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Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.

Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9228-9233. doi: 10.1073/pnas.1802901115. Epub 2018 Aug 27.


Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA.

Wauchope OR, Mitchener MM, Beavers WN, Galligan JJ, Camarillo JM, Sanders WD, Kingsley PJ, Shim HN, Blackwell T, Luong T, deCaestecker M, Fessel JP, Marnett LJ.

Nucleic Acids Res. 2018 Apr 20;46(7):3458-3467. doi: 10.1093/nar/gky089.


Macrophage-dependent impairment of α2-adrenergic autoreceptor inhibition of Ca2+ channels in sympathetic neurons from DOCA-salt but not high-fat diet-induced hypertensive rats.

Mui RK, Fernandes RN, Garver HG, Van Rooijen N, Galligan JJ.

Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H863-H877. doi: 10.1152/ajpheart.00536.2017. Epub 2018 Jan 5.


Beneficial actions of microbiota-derived tryptophan metabolites.

Galligan JJ.

Neurogastroenterol Motil. 2018 Feb;30(2). doi: 10.1111/nmo.13283. Review.


Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

Beavers WN, Rose KL, Galligan JJ, Mitchener MM, Rouzer CA, Tallman KA, Lamberson CR, Wang X, Hill S, Ivanova PT, Brown HA, Zhang B, Porter NA, Marnett LJ.

ACS Chem Biol. 2017 Aug 18;12(8):2062-2069. doi: 10.1021/acschembio.7b00480. Epub 2017 Jun 28.


Insights into the Role of Opioid Receptors in the GI Tract: Experimental Evidence and Therapeutic Relevance.

Galligan JJ, Sternini C.

Handb Exp Pharmacol. 2017;239:363-378. doi: 10.1007/164_2016_116. Review.


5-HT secretion by enterochromaffin cells is a very touching story.

Galligan JJ.

J Physiol. 2017 Jan 1;595(1):3. doi: 10.1113/JP273041. No abstract available.


R-Type Ca2+ channels couple to inhibitory neurotransmission to the longitudinal muscle in the guinea-pig ileum.

Rodriguez-Tapia ES, Naidoo V, DeVries M, Perez-Medina A, Galligan JJ.

Exp Physiol. 2017 Mar 1;102(3):299-313. doi: 10.1113/EP086027. Epub 2017 Jan 25.


Quantitative Analysis and Discovery of Lysine and Arginine Modifications.

Galligan JJ, Kingsley PJ, Wauchope OR, Mitchener MM, Camarillo JM, Wepy JA, Harris PS, Fritz KS, Marnett LJ.

Anal Chem. 2017 Jan 17;89(2):1299-1306. doi: 10.1021/acs.analchem.6b04105. Epub 2016 Dec 30.


From the exposome to mechanistic understanding of chemical-induced adverse effects.

Escher BI, Hackermüller J, Polte T, Scholz S, Aigner A, Altenburger R, Böhme A, Bopp SK, Brack W, Busch W, Chadeau-Hyam M, Covaci A, Eisenträger A, Galligan JJ, Garcia-Reyero N, Hartung T, Hein M, Herberth G, Jahnke A, Kleinjans J, Klüver N, Krauss M, Lamoree M, Lehmann I, Luckenbach T, Miller GW, Müller A, Phillips DH, Reemtsma T, Rolle-Kampczyk U, Schüürmann G, Schwikowski B, Tan YM, Trump S, Walter-Rohde S, Wambaugh JF.

Environ Int. 2017 Feb;99:97-106. doi: 10.1016/j.envint.2016.11.029. Epub 2016 Dec 8. Review.


Histone Adduction and Its Functional Impact on Epigenetics.

Galligan JJ, Marnett LJ.

Chem Res Toxicol. 2017 Jan 17;30(1):376-387. doi: 10.1021/acs.chemrestox.6b00379. Epub 2016 Dec 20.


Upregulation of L-type calcium channels in colonic inhibitory motoneurons of P/Q-type calcium channel-deficient mice.

Rodriguez-Tapia E, Perez-Medina A, Bian X, Galligan JJ.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G763-G774. doi: 10.1152/ajpgi.00263.2016. Epub 2016 Sep 1.


News from the editors of Neurogastroenterology and Motility.

Bredenoord AJ, Browning KN, Mawe GM, Galligan JJ, Simren M.

Neurogastroenterol Motil. 2016 Oct;28(10):1451. doi: 10.1111/nmo.12924. Epub 2016 Aug 3. No abstract available.


Reduced Noradrenergic Signaling in the Spleen Capsule in the Absence of CB1 and CB2 Cannabinoid Receptors.

Simkins TJ, Fried D, Parikh K, Galligan JJ, Goudreau JL, Lookingland KJ, Kaplan BL.

J Neuroimmune Pharmacol. 2016 Dec;11(4):669-679. Epub 2016 Jun 10.


Accumulation of isolevuglandin-modified protein in normal and fibrotic lung.

Mont S, Davies SS, Roberts Second LJ, Mernaugh RL, McDonald WH, Segal BH, Zackert W, Kropski JA, Blackwell TS, Sekhar KR, Galligan JJ, Massion PP, Marnett LJ, Travis EL, Freeman ML.

