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A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria.

Norman BP, Davison AS, Ross GA, Milan AM, Hughes AT, Sutherland H, Jarvis JC, Roberts NB, Gallagher JA, Ranganath LR.

Clin Chem. 2019 Apr;65(4):530-539. doi: 10.1373/clinchem.2018.295345. Epub 2019 Feb 19.


Data on items of AKUSSI in Alkaptonuria collected over three years from the United Kingdom National Alkaptonuria Centre and the impact of nitisinone.

Griffin R, Psarelli EE, Cox TF, Khedr M, Milan AM, Davison AS, Hughes AT, Usher JL, Taylor S, Loftus N, Daroszewska A, West E, Jones A, Briggs M, Fisher M, McCormick M, Judd S, Vinjamuri S, Sireau N, Dillon JP, Devine JM, Hughes G, Harrold J, Barton GJ, Jarvis JC, Gallagher JA, Ranganath LR.

Data Brief. 2018 Sep 12;20:1620-1628. doi: 10.1016/j.dib.2018.09.021. eCollection 2018 Oct.


Species variation in the effects of dewatering treatment on macroalgae.

Gallagher JA, Turner LB, Adams JMM, Barrento S, Dyer PW, Theodorou MK.

J Appl Phycol. 2018;30(4):2305-2316. doi: 10.1007/s10811-018-1420-7. Epub 2018 Feb 20.


Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre.

Ranganath LR, Khedr M, Milan AM, Davison AS, Hughes AT, Usher JL, Taylor S, Loftus N, Daroszewska A, West E, Jones A, Briggs M, Fisher M, McCormick M, Judd S, Vinjamuri S, Griffin R, Psarelli EE, Cox TF, Sireau N, Dillon JP, Devine JM, Hughes G, Harrold J, Barton GJ, Jarvis JC, Gallagher JA.

Mol Genet Metab. 2018 Sep;125(1-2):127-134. doi: 10.1016/j.ymgme.2018.07.011. Epub 2018 Jul 24.


Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone.

Davison AS, Harrold JA, Hughes G, Norman BP, Devine J, Usher J, Hughes AT, Khedr M, Gallagher JA, Milan AM, J C G H, Ranganath LR.

Mol Genet Metab. 2018 Sep;125(1-2):135-143. doi: 10.1016/j.ymgme.2018.07.008. Epub 2018 Jul 19.


Inflammatory and oxidative stress biomarkers in alkaptonuria: data from the DevelopAKUre project.

Braconi D, Giustarini D, Marzocchi B, Peruzzi L, Margollicci M, Rossi R, Bernardini G, Millucci L, Gallagher JA, Le Quan Sang KH, Imrich R, Rovensky J, Al-Sbou M, Ranganath LR, Santucci A.

Osteoarthritis Cartilage. 2018 Aug;26(8):1078-1086. doi: 10.1016/j.joca.2018.05.017. Epub 2018 May 29.


Serum Amino Acid Profiling in Patients with Alkaptonuria Before and After Treatment with Nitisinone.

Davison AS, Norman BP, Smith EA, Devine J, Usher J, Hughes AT, Khedr M, Milan AM, Gallagher JA, Ranganath LR.

JIMD Rep. 2018;41:109-117. doi: 10.1007/8904_2018_109. Epub 2018 May 13.


Alkaptonuria Severity Score Index Revisited: Analysing the AKUSSI and Its Subcomponent Features.

Langford B, Besford M, Hall A, Eddowes L, Timmis O, Gallagher JA, Ranganath L.

JIMD Rep. 2018;41:53-62. doi: 10.1007/8904_2018_98. Epub 2018 Apr 14.


What cell wall components are the best indicators for Miscanthus digestibility and conversion to ethanol following variable pretreatments?

Adams JMM, Winters AL, Hodgson EM, Gallagher JA.

