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Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct.

Voronina VA, Harris FM, Schmahl J, Galligan C, Oristian D, Zamfirova R, Gong G, Bai Y, Fury W, Rajamani S, Walls JR, Poueymirou WT, Esau L, Gale NW, Auerbach W, Murphy AJ, Macdonald LE.

Biol Reprod. 2019 Mar 1;100(3):686-696. doi: 10.1093/biolre/ioy210.


Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature.

Takahashi K, Kim R, Lauhan C, Park Y, Nguyen NG, Vestweber D, Dominguez MG, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW, Takahashi T.

PLoS One. 2017 May 25;12(5):e0177192. doi: 10.1371/journal.pone.0177192. eCollection 2017.


Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1.

Johnson LA, Banerji S, Lawrance W, Gileadi U, Prota G, Holder KA, Roshorm YM, Hanke T, Cerundolo V, Gale NW, Jackson DG.

Nat Immunol. 2017 Jul;18(7):762-770. doi: 10.1038/ni.3750. Epub 2017 May 15.


EphA5 and EphA6: regulation of neuronal and spine morphology.

Das G, Yu Q, Hui R, Reuhl K, Gale NW, Zhou R.

Cell Biosci. 2016 Aug 2;6:48. doi: 10.1186/s13578-016-0115-5. eCollection 2016.


Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice.

Mastaitis J, Eckersdorff M, Min S, Xin Y, Cavino K, Aglione J, Okamoto H, Na E, Stitt T, Dominguez MG, Schmahl JP, Lin C, Gale NW, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J.

Endocrinology. 2015 Dec;156(12):4502-10. doi: 10.1210/en.2015-1257. Epub 2015 Sep 25.


GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

Mastaitis J, Min S, Elvert R, Kannt A, Xin Y, Ochoa F, Gale NW, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1845-9. doi: 10.1073/pnas.1424968112. Epub 2015 Jan 26.


A lymphatic defect causes ocular hypertension and glaucoma in mice.

Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, Onay T, Chen H, Yamaguchi S, Economides AN, Flenniken A, Gale NW, Hong YK, Fawzi A, Liu X, Kume T, Quaggin SE.

J Clin Invest. 2014 Oct;124(10):4320-4. doi: 10.1172/JCI77162. Epub 2014 Sep 9.


EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.

Miao H, Gale NW, Guo H, Qian J, Petty A, Kaspar J, Murphy AJ, Valenzuela DM, Yancopoulos G, Hambardzumyan D, Lathia JD, Rich JN, Lee J, Wang B.

Oncogene. 2015 Jan 29;34(5):558-67. doi: 10.1038/onc.2013.590. Epub 2014 Feb 3.


Design and implementation of a custom built optical projection tomography system.

Wong MD, Dazai J, Walls JR, Gale NW, Henkelman RM.

PLoS One. 2013 Sep 4;8(9):e73491. doi: 10.1371/journal.pone.0073491. eCollection 2013.


Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.

Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Harland RM, Loots GG.

Dev Biol. 2013 Nov 1;383(1):90-105. doi: 10.1016/j.ydbio.2013.08.015. Epub 2013 Aug 29.


Conditionals by inversion provide a universal method for the generation of conditional alleles.

Economides AN, Frendewey D, Yang P, Dominguez MG, Dore AT, Lobov IB, Persaud T, Rojas J, McClain J, Lengyel P, Droguett G, Chernomorsky R, Stevens S, Auerbach W, Dechiara TM, Pouyemirou W, Cruz JM Jr, Feeley K, Mellis IA, Yasenchack J, Hatsell SJ, Xie L, Latres E, Huang L, Zhang Y, Pefanis E, Skokos D, Deckelbaum RA, Croll SD, Davis S, Valenzuela DM, Gale NW, Murphy AJ, Yancopoulos GD.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88. doi: 10.1073/pnas.1217812110. Epub 2013 Aug 5.


Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

Anderson KD, Pan L, Yang XM, Hughes VC, Walls JR, Dominguez MG, Simmons MV, Burfeind P, Xue Y, Wei Y, Macdonald LE, Thurston G, Daly C, Lin HC, Economides AN, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12. doi: 10.1073/pnas.1019761108. Epub 2011 Jan 31.


Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice.