Sci Rep. 2016 Apr 27;6:24919. doi: 10.1038/srep24919.


Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression.

Camarillo JM, Rose KL, Galligan JJ, Xu S, Marnett LJ.

Chem Res Toxicol. 2016 Mar 21;29(3):323-32. doi: 10.1021/acs.chemrestox.5b00485. Epub 2016 Mar 11.


Electrochemical detection of peroxynitrite using hemin-PEDOT functionalized boron-doped diamond microelectrode.

Peteu SF, Whitman BW, Galligan JJ, Swain GM.

Analyst. 2016 Mar 7;141(5):1796-806. doi: 10.1039/c5an02587g.


Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.

Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR.

Redox Biol. 2016 Apr;7:68-77. doi: 10.1016/j.redox.2015.11.013. Epub 2015 Nov 27.


Nuclear Oxidation of a Major Peroxidation DNA Adduct, M1dG, in the Genome.

Wauchope OR, Beavers WN, Galligan JJ, Mitchener MM, Kingsley PJ, Marnett LJ.

Chem Res Toxicol. 2015 Dec 21;28(12):2334-42. doi: 10.1021/acs.chemrestox.5b00340. Epub 2015 Nov 11.


Sex-related differences in small intestinal transit and serotonin dynamics in high-fat-diet-induced obesity in mice.

France M, Skorich E, Kadrofske M, Swain GM, Galligan JJ.

Exp Physiol. 2016 Jan;101(1):81-99. doi: 10.1113/EP085427. Epub 2015 Oct 28.


Macrophage depletion lowers blood pressure and restores sympathetic nerve α2-adrenergic receptor function in mesenteric arteries of DOCA-salt hypertensive rats.

Thang LV, Demel SL, Crawford R, Kaminski NE, Swain GM, Van Rooijen N, Galligan JJ.

Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1186-97. doi: 10.1152/ajpheart.00283.2015. Epub 2015 Aug 28.


BK channel β1-subunit deficiency exacerbates vascular fibrosis and remodelling but does not promote hypertension in high-fat fed obesity in mice.

Xu H, Garver H, Fernandes R, Phelps JT, Harkema JJ, Galligan JJ, Fink GD.

J Hypertens. 2015 Aug;33(8):1611-23. doi: 10.1097/HJH.0000000000000590.


HIV, opiates, and enteric neuron dysfunction.

Galligan JJ.

Neurogastroenterol Motil. 2015 Apr;27(4):449-54. doi: 10.1111/nmo.12539. Review.


Site-specific, intramolecular cross-linking of Pin1 active site residues by the lipid electrophile 4-oxo-2-nonenal.

Aluise CD, Camarillo JM, Shimozu Y, Galligan JJ, Rose KL, Tallman KA, Marnett LJ.

Chem Res Toxicol. 2015 Apr 20;28(4):817-27. doi: 10.1021/acs.chemrestox.5b00038. Epub 2015 Mar 18.


13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase.

Kudalkar SN, Nikas SP, Kingsley PJ, Xu S, Galligan JJ, Rouzer CA, Banerjee S, Ji L, Eno MR, Makriyannis A, Marnett LJ.

J Biol Chem. 2015 Mar 20;290(12):7897-909. doi: 10.1074/jbc.M114.634014. Epub 2015 Feb 2.


Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants.

Benskey MJ, Kuhn NC, Galligan JJ, Garcia J, Boye SE, Hauswirth WW, Mueller C, Boye SL, Manfredsson FP.

Mol Ther. 2015 Mar;23(3):488-500. doi: 10.1038/mt.2015.7. Epub 2015 Jan 16.


Western blot analysis of BK channel β1-subunit expression should be interpreted cautiously when using commercially available antibodies.

Bhattarai Y, Fernandes R, Kadrofske MM, Lockwood LR, Galligan JJ, Xu H.

Physiol Rep. 2014 Oct 28;2(10). pii: e12189. doi: 10.14814/phy2.12189. Print 2014 Oct 1.


Protein modification by adenine propenal.

Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ.

Chem Res Toxicol. 2014 Oct 20;27(10):1732-42. doi: 10.1021/tx500218g. Epub 2014 Sep 24.


Molecular physiology of enteric opioid receptors.

Galligan JJ, Akbarali HI.

Am J Gastroenterol Suppl. 2014 Sep 10;2(1):17-21. doi: 10.1038/ajgsup.2014.5. Review.


Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics.

Galligan JJ, Rose KL, Beavers WN, Hill S, Tallman KA, Tansey WP, Marnett LJ.

J Am Chem Soc. 2014 Aug 27;136(34):11864-6. doi: 10.1021/ja503604t. Epub 2014 Aug 11.


Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR.

Free Radic Biol Med. 2014 Aug;73:411-20. doi: 10.1016/j.freeradbiomed.2014.06.002. Epub 2014 Jun 9.


Altered L-type Ca2+ channel activity contributes to exacerbated hypoperfusion and mortality in smooth muscle cell BK channel-deficient septic mice.

