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Items: 1 to 50 of 88

1.

Reconstitution of the Steroid Receptor Heterocomplex.

Mazaira GI, Galigniana MD.

Methods Mol Biol. 2019;1966:125-135. doi: 10.1007/978-1-4939-9195-2_10.

PMID:
31041743
2.

Nuclear Receptors: A Historical Perspective.

Mazaira GI, Zgajnar NR, Lotufo CM, Daneri-Becerra C, Sivils JC, Soto OB, Cox MB, Galigniana MD.

Methods Mol Biol. 2019;1966:1-5. doi: 10.1007/978-1-4939-9195-2_1.

PMID:
31041734
3.

Heme Oxygenase 1 Impairs Glucocorticoid Receptor Activity in Prostate Cancer.

Leonardi DB, Anselmino N, Brandani JN, Jaworski FM, Páez AV, Mazaira G, Meiss RP, Nuñez M, Nemirovsky SI, Giudice J, Galigniana M, Pecci A, Gueron G, Vazquez E, Cotignola J.

Int J Mol Sci. 2019 Feb 26;20(5). pii: E1006. doi: 10.3390/ijms20051006.

4.

Biological Actions of the Hsp90-binding Immunophilins FKBP51 and FKBP52

Zgajnar NR, De Leo SA, Lotufo CM, Erlejman AG, Piwien-Pilipuk G, Galigniana MD.

Biomolecules. 2019 Feb 1;9(2). pii: E52. doi: 10.3390/biom9020052. Review.

5.

Fe3 O4 nanoparticles mediated synthesis of novel spirooxindole-dihydropyrimidinone molecules as Hsp90 inhibitors.

Maddela S, Makula A, Galigniana MD, Parambi DGT, Federicci F, Mazaira G, Hendawy OM, Dev S, Mathew GE, Mathew B.

Arch Pharm (Weinheim). 2019 Jan;352(1):e1800174. doi: 10.1002/ardp.201800174. Epub 2018 Nov 28.

PMID:
30485473
6.

The Nuclear Receptor Field: A Historical Overview and Future Challenges.

Mazaira GI, Zgajnar NR, Lotufo CM, Daneri-Becerra C, Sivils JC, Soto OB, Cox MB, Galigniana MD.

Nucl Receptor Res. 2018;5. pii: 101320. doi: 10.11131/2018/101320. Epub 2018 Jul 26.

7.

Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90.

Mazaira GI, Daneri-Becerra C, Zgajnar NR, Lotufo CM, Galigniana MD.

Biochem Soc Trans. 2018 Feb 19;46(1):51-65. doi: 10.1042/BST20170335. Epub 2017 Dec 22. Review.

PMID:
29273620
8.

Functional interaction between co-expressed MAGE-A proteins.

Laiseca JE, Ladelfa MF, Cotignola J, Peche LY, Pascucci FA, Castaño BA, Galigniana MD, Schneider C, Monte M.

PLoS One. 2017 May 24;12(5):e0178370. doi: 10.1371/journal.pone.0178370. eCollection 2017.

9.

Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity.

Lagadari M, Zgajnar NR, Gallo LI, Galigniana MD.

Mol Oncol. 2016 Aug;10(7):1086-98. doi: 10.1016/j.molonc.2016.05.002. Epub 2016 May 17.

10.

Editorial: Immunophilins, Protein Chemistry and Cell Biology of a Promising New Class of Drug Targets - Part II.

Galigniana MD.

Curr Mol Pharmacol. 2016;9(2):97-8. No abstract available.

PMID:
26654092
11.

Editorial: Immunophilins, Protein Chemistry and Cell Biology of a Promising New Class of Drug Targets - Part I.

Galigniana MD.

Curr Mol Pharmacol. 2015;9(1):3-4. No abstract available.

PMID:
26653049
12.

Synthetic stigmastanes with dual antiherpetic and immunomodulating activities inhibit ERK and Akt signaling pathways without binding to glucocorticoid receptors.

Michelini FM, Bueno CA, Molinari AM, Galigniana MD, Galagovsky LR, Alché LE, Ramírez JA.

Biochim Biophys Acta. 2016 Jan;1860(1 Pt A):129-39. doi: 10.1016/j.bbagen.2015.10.024. Epub 2015 Oct 28.

PMID:
26518349
13.

Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1.

Dávola ME, Mazaira GI, Galigniana MD, Alché LE, Ramírez JA, Barquero AA.

Antiviral Res. 2015 Oct;122:55-63. doi: 10.1016/j.antiviral.2015.08.002. Epub 2015 Aug 8.

PMID:
26259812
14.

Molecular docking study, synthesis and biological evaluation of Mannich bases as Hsp90 inhibitors.

Gupta SD, Bommaka MK, Mazaira GI, Galigniana MD, Subrahmanyam CV, Gowrishankar NL, Raghavendra NM.

Int J Biol Macromol. 2015 Sep;80:253-9. doi: 10.1016/j.ijbiomac.2015.06.039. Epub 2015 Jun 24.