Shmelkov SV, Hormigo A, Jing D, Proenca CC, Bath KG, Milde T, Shmelkov E, Kushner JS, Baljevic M, Dincheva I, Murphy AJ, Valenzuela DM, Gale NW, Yancopoulos GD, Ninan I, Lee FS, Rafii S.

Nat Med. 2010 May;16(5):598-602, 1p following 602. doi: 10.1038/nm.2125. Epub 2010 Apr 25.


Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis.

Li Z, Huang H, Boland P, Dominguez MG, Burfeind P, Lai KM, Lin HC, Gale NW, Daly C, Auerbach W, Valenzuela D, Yancopoulos GD, Thurston G.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22399-404. doi: 10.1073/pnas.0911189106. Epub 2009 Dec 15.


Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.

Hooper AT, Shmelkov SV, Gupta S, Milde T, Bambino K, Gillen K, Goetz M, Chavala S, Baljevic M, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, Vahdat L, Evans T, Rafii S.

Circ Res. 2009 Jul 17;105(2):201-8. doi: 10.1161/CIRCRESAHA.109.196790. Epub 2009 Jun 18.


Distribution of EphA5 receptor protein in the developing and adult mouse nervous system.

Cooper MA, Crockett DP, Nowakowski RS, Gale NW, Zhou R.

J Comp Neurol. 2009 Jun 1;514(4):310-28. doi: 10.1002/cne.22030.


Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.

Feyerabend TB, Terszowski G, Tietz A, Blum C, Luche H, Gossler A, Gale NW, Radtke F, Fehling HJ, Rodewald HR.

Immunity. 2009 Jan 16;30(1):67-79. doi: 10.1016/j.immuni.2008.10.016. Epub 2008 Dec 24.


CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.

Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, St Clair R, Baljevic M, White I, Jin DK, Chadburn A, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, D'Angelica M, Kemeny N, Lyden D, Rafii S.

J Clin Invest. 2008 Jun;118(6):2111-20. doi: 10.1172/JCI34401.


Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, Lin HC, Yancopoulos GD, Thurston G.

Novartis Found Symp. 2007;283:106-20; discussion 121-5, 238-41.


Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.

Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S.

Nature. 2007 Sep 20;449(7160):346-50.


Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis.

Dominguez MG, Hughes VC, Pan L, Simmons M, Daly C, Anderson K, Noguera-Troise I, Murphy AJ, Valenzuela DM, Davis S, Thurston G, Yancopoulos GD, Gale NW.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3243-8. Epub 2007 Feb 21.


Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.

Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, Yancopoulos GD, Wiegand SJ.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3219-24. Epub 2007 Feb 12.


Abnormal recruitment of periendothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice.

Shimoda H, Bernas MJ, Witte MH, Gale NW, Yancopoulos GD, Kato S.

Cell Tissue Res. 2007 May;328(2):329-37. Epub 2007 Jan 19.


F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.

Poueymirou WT, Auerbach W, Frendewey D, Hickey JF, Escaravage JM, Esau L, Doré AT, Stevens S, Adams NC, Dominguez MG, Gale NW, Yancopoulos GD, DeChiara TM, Valenzuela DM.

Nat Biotechnol. 2007 Jan;25(1):91-9. Epub 2006 Dec 24.


Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, Lin HC, Yancopoulos GD, Thurston G.

Nature. 2006 Dec 21;444(7122):1032-7.


Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1.

Gale NW, Prevo R, Espinosa J, Ferguson DJ, Dominguez MG, Yancopoulos GD, Thurston G, Jackson DG.

Mol Cell Biol. 2007 Jan;27(2):595-604. Epub 2006 Nov 13.


Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function.

Gazzerro E, Deregowski V, Stadmeyer L, Gale NW, Economides AN, Canalis E.

Bone. 2006 Dec;39(6):1252-60. Epub 2006 Aug 24.


Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation.

Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG.

Nat Med. 2006 Feb;12(2):235-9. Epub 2006 Feb 5.


Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.

Amici SA, Dunn WA Jr, Murphy AJ, Adams NC, Gale NW, Valenzuela DM, Yancopoulos GD, Notterpek L.

J Neurosci. 2006 Jan 25;26(4):1179-89.


Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice.