Biotechnol Biofuels. 2018 Mar 14;11:67. doi: 10.1186/s13068-018-1066-3. eCollection 2018.


Draft Genome Assemblies of Xylose-Utilizing Candida tropicalis and Candida boidinii with Potential Application in Biochemical and Biofuel Production.

Somani A, Smith D, Hegarty M, Fernandez-Fuentes N, Ravella SR, Gallagher JA, Bryant DN.

Genome Announc. 2018 Feb 15;6(7). pii: e01594-17. doi: 10.1128/genomeA.01594-17.


Assessment of the Effect of Once Daily Nitisinone Therapy on 24-h Urinary Metadrenalines and 5-Hydroxyindole Acetic Acid Excretion in Patients with Alkaptonuria After 4 Weeks of Treatment.

Davison AS, Norman B, Milan AM, Hughes AT, Khedr M, Rovensky J, Gallagher JA, Ranganath LR.

JIMD Rep. 2018;41:1-10. doi: 10.1007/8904_2017_72. Epub 2017 Nov 17.


Asymptomatic Corneal Keratopathy Secondary to Hypertyrosinaemia Following Low Dose Nitisinone and a Literature Review of Tyrosine Keratopathy in Alkaptonuria.

Khedr M, Judd S, Briggs MC, Hughes AT, Milan AM, Stewart RMK, Lock EA, Gallagher JA, Ranganath LR.

JIMD Rep. 2018;40:31-37. doi: 10.1007/8904_2017_62. Epub 2017 Sep 24.


Could Miscanthus replace maize as the preferred substrate for anaerobic digestion in the United Kingdom? Future breeding strategies.

Purdy SJ, Maddison AL, Nunn CP, Winters A, Timms-Taravella E, Jones CM, Clifton-Brown JC, Donnison IS, Gallagher JA.

Glob Change Biol Bioenergy. 2017 Jun;9(6):1122-1139. doi: 10.1111/gcbb.12419. Epub 2017 Jan 21.


Novel rapid method for the characterisation of polymeric sugars from macroalgae.

Spicer SE, Adams JMM, Thomas DS, Gallagher JA, Winters AL.

J Appl Phycol. 2017;29(3):1507-1513. doi: 10.1007/s10811-016-0995-0. Epub 2016 Nov 16.


Genetic engineering of grass cell wall polysaccharides for biorefining.

Bhatia R, Gallagher JA, Gomez LD, Bosch M.

Plant Biotechnol J. 2017 Sep;15(9):1071-1092. doi: 10.1111/pbi.12764. Epub 2017 Jun 30. Review.


The effect of nitisinone on homogentisic acid and tyrosine: a two-year survey of patients attending the National Alkaptonuria Centre, Liverpool.

Milan AM, Hughes AT, Davison AS, Devine J, Usher J, Curtis S, Khedr M, Gallagher JA, Ranganath LR.

Ann Clin Biochem. 2017 May;54(3):323-330. doi: 10.1177/0004563217691065. Epub 2017 Mar 16.


Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing.

Taylor AM, Hsueh MF, Ranganath LR, Gallagher JA, Dillon JP, Huebner JL, Catterall JB, Kraus VB.

Rheumatology (Oxford). 2017 Jan;56(1):156-164. doi: 10.1093/rheumatology/kew355. Epub 2016 Oct 7.


Dewatering treatments to increase dry matter content of the brown seaweed, kelp (Laminaria digitata ((Hudson) JV Lamouroux)).

Gallagher JA, Turner LB, Adams JMM, Dyer PW, Theodorou MK.

Bioresour Technol. 2017 Jan;224:662-669. doi: 10.1016/j.biortech.2016.11.091. Epub 2016 Nov 24.


Defining the Properties of an Array of -NH2-Modified Substrates for the Induction of a Mature Osteoblast/Osteocyte Phenotype from a Primary Human Osteoblast Population Using Controlled Nanotopography and Surface Chemistry.

