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The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.

Daniels BP, Kofman SB, Smith JR, Norris GT, Snyder AG, Kolb JP, Gao X, Locasale JW, Martinez J, Gale M Jr, Loo YM, Oberst A.

Immunity. 2019 Jan 15;50(1):64-76.e4. doi: 10.1016/j.immuni.2018.11.017. Epub 2019 Jan 8.


Cell-type specificity and functional redundancy of RIG-I-like receptors in innate immune sensing of Coxsackievirus B3 and encephalomyocarditis virus.

Francisco E, Suthar M, Gale M Jr, Rosenfeld AB, Racaniello VR.

Virology. 2018 Dec 11;528:7-18. doi: 10.1016/j.virol.2018.12.003. [Epub ahead of print]


IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection.

Chow KT, Driscoll C, Loo YM, Knoll M, Gale M Jr.

J Leukoc Biol. 2018 Nov 20. doi: 10.1002/JLB.MA0318-136RRR. [Epub ahead of print]


Immune correlates of protection from West Nile virus neuroinvasion and disease.

Graham JB, Swarts JL, Thomas S, Voss KM, Sekine A, Green R, Ireton RC, Gale M Jr, Lund JM.

J Infect Dis. 2018 Oct 26. doi: 10.1093/infdis/jiy623. [Epub ahead of print]


Performance Under Stress: An Eye-Tracking Investigation of the Iowa Gambling Task (IGT).

Simonovic B, Stupple EJN, Gale M, Sheffield D.

Front Behav Neurosci. 2018 Sep 24;12:217. doi: 10.3389/fnbeh.2018.00217. eCollection 2018.


Differential and Overlapping Immune Programs Regulated by IRF3 and IRF5 in Plasmacytoid Dendritic Cells.

Chow KT, Wilkins C, Narita M, Green R, Knoll M, Loo YM, Gale M Jr.

J Immunol. 2018 Nov 15;201(10):3036-3050. doi: 10.4049/jimmunol.1800221. Epub 2018 Oct 8.


Zika virus and the nonmicrocephalic fetus: why we should still worry.

Walker CL, Little ME, Roby JA, Armistead B, Gale M Jr, Rajagopal L, Nelson BR, Ehinger N, Mason B, Nayeri U, Curry CL, Adams Waldorf KM.

Am J Obstet Gynecol. 2019 Jan;220(1):45-56. doi: 10.1016/j.ajog.2018.08.035. Epub 2018 Aug 29. Review.


Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques.

O'Connor MA, Tisoncik-Go J, Lewis TB, Miller CJ, Bratt D, Moats CR, Edlefsen PT, Smedley J, Klatt NR, Gale M Jr, Fuller DH.

Nat Commun. 2018 Aug 22;9(1):3371. doi: 10.1038/s41467-018-05826-w.


Matrix metalloproteinase 28 is regulated by TRIF- and type I IFN-dependent signaling in macrophages.

Long ME, Gong KQ, Volk JS, Eddy WE, Chang MY, Frevert CW, Altemeier WA, Gale M Jr, Liles WC, Manicone AM.

Innate Immun. 2018 Aug;24(6):357-365. doi: 10.1177/1753425918791024. Epub 2018 Aug 1.


Correction for Kumar et al., "Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis".

Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M Jr, Verma S.

J Virol. 2018 Jul 17;92(15). pii: e02176-17. doi: 10.1128/JVI.02176-17. Print 2018 Aug 1. No abstract available.


Interferon-stimulated genes: new platforms and computational approaches.

Green R, Ireton RC, Gale M Jr.

Mamm Genome. 2018 Aug;29(7-8):593-602. doi: 10.1007/s00335-018-9755-6. Epub 2018 Jul 7. Review.


Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Dudley DM, Van Rompay KK, Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Martín CS, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale M Jr, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano SV 3rd, Simmons HA, Mejia A, Friedrich TC, Golos TG, O'Connor DH.

Nat Med. 2018 Aug;24(8):1104-1107. doi: 10.1038/s41591-018-0088-5. Epub 2018 Jul 2.


Looking Forward in Interferon and Cytokine Research: Defining Effector Genes of Interferon and Cytokine Actions.

