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Multimodal imaging provides insight into targeted therapy response in metastatic prostate cancer to the bone.

Hoff BA, Brisset JC, Galbán S, Van Dort M, Smith DC, Reichert ZR, Jacobson JA, Luker GD, Chenevert TL, Ross BD.

Am J Nucl Med Mol Imaging. 2018 Jun 5;8(3):189-199. eCollection 2018.


Ocular Toxicity Profile of ST-162 and ST-168 as Novel Bifunctional MEK/PI3K Inhibitors.

Smith A, Pawar M, Van Dort ME, Galbán S, Welton AR, Thurber GM, Ross BD, Besirli CG.

J Ocul Pharmacol Ther. 2018 Jul/Aug;34(6):477-485. doi: 10.1089/jop.2017.0126. Epub 2018 Apr 30.


Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma.

Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Daylan AEC, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, Lyssiotis CA, Ljungman M, Morton JP, Galbán S, Fearon ER, Pasca di Magliano M.

JCI Insight. 2018 Jan 25;3(2). pii: 97422. doi: 10.1172/jci.insight.97422. eCollection 2018 Jan 25.


Structure-Guided Design and Initial Studies of a Bifunctional MEK/PI3K Inhibitor (ST-168).

Van Dort ME, Galbán S, Nino CA, Hong H, Apfelbaum AA, Luker GD, Thurber GM, Atangcho L, Besirli CG, Ross BD.

ACS Med Chem Lett. 2017 Jul 24;8(8):808-813. doi: 10.1021/acsmedchemlett.7b00111. eCollection 2017 Aug 10.


A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis.

Galbán S, Apfelbaum AA, Espinoza C, Heist K, Haley H, Bedi K, Ljungman M, Galbán CJ, Luker GD, Dort MV, Ross BD.

Mol Cancer Ther. 2017 Nov;16(11):2340-2350. doi: 10.1158/1535-7163.MCT-17-0207. Epub 2017 Aug 3.


CT-Based Local Distribution Metric Improves Characterization of COPD.

Hoff BA, Pompe E, Galbán S, Postma DS, Lammers JJ, Ten Hacken NHT, Koenderman L, Johnson TD, Verleden SE, de Jong PA, Mohamed Hoesein FAA, van den Berge M, Ross BD, Galbán CJ.

Sci Rep. 2017 Jun 7;7(1):2999. doi: 10.1038/s41598-017-02871-1.


MRI-Guided Stereotactic Biopsy of Murine GBM for Spatiotemporal Molecular Genomic Assessment.

Galbán S, Al-Holou WN, Wang H, Welton AR, Heist K, Hu XK, Verhaak RG, Zhu Y, Espinoza C, Chenevert TL, Hoff BA, Galbán CJ, Ross BD.

Tomography. 2017 Mar;3(1):9-15. doi: 10.18383/j.tom.2017.00112.


Semiautomated Workflow for Clinically Streamlined Glioma Parametric Response Mapping.

Keith L, Ross BD, Galbán CJ, Luker GD, Galbán S, Zhao B, Guo X, Chenevert TL, Hoff BA.

Tomography. 2016 Dec;2(4):267-275. doi: 10.18383/j.tom.2016.00181.


Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K).

Van Dort ME, Hong H, Wang H, Nino CA, Lombardi RL, Blanks AE, Galbán S, Ross BD.

J Med Chem. 2016 Mar 24;59(6):2512-22. doi: 10.1021/acs.jmedchem.5b01655. Epub 2016 Mar 15.


Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model.

Lemasson B, Wang H, Galbán S, Li Y, Zhu Y, Heist KA, Tsein C, Chenevert TL, Rehemtulla A, Galbán CJ, Holland EC, Ross BD.

Neoplasia. 2016 Feb;18(2):82-9. doi: 10.1016/j.neo.2015.11.014.


Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer.

Brisset JC, Hoff BA, Chenevert TL, Jacobson JA, Boes JL, Galbán S, Rehemtulla A, Johnson TD, Pienta KJ, Galbán CJ, Meyer CR, Schakel T, Nicolay K, Alva AS, Hussain M, Ross BD.

PLoS One. 2015 Apr 10;10(4):e0123877. doi: 10.1371/journal.pone.0123877. eCollection 2015.


Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.

