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RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions.

Schwerk J, Soveg FW, Ryan AP, Thomas KR, Hatfield LD, Ozarkar S, Forero A, Kell AM, Roby JA, So L, Hyde JL, Gale M Jr, Daugherty MD, Savan R.

Nat Immunol. 2019 Dec;20(12):1610-1620. doi: 10.1038/s41590-019-0527-6. Epub 2019 Nov 18.


Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control.

Barrenas F, Raehtz K, Xu C, Law L, Green RR, Silvestri G, Bosinger SE, Nishida A, Li Q, Lu W, Zhang J, Thomas MJ, Chang J, Smith E, Weiss JM, Dawoud RA, Richter GH, Trichel A, Ma D, Peng X, Komorowski J, Apetrei C, Pandrea I, Gale M Jr.

Nat Commun. 2019 Nov 8;10(1):5101. doi: 10.1038/s41467-019-12987-9.


Acquired resistance to HER2-targeted therapies creates vulnerability to ATP synthase inhibition.

Gale M, Li Y, Cao J, Liu ZZ, Holmbeck MA, Zhang M, Lang SM, Wu L, Do Carmo M, Gupta S, Aoshima K, DiGiovanna MP, Stern DF, Rimm DL, Shadel GS, Chen X, Yan Q.

Cancer Res. 2019 Nov 5. pii: canres.3985.2018. doi: 10.1158/0008-5472.CAN-18-3985. [Epub ahead of print]


Immune Evasion Strategies Used by Zika Virus to Infect the Fetal Eye and Brain.

Nelson BR, Roby JA, Dobyns WB, Rajagopal L, Gale M Jr, Adams Waldorf KM.

Viral Immunol. 2019 Nov 5. doi: 10.1089/vim.2019.0082. [Epub ahead of print]


Immune predictors of mortality following RNA virus infection.

Graham JB, Swarts JL, Menachery VD, Gralinski LE, Schäfer A, Plante KS, Morrison CR, Voss KM, Green R, Choonoo G, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Gale M, Heise MT, Baric RS, Lund JM.

J Infect Dis. 2019 Oct 17. pii: jiz531. doi: 10.1093/infdis/jiz531. [Epub ahead of print]


Gaps in tuberculosis care in West Sepik Province of Papua New Guinea.

Kelebi T, Takarinda KC, Commons R, Sissai B, Yowei J, Gale M.

Public Health Action. 2019 Sep 21;9(Suppl 1):S68-S72. doi: 10.5588/pha.18.0057.


A mortality review of adult inpatients with tuberculosis in Mendi, Papua New Guinea.

Vakadem K, Anota A, Sa'avu M, Ramoni C, Comrie-Thomson L, Gale M, Commons RJ.

Public Health Action. 2019 Sep 21;9(Suppl 1):S62-S67. doi: 10.5588/pha.18.0068.


A retrospective study of tuberculosis outcomes in Gulf Province, Papua New Guinea.

Moses I, Main S, Commons RJ, Robertson B, Mek A, Gale M.

Public Health Action. 2019 Sep 21;9(Suppl 1):S38-S42. doi: 10.5588/pha.18.0069.


Introduction to the Special Issue.

Gale M Jr, Savan R.

J Interferon Cytokine Res. 2019 Oct;39(10):585. doi: 10.1089/jir.2019.29016.mgj. Epub 2019 Sep 13. No abstract available.


Microglia in Memory Decline from Zika Virus and West Nile Virus Infection.

Tisoncik-Go J, Gale M Jr.

Trends Neurosci. 2019 Nov;42(11):757-759. doi: 10.1016/j.tins.2019.08.009. Epub 2019 Sep 5.


Sweating the small stuff: A meta-analysis of skin conductance on the Iowa gambling task.

Simonovic B, Stupple E, Gale M, Sheffield D.

Cogn Affect Behav Neurosci. 2019 Oct;19(5):1097-1112. doi: 10.3758/s13415-019-00744-w.


Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons.

Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R.

Immunity. 2019 Sep 17;51(3):451-464.e6. doi: 10.1016/j.immuni.2019.07.007. Epub 2019 Aug 27.


STING is required for host defense against neuropathological West Nile virus infection.

McGuckin Wuertz K, Treuting PM, Hemann EA, Esser-Nobis K, Snyder AG, Graham JB, Daniels BP, Wilkins C, Snyder JM, Voss KM, Oberst A, Lund J, Gale M Jr.