Fawcett SA, Curran JM, Chen R, Rhodes NP, Murphy MF, Wilson P, Ranganath L, Dillon JP, Gallagher JA, Hunt JA.

Calcif Tissue Int. 2017 Jan;100(1):95-106. doi: 10.1007/s00223-016-0202-y. Epub 2016 Oct 28.


c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines.

Pacheco-Pantoja EL, Dillon JP, Wilson PJ, Fraser WD, Gallagher JA.

Purinergic Signal. 2016 Dec;12(4):647-651. Epub 2016 Jul 20.


Alkaptonuria: An example of a "fundamental disease"--A rare disease with important lessons for more common disorders.

Gallagher JA, Dillon JP, Sireau N, Timmis O, Ranganath LR.

Semin Cell Dev Biol. 2016 Apr;52:53-7. doi: 10.1016/j.semcdb.2016.02.020. Epub 2016 Feb 16. Review.


Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury.

Varley I, Greeves JP, Sale C, Friedman E, Moran DS, Yanovich R, Wilson PJ, Gartland A, Hughes DC, Stellingwerff T, Ranson C, Fraser WD, Gallagher JA.

Purinergic Signal. 2016 Mar;12(1):103-13. doi: 10.1007/s11302-016-9495-6. Epub 2016 Jan 29.


What does the arthropathy of alkaptonuria teach us about disease mechanisms in osteoarthritis and ageing of joints?

Gallagher JA, Ranganath LR, Boyde A.

Rheumatology (Oxford). 2016 Jul;55(7):1151-2. doi: 10.1093/rheumatology/kev401. Epub 2015 Dec 27. No abstract available.


Acute fatal metabolic complications in alkaptonuria.

Davison AS, Milan AM, Gallagher JA, Ranganath LR.

J Inherit Metab Dis. 2016 Mar;39(2):203-10. doi: 10.1007/s10545-015-9902-0. Epub 2015 Nov 23. Review.


Elastic Anisotropy of Trabecular Bone in the Elderly Human Vertebra.

Unnikrishnan GU, Gallagher JA, Hussein AI, Barest GD, Morgan EF.

J Biomech Eng. 2015 Nov;137(11):114503. doi: 10.1115/1.4031415.


Progress in Alkaptonuria--are we near to an effective therapy?

Ranganath LR, Timmis OG, Gallagher JA.

J Inherit Metab Dis. 2015 Sep;38(5):787-9. doi: 10.1007/s10545-015-9888-7. No abstract available.


Fructan synthesis, accumulation, and polymer traits. I. Festulolium chromosome substitution lines.

Gallagher JA, Cairns AJ, Thomas D, Charlton A, Williams P, Turner LB.

Front Plant Sci. 2015 Jul 8;6:486. doi: 10.3389/fpls.2015.00486. eCollection 2015.


Editorial overview: Musculoskeletal: Are there common targets to prevent age-related changes in muscle, cartilage and bone?

Gallagher JA, Russell RG.

Curr Opin Pharmacol. 2015 Jun;22:v-viii. doi: 10.1016/j.coph.2015.05.007. Epub 2015 May 29. No abstract available.


Lessons from rare diseases of cartilage and bone.

Gallagher JA, Ranganath LR, Boyde A.

Curr Opin Pharmacol. 2015 Jun;22:107-14. doi: 10.1016/j.coph.2015.04.002. Epub 2015 May 14. Review.


Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice.

Keenan CM, Preston AJ, Sutherland H, Wilson PJ, Psarelli EE, Cox TF, Ranganath LR, Jarvis JC, Gallagher JA.

JIMD Rep. 2015;24:45-50. doi: 10.1007/8904_2015_437. Epub 2015 May 5.


Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy.

