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Items: 8

1.

Computational protein design enables a novel one-carbon assimilation pathway.

Siegel JB, Smith AL, Poust S, Wargacki AJ, Bar-Even A, Louw C, Shen BW, Eiben CB, Tran HM, Noor E, Gallaher JL, Bale J, Yoshikuni Y, Gelb MH, Keasling JD, Stoddard BL, Lidstrom ME, Baker D.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3704-9. doi: 10.1073/pnas.1500545112. Epub 2015 Mar 9.

2.

Computational design of enone-binding proteins with catalytic activity for the Morita-Baylis-Hillman reaction.

Bjelic S, Nivón LG, Çelebi-Ölçüm N, Kiss G, Rosewall CF, Lovick HM, Ingalls EL, Gallaher JL, Seetharaman J, Lew S, Montelione GT, Hunt JF, Michael FE, Houk KN, Baker D.

ACS Chem Biol. 2013 Apr 19;8(4):749-57. doi: 10.1021/cb3006227. Epub 2013 Jan 30.

3.

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.

Khare SD, Kipnis Y, Greisen P Jr, Takeuchi R, Ashani Y, Goldsmith M, Song Y, Gallaher JL, Silman I, Leader H, Sussman JL, Stoddard BL, Tawfik DS, Baker D.

Nat Chem Biol. 2012 Feb 5;8(3):294-300. doi: 10.1038/nchembio.777.

4.

Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction.

Siegel JB, Zanghellini A, Lovick HM, Kiss G, Lambert AR, St Clair JL, Gallaher JL, Hilvert D, Gelb MH, Stoddard BL, Houk KN, Michael FE, Baker D.

Science. 2010 Jul 16;329(5989):309-13. doi: 10.1126/science.1190239.

5.

Alteration of enzyme specificity by computational loop remodeling and design.

Murphy PM, Bolduc JM, Gallaher JL, Stoddard BL, Baker D.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9215-20. doi: 10.1073/pnas.0811070106. Epub 2009 May 21.

6.

Kemp elimination catalysts by computational enzyme design.

Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D.

Nature. 2008 May 8;453(7192):190-5. doi: 10.1038/nature06879. Epub 2008 Mar 19.

PMID:
18354394
7.

De novo computational design of retro-aldol enzymes.

Jiang L, Althoff EA, Clemente FR, Doyle L, Röthlisberger D, Zanghellini A, Gallaher JL, Betker JL, Tanaka F, Barbas CF 3rd, Hilvert D, Houk KN, Stoddard BL, Baker D.

Science. 2008 Mar 7;319(5868):1387-91. doi: 10.1126/science.1152692.

8.

Leukocyte telomere length predicts cancer risk in Barrett's esophagus.

Risques RA, Vaughan TL, Li X, Odze RD, Blount PL, Ayub K, Gallaher JL, Reid BJ, Rabinovitch PS.

Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2649-55.

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