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Aspirin Inhibits TGFβ2-Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells: Selective acetylation of K56 and K122 in histone H3.

Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski Iv JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH.

Biochem J. 2019 Dec 9. pii: BCJ20190540. doi: 10.1042/BCJ20190540. [Epub ahead of print]


Spinal cord injury alters purinergic neurotransmission to mesenteric arteries in rats.

Sangsiri S, Xu H, Fernandes R, Fink GD, Lujan HL, DiCarlo SE, Galligan JJ.

Am J Physiol Heart Circ Physiol. 2019 Nov 27. doi: 10.1152/ajpheart.00525.2019. [Epub ahead of print]


Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes.

Gaffney DO, Jennings EQ, Anderson CC, Marentette JO, Shi T, Schou Oxvig AM, Streeter MD, Johannsen M, Spiegel DA, Chapman E, Roede JR, Galligan JJ.

Cell Chem Biol. 2019 Nov 20. pii: S2451-9456(19)30363-0. doi: 10.1016/j.chembiol.2019.11.005. [Epub ahead of print]


Effects of high-fat diet on sympathetic neurotransmission in mesenteric arteries from Dahl salt-sensitive rat.

Alula KM, Biltz R, Xu H, Garver H, Laimon-Thomson EL, Fink GD, Galligan JJ.

Auton Neurosci. 2019 Dec;222:102599. doi: 10.1016/j.autneu.2019.102599. Epub 2019 Oct 31.


Optogenetic analysis of neuromuscular transmission in the colon of ChAT-ChR2-YFP BAC transgenic mice.

Perez-Medina AL, Galligan JJ.

Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G569-G579. doi: 10.1152/ajpgi.00089.2019. Epub 2019 Aug 14.


Erratum: Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.

Wepy JA, Galligan JJ, Kingsley PJ, Xu S, Goodman MC, Tallman KA, Rouzer CA, Marnett LJ.

J Lipid Res. 2019 Jul;60(7):1345. doi: 10.1194/jlr.ERR119000139. No abstract available.


NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis.

Grubišić V, Perez-Medina AL, Fried DE, Sévigny J, Robson SC, Galligan JJ, Gulbransen BD.

Am J Physiol Gastrointest Liver Physiol. 2019 Sep 1;317(3):G314-G332. doi: 10.1152/ajpgi.00104.2019. Epub 2019 Jun 12.


Cannabinoid-induced relief of hypermotility in a rat model of the irritable bowel syndrome.

Galligan JJ.

Neurogastroenterol Motil. 2019 Jun;31(6):e13613. doi: 10.1111/nmo.13613.


Chromatin Modifications in Toxicology.

Galligan JJ.

Chem Res Toxicol. 2019 May 20;32(5):794-795. doi: 10.1021/acs.chemrestox.8b00267. Epub 2018 Dec 6.


Profiling of Methylglyoxal Blood Metabolism and Advanced Glycation End-Product Proteome Using a Chemical Probe.

Sibbersen C, Schou Oxvig AM, Bisgaard Olesen S, Nielsen CB, Galligan JJ, Jørgensen KA, Palmfeldt J, Johannsen M.

ACS Chem Biol. 2018 Dec 21;13(12):3294-3305. doi: 10.1021/acschembio.8b00732. Epub 2018 Dec 3.


Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.

Wepy JA, Galligan JJ, Kingsley PJ, Xu S, Goodman MC, Tallman KA, Rouzer CA, Marnett LJ.

J Lipid Res. 2019 Feb;60(2):360-374. doi: 10.1194/jlr.M087890. Epub 2018 Nov 27. Erratum in: J Lipid Res. 2019 Jul;60(7):1345.


5-HT3 receptor signaling in serotonin transporter-knockout rats: a female sex-specific animal model of visceral hypersensitivity.

El-Ayache N, Galligan JJ.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G132-G143. doi: 10.1152/ajpgi.00131.2018. Epub 2018 Oct 25.


Sex Differences in Renal Inflammation and Injury in High-Fat Diet-Fed Dahl Salt-Sensitive Rats.