Nemethova M, Radvanszky J, Kadasi L, Ascher DB, Pires DE, Blundell TL, Porfirio B, Mannoni A, Santucci A, Milucci L, Sestini S, Biolcati G, Sorge F, Aurizi C, Aquaron R, Alsbou M, Lourenço CM, Ramadevi K, Ranganath LR, Gallagher JA, van Kan C, Hall AK, Olsson B, Sireau N, Ayoob H, Timmis OG, Sang KH, Genovese F, Imrich R, Rovensky J, Srinivasaraghavan R, Bharadwaj SK, Spiegel R, Zatkova A.

Eur J Hum Genet. 2016 Jan;24(1):66-72. doi: 10.1038/ejhg.2015.60. Epub 2015 Mar 25.


Investigating the Robustness and Diagnostic Potential of Extracellular Matrix Remodelling Biomarkers in Alkaptonuria.

Genovese F, Siebuhr AS, Musa K, Gallagher JA, Milan AM, Karsdal MA, Rovensky J, Bay-Jensen AC, Ranganath LR.

JIMD Rep. 2015;24:29-37. doi: 10.1007/8904_2015_430. Epub 2015 Mar 19.


Serum markers in alkaptonuria: simultaneous analysis of homogentisic acid, tyrosine and nitisinone by liquid chromatography tandem mass spectrometry.

Hughes AT, Milan AM, Davison AS, Christensen P, Ross G, Gallagher JA, Dutton JJ, Ranganath LR.

Ann Clin Biochem. 2015 Sep;52(Pt 5):597-605. doi: 10.1177/0004563215571969. Epub 2015 Jan 27.


Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment.

Ranganath LR, Milan AM, Hughes AT, Dutton JJ, Fitzgerald R, Briggs MC, Bygott H, Psarelli EE, Cox TF, Gallagher JA, Jarvis JC, van Kan C, Hall AK, Laan D, Olsson B, Szamosi J, Rudebeck M, Kullenberg T, Cronlund A, Svensson L, Junestrand C, Ayoob H, Timmis OG, Sireau N, Le Quan Sang KH, Genovese F, Braconi D, Santucci A, Nemethova M, Zatkova A, McCaffrey J, Christensen P, Ross G, Imrich R, Rovensky J.

Ann Rheum Dis. 2016 Feb;75(2):362-7. doi: 10.1136/annrheumdis-2014-206033. Epub 2014 Dec 4.


On fragmenting, densely mineralised acellular protrusions into articular cartilage and their possible role in osteoarthritis.

Boyde A, Davis GR, Mills D, Zikmund T, Cox TM, Adams VL, Niker A, Wilson PJ, Dillon JP, Ranganath LR, Jeffery N, Jarvis JC, Gallagher JA.

J Anat. 2014 Oct;225(4):436-46. doi: 10.1111/joa.12226. Epub 2014 Jul 31.


Reversible keratopathy due to hypertyrosinaemia following intermittent low-dose nitisinone in alkaptonuria: a case report.

Stewart RM, Briggs MC, Jarvis JC, Gallagher JA, Ranganath L.

JIMD Rep. 2014;17:1-6. doi: 10.1007/8904_2014_307. Epub 2014 Jul 6.


Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle.

Vickerton P, Jarvis JC, Gallagher JA, Akhtar R, Sutherland H, Jeffery N.

Proc Biol Sci. 2014 Aug 7;281(1788):20140786. doi: 10.1098/rspb.2014.0786.


Urine homogentisic acid and tyrosine: simultaneous analysis by liquid chromatography tandem mass spectrometry.

Hughes AT, Milan AM, Christensen P, Ross G, Davison AS, Gallagher JA, Dutton JJ, Ranganath LR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jul 15;963:106-12. doi: 10.1016/j.jchromb.2014.06.002. Epub 2014 Jun 7.


Differential effects of adiponectin in osteoblast-like cells.

Pacheco-Pantoja EL, Fraser WD, Wilson PJ, Gallagher JA.

J Recept Signal Transduct Res. 2014 Oct;34(5):351-60. doi: 10.3109/10799893.2014.898658. Epub 2014 Mar 27.


