, Galton VA, Banga JP, Atkins S, Morishita Y, Neumann S, Latif R, Gershengorn MC, Smith TJ, Arvan P.

J Biol Chem. 2017 Sep 15;292(37):15434-15444. doi: 10.1074/jbc.M117.784447. Epub 2017 Jul 25.

3.

The ups and downs of the thyroxine pro-hormone hypothesis.

Galton VA.

Mol Cell Endocrinol. 2017 Dec 15;458:105-111. doi: 10.1016/j.mce.2017.01.029. Epub 2017 Jan 24.

PMID:
28130114
4.

MCT8 Deficiency in Male Mice Mitigates the Phenotypic Abnormalities Associated With the Absence of a Functional Type 3 Deiodinase.

Stohn JP, Martinez ME, Matoin K, Morte B, Bernal J, Galton VA, St Germain D, Hernandez A.

Endocrinology. 2016 Aug;157(8):3266-77. doi: 10.1210/en.2016-1162. Epub 2016 Jun 2.

5.

Type 1 Deiodinase Regulates ApoA-I Gene Expression and ApoA-I Synthesis Independent of Thyroid Hormone Signaling.

Liu J, Hernandez-Ono A, Graham MJ, Galton VA, Ginsberg HN.

Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1356-66. doi: 10.1161/ATVBAHA.116.307330. Epub 2016 May 5.

6.

The Type 3 Deiodinase Is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis.

Martinez ME, Karaczyn A, Stohn JP, Donnelly WT, Croteau W, Peeters RP, Galton VA, Forrest D, St Germain D, Hernandez A.

Endocrinology. 2016 Mar;157(3):1276-88. doi: 10.1210/en.2015-1910. Epub 2016 Jan 4.

7.

Life without the iodothyronine deiodinases.

Galton VA, de Waard E, Parlow AF, St Germain DL, Hernandez A.

Endocrinology. 2014 Oct;155(10):4081-7. doi: 10.1210/en.2014-1184. Epub 2014 Jun 20.

8.
9.

American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.

Bianco AC, Anderson G, Forrest D, Galton VA, Gereben B, Kim BW, Kopp PA, Liao XH, Obregon MJ, Peeters RP, Refetoff S, Sharlin DS, Simonides WS, Weiss RE, Williams GR; American Thyroid Association Task Force on Approaches and Strategies to Investigate Thyroid Hormone Economy and Action.

Thyroid. 2014 Jan;24(1):88-168. doi: 10.1089/thy.2013.0109. Epub 2013 Dec 12.

10.

The history of 3,5,3'-triiodothyronine.

Galton VA.

Thyroid. 2013 Jan;23(1):9-13. doi: 10.1089/thy.2012.0462. No abstract available.

PMID:
23075456
11.

Is the kidney a major storage site for thyroxine as thyroxine glucuronide?

Buitendijk M, Galton VA.

Thyroid. 2012 Feb;22(2):187-91. doi: 10.1089/thy.2011.0307. Epub 2011 Dec 16.

12.

Distinct roles of deiodinases on the phenotype of Mct8 defect: a comparison of eight different mouse genotypes.

Liao XH, Di Cosmo C, Dumitrescu AM, Hernandez A, Van Sande J, St Germain DL, Weiss RE, Galton VA, Refetoff S.

Endocrinology. 2011 Mar;152(3):1180-91. doi: 10.1210/en.2010-0900. Epub 2011 Feb 1.

13.

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts.

Bassett JH, Boyde A, Howell PG, Bassett RH, Galliford TM, Archanco M, Evans H, Lawson MA, Croucher P, St Germain DL, Galton VA, Williams GR.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7604-9. doi: 10.1073/pnas.0911346107. Epub 2010 Apr 5.

14.

Thyroid hormone-regulated mouse cerebral cortex genes are differentially dependent on the source of the hormone: a study in monocarboxylate transporter-8- and deiodinase-2-deficient mice.

Morte B, Ceballos A, Diez D, Grijota-Martínez C, Dumitrescu AM, Di Cosmo C, Galton VA, Refetoff S, Bernal J.