PLoS Pathog. 2019 Aug 15;15(8):e1007899. doi: 10.1371/journal.ppat.1007899. eCollection 2019 Aug.


Risk of Zika microcephaly correlates with features of maternal antibodies.

Robbiani DF, Olsen PC, Costa F, Wang Q, Oliveira TY, Nery N Jr, Aromolaran A, do Rosário MS, Sacramento GA, Cruz JS, Khouri R, Wunder EA Jr, Mattos A, de Paula Freitas B, Sarno M, Archanjo G, Daltro D, Carvalho GBS, Pimentel K, de Siqueira IC, de Almeida JRM, Henriques DF, Lima JA, Vasconcelos PFC, Schaefer-Babajew D, Azzopardi SA, Bozzacco L, Gazumyan A, Belfort R Jr, Alcântara AP, Carvalho G, Moreira L, Araujo K, Reis MG, Keesler RI, Coffey LL, Tisoncik-Go J, Gale M Jr, Rajagopal L, Adams Waldorf KM, Dudley DM, Simmons HA, Mejia A, O'Connor DH, Steinbach RJ, Haese N, Smith J, Lewis A, Colgin L, Roberts V, Frias A, Kelleher M, Hirsch A, Streblow DN, Rice CM, MacDonald MR, de Almeida ARP, Van Rompay KKA, Ko AI, Nussenzweig MC.

J Exp Med. 2019 Oct 7;216(10):2302-2315. doi: 10.1084/jem.20191061. Epub 2019 Aug 14.


RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection.

Stone AEL, Green R, Wilkins C, Hemann EA, Gale M Jr.

Nat Commun. 2019 Aug 13;10(1):3649. doi: 10.1038/s41467-019-11250-5.


Ellagic acid promotes browning of white adipose tissues in high-fat diet-induced obesity in rats through suppressing white adipocyte maintaining genes.

Wang L, Wei Y, Ning C, Zhang M, Fan P, Lei D, Du J, Gale M, Ma Y, Yang Y.

Endocr J. 2019 Oct 28;66(10):923-936. doi: 10.1507/endocrj.EJ18-0467. Epub 2019 Jul 9.


Dendritic cell-associated MAVS is required to control West Nile virus replication and ensuing humoral immune responses.

Roe K, Giordano D, Young LB, Draves KE, Holder U, Suthar MS, Gale M Jr, Clark EA.

PLoS One. 2019 Jun 26;14(6):e0218928. doi: 10.1371/journal.pone.0218928. eCollection 2019.


Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.

Hemann EA, Green R, Turnbull JB, Langlois RA, Savan R, Gale M Jr.

Nat Immunol. 2019 Aug;20(8):1035-1045. doi: 10.1038/s41590-019-0408-z. Epub 2019 Jun 24.


Repeatability of Adaptive Optics Automated Cone Measurements in Subjects With Retinitis Pigmentosa and Novel Metrics for Assessment of Image Quality.

Gale MJ, Harman GA, Chen J, Pennesi ME.

Transl Vis Sci Technol. 2019 May 8;8(3):17. doi: 10.1167/tvst.8.3.17. eCollection 2019 May.


DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus Infection.

Pattabhi S, Knoll ML, Gale M , Jr, Loo YM.

J Interferon Cytokine Res. 2019 Jun;39(6):331-346. doi: 10.1089/jir.2018.0163. Epub 2019 May 15.


Comparative Analysis of African and Asian Lineage-Derived Zika Virus Strains Reveals Differences in Activation of and Sensitivity to Antiviral Innate Immunity.

Esser-Nobis K, Aarreberg LD, Roby JA, Fairgrieve MR, Green R, Gale M Jr.

J Virol. 2019 Jun 14;93(13). pii: e00640-19. doi: 10.1128/JVI.00640-19. Print 2019 Jul 1.


Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.

Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M Jr, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR.

PLoS Pathog. 2019 Apr 11;15(4):e1007672. doi: 10.1371/journal.ppat.1007672. eCollection 2019 Apr.


Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.

Aarreberg LD, Esser-Nobis K, Driscoll C, Shuvarikov A, Roby JA, Gale M Jr.

Mol Cell. 2019 May 16;74(4):801-815.e6. doi: 10.1016/j.molcel.2019.02.038. Epub 2019 Apr 2.


Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection.