PMID:
26116388
15.

Regulation of NF-κB signalling cascade by immunophilins.

Lagadari M, De Leo SA, Camisay MF, Galigniana MD, Erlejman AG.

Curr Mol Pharmacol. 2016;9(2):99-108. Review.

PMID:
25986566
16.

Biological relevance of Hsp90-binding immunophilins in cancer development and treatment.

Mazaira GI, Camisay MF, De Leo S, Erlejman AG, Galigniana MD.

Int J Cancer. 2016 Feb 15;138(4):797-808. doi: 10.1002/ijc.29509. Epub 2015 Mar 24. Review.

17.

2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: rational identification of a new anticancer lead.

Dutta Gupta S, Revathi B, Mazaira GI, Galigniana MD, Subrahmanyam CV, Gowrishankar NL, Raghavendra NM.

Bioorg Chem. 2015 Apr;59:97-105. doi: 10.1016/j.bioorg.2015.02.003. Epub 2015 Feb 14.

PMID:
25727264
18.

Functions of the Hsp90-binding FKBP immunophilins.

Guy NC, Garcia YA, Sivils JC, Galigniana MD, Cox MB.

Subcell Biochem. 2015;78:35-68. doi: 10.1007/978-3-319-11731-7_2. Review.

PMID:
25487015
19.

NF-κB transcriptional activity is modulated by FK506-binding proteins FKBP51 and FKBP52: a role for peptidyl-prolyl isomerase activity.

Erlejman AG, De Leo SA, Mazaira GI, Molinari AM, Camisay MF, Fontana V, Cox MB, Piwien-Pilipuk G, Galigniana MD.

J Biol Chem. 2014 Sep 19;289(38):26263-76. doi: 10.1074/jbc.M114.582882. Epub 2014 Aug 7.

20.

The biology of molecular chaperones--very complex activities for quite simple proteins.

Galigniana MD.

Curr Protein Pept Sci. 2014 May;15(3):169-70. No abstract available.

PMID:
24766259
21.

Molecular chaperone activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52.

Erlejman AG, Lagadari M, Harris DC, Cox MB, Galigniana MD.

Curr Protein Pept Sci. 2014 May;15(3):205-15. Review.

PMID:
24694367
22.

Molecular docking study, synthesis and biological evaluation of Schiff bases as Hsp90 inhibitors.

Dutta Gupta S, Snigdha D, Mazaira GI, Galigniana MD, Subrahmanyam CV, Gowrishankar NL, Raghavendra NM.

Biomed Pharmacother. 2014 Apr;68(3):369-76. doi: 10.1016/j.biopha.2014.01.003. Epub 2014 Jan 15.

PMID:
24486109
23.

Regulatory role of the 90-kDa-heat-shock protein (Hsp90) and associated factors on gene expression.

Erlejman AG, Lagadari M, Toneatto J, Piwien-Pilipuk G, Galigniana MD.

Biochim Biophys Acta. 2014 Feb;1839(2):71-87. doi: 10.1016/j.bbagrm.2013.12.006. Epub 2014 Jan 3. Review.

PMID:
24389346
24.

Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation.

Toneatto J, Guber S, Charó NL, Susperreguy S, Schwartz J, Galigniana MD, Piwien-Pilipuk G.

J Cell Sci. 2013 Dec 1;126(Pt 23):5357-68. doi: 10.1242/jcs.125799. Epub 2013 Oct 7.

25.

Molecular basis of mineralocorticoid receptor action in the nervous system.

Molinari AM, Machado-Rada MY, Mazaira GI, Erlejman AG, Galigniana MD.

CNS Neurol Disord Drug Targets. 2013 Dec;12(8):1163-74. Review.

PMID:
24040819
26.

Steroid-dependent management of biological responses in the nervous system.

Galigniana MD.

CNS Neurol Disord Drug Targets. 2013 Dec;12(8):1143-5. No abstract available.

PMID:
24040814
27.

Hsp90-binding immunophilins as a potential new platform for drug treatment.

Erlejman AG, Lagadari M, Galigniana MD.

Future Med Chem. 2013 Apr;5(5):591-607. doi: 10.4155/fmc.13.7. Review.

PMID:
23573975
28.
29.

Steroid receptor coupling becomes nuclear.

Galigniana MD.

Chem Biol. 2012 Jun 22;19(6):662-3. doi: 10.1016/j.chembiol.2012.06.001.

30.

Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51.

Galigniana NM, Ballmer LT, Toneatto J, Erlejman AG, Lagadari M, Galigniana MD.

J Neurochem. 2012 Jul;122(1):4-18. doi: 10.1111/j.1471-4159.2012.07775.x. Epub 2012 May 21. Review.

31.

The neuroregenerative mechanism mediated by the Hsp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation.

Quintá HR, Galigniana MD.

Br J Pharmacol. 2012 May;166(2):637-49. doi: 10.1111/j.1476-5381.2011.01783.x.

32.

