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Items: 1 to 50 of 210

1.

NAADP Receptors.

Galione A.

Cold Spring Harb Perspect Biol. 2019 Jun 10. pii: a035071. doi: 10.1101/cshperspect.a035071. [Epub ahead of print]

PMID:
31182546
2.

A multiscale analysis in CD38-/- mice unveils major prefrontal cortex dysfunctions.

Martucci LL, Amar M, Chaussenot R, Benet G, Bauer O, de Zélicourt A, Nosjean A, Launay JM, Callebert J, Sebrié C, Galione A, Edeline JM, de la Porte S, Fossier P, Granon S, Vaillend C, Cancela JM.

FASEB J. 2019 May;33(5):5823-5835. doi: 10.1096/fj.201800489R. Epub 2019 Mar 7.

3.

Revealing the secrets of secretion.

Galione A, Davis LC.

Elife. 2018 Nov 30;7. pii: e43512. doi: 10.7554/eLife.43512.

4.

Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling.

Foster WJ, Taylor HBC, Padamsey Z, Jeans AF, Galione A, Emptage NJ.

Sci Signal. 2018 Nov 27;11(558). pii: eaat9093. doi: 10.1126/scisignal.aat9093.

5.

Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos.

Kelu JJ, Webb SE, Galione A, Miller AL.

Dev Biol. 2019 Jan 15;445(2):211-225. doi: 10.1016/j.ydbio.2018.11.005. Epub 2018 Nov 14.

6.

TPC2-mediated Ca2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons.

Kelu JJ, Webb SE, Galione A, Miller AL.

Dev Biol. 2018 Jun 1;438(1):57-68. doi: 10.1016/j.ydbio.2018.02.011. Epub 2018 Mar 23.

7.

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

Hamilton A, Zhang Q, Salehi A, Willems M, Knudsen JG, Ringgaard AK, Chapman CE, Gonzalez-Alvarez A, Surdo NC, Zaccolo M, Basco D, Johnson PRV, Ramracheya R, Rutter GA, Galione A, Rorsman P, Tarasov AI.

Diabetes. 2018 Jun;67(6):1128-1139. doi: 10.2337/db17-1102. Epub 2018 Mar 21.

8.

Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling.

Lin WK, Bolton EL, Cortopassi WA, Wang Y, O'Brien F, Maciejewska M, Jacobson MP, Garnham C, Ruas M, Parrington J, Lei M, Sitsapesan R, Galione A, Terrar DA.

J Biol Chem. 2017 Aug 11;292(32):13243-13257. doi: 10.1074/jbc.M117.789347. Epub 2017 May 24.

9.

Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.

Kelu JJ, Webb SE, Parrington J, Galione A, Miller AL.

Dev Biol. 2017 May 15;425(2):109-129. doi: 10.1016/j.ydbio.2017.03.031. Epub 2017 Apr 6.

10.

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.

Aston D, Capel RA, Ford KL, Christian HC, Mirams GR, Rog-Zielinska EA, Kohl P, Galione A, Burton RA, Terrar DA.

Sci Rep. 2017 Jan 17;7:40620. doi: 10.1038/srep40620.

11.

Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart.

Wang Y, Lin WK, Crawford W, Ni H, Bolton EL, Khan H, Shanks J, Bub G, Wang X, Paterson DJ, Zhang H, Galione A, Ebert SN, Terrar DA, Lei M.

Sci Rep. 2017 Jan 13;7:40687. doi: 10.1038/srep40687.

12.

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.

Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RVV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Williams A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM.

Wellcome Open Res. 2016 Nov 18;1:18. doi: 10.12688/wellcomeopenres.10036.2.

13.

Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels.

Rodrigues T, Sieglitz F, Somovilla VJ, Cal PM, Galione A, Corzana F, Bernardes GJ.

Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11077-81. doi: 10.1002/anie.201604336. Epub 2016 Jul 8.

14.

Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells.

Davis LC, Platt FM, Galione A.

Messenger (Los Angel). 2015 Jun;4(1):53-66.

15.

Two-Pore Channels: Lessons from Mutant Mouse Models.

Ruas M, Galione A, Parrington J.

Messenger (Los Angel). 2015 Jun;4(1):4-22.

16.

Carvedilol inhibits cADPR- and IP3-induced Ca2+ release.

Morgan AJ, Bampali K, Ruas M, Factor C, Back TG, Chen SRW, Galione A.

Messenger (Los Angel). 2016 Jun 1;5(1-2):92-99. doi: 10.1166/msr.2016.1050.

17.

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.

Cane MC, Parrington J, Rorsman P, Galione A, Rutter GA.