Gale M Jr.

J Interferon Cytokine Res. 2018 Jun;38(6):235. doi: 10.1089/jir.2018.29008.mgj. No abstract available.


Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk.

Strange DP, Green R, Siemann DN, Gale M Jr, Verma S.

Sci Rep. 2018 Jun 7;8(1):8702. doi: 10.1038/s41598-018-27027-7.


Understanding the Expanding Roles of Interferon and Cytokines in Health and Disease.

Gale M Jr.

J Interferon Cytokine Res. 2018 May;38(5):195-196. doi: 10.1089/jir.2018.29007-mgj. No abstract available.


Longitudinal ophthalmic findings in a child with Helsmoortel-Van der Aa Syndrome.

Gale MJ, Titus HE, Harman GA, Alabduljalil T, Dennis A, Wilson JL, Koeller DM, Finanger E, Blasco PA, Chiang PW, Karr DJ, Yang P.

Am J Ophthalmol Case Rep. 2018 Mar 13;10:244-248. doi: 10.1016/j.ajoc.2018.03.015. eCollection 2018 Jun.


Femur-sparing pattern of abnormal fetal growth in pregnant women from New York City after maternal Zika virus infection.

Walker CL, Merriam AA, Ohuma EO, Dighe MK, Gale M Jr, Rajagopal L, Papageorghiou AT, Gyamfi-Bannerman C, Adams Waldorf KM.

Am J Obstet Gynecol. 2018 Aug;219(2):187.e1-187.e20. doi: 10.1016/j.ajog.2018.04.047. Epub 2018 May 5.


Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.

Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M Jr, Denison MR, Perlman S.

MBio. 2018 May 1;9(3). pii: e00272-18. doi: 10.1128/mBio.00272-18.


RIG-I and Other RNA Sensors in Antiviral Immunity.

Chow KT, Gale M Jr, Loo YM.

Annu Rev Immunol. 2018 Apr 26;36:667-694. doi: 10.1146/annurev-immunol-042617-053309.


Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses.

Aarreberg LD, Wilkins C, Ramos HJ, Green R, Davis MA, Chow K, Gale M Jr.

MBio. 2018 Mar 20;9(2). pii: e00342-18. doi: 10.1128/mBio.00342-18.


Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates.

Mitchell T, MacDonald JW, Srinouanpranchanh S, Bammler TK, Merillat S, Boldenow E, Coleman M, Agnew K, Baldessari A, Stencel-Baerenwald JE, Tisoncik-Go J, Green RR, Gale MJ Jr, Rajagopal L, Adams Waldorf KM.

Am J Obstet Gynecol. 2018 Apr;218(4):438.e1-438.e16. doi: 10.1016/j.ajog.2018.01.009. Epub 2018 Feb 21.


Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.

Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr, Silvestri G, Chahroudi A, Klatt NR, Sodora DL.

PLoS Pathog. 2018 Feb 21;14(2):e1006871. doi: 10.1371/journal.ppat.1006871. eCollection 2018 Feb.


Splenic macrophages are required for protective innate immunity against West Nile virus.

Bryan MA, Giordano D, Draves KE, Green R, Gale M Jr, Clark EA.

PLoS One. 2018 Feb 6;13(2):e0191690. doi: 10.1371/journal.pone.0191690. eCollection 2018.


Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain.

Adams Waldorf KM, Nelson BR, Stencel-Baerenwald JE, Studholme C, Kapur RP, Armistead B, Walker CL, Merillat S, Vornhagen J, Tisoncik-Go J, Baldessari A, Coleman M, Dighe MK, Shaw DWW, Roby JA, Santana-Ufret V, Boldenow E, Li J, Gao X, Davis MA, Swanstrom JA, Jensen K, Widman DG, Baric RS, Medwid JT, Hanley KA, Ogle J, Gough GM, Lee W, English C, Durning WM, Thiel J, Gatenby C, Dewey EC, Fairgrieve MR, Hodge RD, Grant RF, Kuller L, Dobyns WB, Hevner RF, Gale M Jr, Rajagopal L.

