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The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design.

Besneux M, Greenshields-Watson A, Scurr MJ, MacLachlan BJ, Christian A, Davies MM, Hargest R, Phillips S, Godkin A, Gallimore A.

Cancer Immunol Immunother. 2019 Feb;68(2):247-256. doi: 10.1007/s00262-018-2266-1. Epub 2018 Nov 7.


Defining High Endothelial Venules and Tertiary Lymphoid Structures in Cancer.

Jones E, Gallimore A, Ager A.

Methods Mol Biol. 2018;1845:99-118. doi: 10.1007/978-1-4939-8709-2_7.


Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors.

Vermeersch E, Liénart S, Collignon A, Lucas S, Gallimore A, Gysemans C, Unutmaz D, Vanhoorelbeke K, De Meyer SF, Maes W, Deckmyn H.

Cell Immunol. 2018 Oct;332:129-133. doi: 10.1016/j.cellimm.2018.07.011. Epub 2018 Jul 30.


Oncogenic osteomalacia: diagnosis, localisation, and cure.

Mumford E, Marks J, Wagner T, Gallimore A, Gane S, Walsh SB.

Lancet Oncol. 2018 Jul;19(7):e365. doi: 10.1016/S1470-2045(18)30276-6. Epub 2018 Jun 29. No abstract available.


Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.

May S, Owen H, Phesse TJ, Greenow KR, Jones GR, Blackwood A, Cook PC, Towers C, Gallimore AM, Williams GT, Stürzl M, Britzen-Laurent N, Sansom OJ, MacDonald AS, Bird AP, Clarke AR, Parry L.

J Pathol. 2018 Jul;245(3):270-282. doi: 10.1002/path.5074. Epub 2018 May 16.


Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

Miles JJ, Tan MP, Dolton G, Edwards ES, Galloway SA, Laugel B, Clement M, Makinde J, Ladell K, Matthews KK, Watkins TS, Tungatt K, Wong Y, Lee HS, Clark RJ, Pentier JM, Attaf M, Lissina A, Ager A, Gallimore A, Rizkallah PJ, Gras S, Rossjohn J, Burrows SR, Cole DK, Price DA, Sewell AK.

J Clin Invest. 2018 Apr 2;128(4):1569-1580. doi: 10.1172/JCI91512. Epub 2018 Mar 12.


T-cell modulation by cyclophosphamide for tumour therapy.

Hughes E, Scurr M, Campbell E, Jones E, Godkin A, Gallimore A.

Immunology. 2018 May;154(1):62-68. doi: 10.1111/imm.12913. Epub 2018 Mar 9. Review.


Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development.

Hill DG, Yu L, Gao H, Balic JJ, West A, Oshima H, McLeod L, Oshima M, Gallimore A, D'Costa K, Bhathal PS, Sievert W, Ferrero RL, Jenkins BJ, Jones GW.

Int J Cancer. 2018 Jul 1;143(1):167-178. doi: 10.1002/ijc.31298. Epub 2018 Feb 19.


Switching On Depression and Potentiation in the Cerebellum.

Gallimore AR, Kim T, Tanaka-Yamamoto K, De Schutter E.

Cell Rep. 2018 Jan 16;22(3):722-733. doi: 10.1016/j.celrep.2017.12.084.


Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Colbeck EJ, Ager A, Gallimore A, Jones GW.

Front Immunol. 2017 Dec 19;8:1830. doi: 10.3389/fimmu.2017.01830. eCollection 2017. Review.


Treg Depletion Licenses T Cell-Driven HEV Neogenesis and Promotes Tumor Destruction.

Colbeck EJ, Jones E, Hindley JP, Smart K, Schulz R, Browne M, Cutting S, Williams A, Parry L, Godkin A, Ware CF, Ager A, Gallimore A.

Cancer Immunol Res. 2017 Nov;5(11):1005-1015. doi: 10.1158/2326-6066.CIR-17-0131. Epub 2017 Sep 25.


Effect of Modified Vaccinia Ankara-5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer: A Randomized Clinical Trial.

Scurr M, Pembroke T, Bloom A, Roberts D, Thomson A, Smart K, Bridgeman H, Adams R, Brewster A, Jones R, Gwynne S, Blount D, Harrop R, Wright M, Hills R, Gallimore A, Godkin A.