Fernandes R, Garver H, Harkema JR, Galligan JJ, Fink GD, Xu H.

Hypertension. 2018 Nov;72(5):e43-e52. doi: 10.1161/HYPERTENSIONAHA.118.11485.


Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.

Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9228-9233. doi: 10.1073/pnas.1802901115. Epub 2018 Aug 27.


Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA.

Wauchope OR, Mitchener MM, Beavers WN, Galligan JJ, Camarillo JM, Sanders WD, Kingsley PJ, Shim HN, Blackwell T, Luong T, deCaestecker M, Fessel JP, Marnett LJ.

Nucleic Acids Res. 2018 Apr 20;46(7):3458-3467. doi: 10.1093/nar/gky089.


Macrophage-dependent impairment of α2-adrenergic autoreceptor inhibition of Ca2+ channels in sympathetic neurons from DOCA-salt but not high-fat diet-induced hypertensive rats.

Mui RK, Fernandes RN, Garver HG, Van Rooijen N, Galligan JJ.

Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H863-H877. doi: 10.1152/ajpheart.00536.2017. Epub 2018 Jan 5.


Beneficial actions of microbiota-derived tryptophan metabolites.

Galligan JJ.

Neurogastroenterol Motil. 2018 Feb;30(2). doi: 10.1111/nmo.13283. Review.


Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

Beavers WN, Rose KL, Galligan JJ, Mitchener MM, Rouzer CA, Tallman KA, Lamberson CR, Wang X, Hill S, Ivanova PT, Brown HA, Zhang B, Porter NA, Marnett LJ.

ACS Chem Biol. 2017 Aug 18;12(8):2062-2069. doi: 10.1021/acschembio.7b00480. Epub 2017 Jun 28.


Insights into the Role of Opioid Receptors in the GI Tract: Experimental Evidence and Therapeutic Relevance.

Galligan JJ, Sternini C.

Handb Exp Pharmacol. 2017;239:363-378. doi: 10.1007/164_2016_116. Review.


5-HT secretion by enterochromaffin cells is a very touching story.

Galligan JJ.

J Physiol. 2017 Jan 1;595(1):3. doi: 10.1113/JP273041. No abstract available.


R-Type Ca2+ channels couple to inhibitory neurotransmission to the longitudinal muscle in the guinea-pig ileum.

Rodriguez-Tapia ES, Naidoo V, DeVries M, Perez-Medina A, Galligan JJ.

Exp Physiol. 2017 Mar 1;102(3):299-313. doi: 10.1113/EP086027. Epub 2017 Jan 25.


Quantitative Analysis and Discovery of Lysine and Arginine Modifications.

Galligan JJ, Kingsley PJ, Wauchope OR, Mitchener MM, Camarillo JM, Wepy JA, Harris PS, Fritz KS, Marnett LJ.

Anal Chem. 2017 Jan 17;89(2):1299-1306. doi: 10.1021/acs.analchem.6b04105. Epub 2016 Dec 30.


From the exposome to mechanistic understanding of chemical-induced adverse effects.

Escher BI, Hackermüller J, Polte T, Scholz S, Aigner A, Altenburger R, Böhme A, Bopp SK, Brack W, Busch W, Chadeau-Hyam M, Covaci A, Eisenträger A, Galligan JJ, Garcia-Reyero N, Hartung T, Hein M, Herberth G, Jahnke A, Kleinjans J, Klüver N, Krauss M, Lamoree M, Lehmann I, Luckenbach T, Miller GW, Müller A, Phillips DH, Reemtsma T, Rolle-Kampczyk U, Schüürmann G, Schwikowski B, Tan YM, Trump S, Walter-Rohde S, Wambaugh JF.

Environ Int. 2017 Feb;99:97-106. doi: 10.1016/j.envint.2016.11.029. Epub 2016 Dec 8. Review.


Histone Adduction and Its Functional Impact on Epigenetics.

Galligan JJ, Marnett LJ.

Chem Res Toxicol. 2017 Jan 17;30(1):376-387. doi: 10.1021/acs.chemrestox.6b00379. Epub 2016 Dec 20.