Endocrinology. 2010 May;151(5):2381-7. doi: 10.1210/en.2009-0944. Epub 2010 Mar 8.

15.

Life without thyroxine to 3,5,3'-triiodothyronine conversion: studies in mice devoid of the 5'-deiodinases.

Galton VA, Schneider MJ, Clark AS, St Germain DL.

Endocrinology. 2009 Jun;150(6):2957-63. doi: 10.1210/en.2008-1572. Epub 2009 Feb 5.

16.

Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challenges.

St Germain DL, Galton VA, Hernandez A.

Endocrinology. 2009 Mar;150(3):1097-107. doi: 10.1210/en.2008-1588. Epub 2009 Jan 29. Review.

17.

A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function.

Ng L, Hernandez A, He W, Ren T, Srinivas M, Ma M, Galton VA, St Germain DL, Forrest D.

Endocrinology. 2009 Apr;150(4):1952-60. doi: 10.1210/en.2008-1419. Epub 2008 Dec 18. Erratum in: Endocrinology. 2009 May;150(5):2499.

18.

Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis.

Hernandez A, Martinez ME, Liao XH, Van Sande J, Refetoff S, Galton VA, St Germain DL.

Endocrinology. 2007 Dec;148(12):5680-7. Epub 2007 Sep 6.

PMID:
17823249
19.

Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient rodent brain during development.

Galton VA, Wood ET, St Germain EA, Withrow CA, Aldrich G, St Germain GM, Clark AS, St Germain DL.

Endocrinology. 2007 Jul;148(7):3080-8. Epub 2007 Mar 1.

PMID:
17332058
20.

Type 3 deiodinase is critical for the maturation and function of the thyroid axis.

Hernandez A, Martinez ME, Fiering S, Galton VA, St Germain D.

J Clin Invest. 2006 Feb;116(2):476-84. Epub 2006 Jan 12.

21.

Targeted disruption of the type 1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in mice.

Schneider MJ, Fiering SN, Thai B, Wu SY, St Germain E, Parlow AF, St Germain DL, Galton VA.

Endocrinology. 2006 Jan;147(1):580-9. Epub 2005 Oct 13.

PMID:
16223863
22.

Insights into the role of deiodinases from studies of genetically modified animals.

St Germain DL, Hernandez A, Schneider MJ, Galton VA.

Thyroid. 2005 Aug;15(8):905-16. Review.

PMID:
16131333
23.

The roles of the iodothyronine deiodinases in mammalian development.

Galton VA.

Thyroid. 2005 Aug;15(8):823-34. Review.

PMID:
16131325
24.

Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase.

Ng L, Goodyear RJ, Woods CA, Schneider MJ, Diamond E, Richardson GP, Kelley MW, Germain DL, Galton VA, Forrest D.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3474-9. Epub 2004 Mar 1.

25.

Determinants of iodothyronine deiodinase activities in rodent uterus.

Wasco EC, Martinez E, Grant KS, St Germain EA, St Germain DL, Galton VA.

Endocrinology. 2003 Oct;144(10):4253-61. Epub 2003 Jul 10.

PMID:
12959985
26.

The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts.

Hernandez A, Fiering S, Martinez E, Galton VA, St Germain D.

Endocrinology. 2002 Nov;143(11):4483-6.

PMID:
12399446
27.

Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4.

Schneider MJ, Fiering SN, Pallud SE, Parlow AF, St Germain DL, Galton VA.

Mol Endocrinol. 2001 Dec;15(12):2137-48.

PMID:
11731615
28.

The type 2 iodothyronine deiodinase is expressed in the rat uterus and induced during pregnancy.

Galton VA, Martinez E, Hernandez A, St Germain EA, Bates JM, St Germain DL.

Endocrinology. 2001 May;142(5):2123-8.

PMID:
11316780
29.

Iodothyronine sulfotransferase activity in rat uterus during gestation.

Wu SY, Huang WS, Fisher DA, Florsheim WH, St Germain DL, Galton VA.

Pediatr Res. 2000 Dec;48(6):847-51.

