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Items: 19


Continuation of Newly Initiated Midodrine Therapy: Appropriate in Patients With Heart Failure?

Reed BN, Gale SE, Ramani G.

Crit Care Med. 2019 Oct;47(10):e845. doi: 10.1097/CCM.0000000000003914. No abstract available.


An aspirin a day? Clinical utility of aspirin therapy for the primary prevention of cardiovascular disease.

Plazak ME, Mouradjian MT, Watson K, Reed BN, Noel ZR, Devabhakthuni S, Gale SE.

Expert Rev Cardiovasc Ther. 2019 Aug;17(8):561-573. doi: 10.1080/14779072.2019.1642108. Epub 2019 Jul 18.


2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease.

Davidson J, Molitor E, Moores S, Gale SE, Subramanian K, Jiang X, Sidhu R, Kell P, Zhang J, Fujiwara H, Davidson C, Helquist P, Melancon BJ, Grigalunas M, Liu G, Salahi F, Wiest O, Xu X, Porter FD, Pipalia NH, Cruz DL, Holson EB, Schaffer JE, Walkley SU, Maxfield FR, Ory DS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1545-1561. doi: 10.1016/j.bbalip.2019.04.011. Epub 2019 Apr 30.


Alemtuzumab Induction Versus Conventional Immunosuppression in Heart Transplant Recipients.

Gale SE, Ravichandran B, Ton VK, Pham S, Reed BN.

J Cardiovasc Pharmacol Ther. 2019 Sep;24(5):435-441. doi: 10.1177/1074248419841635. Epub 2019 Apr 29.


Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking.

Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE.

J Lipid Res. 2019 Mar;60(3):707-716. doi: 10.1194/jlr.D091470. Epub 2019 Jan 7.


Antihyperglycemic Medications and Impact on Cardiovascular Outcomes: A Review of Current Evidence.

Gale SE, Poon JL, Watson K.

Pharmacotherapy. 2018 May 25. doi: 10.1002/phar.2128. [Epub ahead of print] Review.


Development of a bile acid-based newborn screen for Niemann-Pick disease type C.

Jiang X, Sidhu R, Mydock-McGrane L, Hsu FF, Covey DF, Scherrer DE, Earley B, Gale SE, Farhat NY, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Reunert J, Marquardt T, Runz H, Giugliani R, Schaffer JE, Ory DS.

Sci Transl Med. 2016 May 4;8(337):337ra63. doi: 10.1126/scitranslmed.aaf2326.


A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.

Iaea DB, Gale SE, Bielska AA, Krishnan K, Fujiwara H, Jiang H, Maxfield FR, Schlesinger PH, Covey DF, Schaffer JE, Ory DS.

J Lipid Res. 2015 Dec;56(12):2408-19. doi: 10.1194/jlr.D064287. Epub 2015 Oct 24.


snoRNA U17 regulates cellular cholesterol trafficking.

Jinn S, Brandis KA, Ren A, Chacko A, Dudley-Rucker N, Gale SE, Sidhu R, Fujiwara H, Jiang H, Olsen BN, Schaffer JE, Ory DS.

Cell Metab. 2015 Jun 2;21(6):855-67. doi: 10.1016/j.cmet.2015.04.010. Epub 2015 May 14.


Ombitasvir/paritaprevir/ritonavir and dasabuvir tablets for hepatitis C virus genotype 1 infection.

Klibanov OM, Gale SE, Santevecchi B.

Ann Pharmacother. 2015 May;49(5):566-81. doi: 10.1177/1060028015570729. Epub 2015 Feb 13. Review.


Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling.

Bielska AA, Olsen BN, Gale SE, Mydock-McGrane L, Krishnan K, Baker NA, Schlesinger PH, Covey DF, Ory DS.

Biochemistry. 2014 May 13;53(18):3042-51. doi: 10.1021/bi5000096. Epub 2014 May 1.


Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease.

Porter FD, Scherrer DE, Lanier MH, Langmade SJ, Molugu V, Gale SE, Olzeski D, Sidhu R, Dietzen DJ, Fu R, Wassif CA, Yanjanin NM, Marso SP, House J, Vite C, Schaffer JE, Ory DS.

Sci Transl Med. 2010 Nov 3;2(56):56ra81. doi: 10.1126/scitranslmed.3001417.


Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions.

Gale SE, Westover EJ, Dudley N, Krishnan K, Merlin S, Scherrer DE, Han X, Zhai X, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, Ory DS.

J Biol Chem. 2009 Jan 16;284(3):1755-64. doi: 10.1074/jbc.M807210200. Epub 2008 Nov 6.


Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding.

Gelsthorpe ME, Baumann N, Millard E, Gale SE, Langmade SJ, Schaffer JE, Ory DS.

J Biol Chem. 2008 Mar 28;283(13):8229-36. doi: 10.1074/jbc.M708735200. Epub 2008 Jan 23.


Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death.

Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, Schaffer JE.

J Lipid Res. 2006 Dec;47(12):2726-37. Epub 2006 Sep 7.


Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.

Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13807-12. Epub 2006 Aug 29.


A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.

Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS.

J Biol Chem. 2006 Apr 21;281(16):11082-9. Epub 2006 Feb 22.


The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol.

Millard EE, Gale SE, Dudley N, Zhang J, Schaffer JE, Ory DS.

J Biol Chem. 2005 Aug 5;280(31):28581-90. Epub 2005 May 20.


Metal complexes of anti-inflammatory drugs. Part VIII: Suprofen complex of copper(II).

Underhill AE, Bougourd SA, Flugge ML, Gale SE, Gomm PS.

J Inorg Biochem. 1993 Nov 1;52(2):139-44.


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