Upregulation of L-type calcium channels in colonic inhibitory motoneurons of P/Q-type calcium channel-deficient mice.

Rodriguez-Tapia E, Perez-Medina A, Bian X, Galligan JJ.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G763-G774. doi: 10.1152/ajpgi.00263.2016. Epub 2016 Sep 1.


News from the editors of Neurogastroenterology and Motility.

Bredenoord AJ, Browning KN, Mawe GM, Galligan JJ, Simren M.

Neurogastroenterol Motil. 2016 Oct;28(10):1451. doi: 10.1111/nmo.12924. Epub 2016 Aug 3. No abstract available.


Reduced Noradrenergic Signaling in the Spleen Capsule in the Absence of CB1 and CB2 Cannabinoid Receptors.

Simkins TJ, Fried D, Parikh K, Galligan JJ, Goudreau JL, Lookingland KJ, Kaplan BL.

J Neuroimmune Pharmacol. 2016 Dec;11(4):669-679. Epub 2016 Jun 10.


Accumulation of isolevuglandin-modified protein in normal and fibrotic lung.

Mont S, Davies SS, Roberts Second LJ, Mernaugh RL, McDonald WH, Segal BH, Zackert W, Kropski JA, Blackwell TS, Sekhar KR, Galligan JJ, Massion PP, Marnett LJ, Travis EL, Freeman ML.

Sci Rep. 2016 Apr 27;6:24919. doi: 10.1038/srep24919.


Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression.

Camarillo JM, Rose KL, Galligan JJ, Xu S, Marnett LJ.

Chem Res Toxicol. 2016 Mar 21;29(3):323-32. doi: 10.1021/acs.chemrestox.5b00485. Epub 2016 Mar 11.


Electrochemical detection of peroxynitrite using hemin-PEDOT functionalized boron-doped diamond microelectrode.

Peteu SF, Whitman BW, Galligan JJ, Swain GM.

Analyst. 2016 Mar 7;141(5):1796-806. doi: 10.1039/c5an02587g.


Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.

Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR.

Redox Biol. 2016 Apr;7:68-77. doi: 10.1016/j.redox.2015.11.013. Epub 2015 Nov 27.


Nuclear Oxidation of a Major Peroxidation DNA Adduct, M1dG, in the Genome.

Wauchope OR, Beavers WN, Galligan JJ, Mitchener MM, Kingsley PJ, Marnett LJ.

Chem Res Toxicol. 2015 Dec 21;28(12):2334-42. doi: 10.1021/acs.chemrestox.5b00340. Epub 2015 Nov 11.


Sex-related differences in small intestinal transit and serotonin dynamics in high-fat-diet-induced obesity in mice.

France M, Skorich E, Kadrofske M, Swain GM, Galligan JJ.

Exp Physiol. 2016 Jan;101(1):81-99. doi: 10.1113/EP085427. Epub 2015 Oct 28.


Macrophage depletion lowers blood pressure and restores sympathetic nerve α2-adrenergic receptor function in mesenteric arteries of DOCA-salt hypertensive rats.

Thang LV, Demel SL, Crawford R, Kaminski NE, Swain GM, Van Rooijen N, Galligan JJ.

Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1186-97. doi: 10.1152/ajpheart.00283.2015. Epub 2015 Aug 28.


BK channel β1-subunit deficiency exacerbates vascular fibrosis and remodelling but does not promote hypertension in high-fat fed obesity in mice.

Xu H, Garver H, Fernandes R, Phelps JT, Harkema JJ, Galligan JJ, Fink GD.

J Hypertens. 2015 Aug;33(8):1611-23. doi: 10.1097/HJH.0000000000000590.


HIV, opiates, and enteric neuron dysfunction.

Galligan JJ.

Neurogastroenterol Motil. 2015 Apr;27(4):449-54. doi: 10.1111/nmo.12539. Review.


Site-specific, intramolecular cross-linking of Pin1 active site residues by the lipid electrophile 4-oxo-2-nonenal.

Aluise CD, Camarillo JM, Shimozu Y, Galligan JJ, Rose KL, Tallman KA, Marnett LJ.