Xu H, Garver H, Fernandes R, Galligan JJ, Fink GD.

Am J Physiol Regul Integr Comp Physiol. 2014 Jul 15;307(2):R138-48.


Electrochemical activation of diamond microelectrodes: implications for the in vitro measurement of serotonin in the bowel.

Duran B, Brocenschi RF, France M, Galligan JJ, Swain GM.

Analyst. 2014 Jun 21;139(12):3160-6. doi: 10.1039/c4an00506f. Epub 2014 May 7.


Increased catecholamine secretion from single adrenal chromaffin cells in DOCA-salt hypertension is associated with potassium channel dysfunction.

Fhaner MJ, Galligan JJ, Swain GM.

ACS Chem Neurosci. 2013 Oct 16;4(10):1404-13. doi: 10.1021/cn400115v. Epub 2013 Aug 30.


Visceral hypersensitivity in female but not in male serotonin transporter knockout rats.

Galligan JJ, Patel BA, Schneider SP, Wang H, Zhao H, Novotny M, Bian X, Kabeer R, Fried D, Swain GM.

Neurogastroenterol Motil. 2013 Jun;25(6):e373-81. doi: 10.1111/nmo.12133. Epub 2013 Apr 17.


Impaired function of prejunctional adenosine A1 receptors expressed by perivascular sympathetic nerves in DOCA-salt hypertensive rats.

Sangsiri S, Dong H, Swain GM, Galligan JJ, Xu H.

J Pharmacol Exp Ther. 2013 Apr;345(1):32-40. doi: 10.1124/jpet.112.199612. Epub 2013 Feb 8.


Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver.

Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR.

J Lipid Res. 2013 May;54(5):1335-45. doi: 10.1194/jlr.M034892. Epub 2013 Jan 28.


The human protein disulfide isomerase gene family.

Galligan JJ, Petersen DR.

Hum Genomics. 2012 Jul 5;6:6. doi: 10.1186/1479-7364-6-6.


Impaired propulsive motility in the distal but not proximal colon of BK channel β1-subunit knockout mice.

France M, Bhattarai Y, Galligan JJ, Xu H.

Neurogastroenterol Motil. 2012 Sep;24(9):e450-9. doi: 10.1111/j.1365-2982.2012.01981.x. Epub 2012 Jul 26.


Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.

Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR.

J Toxicol. 2012;2012:207594. doi: 10.1155/2012/207594. Epub 2012 Jul 5.


Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.

Smathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DR.

PLoS One. 2012;7(6):e38459. doi: 10.1371/journal.pone.0038459. Epub 2012 Jun 6.


Protein carbonylation in a murine model for early alcoholic liver disease.

Galligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DR.

Chem Res Toxicol. 2012 May 21;25(5):1012-21. doi: 10.1021/tx300002q. Epub 2012 May 1.


Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.

Tack J, Camilleri M, Chang L, Chey WD, Galligan JJ, Lacy BE, Müller-Lissner S, Quigley EM, Schuurkes J, De Maeyer JH, Stanghellini V.

Aliment Pharmacol Ther. 2012 Apr;35(7):745-67. doi: 10.1111/j.1365-2036.2012.05011.x. Epub 2012 Feb 22. Review.


Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.

Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.

J Proteome Res. 2012 Mar 2;11(3):1633-43. doi: 10.1021/pr2008384. Epub 2012 Feb 21.


Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.

Hoffman JM, Tyler K, MacEachern SJ, Balemba OB, Johnson AC, Brooks EM, Zhao H, Swain GM, Moses PL, Galligan JJ, Sharkey KA, Greenwood-Van Meerveld B, Mawe GM.

Gastroenterology. 2012 Apr;142(4):844-854.e4. doi: 10.1053/j.gastro.2011.12.041. Epub 2012 Jan 4.


Vascular BK channel deficiency exacerbates organ damage and mortality in endotoxemic mice.

Xu H, Wang Y, Garver H, Galligan JJ, Fink GD.

J Cardiovasc Pharmacol. 2012 Mar;59(3):207-14. doi: 10.1097/FJC.0b013e31823b493b.


Requirement for functional BK channels in maintaining oscillation in venomotor tone revealed by species differences in expression of the β1 accessory subunits.

Xu H, Kandlikar SS, Westcott EB, Fink GD, Galligan JJ.

J Cardiovasc Pharmacol. 2012 Jan;59(1):29-36. doi: 10.1097/FJC.0b013e318233614c.


Improvements in the Formation of Boron-Doped Diamond Coatings on Platinum Wires Using the Novel Nucleation Process (NNP).

Fhaner M, Zhao H, Bian X, Galligan JJ, Swain GM.

Diam Relat Mater. 2011 Feb;20(2):75-83.


4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.

Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR.

Chem Res Toxicol. 2011 May 16;24(5):651-62. doi: 10.1021/tx100355a. Epub 2011 Apr 14.


Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.

Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N Jr, Petersen DR.

Mol Pharmacol. 2011 Jun;79(6):941-52. doi: 10.1124/mol.110.069534. Epub 2011 Mar 17.

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