PMID:
11102557
30.

Effects of selenium deficiency on tissue selenium content, deiodinase activity, and thyroid hormone economy in the rat during development.

Bates JM, Spate VL, Morris JS, St Germain DL, Galton VA.

Endocrinology. 2000 Jul;141(7):2490-500.

PMID:
10875250
31.

Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase.

Galton VA, Martinez E, Hernandez A, St Germain EA, Bates JM, St Germain DL.

J Clin Invest. 1999 Apr;103(7):979-87.

32.

Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase.

Davey JC, Schneider MJ, Becker KB, Galton VA.

Endocrinology. 1999 Feb;140(2):1022-5.

PMID:
9927339
33.

Expression profiles of the three iodothyronine deiodinases, D1, D2, and D3, in the developing rat.

Bates JM, St Germain DL, Galton VA.

Endocrinology. 1999 Feb;140(2):844-51.

PMID:
9927314
34.

The deiodinase family of selenoproteins.

St Germain DL, Galton VA.

Thyroid. 1997 Aug;7(4):655-68. Review.

PMID:
9292958
35.

The type 2 and type 3 iodothyronine deiodinases play important roles in coordinating development in Rana catesbeiana tadpoles.

Becker KB, Stephens KC, Davey JC, Schneider MJ, Galton VA.

Endocrinology. 1997 Jul;138(7):2989-97.

PMID:
9202244
37.

Cloning of a cDNA for the type II iodothyronine deiodinase.

Davey JC, Becker KB, Schneider MJ, St Germain DL, Galton VA.

J Biol Chem. 1995 Nov 10;270(45):26786-9.

38.

The type III 5-deiodinase in Rana catesbeiana tadpoles is encoded by a thyroid hormone-responsive gene.

Becker KB, Schneider MJ, Davey JC, Galton VA.

Endocrinology. 1995 Oct;136(10):4424-31.

PMID:
7664662
39.
40.

A thyroid hormone-regulated gene in Xenopus laevis encodes a type III iodothyronine 5-deiodinase.

St Germain DL, Schwartzman RA, Croteau W, Kanamori A, Wang Z, Brown DD, Galton VA.

Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11282. No abstract available.

41.

A thyroid hormone-regulated gene in Xenopus laevis encodes a type III iodothyronine 5-deiodinase.

St Germain DL, Schwartzman RA, Croteau W, Kanamori A, Wang Z, Brown DD, Galton VA.

Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7767-71. Erratum in: Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11282.

42.

Cloning of a thyroid hormone-responsive Rana catesbeiana c-erbA-beta gene.

Davey JC, Schneider MJ, Galton VA.

Dev Genet. 1994;15(4):339-46.

PMID:
7923937
43.

Rana catesbeiana tadpole red blood cells express an alpha, but not a beta, c-erbA gene.

Schneider MJ, Davey JC, Galton VA.

Endocrinology. 1993 Dec;133(6):2488-95.

PMID:
8243269
44.

The role of thyroid hormone in amphibian metamorphosis.

Galton VA.

Trends Endocrinol Metab. 1992 Apr;3(3):96-100.

PMID:
18407086
45.
46.

The role of thyroid hormone in the regulation of hepatic carbamyl phosphate synthetase activity in Rana catesbeiana.

Galton VA, Morganelli CM, Schneider MJ, Yee K.

Endocrinology. 1991 Nov;129(5):2298-304.

PMID:
1935768
47.

The ontogeny of iodothyronine deiodinase systems in liver and intestine of the rat.

Galton VA, McCarthy PT, St Germain DL.

Endocrinology. 1991 Apr;128(4):1717-22.

PMID:
2004598
48.

Regulation of c-erbA-alpha messenger RNA species in tadpole erythrocytes by thyroid hormone.

Schneider MJ, Galton VA.

Mol Endocrinol. 1991 Feb;5(2):201-8.

PMID:
1645454
49.
50.

Deiodination of thyroxine and related compounds.

Galton VA.

Thyroid. 1990;1(1):43-8. No abstract available.

PMID:
2135982

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