JAMA Oncol. 2017 Oct 12;3(10):e172579. doi: 10.1001/jamaoncol.2017.2579. Epub 2017 Oct 12.


Low-Dose Cyclophosphamide Induces Antitumor T-Cell Responses, which Associate with Survival in Metastatic Colorectal Cancer.

Scurr M, Pembroke T, Bloom A, Roberts D, Thomson A, Smart K, Bridgeman H, Adams R, Brewster A, Jones R, Gwynne S, Blount D, Harrop R, Hills R, Gallimore A, Godkin A.

Clin Cancer Res. 2017 Nov 15;23(22):6771-6780. doi: 10.1158/1078-0432.CCR-17-0895. Epub 2017 Aug 29.


Two-dimensional knowledge-based volumetric reconstruction of the right ventricle documents short-term improvement in pulmonary hypertension.

Schwaiger JP, Knight DS, Kaier T, Gallimore A, Denton CP, Schreiber BE, Handler C, Coghlan JG.

Echocardiography. 2017 Jun;34(6):817-824. doi: 10.1111/echo.13541. Epub 2017 Jun 13.


Feasibility and acceptability of introducing routine antenatal contraceptive counselling and provision of contraception after delivery: the APPLES pilot evaluation.

Cameron ST, Craig A, Sim J, Gallimore A, Cowan S, Dundas K, Heller R, Milne D, Lakha F.

BJOG. 2017 Dec;124(13):2009-2015. doi: 10.1111/1471-0528.14674. Epub 2017 May 19.


Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells.

Chen HC, Joalland N, Bridgeman JS, Alchami FS, Jarry U, Khan MWA, Piggott L, Shanneik Y, Li J, Herold MJ, Herrmann T, Price DA, Gallimore AM, Clarkson RW, Scotet E, Moser B, Eberl M.

Immunol Cell Biol. 2017 Aug;95(7):620-629. doi: 10.1038/icb.2017.21. Epub 2017 Mar 30.


Note: Improved heater design for high-temperature hollow cathodes.

McDonald MS, Gallimore AD, Goebel DM.

Rev Sci Instrum. 2017 Feb;88(2):026104. doi: 10.1063/1.4976728.


A Model for the Application of Target-Controlled Intravenous Infusion for a Prolonged Immersive DMT Psychedelic Experience.

Gallimore AR, Strassman RJ.

Front Pharmacol. 2016 Jul 14;7:211. doi: 10.3389/fphar.2016.00211. eCollection 2016.


A Computational Model for the AMPA Receptor Phosphorylation Master Switch Regulating Cerebellar Long-Term Depression.

Gallimore AR, Aricescu AR, Yuzaki M, Calinescu R.

PLoS Comput Biol. 2016 Jan 25;12(1):e1004664. doi: 10.1371/journal.pcbi.1004664. eCollection 2016 Jan.


Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.

Colbeck EJ, Hindley JP, Smart K, Jones E, Bloom A, Bridgeman H, McPherson RC, Turner DG, Ladell K, Price DA, O'Connor RA, Anderton SM, Godkin AJ, Gallimore AM.

Oncotarget. 2015 Sep 22;6(28):24649-59. doi: 10.18632/oncotarget.5584.


Restructuring consciousness -the psychedelic state in light of integrated information theory.

Gallimore AR.

Front Hum Neurosci. 2015 Jun 12;9:346. doi: 10.3389/fnhum.2015.00346. eCollection 2015.


Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry.

Santegoets SJ, Dijkgraaf EM, Battaglia A, Beckhove P, Britten CM, Gallimore A, Godkin A, Gouttefangeas C, de Gruijl TD, Koenen HJ, Scheffold A, Shevach EM, Staats J, Taskén K, Whiteside TL, Kroep JR, Welters MJ, van der Burg SH.

Cancer Immunol Immunother. 2015 Oct;64(10):1271-86. doi: 10.1007/s00262-015-1729-x. Epub 2015 Jun 28.


High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression.

Bento DC, Jones E, Junaid S, Tull J, Williams GT, Godkin A, Ager A, Gallimore A.

Oncoimmunology. 2015 Apr 2;4(3):e974374. eCollection 2015 Mar.


Tracking the kinetics of intrahepatic immune responses by repeated fine needle aspiration of the liver.

Pembroke T, Gallimore A, Godkin A.

