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Items: 23


ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.

Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros AC, Woods M, Fu B, Yang F, Chen E, Ostermaier M, Stankovic T, Ponstingl H, Herzog M, Yusa K, Martinez FM, Durant ST, Galanty Y, Beli P, Adams DJ, Bradley A, Metzakopian E, Forment JV, Jackson SP.

Nat Commun. 2019 Jan 8;10(1):87. doi: 10.1038/s41467-018-07729-2.


Predicting the mutations generated by repair of Cas9-induced double-strand breaks.

Allen F, Crepaldi L, Alsinet C, Strong AJ, Kleshchevnikov V, De Angeli P, Páleníková P, Khodak A, Kiselev V, Kosicki M, Bassett AR, Harding H, Galanty Y, Muñoz-Martínez F, Metzakopian E, Jackson SP, Parts L.

Nat Biotechnol. 2018 Nov 27. doi: 10.1038/nbt.4317. [Epub ahead of print]


Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.

Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP.

Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18.


Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.

Asim M, Tarish F, Zecchini HI, Sanjiv K, Gelali E, Massie CE, Baridi A, Warren AY, Zhao W, Ogris C, McDuffus LA, Mascalchi P, Shaw G, Dev H, Wadhwa K, Wijnhoven P, Forment JV, Lyons SR, Lynch AG, O'Neill C, Zecchini VR, Rennie PS, Baniahmad A, Tavaré S, Mills IG, Galanty Y, Crosetto N, Schultz N, Neal D, Helleday T.

Nat Commun. 2017 Aug 29;8(1):374. doi: 10.1038/s41467-017-00393-y.


The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).

Silva AP, Ryan DP, Galanty Y, Low JK, Vandevenne M, Jackson SP, Mackay JP.

J Biol Chem. 2016 Jan 8;291(2):924-38. doi: 10.1074/jbc.M115.683227. Epub 2015 Nov 12.


Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

Schmidt CK, Galanty Y, Sczaniecka-Clift M, Coates J, Jhujh S, Demir M, Cornwell M, Beli P, Jackson SP.

Nat Cell Biol. 2015 Nov;17(11):1458-1470. doi: 10.1038/ncb3260. Epub 2015 Oct 26.


Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.

Brown JS, Lukashchuk N, Sczaniecka-Clift M, Britton S, le Sage C, Calsou P, Beli P, Galanty Y, Jackson SP.

Cell Rep. 2015 May 5;11(5):704-14. doi: 10.1016/j.celrep.2015.03.058. Epub 2015 Apr 23.


The COP9 signalosome is vital for timely repair of DNA double-strand breaks.

Meir M, Galanty Y, Kashani L, Blank M, Khosravi R, Fernández-Ávila MJ, Cruz-García A, Star A, Shochot L, Thomas Y, Garrett LJ, Chamovitz DA, Bodine DM, Kurz T, Huertas P, Ziv Y, Shiloh Y.

Nucleic Acids Res. 2015 May 19;43(9):4517-30. doi: 10.1093/nar/gkv270. Epub 2015 Apr 8.


TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Blackford AN, Nieminuszczy J, Schwab RA, Galanty Y, Jackson SP, Niedzwiedz W.

Mol Cell. 2015 Mar 19;57(6):1133-1141. doi: 10.1016/j.molcel.2015.02.012.


CtIP tetramer assembly is required for DNA-end resection and repair.

Davies OR, Forment JV, Sun M, Belotserkovskaya R, Coates J, Galanty Y, Demir M, Morton CR, Rzechorzek NJ, Jackson SP, Pellegrini L.

Nat Struct Mol Biol. 2015 Feb;22(2):150-157. doi: 10.1038/nsmb.2937. Epub 2015 Jan 5.


Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.

Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, Clague MJ, Urbé S, Jackson SP.

Nat Cell Biol. 2014 Oct;16(10):1016-26, 1-8. doi: 10.1038/ncb3028. Epub 2014 Sep 7.


USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.

Knobel PA, Belotserkovskaya R, Galanty Y, Schmidt CK, Jackson SP, Stracker TH.

Mol Cell Biol. 2014 Jun;34(11):2062-74. doi: 10.1128/MCB.00197-14. Epub 2014 Mar 31.


RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

Galanty Y, Belotserkovskaya R, Coates J, Jackson SP.

Genes Dev. 2012 Jun 1;26(11):1179-95. doi: 10.1101/gad.188284.112.


Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4.

Polo SE, Kaidi A, Baskcomb L, Galanty Y, Jackson SP.

EMBO J. 2010 Sep 15;29(18):3130-9. doi: 10.1038/emboj.2010.188. Epub 2010 Aug 6.


Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.

Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP.

Nature. 2009 Dec 17;462(7275):935-9. doi: 10.1038/nature08657.


The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

Morris JR, Boutell C, Keppler M, Densham R, Weekes D, Alamshah A, Butler L, Galanty Y, Pangon L, Kiuchi T, Ng T, Solomon E.

Nature. 2009 Dec 17;462(7275):886-90. doi: 10.1038/nature08593.


Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.

Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y.

Nat Cell Biol. 2006 Aug;8(8):870-6. Epub 2006 Jul 23.


Absence of mutations in ATM, the gene responsible for ataxia telangiectasia in patients with cerebellar ataxia.

Hassin-Baer S, Bar-Shira A, Gilad S, Galanty Y, Khosravi R, Lossos A, Giladi N, Weitz R, Ben-Zeev B, Goldhammer Y, Shiloh Y.

J Neurol. 1999 Aug;246(8):716-9.


Cloning and expression of large mammalian cDNAs: lessons from ATM.

Shiloh Y, Bar-Shira A, Galanty Y, Ziv Y.

Genet Eng (N Y). 1998;20:239-48. Review. No abstract available.


Genotype-phenotype relationships in ataxia-telangiectasia and variants.

Gilad S, Chessa L, Khosravi R, Russell P, Galanty Y, Piane M, Gatti RA, Jorgensen TJ, Shiloh Y, Bar-Shira A.

Am J Hum Genet. 1998 Mar;62(3):551-61.


Identification of ATM mutations using extended RT-PCR and restriction endonuclease fingerprinting, and elucidation of the repertoire of A-T mutations in Israel.

Gilad S, Khosravi R, Harnik R, Ziv Y, Shkedy D, Galanty Y, Frydman M, Levi J, Sanal O, Chessa L, Smeets D, Shiloh Y, Bar-Shira A.

Hum Mutat. 1998;11(1):69-75.


[Familial adenomatous polyposis: establishing a registry and genetic and molecular analysis].

Shomrat R, Bruchim R, Galanty Y, Samuel Z, Legum C, Rabau M, Rozen P.

Harefuah. 1997 Jan 15;132(2):81-6, 151, 152. Hebrew.


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