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Items: 48


Manipulation of Salmonella Typhi Gene Expression Impacts Innate Cell Responses in the Human Intestinal Mucosa.

Salerno-Gonçalves R, Galen JE, Levine MM, Fasano A, Sztein MB.

Front Immunol. 2018 Nov 1;9:2543. doi: 10.3389/fimmu.2018.02543. eCollection 2018.


Overexpression of O-polysaccharide chain length regulators in Gram-negative bacteria using the Wzx-/Wzy-dependent pathway enhances production of defined modal length O-polysaccharide polymers for use as haptens in glycoconjugate vaccines.

Hegerle N, Bose J, Ramachandran G, Galen JE, Levine MM, Simon R, Tennant SM.

J Appl Microbiol. 2018 Aug;125(2):575-585. doi: 10.1111/jam.13772. Epub 2018 May 15.


Development of a glycoconjugate vaccine to prevent invasive Salmonella Typhimurium infections in sub-Saharan Africa.

Baliban SM, Yang M, Ramachandran G, Curtis B, Shridhar S, Laufer RS, Wang JY, Van Druff J, Higginson EE, Hegerle N, Varney KM, Galen JE, Tennant SM, Lees A, MacKerell AD Jr, Levine MM, Simon R.

PLoS Negl Trop Dis. 2017 Apr 7;11(4):e0005493. doi: 10.1371/journal.pntd.0005493. eCollection 2017 Apr.


Live Attenuated Human Salmonella Vaccine Candidates: Tracking the Pathogen in Natural Infection and Stimulation of Host Immunity.

Galen JE, Buskirk AD, Tennant SM, Pasetti MF.

EcoSal Plus. 2016 Nov;7(1). doi: 10.1128/ecosalplus.ESP-0010-2016. Review.


Opsonophagocytic Assay To Evaluate Immunogenicity of Nontyphoidal Salmonella Vaccines.

Ramachandran G, Boyd MA, MacSwords J, Higginson EE, Simon R, Galen JE, Pasetti MF, Levine MM, Tennant SM.

Clin Vaccine Immunol. 2016 Jun 6;23(6):520-523. doi: 10.1128/CVI.00106-16. Print 2016 Jun.


Refined live attenuated Salmonella enterica serovar Typhimurium and Enteritidis vaccines mediate homologous and heterologous serogroup protection in mice.

Tennant SM, Schmidlein P, Simon R, Pasetti MF, Galen JE, Levine MM.

Infect Immun. 2015 Dec;83(12):4504-12. doi: 10.1128/IAI.00924-15. Epub 2015 Sep 8.


Adaptation of red blood cell lysis represents a fundamental breakthrough that improves the sensitivity of Salmonella detection in blood.

Boyd MA, Tennant SM, Melendez JH, Toema D, Galen JE, Geddes CD, Levine MM.

J Appl Microbiol. 2015 May;118(5):1199-209. doi: 10.1111/jam.12769. Epub 2015 Mar 12.


A bivalent typhoid live vector vaccine expressing both chromosome- and plasmid-encoded Yersinia pestis antigens fully protects against murine lethal pulmonary plague infection.

Galen JE, Wang JY, Carrasco JA, Lloyd SA, Mellado-Sanchez G, Diaz-McNair J, Franco O, Buskirk AD, Nataro JP, Pasetti MF.

Infect Immun. 2015 Jan;83(1):161-72. doi: 10.1128/IAI.02443-14. Epub 2014 Oct 20.


Serum bactericidal assays to evaluate typhoidal and nontyphoidal Salmonella vaccines.

Boyd MA, Tennant SM, Saague VA, Simon R, Muhsen K, Ramachandran G, Cross AS, Galen JE, Pasetti MF, Levine MM.

Clin Vaccine Immunol. 2014 May;21(5):712-21. doi: 10.1128/CVI.00115-14. Epub 2014 Mar 12.


The delicate balance in genetically engineering live vaccines.

Galen JE, Curtiss R 3rd.

Vaccine. 2014 Jul 31;32(35):4376-85. doi: 10.1016/j.vaccine.2013.12.026. Epub 2013 Dec 23. Review.


Sustained protection in mice immunized with fractional doses of Salmonella Enteritidis core and O polysaccharide-flagellin glycoconjugates.

Simon R, Wang JY, Boyd MA, Tulapurkar ME, Ramachandran G, Tennant SM, Pasetti M, Galen JE, Levine MM.