Ishida Y, Kakuni M, Bang BR, Sugahara G, Lau DT, Tateno-Mukaidani C, Li M, Gale M Jr, Saito T.

J Interferon Cytokine Res. 2019 Mar;39(3):133-146. doi: 10.1089/jir.2018.0103. Erratum in: J Interferon Cytokine Res. 2019 May;39(5):315.


Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation.

Negash AA, Olson RM, Griffin S, Gale M Jr.

PLoS Pathog. 2019 Feb 27;15(2):e1007593. doi: 10.1371/journal.ppat.1007593. eCollection 2019 Feb.


Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation.

Davis MA, Fairgrieve MR, Den Hartigh A, Yakovenko O, Duvvuri B, Lood C, Thomas WE, Fink SL, Gale M Jr.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5061-5070. doi: 10.1073/pnas.1818598116. Epub 2019 Feb 22.


Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt Disease Using En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography.

Alabduljalil T, Patel RC, Alqahtani AA, Gao SS, Gale MJ, Zhang M, Jia Y, Huang D, Chiang PW, Chen R, Wang J, Weleber RG, Pennesi ME, Yang P.

Am J Ophthalmol. 2019 Jun;202:79-90. doi: 10.1016/j.ajo.2019.02.007. Epub 2019 Feb 14.


The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.

Daniels BP, Kofman SB, Smith JR, Norris GT, Snyder AG, Kolb JP, Gao X, Locasale JW, Martinez J, Gale M Jr, Loo YM, Oberst A.

Immunity. 2019 Jan 15;50(1):64-76.e4. doi: 10.1016/j.immuni.2018.11.017. Epub 2019 Jan 8.


Cell-type specificity and functional redundancy of RIG-I-like receptors in innate immune sensing of Coxsackievirus B3 and encephalomyocarditis virus.

Francisco E, Suthar M, Gale M Jr, Rosenfeld AB, Racaniello VR.

Virology. 2019 Feb;528:7-18. doi: 10.1016/j.virol.2018.12.003. Epub 2018 Dec 11.


IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection.

Chow KT, Driscoll C, Loo YM, Knoll M, Gale M Jr.

J Leukoc Biol. 2019 Feb;105(2):411-425. doi: 10.1002/JLB.MA0318-136RRR. Epub 2018 Nov 20.


Immune Correlates of Protection From West Nile Virus Neuroinvasion and Disease.

Graham JB, Swarts JL, Thomas S, Voss KM, Sekine A, Green R, Ireton RC, Gale M, Lund JM.

J Infect Dis. 2019 Mar 15;219(7):1162-1171. doi: 10.1093/infdis/jiy623.


Performance Under Stress: An Eye-Tracking Investigation of the Iowa Gambling Task (IGT).

Simonovic B, Stupple EJN, Gale M, Sheffield D.

Front Behav Neurosci. 2018 Sep 24;12:217. doi: 10.3389/fnbeh.2018.00217. eCollection 2018.


Differential and Overlapping Immune Programs Regulated by IRF3 and IRF5 in Plasmacytoid Dendritic Cells.

Chow KT, Wilkins C, Narita M, Green R, Knoll M, Loo YM, Gale M Jr.

J Immunol. 2018 Nov 15;201(10):3036-3050. doi: 10.4049/jimmunol.1800221. Epub 2018 Oct 8.


Zika virus and the nonmicrocephalic fetus: why we should still worry.

Walker CL, Little ME, Roby JA, Armistead B, Gale M Jr, Rajagopal L, Nelson BR, Ehinger N, Mason B, Nayeri U, Curry CL, Adams Waldorf KM.

Am J Obstet Gynecol. 2019 Jan;220(1):45-56. doi: 10.1016/j.ajog.2018.08.035. Epub 2018 Aug 29. Review.


Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques.

O'Connor MA, Tisoncik-Go J, Lewis TB, Miller CJ, Bratt D, Moats CR, Edlefsen PT, Smedley J, Klatt NR, Gale M Jr, Fuller DH.

Nat Commun. 2018 Aug 22;9(1):3371. doi: 10.1038/s41467-018-05826-w.


Matrix metalloproteinase 28 is regulated by TRIF- and type I IFN-dependent signaling in macrophages.

Long ME, Gong KQ, Volk JS, Eddy WE, Chang MY, Frevert CW, Altemeier WA, Gale M Jr, Liles WC, Manicone AM.