Van Dort ME, Galbán S, Wang H, Sebolt-Leopold J, Whitehead C, Hong H, Rehemtulla A, Ross BD.

Bioorg Med Chem. 2015 Apr 1;23(7):1386-94. doi: 10.1016/j.bmc.2015.02.053. Epub 2015 Mar 6.


Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.

Bowman BM, Sebolt KA, Hoff BA, Boes JL, Daniels DL, Heist KA, Galbán CJ, Patel RM, Zhang J, Beer DG, Ross BD, Rehemtulla A, Galbán S.

Sci Signal. 2015 Jan 27;8(361):ra9. doi: 10.1126/scisignal.2005607. Erratum in: Sci Signal. 2015 Mar 17;8(368):er3.


Apoptosis imaging for monitoring DR5 antibody accumulation and pharmacodynamics in brain tumors noninvasively.

Weber TG, Osl F, Renner A, Pöschinger T, Galbán S, Rehemtulla A, Scheuer W.

Cancer Res. 2014 Apr 1;74(7):1913-23. doi: 10.1158/0008-5472.CAN-13-3001. Epub 2014 Feb 7.


Impact of perfusion map analysis on early survival prediction accuracy in glioma patients.

Lemasson B, Chenevert TL, Lawrence TS, Tsien C, Sundgren PC, Meyer CR, Junck L, Boes J, Galbán S, Johnson TD, Rehemtulla A, Ross BD, Galbán CJ.

Transl Oncol. 2013 Dec 1;6(6):766-74. eCollection 2013 Dec 1.


Diffusion-Weighted MRI as a Biomarker of Tumor Radiation Treatment Response Heterogeneity: A Comparative Study of Whole-Volume Histogram Analysis versus Voxel-Based Functional Diffusion Map Analysis.

Lemasson B, Galbán CJ, Boes JL, Li Y, Zhu Y, Heist KA, Johnson TD, Chenevert TL, Galbán S, Rehemtulla A, Ross BD.

Transl Oncol. 2013 Oct 1;6(5):554-61. eCollection 2013.


Imaging proteolytic activity in live cells and animal models.

Galbán S, Jeon YH, Bowman BM, Stevenson J, Sebolt KA, Sharkey LM, Lafferty M, Hoff BA, Butler BL, Wigdal SS, Binkowski BF, Otto P, Zimmerman K, Vidugiris G, Encell LP, Fan F, Wood KV, Galbán CJ, Ross BD, Rehemtulla A.

PLoS One. 2013 Jun 11;8(6):e66248. doi: 10.1371/journal.pone.0066248. Print 2013.


DW-MRI as a Predictive Biomarker of Radiosensitization of GBM through Targeted Inhibition of Checkpoint Kinases.

Williams TM, Galbán S, Li F, Heist KA, Galbán CJ, Lawrence TS, Holland EC, Thomae TL, Chenevert TL, Rehemtulla A, Ross BD.

Transl Oncol. 2013 Apr;6(2):133-42. Epub 2013 Apr 1.


Multimodality imaging of tumor and bone response in a mouse model of bony metastasis.

Hoff BA, Chughtai K, Jeon YH, Kozloff K, Galbán S, Rehemtulla A, Ross BD, Galbán CJ.

Transl Oncol. 2012 Dec;5(6):415-21. Epub 2012 Dec 1.


Metastatic pancreatic cancer is dependent on oncogenic Kras in mice.

Collins MA, Brisset JC, Zhang Y, Bednar F, Pierre J, Heist KA, Galbán CJ, Galbán S, di Magliano MP.

PLoS One. 2012;7(12):e49707. doi: 10.1371/journal.pone.0049707. Epub 2012 Dec 3.


Molecular imaging reveals a role for AKT in resistance to cisplatin for ovarian endometrioid adenocarcinoma.

Wang H, Galbán S, Wu R, Bowman BM, Witte A, Vetter K, Galbán CJ, Ross BD, Cho KR, Rehemtulla A.

Clin Cancer Res. 2013 Jan 1;19(1):158-69. doi: 10.1158/1078-0432.CCR-12-2380. Epub 2012 Oct 24.


Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression.

Galbán CJ, Han MK, Boes JL, Chughtai KA, Meyer CR, Johnson TD, Galbán S, Rehemtulla A, Kazerooni EA, Martinez FJ, Ross BD.

