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Items: 1 to 50 of 224

1.

Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists.

Yamazaki T, Hannani D, Poirier-Colame V, Ladoire S, Locher C, Sistigu A, Prada N, Adjemian S, Catani JP, Freudenberg M, Galanos C, André F, Kroemer G, Zitvogel L.

Cell Death Differ. 2014 Jan;21(1):69-78. doi: 10.1038/cdd.2013.72. Epub 2013 Jun 28.

2.

Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.

Fejer G, Wegner MD, Györy I, Cohen I, Engelhard P, Voronov E, Manke T, Ruzsics Z, Dölken L, Prazeres da Costa O, Branzk N, Huber M, Prasse A, Schneider R, Apte RN, Galanos C, Freudenberg MA.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2191-8. doi: 10.1073/pnas.1302877110. Epub 2013 May 24.

3.

Bacterial sensing, cell signaling, and modulation of the immune response during sepsis.

Salomao R, Brunialti MK, Rapozo MM, Baggio-Zappia GL, Galanos C, Freudenberg M.

Shock. 2012 Aug;38(3):227-42. doi: 10.1097/SHK.0b013e318262c4b0. Review.

PMID:
22777111
4.

TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes.

Tchaptchet S, Gumenscheimer M, Kalis C, Freudenberg N, Hölscher C, Kirschning CJ, Lamers M, Galanos C, Freudenberg MA.

PLoS One. 2012;7(6):e39155. doi: 10.1371/journal.pone.0039155. Epub 2012 Jun 22.

5.

Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells.

Keck S, Müller I, Fejer G, Savic I, Tchaptchet S, Nielsen PJ, Galanos C, Huber M, Freudenberg MA.

J Immunol. 2011 May 1;186(9):5478-88. doi: 10.4049/jimmunol.1000458. Epub 2011 Mar 25.

6.

Lipopolysaccharide-induced expression of cell surface receptors and cell activation of neutrophils and monocytes in whole human blood.

Gomes NE, Brunialti MK, Mendes ME, Freudenberg M, Galanos C, Salomão R.

Braz J Med Biol Res. 2010 Sep;43(9):853-8. Epub 2010 Aug 16.

7.

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel.

Schmidt M, Raghavan B, Müller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ, Galanos C, Roth J, Skerra A, Martin SF, Freudenberg MA, Goebeler M.

Nat Immunol. 2010 Sep;11(9):814-9. doi: 10.1038/ni.1919. Epub 2010 Aug 15.

PMID:
20711192
8.

Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes.

Tchaptchet S, Kirberg J, Freudenberg N, Schamel WW, Galanos C, Freudenberg MA.

Eur J Immunol. 2010 Sep;40(9):2506-16. doi: 10.1002/eji.200939860.

9.

Tumour Biology: tumour-associated inflammation versus antitumor immunity.

Müller-Hübenthal B, Azemar M, Lorenzen D, Huber M, Freudenberg MA, Galanos C, Unger C, Hildenbrand B.

Anticancer Res. 2009 Nov;29(11):4795-805. Review.

10.

Innate and adaptive immune responses in contact dermatitis: analogy with infections.

Freudenberg MA, Esser PR, Jakob T, Galanos C, Martin SF.

G Ital Dermatol Venereol. 2009 Apr;144(2):173-85. Review.

PMID:
19357624
11.

Enhanced B-cell activation mediated by TLR4 and BCR crosstalk.

Minguet S, Dopfer EP, Pollmer C, Freudenberg MA, Galanos C, Reth M, Huber M, Schamel WW.

Eur J Immunol. 2008 Sep;38(9):2475-87. doi: 10.1002/eji.200738094.

12.

Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity.

Martin SF, Dudda JC, Bachtanian E, Lembo A, Liller S, Dürr C, Heimesaat MM, Bereswill S, Fejer G, Vassileva R, Jakob T, Freudenberg N, Termeer CC, Johner C, Galanos C, Freudenberg MA.

J Exp Med. 2008 Sep 1;205(9):2151-62. doi: 10.1084/jem.20070509. Epub 2008 Aug 25.

13.

Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity.

Freudenberg MA, Tchaptchet S, Keck S, Fejer G, Huber M, Schütze N, Beutler B, Galanos C.

Immunobiology. 2008;213(3-4):193-203. doi: 10.1016/j.imbio.2007.11.008. Epub 2007 Dec 27. Review.

PMID:
18406367
14.

Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections.

Gumenscheimer M, Balkow S, Simon MM, Jirillo E, Galanos C, Freudenberg MA.