Innate Immun. 2018 Aug;24(6):357-365. doi: 10.1177/1753425918791024. Epub 2018 Aug 1.


Correction for Kumar et al., "Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis".

Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M Jr, Verma S.

J Virol. 2018 Jul 17;92(15). pii: e02176-17. doi: 10.1128/JVI.02176-17. Print 2018 Aug 1. No abstract available.


Interferon-stimulated genes: new platforms and computational approaches.

Green R, Ireton RC, Gale M Jr.

Mamm Genome. 2018 Aug;29(7-8):593-602. doi: 10.1007/s00335-018-9755-6. Epub 2018 Jul 7. Review.


Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Dudley DM, Van Rompay KK, Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Martín CS, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale M Jr, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano SV 3rd, Simmons HA, Mejia A, Friedrich TC, Golos TG, O'Connor DH.

Nat Med. 2018 Aug;24(8):1104-1107. doi: 10.1038/s41591-018-0088-5. Epub 2018 Jul 2.


Looking Forward in Interferon and Cytokine Research: Defining Effector Genes of Interferon and Cytokine Actions.

Gale M Jr.

J Interferon Cytokine Res. 2018 Jun;38(6):235. doi: 10.1089/jir.2018.29008.mgj. No abstract available.


Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk.

Strange DP, Green R, Siemann DN, Gale M Jr, Verma S.

Sci Rep. 2018 Jun 7;8(1):8702. doi: 10.1038/s41598-018-27027-7.


Understanding the Expanding Roles of Interferon and Cytokines in Health and Disease.

Gale M Jr.

J Interferon Cytokine Res. 2018 May;38(5):195-196. doi: 10.1089/jir.2018.29007-mgj. No abstract available.


Longitudinal ophthalmic findings in a child with Helsmoortel-Van der Aa Syndrome.

Gale MJ, Titus HE, Harman GA, Alabduljalil T, Dennis A, Wilson JL, Koeller DM, Finanger E, Blasco PA, Chiang PW, Karr DJ, Yang P.

Am J Ophthalmol Case Rep. 2018 Mar 13;10:244-248. doi: 10.1016/j.ajoc.2018.03.015. eCollection 2018 Jun.


Femur-sparing pattern of abnormal fetal growth in pregnant women from New York City after maternal Zika virus infection.

Walker CL, Merriam AA, Ohuma EO, Dighe MK, Gale M Jr, Rajagopal L, Papageorghiou AT, Gyamfi-Bannerman C, Adams Waldorf KM.

Am J Obstet Gynecol. 2018 Aug;219(2):187.e1-187.e20. doi: 10.1016/j.ajog.2018.04.047. Epub 2018 May 5.


Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.

Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M Jr, Denison MR, Perlman S.

MBio. 2018 May 1;9(3). pii: e00272-18. doi: 10.1128/mBio.00272-18.


RIG-I and Other RNA Sensors in Antiviral Immunity.

Chow KT, Gale M Jr, Loo YM.

Annu Rev Immunol. 2018 Apr 26;36:667-694. doi: 10.1146/annurev-immunol-042617-053309.


Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses.

Aarreberg LD, Wilkins C, Ramos HJ, Green R, Davis MA, Chow K, Gale M Jr.

MBio. 2018 Mar 20;9(2). pii: e00342-18. doi: 10.1128/mBio.00342-18.


Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates.

Mitchell T, MacDonald JW, Srinouanpranchanh S, Bammler TK, Merillat S, Boldenow E, Coleman M, Agnew K, Baldessari A, Stencel-Baerenwald JE, Tisoncik-Go J, Green RR, Gale MJ Jr, Rajagopal L, Adams Waldorf KM.

Am J Obstet Gynecol. 2018 Apr;218(4):438.e1-438.e16. doi: 10.1016/j.ajog.2018.01.009. Epub 2018 Feb 21.


Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.

Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr, Silvestri G, Chahroudi A, Klatt NR, Sodora DL.

PLoS Pathog. 2018 Feb 21;14(2):e1006871. doi: 10.1371/journal.ppat.1006871. eCollection 2018 Feb.


Splenic macrophages are required for protective innate immunity against West Nile virus.

Bryan MA, Giordano D, Draves KE, Green R, Gale M Jr, Clark EA.

PLoS One. 2018 Feb 6;13(2):e0191690. doi: 10.1371/journal.pone.0191690. eCollection 2018.

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