PLoS One. 2013 May 31;8(5):e64680. doi: 10.1371/journal.pone.0064680. Print 2013.


Novel methods for expression of foreign antigens in live vector vaccines.

Wang JY, Harley RH, Galen JE.

Hum Vaccin Immunother. 2013 Jul;9(7):1558-64. doi: 10.4161/hv.23248. Epub 2013 Feb 13.


Characterization of systemic and pneumonic murine models of plague infection using a conditionally virulent strain.

Mellado-Sanchez G, Ramirez K, Drachenberg CB, Diaz-McNair J, Rodriguez AL, Galen JE, Nataro JP, Pasetti MF.

Comp Immunol Microbiol Infect Dis. 2013 Mar;36(2):113-28. doi: 10.1016/j.cimid.2012.10.005. Epub 2012 Nov 26.


Cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines.

Gat O, Galen JE, Tennant S, Simon R, Blackwelder WC, Silverman DJ, Pasetti MF, Levine MM.

PLoS Negl Trop Dis. 2011 Nov;5(11):e1373. doi: 10.1371/journal.pntd.0001373. Epub 2011 Nov 1.


Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving as live oral vaccines and as reagent strains.

Tennant SM, Wang JY, Galen JE, Simon R, Pasetti MF, Gat O, Levine MM.

Infect Immun. 2011 Oct;79(10):4175-85. doi: 10.1128/IAI.05278-11. Epub 2011 Aug 1.


Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidis.

Simon R, Tennant SM, Wang JY, Schmidlein PJ, Lees A, Ernst RK, Pasetti MF, Galen JE, Levine MM.

Infect Immun. 2011 Oct;79(10):4240-9. doi: 10.1128/IAI.05484-11. Epub 2011 Aug 1.


Mouse models to assess the efficacy of non-typhoidal Salmonella vaccines: revisiting the role of host innate susceptibility and routes of challenge.

Simon R, Tennant SM, Galen JE, Levine MM.

Vaccine. 2011 Jul 18;29(32):5094-106. doi: 10.1016/j.vaccine.2011.05.022. Epub 2011 May 25. Review.


Ultra-fast and sensitive detection of non-typhoidal Salmonella using microwave-accelerated metal-enhanced fluorescence ("MAMEF").

Tennant SM, Zhang Y, Galen JE, Geddes CD, Levine MM.

PLoS One. 2011 Apr 8;6(4):e18700. doi: 10.1371/journal.pone.0018700.


Identification by PCR of non-typhoidal Salmonella enterica serovars associated with invasive infections among febrile patients in Mali.

Tennant SM, Diallo S, Levy H, Livio S, Sow SO, Tapia M, Fields PI, Mikoleit M, Tamboura B, Kotloff KL, Nataro JP, Galen JE, Levine MM.

PLoS Negl Trop Dis. 2010 Mar 9;4(3):e621. doi: 10.1371/journal.pntd.0000621.


A new generation of stable, nonantibiotic, low-copy-number plasmids improves immune responses to foreign antigens in Salmonella enterica serovar Typhi live vectors.

Galen JE, Wang JY, Chinchilla M, Vindurampulle C, Vogel JE, Levy H, Blackwelder WC, Pasetti MF, Levine MM.

Infect Immun. 2010 Jan;78(1):337-47. doi: 10.1128/IAI.00916-09. Epub 2009 Nov 2.


Salmonella enterica serovar Typhi live vector vaccines finally come of age.

Galen JE, Pasetti MF, Tennant S, Ruiz-Olvera P, Sztein MB, Levine MM.

Immunol Cell Biol. 2009 Jul;87(5):400-12. doi: 10.1038/icb.2009.31. Epub 2009 May 5. Review.


Mucosal immunization with attenuated Salmonella enterica serovar Typhi expressing protective antigen of anthrax toxin (PA83) primes monkeys for accelerated serum antibody responses to parenteral PA83 vaccine.

Galen JE, Chinchilla M, Pasetti MF, Wang JY, Zhao L, Arciniega-Martinez I, Silverman DJ, Levine MM.

J Infect Dis. 2009 Feb 1;199(3):326-35. doi: 10.1086/596066.


Use of mchI encoding immunity to the antimicrobial peptide microcin H47 as a plasmid selection marker in attenuated bacterial live vectors.