Pitera JE, Woolf AS, Gale NW, Yancopoulos GD, Yuan HT.

Am J Pathol. 2004 Dec;165(6):1895-906.


Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, Thurston G, Yancopoulos GD.

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15949-54. Epub 2004 Nov 1.


Recognition of single-stranded RNA viruses by Toll-like receptor 7.

Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA.

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5598-603. Epub 2004 Mar 19.


Loss-of-function analysis of EphA receptors in retinotectal mapping.

Feldheim DA, Nakamoto M, Osterfield M, Gale NW, DeChiara TM, Rohatgi R, Yancopoulos GD, Flanagan JG.

J Neurosci. 2004 Mar 10;24(10):2542-50.


Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm.

Williams SE, Mann F, Erskine L, Sakurai T, Wei S, Rossi DJ, Gale NW, Holt CE, Mason CA, Henkemeyer M.

Neuron. 2003 Sep 11;39(6):919-35.


Complementary and coordinated roles of the VEGFs and angiopoietins during normal and pathologic vascular formation.

Gale NW, Thurston G, Davis S, Wiegand SJ, Holash J, Rudge JS, Yancopoulos GD.

Cold Spring Harb Symp Quant Biol. 2002;67:267-73. No abstract available.


High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.

Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD.

Nat Biotechnol. 2003 Jun;21(6):652-9. Epub 2003 May 5.


Lac z Histochemistry and immunohistochemistry reveal ephrin-B ligand expression in the inner ear.

Bianchi LM, Dinsio K, Davoli K, Gale NW.

J Histochem Cytochem. 2002 Dec;50(12):1641-5.


Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

Gale NW, Thurston G, Hackett SF, Renard R, Wang Q, McClain J, Martin C, Witte C, Witte MH, Jackson D, Suri C, Campochiaro PA, Wiegand SJ, Yancopoulos GD.

Dev Cell. 2002 Sep;3(3):411-23.


Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells.

Oike Y, Ito Y, Hamada K, Zhang XQ, Miyata K, Arai F, Inada T, Araki K, Nakagata N, Takeya M, Kisanuki YY, Yanagisawa M, Gale NW, Suda T.

Blood. 2002 Aug 15;100(4):1326-33.


Mistargeting hippocampal axons by expression of a truncated Eph receptor.

Yue Y, Chen ZY, Gale NW, Blair-Flynn J, Hu TJ, Yue X, Cooper M, Crockett DP, Yancopoulos GD, Tessarollo L, Zhou R.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10777-82. Epub 2002 Jul 17.


EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells.

Kim I, Ryu YS, Kwak HJ, Ahn SY, Oh JL, Yancopoulos GD, Gale NW, Koh GY.

FASEB J. 2002 Jul;16(9):1126-8. Epub 2002 May 21.


Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells.

Zhang XQ, Takakura N, Oike Y, Inada T, Gale NW, Yancopoulos GD, Suda T.

Blood. 2001 Aug 15;98(4):1028-37.


Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control.

Kullander K, Croll SD, Zimmer M, Pan L, McClain J, Hughes V, Zabski S, DeChiara TM, Klein R, Yancopoulos GD, Gale NW.

Genes Dev. 2001 Apr 1;15(7):877-88.


Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells.

Gale NW, Baluk P, Pan L, Kwan M, Holash J, DeChiara TM, McDonald DM, Yancopoulos GD.

Dev Biol. 2001 Feb 15;230(2):151-60.


EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.

Dalva MB, Takasu MA, Lin MZ, Shamah SM, Hu L, Gale NW, Greenberg ME.

Cell. 2000 Dec 8;103(6):945-56.


Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone.

Conover JC, Doetsch F, Garcia-Verdugo JM, Gale NW, Yancopoulos GD, Alvarez-Buylla A.

Nat Neurosci. 2000 Nov;3(11):1091-7.


Vascular-specific growth factors and blood vessel formation.

Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J.

Nature. 2000 Sep 14;407(6801):242-8. Review.


Axon guidance in the mouse optic chiasm: retinal neurite inhibition by ephrin "A"-expressing hypothalamic cells in vitro.

Marcus RC, Matthews GA, Gale NW, Yancopoulos GD, Mason CA.

Dev Biol. 2000 May 1;221(1):132-47.

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