Nat Med. 2012 Nov;18(11):1711-5. doi: 10.1038/nm.2971. Epub 2012 Oct 7.


Parametric response mapping of CT images provides early detection of local bone loss in a rat model of osteoporosis.

Hoff BA, Kozloff KM, Boes JL, Brisset JC, Galbán S, Van Poznak CH, Jacobson JA, Johnson TD, Meyer CR, Rehemtulla A, Ross BD, Galbán CJ.

Bone. 2012 Jul;51(1):78-84. doi: 10.1016/j.bone.2012.04.005. Epub 2012 Apr 17.


DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma.

Galbán S, Lemasson B, Williams TM, Li F, Heist KA, Johnson TD, Leopold JS, Chenevert TL, Lawrence TS, Rehemtulla A, Mikkelsen T, Holland EC, Galbán CJ, Ross BD.

PLoS One. 2012;7(4):e35857. doi: 10.1371/journal.pone.0035857. Epub 2012 Apr 20.


Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer.

Williams TM, Flecha AR, Keller P, Ram A, Karnak D, Galbán S, Galbán CJ, Ross BD, Lawrence TS, Rehemtulla A, Sebolt-Leopold J.

Mol Cancer Ther. 2012 May;11(5):1193-202. doi: 10.1158/1535-7163.MCT-12-0098. Epub 2012 Mar 12.


Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.

Collins MA, Bednar F, Zhang Y, Brisset JC, Galbán S, Galbán CJ, Rakshit S, Flannagan KS, Adsay NV, Pasca di Magliano M.

J Clin Invest. 2012 Feb;122(2):639-53. doi: 10.1172/JCI59227. Epub 2012 Jan 9.


DCE and DW-MRI monitoring of vascular disruption following VEGF-Trap treatment of a rat glioma model.

Hoff BA, Bhojani MS, Rudge J, Chenevert TL, Meyer CR, Galbán S, Johnson TD, Leopold JS, Rehemtulla A, Ross BD, Galbán CJ.

NMR Biomed. 2012 Jul;25(7):935-42. doi: 10.1002/nbm.1814. Epub 2011 Dec 22.


Prospective analysis of parametric response map-derived MRI biomarkers: identification of early and distinct glioma response patterns not predicted by standard radiographic assessment.

Galbán CJ, Chenevert TL, Meyer CR, Tsien C, Lawrence TS, Hamstra DA, Junck L, Sundgren PC, Johnson TD, Galbán S, Sebolt-Leopold JS, Rehemtulla A, Ross BD.

Clin Cancer Res. 2011 Jul 15;17(14):4751-60. doi: 10.1158/1078-0432.CCR-10-2098. Epub 2011 Apr 28.


Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma.

Pitter KL, Galbán CJ, Galbán S, Tehrani OS, Li F, Charles N, Bradbury MS, Becher OJ, Chenevert TL, Rehemtulla A, Ross BD, Holland EC, Hambardzumyan D.

PLoS One. 2011 Jan 18;6(1):e14545. doi: 10.1371/journal.pone.0014545. Erratum in: PLoS One. 2011;6(1). doi: 10.1371/annotation/66641ad6-afb9-4d3c-ade6-73fcd5aab061. Saeed-Tehrani, Omid [corrected to Tehrani, Omid Saeed].


Applications of molecular imaging.

Galbán CJ, Galbán S, Van Dort ME, Luker GD, Bhojani MS, Rehemtulla A, Ross BD.

Prog Mol Biol Transl Sci. 2010;95:237-98. doi: 10.1016/B978-0-12-385071-3.00009-5. Review.


Diffusion-weighted MRI for assessment of early cancer treatment response.

Galbán S, Brisset JC, Rehemtulla A, Chenevert TL, Ross BD, Galbán CJ.

Curr Pharm Biotechnol. 2010 Sep 1;11(6):701-8. Review.


Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination.

Brady GF, Galbán S, Liu X, Basrur V, Gitlin JD, Elenitoba-Johnson KS, Wilson TE, Duckett CS.

Mol Cell Biol. 2010 Apr;30(8):1923-36. doi: 10.1128/MCB.00900-09. Epub 2010 Feb 12.


Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT.