Chem Res Toxicol. 2015 Apr 20;28(4):817-27. doi: 10.1021/acs.chemrestox.5b00038. Epub 2015 Mar 18.


13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase.

Kudalkar SN, Nikas SP, Kingsley PJ, Xu S, Galligan JJ, Rouzer CA, Banerjee S, Ji L, Eno MR, Makriyannis A, Marnett LJ.

J Biol Chem. 2015 Mar 20;290(12):7897-909. doi: 10.1074/jbc.M114.634014. Epub 2015 Feb 2.


Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants.

Benskey MJ, Kuhn NC, Galligan JJ, Garcia J, Boye SE, Hauswirth WW, Mueller C, Boye SL, Manfredsson FP.

Mol Ther. 2015 Mar;23(3):488-500. doi: 10.1038/mt.2015.7. Epub 2015 Jan 16.


Western blot analysis of BK channel β1-subunit expression should be interpreted cautiously when using commercially available antibodies.

Bhattarai Y, Fernandes R, Kadrofske MM, Lockwood LR, Galligan JJ, Xu H.

Physiol Rep. 2014 Oct 28;2(10). pii: e12189. doi: 10.14814/phy2.12189. Print 2014 Oct 1.


Protein modification by adenine propenal.

Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ.

Chem Res Toxicol. 2014 Oct 20;27(10):1732-42. doi: 10.1021/tx500218g. Epub 2014 Sep 24.


Molecular physiology of enteric opioid receptors.

Galligan JJ, Akbarali HI.

Am J Gastroenterol Suppl. 2014 Sep 10;2(1):17-21. doi: 10.1038/ajgsup.2014.5. Review.


Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics.

Galligan JJ, Rose KL, Beavers WN, Hill S, Tallman KA, Tansey WP, Marnett LJ.

J Am Chem Soc. 2014 Aug 27;136(34):11864-6. doi: 10.1021/ja503604t. Epub 2014 Aug 11.


Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR.

Free Radic Biol Med. 2014 Aug;73:411-20. doi: 10.1016/j.freeradbiomed.2014.06.002. Epub 2014 Jun 9.


Altered L-type Ca2+ channel activity contributes to exacerbated hypoperfusion and mortality in smooth muscle cell BK channel-deficient septic mice.

Xu H, Garver H, Fernandes R, Galligan JJ, Fink GD.

Am J Physiol Regul Integr Comp Physiol. 2014 Jul 15;307(2):R138-48.


Electrochemical activation of diamond microelectrodes: implications for the in vitro measurement of serotonin in the bowel.

Duran B, Brocenschi RF, France M, Galligan JJ, Swain GM.

Analyst. 2014 Jun 21;139(12):3160-6. doi: 10.1039/c4an00506f. Epub 2014 May 7.


Increased catecholamine secretion from single adrenal chromaffin cells in DOCA-salt hypertension is associated with potassium channel dysfunction.

Fhaner MJ, Galligan JJ, Swain GM.

ACS Chem Neurosci. 2013 Oct 16;4(10):1404-13. doi: 10.1021/cn400115v. Epub 2013 Aug 30.


Visceral hypersensitivity in female but not in male serotonin transporter knockout rats.

Galligan JJ, Patel BA, Schneider SP, Wang H, Zhao H, Novotny M, Bian X, Kabeer R, Fried D, Swain GM.

Neurogastroenterol Motil. 2013 Jun;25(6):e373-81. doi: 10.1111/nmo.12133. Epub 2013 Apr 17.


Impaired function of prejunctional adenosine A1 receptors expressed by perivascular sympathetic nerves in DOCA-salt hypertensive rats.

Sangsiri S, Dong H, Swain GM, Galligan JJ, Xu H.

J Pharmacol Exp Ther. 2013 Apr;345(1):32-40. doi: 10.1124/jpet.112.199612. Epub 2013 Feb 8.


Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver.

Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR.

J Lipid Res. 2013 May;54(5):1335-45. doi: 10.1194/jlr.M034892. Epub 2013 Jan 28.

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