J Immunol Methods. 2015 Sep;424:131-5. doi: 10.1016/j.jim.2015.04.011. Epub 2015 Apr 22.


Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma.

Ford CA, Petrova S, Pound JD, Voss JJ, Melville L, Paterson M, Farnworth SL, Gallimore AM, Cuff S, Wheadon H, Dobbin E, Ogden CA, Dumitriu IE, Dunbar DR, Murray PG, Ruckerl D, Allen JE, Hume DA, van Rooijen N, Goodlad JR, Freeman TC, Gregory CD.

Curr Biol. 2015 Mar 2;25(5):577-88. doi: 10.1016/j.cub.2014.12.059. Epub 2015 Feb 19.


Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer.

Scurr MJ, Brown CM, Costa Bento DF, Betts GJ, Rees BI, Hills RK, Gallimore A, Godkin A.

J Natl Cancer Inst. 2015 Feb 9;107(4). pii: djv001. doi: 10.1093/jnci/djv001. Print 2015 Apr.


CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue.

Stack G, Jones E, Marsden M, Stacey MA, Snelgrove RJ, Lacaze P, Jacques LC, Cuff SM, Stanton RJ, Gallimore AM, Hussell T, Wilkinson GW, Ghazal P, Taylor PR, Humphreys IR.

PLoS Pathog. 2015 Feb 5;11(2):e1004641. doi: 10.1371/journal.ppat.1004641. eCollection 2015 Feb.


A distinct chemokine axis does not account for enrichment of Foxp3(+)  CD4(+) T cells in carcinogen-induced fibrosarcomas.

Ondondo B, Colbeck E, Jones E, Smart K, Lauder SN, Hindley J, Godkin A, Moser B, Ager A, Gallimore A.

Immunology. 2015 May;145(1):94-104. doi: 10.1111/imm.12430. Erratum in: Immunology. 2015 Oct;146(2):347.


A cavity ring-down spectroscopy sensor for real-time Hall thruster erosion measurements.

Lee BC, Huang W, Tao L, Yamamoto N, Gallimore AD, Yalin AP.

Rev Sci Instrum. 2014 May;85(5):053111. doi: 10.1063/1.4879135.


Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G, Stack G, Jones E, Klenerman P, Gallimore AM, Taylor PR, Snelgrove RJ, Lawley TD, Dougan G, Benedict CA, Jones SA, Wilkinson GW, Humphreys IR.

Cell Host Microbe. 2014 Apr 9;15(4):471-83. doi: 10.1016/j.chom.2014.03.003.


Validation and evaluation of a novel time-resolved laser-induced fluorescence technique.

Durot CJ, Gallimore AD, Smith TB.

Rev Sci Instrum. 2014 Jan;85(1):013508. doi: 10.1063/1.4856635.


Escalating regulation of 5T4-specific IFN-γ+ CD4+ T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy.

Scurr M, Bloom A, Pembroke T, Srinivasan R, Brown C, Smart K, Bridgeman H, Davies M, Hargest R, Phillips S, Christian A, Hockey T, Gallimore A, Godkin A.

Cancer Immunol Res. 2013 Dec;1(6). doi: 10.1158/2326-6066.CIR-13-0035.


Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cells via blood vessels and lymphatics.

Ondondo B, Jones E, Hindley J, Cutting S, Smart K, Bridgeman H, Matthews KK, Ladell K, Price DA, Jackson DG, Godkin A, Ager A, Gallimore A.

Int J Cancer. 2014 May 1;134(9):2156-67. doi: 10.1002/ijc.28556. Epub 2013 Nov 8.


Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells.

Scurr M, Ladell K, Besneux M, Christian A, Hockey T, Smart K, Bridgeman H, Hargest R, Phillips S, Davies M, Price D, Gallimore A, Godkin A.

Mucosal Immunol. 2014 Mar;7(2):428-39. doi: 10.1038/mi.2013.62. Epub 2013 Sep 25.


Home sweet home: the tumor microenvironment as a haven for regulatory T cells.

Ondondo B, Jones E, Godkin A, Gallimore A.

Front Immunol. 2013 Jul 16;4:197. doi: 10.3389/fimmu.2013.00197. eCollection 2013.


Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology.