FKBP51 and FKBP52 in signaling and disease.

Storer CL, Dickey CA, Galigniana MD, Rein T, Cox MB.

Trends Endocrinol Metab. 2011 Dec;22(12):481-90. doi: 10.1016/j.tem.2011.08.001. Epub 2011 Aug 31. Review.

33.

Management of cytoskeleton architecture by molecular chaperones and immunophilins.

Quintá HR, Galigniana NM, Erlejman AG, Lagadari M, Piwien-Pilipuk G, Galigniana MD.

Cell Signal. 2011 Dec;23(12):1907-20. doi: 10.1016/j.cellsig.2011.07.023. Epub 2011 Aug 12. Review.

34.

The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress.

Gallo LI, Lagadari M, Piwien-Pilipuk G, Galigniana MD.

J Biol Chem. 2011 Aug 26;286(34):30152-60. doi: 10.1074/jbc.M111.256610. Epub 2011 Jul 5.

35.

System among the corticosteroids: specificity and molecular dynamics.

Brookes JC, Galigniana MD, Harker AH, Stoneham AM, Vinson GP.

J R Soc Interface. 2012 Jan 7;9(66):43-53. doi: 10.1098/rsif.2011.0183. Epub 2011 May 25.

36.

Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52).

Sivils JC, Storer CL, Galigniana MD, Cox MB.

Curr Opin Pharmacol. 2011 Aug;11(4):314-9. doi: 10.1016/j.coph.2011.03.010. Epub 2011 Apr 19. Review.

37.

Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore.

Galigniana MD, Echeverría PC, Erlejman AG, Piwien-Pilipuk G.

Nucleus. 2010 Jul-Aug;1(4):299-308. doi: 10.4161/nucl.1.4.11743.

38.

Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth.

Quintá HR, Maschi D, Gomez-Sanchez C, Piwien-Pilipuk G, Galigniana MD.

J Neurochem. 2010 Nov;115(3):716-34. doi: 10.1111/j.1471-4159.2010.06970.x. Epub 2010 Sep 28.

39.

The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events.

Galigniana MD, Erlejman AG, Monte M, Gomez-Sanchez C, Piwien-Pilipuk G.

Mol Cell Biol. 2010 Mar;30(5):1285-98. doi: 10.1128/MCB.01190-09. Epub 2009 Dec 28.

40.

Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.

Echeverría PC, Mazaira G, Erlejman A, Gomez-Sanchez C, Piwien Pilipuk G, Galigniana MD.

Mol Cell Biol. 2009 Sep;29(17):4788-97. doi: 10.1128/MCB.00649-09. Epub 2009 Jul 6.

42.

The p160 nuclear receptor co-activator RAC3 exerts an anti-apoptotic role through a cytoplasmatic action.

Colo GP, Rubio MF, Nojek IM, Werbajh SE, Echeverría PC, Alvarado CV, Nahmod VE, Galigniana MD, Costas MA.

Oncogene. 2008 Apr 10;27(17):2430-44. Epub 2007 Oct 29.

PMID:
17968310
43.

Evidence for NL1-independent nuclear translocation of the mineralocorticoid receptor.

Piwien Pilipuk G, Vinson GP, Sanchez CG, Galigniana MD.

Biochemistry. 2007 Feb 6;46(5):1389-97.

PMID:
17260968
44.

Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced, and bind HSP90.

Aviezer-Hagai K, Skovorodnikova J, Galigniana M, Farchi-Pisanty O, Maayan E, Bocovza S, Efrat Y, von Koskull-Döring P, Ohad N, Breiman A.

Plant Mol Biol. 2007 Jan;63(2):237-55. Epub 2006 Nov 2.

PMID:
17080288
45.

Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes.

Presman DM, Hoijman E, Ceballos NR, Galigniana MD, Pecci A.

Endocrinology. 2006 Nov;147(11):5452-9. Epub 2006 Aug 17.

PMID:
16916958
46.

Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation.

Salatino M, Beguelin W, Peters MG, Carnevale R, Proietti CJ, Galigniana MD, Vedoy CG, Schillaci R, Charreau EH, Sogayar MC, Elizalde PV.

Oncogene. 2006 Dec 14;25(59):7723-39. Epub 2006 Jun 26.

PMID:
16799639
47.

Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex.

Galigniana MD, Morishima Y, Gallay PA, Pratt WB.

J Biol Chem. 2004 Dec 31;279(53):55754-9. Epub 2004 Oct 20.

48.

Evidence for glucocorticoid receptor transport on microtubules by dynein.

Harrell JM, Murphy PJ, Morishima Y, Chen H, Mansfield JF, Galigniana MD, Pratt WB.

J Biol Chem. 2004 Dec 24;279(52):54647-54. Epub 2004 Oct 13.

49.

Role of molecular chaperones in steroid receptor action.

Pratt WB, Galigniana MD, Morishima Y, Murphy PJ.

Essays Biochem. 2004;40:41-58. Review.

PMID:
15242338

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