Nat Med. 2018 Mar;24(3):368-374. doi: 10.1038/nm.4485. Epub 2018 Feb 5.


cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.

Hahn WO, Butler NS, Lindner SE, Akilesh HM, Sather DN, Kappe SH, Hamerman JA, Gale M Jr, Liles WC, Pepper M.

JCI Insight. 2018 Jan 25;3(2). pii: 94142. doi: 10.1172/jci.insight.94142. [Epub ahead of print]


Interferon Lambda Genetics and Biology in Regulation of Viral Control.

Hemann EA, Gale M Jr, Savan R.

Front Immunol. 2017 Dec 6;8:1707. doi: 10.3389/fimmu.2017.01707. eCollection 2017. Review.


Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization.

Giordano D, Draves KE, Young LB, Roe K, Bryan MA, Dresch C, Richner JM, Diamond MS, Gale M Jr, Clark EA.

PLoS Pathog. 2017 Nov 27;13(11):e1006743. doi: 10.1371/journal.ppat.1006743. eCollection 2017 Nov.


Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine.

Li J, Baird MA, Davis MA, Tai W, Zweifel LS, Adams Waldorf KM, Gale M Jr, Rajagopal L, Pierce RH, Gao X.

Nat Biomed Eng. 2017;1. pii: 0082. doi: 10.1038/s41551-017-0082. Epub 2017 Jun 5.


Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.

Burchill MA, Roby JA, Crochet N, Wind-Rotolo M, Stone AE, Edwards MG, Dran RJ, Kriss MS, Gale M Jr, Rosen HR.

PLoS One. 2017 Oct 17;12(10):e0186213. doi: 10.1371/journal.pone.0186213. eCollection 2017.


Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs.

Chang MY, Kang I, Gale M Jr, Manicone AM, Kinsella MG, Braun KR, Wigmosta T, Parks WC, Altemeier WA, Wight TN, Frevert CW.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1069-L1086. doi: 10.1152/ajplung.00353.2017. Epub 2017 Sep 14.


Demographic and geographical risk factors for gonorrhoea and chlamydia in greater Western Sydney, 2003-2013.

Gale M, Hayen A, Truman G, Varma R, Forssman BL, MacIntyre CR.

Commun Dis Intell Q Rep. 2017 Jun 30;41(2):E134-E141.


RNA PAMPs as Molecular Tools for Evaluating RIG-I Function in Innate Immunity.

Ireton RC, Wilkins C, Gale M Jr.

Methods Mol Biol. 2017;1656:119-129. doi: 10.1007/978-1-4939-7237-1_6.


A Patient on Airway Pressure Release Ventilation With Sudden Hemodynamic Collapse.

Chen LL, Mead E, Gale MJ.

Chest. 2017 Jul;152(1):e7-e9. doi: 10.1016/j.chest.2017.01.041. No abstract available.


Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross.

Green R, Wilkins C, Thomas S, Sekine A, Hendrick DM, Voss K, Ireton RC, Mooney M, Go JT, Choonoo G, Jeng S, de Villena FP, Ferris MT, McWeeney S, Gale M Jr.

G3 (Bethesda). 2017 Jun 7;7(6):1665-1682. doi: 10.1534/g3.117.041624.


The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.

Nat Immunol. 2017 Jul;18(7):744-752. doi: 10.1038/ni.3766. Epub 2017 May 29.


RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.

Daniels BP, Snyder AG, Olsen TM, Orozco S, Oguin TH 3rd, Tait SWG, Martinez J, Gale M Jr, Loo YM, Oberst A.

Cell. 2017 Apr 6;169(2):301-313.e11. doi: 10.1016/j.cell.2017.03.011. Epub 2017 Mar 30.


Engineering Pak1 Allosteric Switches.

Dagliyan O, Karginov AV, Yagishita S, Gale ME, Wang H, DerMardirossian C, Wells CM, Dokholyan NV, Kasai H, Hahn KM.

ACS Synth Biol. 2017 Jul 21;6(7):1257-1262. doi: 10.1021/acssynbio.6b00359. Epub 2017 Apr 6.


Beyond sensing: Retinoic acid inducible gene-I (RIG-I) continues to expand its antiviral effector functions.