Lauder SN, Jones E, Smart K, Bloom A, Williams AS, Hindley JP, Ondondo B, Taylor PR, Clement M, Fielding C, Godkin AJ, Jones SA, Gallimore AM.

Eur J Immunol. 2013 Oct;43(10):2613-25. doi: 10.1002/eji.201243018. Epub 2013 Aug 12.


Flow cytometry makes all the difference.

Pembroke T, Gallimore A, Godkin A.

J Hepatol. 2013 Oct;59(4):909-10. doi: 10.1016/j.jhep.2013.05.047. Epub 2013 Jun 20. No abstract available.


High endothelial venules: Help or hindrance in the quest for antitumor immunity?

Gallimore A, Godkin A, Ager A.

Oncoimmunology. 2013 May 1;2(5):e24272.


The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon α treatment.

Pembroke T, Christian A, Jones E, Hills RK, Wang EC, Gallimore AM, Godkin A.

Gut. 2014 Mar;63(3):515-24. doi: 10.1136/gutjnl-2013-304472. Epub 2013 May 11.


Epithelial barriers, microbiota, and colorectal cancer.

Gallimore AM, Godkin A.

N Engl J Med. 2013 Jan 17;368(3):282-4. doi: 10.1056/NEJMcibr1212341. No abstract available.


Rapid innate control of antigen abrogates adaptive immunity.

Pembroke TP, Gallimore AM, Godkin A.

Immunology. 2013 Apr;138(4):293-7. doi: 10.1111/imm.12048. Review.


Hunting for clues: Regulatory T cells and colorectal cancer.

Gallimore A, Godkin A.

Oncoimmunology. 2012 Oct 1;1(7):1163-1164.


T cell subsets and colorectal cancer: discerning the good from the bad.

Scurr M, Gallimore A, Godkin A.

Cell Immunol. 2012 Sep;279(1):21-4. doi: 10.1016/j.cellimm.2012.08.004. Epub 2012 Sep 14. Review.


External auditory canal paraganglioma: an atypical presentation.

Grover N, Amen F, Gallimore A, Brookes G.

J Laryngol Otol. 2012 Dec;126(12):1278-80. doi: 10.1017/S0022215112002162. Epub 2012 Oct 1.


Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity.

Humphreys IR, Clement M, Marsden M, Ladell K, McLaren JE, Smart K, Hindley JP, Bridgeman HM, van den Berg HA, Price DA, Ager A, Wooldridge L, Godkin A, Gallimore AM.

Eur J Immunol. 2012 Dec;42(12):3235-42. doi: 10.1002/eji.201242575. Epub 2012 Oct 16.


T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion.

Hindley JP, Jones E, Smart K, Bridgeman H, Lauder SN, Ondondo B, Cutting S, Ladell K, Wynn KK, Withers D, Price DA, Ager A, Godkin AJ, Gallimore AM.

Cancer Res. 2012 Nov 1;72(21):5473-82. doi: 10.1158/0008-5472.CAN-12-1912. Epub 2012 Sep 7.


Complement-induced protection: an explanation for the limitations of cell-based tumour immunotherapies.

Kempshall E, Thebault S, Morgan BP, Harris CL, Gallimore A.

Immunol Cell Biol. 2012 Oct;90(9):869-71. doi: 10.1038/icb.2012.30. Epub 2012 Jul 10.


Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+ T-cell immunity.

Pembroke T, Rees I, Gallagher K, Jones E, Mizen P, Navruzov T, Freedman A, Fielding C, Humphreys IR, Wang EC, Gallimore AM, Godkin A.

Eur J Immunol. 2012 Sep;42(9):2383-94. doi: 10.1002/eji.201142072. Epub 2012 Aug 6.


The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.

Twohig JP, Marsden M, Cuff SM, Ferdinand JR, Gallimore AM, Perks WV, Al-Shamkhani A, Humphreys IR, Wang EC.

FASEB J. 2012 Aug;26(8):3575-86. doi: 10.1096/fj.11-200618. Epub 2012 May 16.


Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection.

Cole DK, Gallagher K, Lemercier B, Holland CJ, Junaid S, Hindley JP, Wynn KK, Gostick E, Sewell AK, Gallimore AM, Ladell K, Price DA, Gougeon ML, Godkin A.

Nat Commun. 2012 Feb 7;3:665. doi: 10.1038/ncomms1665.

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