Soluble phenolic compounds in fresh and ensiled orchard grass (Dactylis glomerata L.), a common species in permanent pastures with potential as a biomass feedstock.

Hauck B, Gallagher JA, Morris SM, Leemans D, Winters AL.

J Agric Food Chem. 2014 Jan 15;62(2):468-75. doi: 10.1021/jf4040749. Epub 2013 Dec 31.


Adiponectin receptors are present in RANK-L-induced multinucleated osteoclast-like cells.

Pacheco-Pantoja EL, Waring VJ, Wilson PJ, Fraser WD, Gallagher JA.

J Recept Signal Transduct Res. 2013 Oct;33(5):291-7. doi: 10.3109/10799893.2013.828070. Epub 2013 Aug 23.


Rethinking ethics: employed physicians, ACOs, high costs prompt review.

Slosar JP, Gallagher JA, Worsley S.

Health Prog. 2013 Jul-Aug;94(4):44-51. No abstract available.


Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone.

Preston AJ, Keenan CM, Sutherland H, Wilson PJ, Wlodarski B, Taylor AM, Williams DP, Ranganath LR, Gallagher JA, Jarvis JC.

Ann Rheum Dis. 2014 Jan;73(1):284-9. doi: 10.1136/annrheumdis-2012-202878. Epub 2013 Mar 19.


Recent advances in management of alkaptonuria (invited review; best practice article).

Ranganath LR, Jarvis JC, Gallagher JA.

J Clin Pathol. 2013 May;66(5):367-73. doi: 10.1136/jclinpath-2012-200877. Epub 2013 Mar 13. Review.


Distribution of purinergic P2X receptors in the equine digit, cervical spinal cord and dorsal root ganglia.

Zamboulis DE, Senior JM, Clegg PD, Gallagher JA, Carter SD, Milner PI.

Purinergic Signal. 2013 Sep;9(3):383-93. doi: 10.1007/s11302-013-9356-5. Epub 2013 Feb 6.


HCEC pearls and pitfalls: suggested do's and don't's for healthcare ethics consultants.

American Society for Bioethics and Humanities Clinical Ethics Consultation Affairs Standing Committee, Carrese JA, Antommaria AH, Berkowitz KA, Berger J, Carrese J, Childs BH, Derse AR, Gallagher C, Gallagher JA, Goodman-Crews P, Heesters A, Jurchak M, Mitchell C, Mokwyune N, Parsi K, Powell T, Powderly KE, Rosell T, Shelton W, Smith ML, Spike J, Tarzian A, Wocial L.

J Clin Ethics. 2012 Fall;23(3):234-40.


Monitoring real-time enzymatic hydrolysis of Distillers Dried Grains with Solubles (DDGS) by dielectric spectroscopy following hydrothermal pre-treatment by steam explosion.

Bryant DN, Firth E, Kaderbhai N, Taylor S, Morris SM, Logan D, Garcia N, Ellis A, Martin SM, Gallagher JA.

Bioresour Technol. 2013 Jan;128:765-8. doi: 10.1016/j.biortech.2012.09.021. Epub 2012 Sep 15.


Cooperative assembly of Zn cross-linked artificial tripeptides with pendant hydroxyquinoline ligands.

Zhang M, Gallagher JA, Coppock MB, Pantzar LM, Williams ME.

Inorg Chem. 2012 Nov 5;51(21):11315-23. doi: 10.1021/ic3004504. Epub 2012 Oct 5.


Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition.

Taylor AM, Preston AJ, Paulk NK, Sutherland H, Keenan CM, Wilson PJ, Wlodarski B, Grompe M, Ranganath LR, Gallagher JA, Jarvis JC.

Osteoarthritis Cartilage. 2012 Aug;20(8):880-6. doi: 10.1016/j.joca.2012.04.013. Epub 2012 Apr 24.

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