Cell Calcium. 2016 Jan;59(1):32-40. doi: 10.1016/j.ceca.2015.12.004. Epub 2015 Dec 23.

18.

Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca(2+) signaling during myogenesis in intact zebrafish.

Kelu JJ, Chan HL, Webb SE, Cheng AH, Ruas M, Parrington J, Galione A, Miller AL.

Int J Dev Biol. 2015;59(7-9):313-25. doi: 10.1387/ijdb.150206am.

19.

Intracellular sphingosine releases calcium from lysosomes.

Höglinger D, Haberkant P, Aguilera-Romero A, Riezman H, Porter FD, Platt FM, Galione A, Schultz C.

Elife. 2015 Nov 27;4. pii: e10616. doi: 10.7554/eLife.10616.

20.

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P.

J Clin Invest. 2015 Dec;125(12):4714-28. doi: 10.1172/JCI81975. Epub 2015 Nov 16.

21.

Ebolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes.

Simmons JA, D'Souza RS, Ruas M, Galione A, Casanova JE, White JM.

J Virol. 2015 Oct 14;90(1):605-10. doi: 10.1128/JVI.01828-15. Print 2016 Jan 1.

22.

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.

Capel RA, Bolton EL, Lin WK, Aston D, Wang Y, Liu W, Wang X, Burton RA, Bloor-Young D, Shade KT, Ruas M, Parrington J, Churchill GC, Lei M, Galione A, Terrar DA.

J Biol Chem. 2015 Dec 11;290(50):30087-98. doi: 10.1074/jbc.M115.684076. Epub 2015 Oct 5.

23.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248. Epub 2015 Jul 7.

24.

TPC: the NAADP discovery channel?

Morgan AJ, Davis LC, Ruas M, Galione A.

Biochem Soc Trans. 2015 Jun;43(3):384-9. doi: 10.1042/BST20140300. Review.

PMID:
26009180
25.

Reply to "TPC1 Knockout Knocks Out TPC1".

Ruas M, Galione A, Parrington J.

Mol Cell Biol. 2015 May;35(10):1884. doi: 10.1128/MCB.00083-15. No abstract available.

26.

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.

Ruas M, Davis LC, Chen CC, Morgan AJ, Chuang KT, Walseth TF, Grimm C, Garnham C, Powell T, Platt N, Platt FM, Biel M, Wahl-Schott C, Parrington J, Galione A.

EMBO J. 2015 Jul 2;34(13):1743-58. doi: 10.15252/embj.201490009. Epub 2015 Apr 14.

27.

Imaging approaches to measuring lysosomal calcium.

Morgan AJ, Davis LC, Galione A.

Methods Cell Biol. 2015;126:159-95. doi: 10.1016/bs.mcb.2014.10.031. Epub 2015 Jan 19.

PMID:
25665446
28.

Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.

Lin PH, Duann P, Komazaki S, Park KH, Li H, Sun M, Sermersheim M, Gumpper K, Parrington J, Galione A, Evans AM, Zhu MX, Ma J.

J Biol Chem. 2015 Feb 6;290(6):3377-89. doi: 10.1074/jbc.M114.608471. Epub 2014 Dec 5.

29.

A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells.

Galione A.

Cell Calcium. 2015 Jul;58(1):27-47. doi: 10.1016/j.ceca.2014.09.010. Epub 2014 Oct 7. Review.

PMID:
25449298
30.

The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption.

Cheng X, Hookway ES, Kashima T, Oppermann U, Galione A, Athanasou NA.

Calcif Tissue Int. 2015 Jan;96(1):73-9. doi: 10.1007/s00223-014-9939-3. Epub 2014 Nov 30.

31.

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.

Favia A, Desideri M, Gambara G, D'Alessio A, Ruas M, Esposito B, Del Bufalo D, Parrington J, Ziparo E, Palombi F, Galione A, Filippini A.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4706-15. doi: 10.1073/pnas.1406029111. Epub 2014 Oct 20.

32.

Synthesis of caged NAADP.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076943. doi: 10.1101/pdb.prot076943.

PMID:
25275103
33.

Measurement of luminal pH of acidic stores as a readout for NAADP action.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076935. doi: 10.1101/pdb.prot076935.

PMID:
25275102
34.

Synthesis of NAADP-AM as a membrane-permeant NAADP analog.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076927. doi: 10.1101/pdb.prot076927.

PMID:
25275101
35.

Identification of a novel gene for diabetic traits in rats, mice, and humans.

Tsaih SW, Holl K, Jia S, Kaldunski M, Tschannen M, He H, Andrae JW, Li SH, Stoddard A, Wiederhold A, Parrington J, Ruas da Silva M, Galione A, Meigs J; Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) Investigators, Hoffmann RG, Simpson P, Jacob H, Hessner M, Solberg Woods LC.