Fang CM, Wang JY, Chinchilla M, Levine MM, Blackwelder WC, Galen JE.

Infect Immun. 2008 Oct;76(10):4422-30. doi: 10.1128/IAI.00487-08. Epub 2008 Jul 28.


PCR method to identify Salmonella enterica serovars Typhi, Paratyphi A, and Paratyphi B among Salmonella Isolates from the blood of patients with clinical enteric fever.

Levy H, Diallo S, Tennant SM, Livio S, Sow SO, Tapia M, Fields PI, Mikoleit M, Tamboura B, Kotloff KL, Lagos R, Nataro JP, Galen JE, Levine MM.

J Clin Microbiol. 2008 May;46(5):1861-6. doi: 10.1128/JCM.00109-08. Epub 2008 Mar 26.


Enhanced immunity to Plasmodium falciparum circumsporozoite protein (PfCSP) by using Salmonella enterica serovar Typhi expressing PfCSP and a PfCSP-encoding DNA vaccine in a heterologous prime-boost strategy.

Chinchilla M, Pasetti MF, Medina-Moreno S, Wang JY, Gomez-Duarte OG, Stout R, Levine MM, Galen JE.

Infect Immun. 2007 Aug;75(8):3769-79. Epub 2007 May 14.


Oral administration of a Salmonella enterica-based vaccine expressing Bacillus anthracis protective antigen confers protection against aerosolized B. anthracis.

Stokes MG, Titball RW, Neeson BN, Galen JE, Walker NJ, Stagg AJ, Jenner DC, Thwaite JE, Nataro JP, Baillie LW, Atkins HS.

Infect Immun. 2007 Apr;75(4):1827-34. Epub 2006 Dec 4.


Properties of haemolysin E (HlyE) from a pathogenic Escherichia coli avian isolate and studies of HlyE export.

Wyborn NR, Clark A, Roberts RE, Jamieson SJ, Tzokov S, Bullough PA, Stillman TJ, Artymiuk PJ, Galen JE, Zhao L, Levine MM, Green J.

Microbiology. 2004 May;150(Pt 5):1495-505.


Fitness cost of the green fluorescent protein in gastrointestinal bacteria.

Rang C, Galen JE, Kaper JB, Chao L.

Can J Microbiol. 2003 Sep;49(9):531-7.


Can a 'flawless' live vector vaccine strain be engineered?

Galen JE, Levine MM.

Trends Microbiol. 2001 Aug;9(8):372-6.


Construction, genotypic and phenotypic characterization, and immunogenicity of attenuated DeltaguaBA Salmonella enterica serovar Typhi strain CVD 915.

Wang JY, Pasetti MF, Noriega FR, Anderson RJ, Wasserman SS, Galen JE, Sztein MB, Levine MM.

Infect Immun. 2001 Aug;69(8):4734-41.


Optimization of plasmid maintenance in the attenuated live vector vaccine strain Salmonella typhi CVD 908-htrA.

Galen JE, Nair J, Wang JY, Wasserman SS, Tanner MK, Sztein MB, Levine MM.

Infect Immun. 1999 Dec;67(12):6424-33.


A murine model of intranasal immunization to assess the immunogenicity of attenuated Salmonella typhi live vector vaccines in stimulating serum antibody responses to expressed foreign antigens.

Galen JE, Gomez-Duarte OG, Losonsky GA, Halpern JL, Lauderbaugh CS, Kaintuck S, Reymann MK, Levine MM.

Vaccine. 1997 Apr-May;15(6-7):700-8.


CVD110, an attenuated Vibrio cholerae O1 El Tor live oral vaccine strain.

Michalski J, Galen JE, Fasano A, Kaper JB.

Infect Immun. 1993 Oct;61(10):4462-8.


Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae virulence cassette.

Trucksis M, Galen JE, Michalski J, Fasano A, Kaper JB.

Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5267-71.


Role of Vibrio cholerae neuraminidase in the function of cholera toxin.

Galen JE, Ketley JM, Fasano A, Richardson SH, Wasserman SS, Kaper JB.

Infect Immun. 1992 Feb;60(2):406-15.


Development and testing of a synthetic oligonucleotide probe for the detection of pathogenic Yersinia strains.

Miliotis MD, Galen JE, Kaper JB, Morris JG Jr.

J Clin Microbiol. 1989 Jul;27(7):1667-70.


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