Stone AEL, Gale MJ Jr.

Hepatology. 2017 Jun;65(6):1792-1795. doi: 10.1002/hep.29161. Epub 2017 May 3. No abstract available.


A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response.

Probst P, Grigg JB, Wang M, Muñoz E, Loo YM, Ireton RC, Gale M Jr, Iadonato SP, Bedard KM.

Vaccine. 2017 Apr 4;35(15):1964-1971. doi: 10.1016/j.vaccine.2017.01.053. Epub 2017 Mar 6.


Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection.

Daniels BP, Jujjavarapu H, Durrant DM, Williams JL, Green RR, White JP, Lazear HM, Gale M Jr, Diamond MS, Klein RS.

J Clin Invest. 2017 Mar 1;127(3):843-856. doi: 10.1172/JCI88720. Epub 2017 Jan 30.


MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D.

Gutierrez KD, Davis MA, Daniels BP, Olsen TM, Ralli-Jain P, Tait SW, Gale M Jr, Oberst A.

J Immunol. 2017 Mar 1;198(5):2156-2164. doi: 10.4049/jimmunol.1601757. Epub 2017 Jan 27.


Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection.

Da Costa A, Garza E, Graham JB, Swarts JL, Soerens AG, Gale M, Lund JM.

Sci Rep. 2017 Jan 17;7:40720. doi: 10.1038/srep40720.


MAVS Is Essential for Primary CD4+ T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection.

Luo H, Winkelmann E, Xie G, Fang R, Peng BH, Li L, Lazear HM, Paessler S, Diamond MS, Gale M Jr, Barrett AD, Wang T.

J Virol. 2017 Feb 28;91(6). pii: e02097-16. doi: 10.1128/JVI.02097-16. Print 2017 Mar 15.


Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission.

Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M Jr, Golden-Mason L, Winn VD, Rosen HR.

J Immunol. 2017 Jan 15;198(2):972. doi: 10.4049/jimmunol.1601926. No abstract available.


RNA-Seq in the Collaborative Cross.

Green R, Wilkins C, Ferris MT, Gale M Jr.

Methods Mol Biol. 2017;1488:251-263.


Transcriptional profiles of WNV neurovirulence in a genetically diverse Collaborative Cross population.

Green R, Wilkins C, Thomas S, Sekine A, Ireton RC, Ferris MT, Hendrick DM, Voss K, Pardo-Manuel de Villena F, Baric RS, Heise MT, Gale M Jr.

Genom Data. 2016 Oct 14;10:137-140. eCollection 2016 Dec.


Identifying protective host gene expression signatures within the spleen during West Nile virus infection in the collaborative cross model.

Green R, Wilkins C, Thomas S, Sekine A, Ireton RC, Ferris MT, Hendrick DM, Voss K, de Villena FP, Baric R, Heise M, Gale M Jr.

Genom Data. 2016 Oct 14;10:114-117. eCollection 2016 Dec.


Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling.

Jarret A, McFarland AP, Horner SM, Kell A, Schwerk J, Hong M, Badil S, Joslyn RC, Baker DP, Carrington M, Hagedorn CH, Gale M Jr, Savan R.

Nat Med. 2016 Dec;22(12):1475-1481. doi: 10.1038/nm.4211. Epub 2016 Nov 14.


A Mouse Model of Chronic West Nile Virus Disease.

Graham JB, Swarts JL, Wilkins C, Thomas S, Green R, Sekine A, Voss KM, Ireton RC, Mooney M, Choonoo G, Miller DR, Treuting PM, Pardo Manuel de Villena F, Ferris MT, McWeeney S, Gale M Jr, Lund JM.

PLoS Pathog. 2016 Nov 2;12(11):e1005996. doi: 10.1371/journal.ppat.1005996. eCollection 2016 Nov.


Interferon lambda 4 expression is suppressed by the host during viral infection.

Hong M, Schwerk J, Lim C, Kell A, Jarret A, Pangallo J, Loo YM, Liu S, Hagedorn CH, Gale M Jr, Savan R.

J Exp Med. 2016 Nov 14;213(12):2539-2552. Epub 2016 Oct 31.

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