Genetics. 2014 Sep;198(1):17-29. doi: 10.1534/genetics.114.162982.

36.

Synthesis of [³²P]NAADP for the radioreceptor binding assay.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Sep 2;2014(9):993-5. doi: 10.1101/pdb.prot076919.

PMID:
25183813
37.

Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca²⁺ release.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Sep 2;2014(9):988-92. doi: 10.1101/pdb.prot076901.

PMID:
25183812
38.

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.

Ruas M, Chuang KT, Davis LC, Al-Douri A, Tynan PW, Tunn R, Teboul L, Galione A, Parrington J.

Mol Cell Biol. 2014 Nov;34(21):3981-92. doi: 10.1128/MCB.00113-14. Epub 2014 Aug 18.

39.

Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+.

Pitt SJ, Lam AK, Rietdorf K, Galione A, Sitsapesan R.

Sci Signal. 2014 May 20;7(326):ra46. doi: 10.1126/scisignal.2004854.

40.

Preparation and use of sea urchin egg homogenates.

Morgan AJ, Galione A.

Methods Mol Biol. 2014;1128:161-73. doi: 10.1007/978-1-62703-974-1_10.

PMID:
24567213
41.

'Click cyclic ADP-ribose': a neutral second messenger mimic.

Swarbrick JM, Graeff R, Garnham C, Thomas MP, Galione A, Potter BV.

Chem Commun (Camb). 2014 Mar 7;50(19):2458-61. doi: 10.1039/c3cc49249d. Epub 2014 Jan 23.

42.

Two-pore channels (TPCs): current controversies.

Morgan AJ, Galione A.

Bioessays. 2014 Feb;36(2):173-83. doi: 10.1002/bies.201300118. Epub 2013 Nov 26.

PMID:
24277557
43.

Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1.

Speak AO, Te Vruchte D, Davis LC, Morgan AJ, Smith DA, Yanjanin NM, Simmons L, Hartung R, Runz H, Mengel E, Beck M, Imrie J, Jacklin E, Wraith JE, Hendriksz C, Lachmann R, Cognet C, Sidhu R, Fujiwara H, Ory DS, Galione A, Porter FD, Vivier E, Platt FM.

Blood. 2014 Jan 2;123(1):51-60. doi: 10.1182/blood-2013-03-488692. Epub 2013 Nov 14.

44.

Hax-1 identified as a two-pore channel (TPC)-binding protein.

Lam AK, Galione A, Lai FA, Zissimopoulos S.

FEBS Lett. 2013 Nov 29;587(23):3782-6. doi: 10.1016/j.febslet.2013.10.031. Epub 2013 Nov 1.

45.

The endoplasmic reticulum and junctional membrane communication during calcium signaling.

Lam AK, Galione A.

Biochim Biophys Acta. 2013 Nov;1833(11):2542-59. doi: 10.1016/j.bbamcr.2013.06.004. Epub 2013 Jun 13. Review.

46.

Cytolytic granules supply Ca(2+) for their own exocytosis via NAADP and resident two-pore channels.

Davis LC, Galione A.

Commun Integr Biol. 2013 May 1;6(3):e24175. doi: 10.4161/cib.24175. Epub 2013 Apr 9.

47.

Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles.

Morgan AJ, Davis LC, Wagner SK, Lewis AM, Parrington J, Churchill GC, Galione A.

J Cell Biol. 2013 Mar 18;200(6):789-805. doi: 10.1083/jcb.201204078. Epub 2013 Mar 11.

48.

NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

Davis LC, Morgan AJ, Chen JL, Snead CM, Bloor-Young D, Shenderov E, Stanton-Humphreys MN, Conway SJ, Churchill GC, Parrington J, Cerundolo V, Galione A.

Curr Biol. 2012 Dec 18;22(24):2331-7. doi: 10.1016/j.cub.2012.10.035. Epub 2012 Nov 21.

49.

The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release.

Morgan AJ, Parrington J, Galione A.

Cell Calcium. 2012 Dec;52(6):481-7. doi: 10.1016/j.ceca.2012.09.001. Epub 2012 Oct 23.

50.

β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.

Lewis AM, Aley PK, Roomi A, Thomas JM, Masgrau R, Garnham C, Shipman K, Paramore C, Bloor-Young D, Sanders LE, Terrar DA, Galione A, Churchill GC.

Biochem Biophys Res Commun. 2012 Oct 19;427(2):326-9. doi: 10.1016/j.bbrc.2012.09.054. Epub 2012 Sep 18.

PMID:
22995315

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