Fernau NS, Fugmann D, Leyendecker M, Reimann K, Grether-Beck S, Galban S, Ale-Agha N, Krutmann J, Klotz LO.

J Biol Chem. 2010 Feb 5;285(6):3896-904. doi: 10.1074/jbc.M109.081430. Epub 2009 Nov 16.


HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity.

Ale-Agha N, Galban S, Sobieroy C, Abdelmohsen K, Gorospe M, Sies H, Klotz LO.

Hepatology. 2009 Nov;50(5):1567-76. doi: 10.1002/hep.23146.


Factors interacting with HIF-1alpha mRNA: novel therapeutic targets.

Galbán S, Gorospe M.

Curr Pharm Des. 2009;15(33):3853-60. Review.


XIAP as a ubiquitin ligase in cellular signaling.

Galbán S, Duckett CS.

Cell Death Differ. 2010 Jan;17(1):54-60. doi: 10.1038/cdd.2009.81. Review.


Ubiquitin-mediated proteolysis of HuR by heat shock.

Abdelmohsen K, Srikantan S, Yang X, Lal A, Kim HH, Kuwano Y, Galban S, Becker KG, Kamara D, de Cabo R, Gorospe M.

EMBO J. 2009 May 6;28(9):1271-82. doi: 10.1038/emboj.2009.67. Epub 2009 Mar 26.


Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation.

Csomos RA, Wright CW, Galbán S, Oetjen KA, Duckett CS.

Biochem J. 2009 Apr 28;420(1):83-91. doi: 10.1042/BJ20082140.


Caspases and IAPs: a dance of death ensures cell survival.

Galbán S, Brady GF, Duckett CS.

Mol Cell. 2008 Nov 21;32(4):462-3. doi: 10.1016/j.molcel.2008.11.005.


Cytoprotective effects of IAPs revealed by a small molecule antagonist.

Galbán S, Hwang C, Rumble JM, Oetjen KA, Wright CW, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Duckett CS.

Biochem J. 2009 Feb 1;417(3):765-71. doi: 10.1042/BJ20081677.


Nuclear HuR accumulation through phosphorylation by Cdk1.

Kim HH, Abdelmohsen K, Lal A, Pullmann R Jr, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, Gorospe M.

Genes Dev. 2008 Jul 1;22(13):1804-15. doi: 10.1101/gad.1645808.


Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP.

Wilkinson JC, Wilkinson AS, Galbán S, Csomos RA, Duckett CS.

Mol Cell Biol. 2008 Jan;28(1):237-47. Epub 2007 Oct 29.


RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.

Galbán S, Kuwano Y, Pullmann R Jr, Martindale JL, Kim HH, Lal A, Abdelmohsen K, Yang X, Dang Y, Liu JO, Lewis SM, Holcik M, Gorospe M.

Mol Cell Biol. 2008 Jan;28(1):93-107. Epub 2007 Oct 29.


Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells.

Abdelmohsen K, Sauerbier E, Ale-Agha N, Beier J, Walter P, Galban S, Stuhlmann D, Sies H, Klotz LO.

Biochem Biophys Res Commun. 2007 Dec 14;364(2):313-7. Epub 2007 Oct 11.


Phosphorylation of HuR by Chk2 regulates SIRT1 expression.

Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M.

Mol Cell. 2007 Feb 23;25(4):543-57.


Posttranscriptional derepression of GADD45alpha by genotoxic stress.

Lal A, Abdelmohsen K, Pullmann R, Kawai T, Galban S, Yang X, Brewer G, Gorospe M.

Mol Cell. 2006 Apr 7;22(1):117-28.


Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR.

Kawai T, Lal A, Yang X, Galban S, Mazan-Mamczarz K, Gorospe M.

Mol Cell Biol. 2006 Apr;26(8):3295-307.


Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1.

López de Silanes I, Galbán S, Martindale JL, Yang X, Mazan-Mamczarz K, Indig FE, Falco G, Zhan M, Gorospe M.

Mol Cell Biol. 2005 Nov;25(21):9520-31.


Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells.

Galbán S, Martindale JL, Mazan-Mamczarz K, López de Silanes I, Fan J, Wang W, Decker J, Gorospe M.

Mol Cell Biol. 2003 Oct;23(20):7083-95.

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