Med Microbiol Immunol. 2007 Jun;196(2):79-88. Epub 2006 Nov 29.

PMID:
17136407
15.

Stimulation of mast cells via FcvarepsilonR1 and TLR2: the type of ligand determines the outcome.

Fehrenbach K, Port F, Grochowy G, Kalis C, Bessler W, Galanos C, Krystal G, Freudenberg M, Huber M.

Mol Immunol. 2007 Mar;44(8):2087-94. Epub 2006 Nov 13.

PMID:
17095089
16.

R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells.

Huber M, Kalis C, Keck S, Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Beutler B, Galanos C, Freudenberg MA.

Eur J Immunol. 2006 Mar;36(3):701-11.

18.

CD14 is required for MyD88-independent LPS signaling.

Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B.

Nat Immunol. 2005 Jun;6(6):565-70. Epub 2005 May 15.

PMID:
15895089
19.

Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes.

Kalis C, Gumenscheimer M, Freudenberg N, Tchaptchet S, Fejer G, Heit A, Akira S, Galanos C, Freudenberg MA.

J Immunol. 2005 Apr 1;174(7):4295-300.

20.

Chemokine gene expression in toll-like receptor-competent and -deficient mice infected with Leishmania major.

Antoniazi S, Price HP, Kropf P, Freudenberg MA, Galanos C, Smith DF, Müller I.

Infect Immun. 2004 Sep;72(9):5168-74.

21.

Infection of C57BL/10ScCr and C57BL/10ScNCr mice with Leishmania major reveals a role for Toll-like receptor 4 in the control of parasite replication.

Kropf P, Freudenberg N, Kalis C, Modolell M, Herath S, Galanos C, Freudenberg M, Müller I.

J Leukoc Biol. 2004 Jul;76(1):48-57. Epub 2004 Mar 23.

PMID:
15039466
22.

Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major.

Kropf P, Freudenberg MA, Modolell M, Price HP, Herath S, Antoniazi S, Galanos C, Smith DF, Müller I.

Infect Immun. 2004 Apr;72(4):1920-8.

23.

Role of interferons in LPS hypersensitivity.

Freudenberg MA, Kalis C, Chvatchko Y, Merlin T, Gumenscheimer M, Galanos C.

J Endotoxin Res. 2003;9(5):308-12. Review.

PMID:
14577847
24.

[Effect of adenosine on intravascular accumulation of leukocytes and tissue damage in striated muscle in endotoxemia].

Nolte D, Kinner B, Schütze E, Leiderer R, Galanos C, Messmer K.

Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):173-5. German.

PMID:
14518236
25.

Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice.

Lembo A, Kalis C, Kirschning CJ, Mitolo V, Jirillo E, Wagner H, Galanos C, Freudenberg MA.

Infect Immun. 2003 Oct;71(10):6058-62.

26.

TNF revisited: TNF-independent antitumor activity in sera of mice sensitized with Propionibacterium acnes and challenged with lipopolysaccharide.

Schwamberger G, Hammerl P, Ferber E, Freudenberg M, Galanos C.

J Leukoc Biol. 2003 Dec;74(6):1056-63. Epub 2003 Nov 21.

PMID:
12960265
29.

Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice.

Kalis C, Kanzler B, Lembo A, Poltorak A, Galanos C, Freudenberg MA.

Eur J Immunol. 2003 Mar;33(3):798-805.

30.

Antitumor effect of the human immunodeficiency virus protease inhibitor ritonavir: induction of tumor-cell apoptosis associated with perturbation of proteasomal proteolysis.

Gaedicke S, Firat-Geier E, Constantiniu O, Lucchiari-Hartz M, Freudenberg M, Galanos C, Niedermann G.

Cancer Res. 2002 Dec 1;62(23):6901-8.

31.
32.
33.

Influence of EDTA and heparin on lipopolysaccharide binding and cell activation, evaluated at single-cell level in whole blood.

Brunialti MK, Kallás EG, Freudenberg M, Galanos C, Salomao R.

Cytometry. 2002 Feb 15;50(1):14-8.

PMID:
11857593
34.

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T, Miyake K, Freudenberg M, Galanos C, Simon JC.

J Exp Med. 2002 Jan 7;195(1):99-111.

35.

Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria.

Freudenberg MA, Merlin T, Gumenscheimer M, Kalis C, Landmann R, Galanos C.

Microbes Infect. 2001 Nov-Dec;3(14-15):1213-22. Review.

PMID:
11755409
36.

Differential clearance and induction of host responses by various administered or released lipopolysaccharides.

Hasunuma R, Morita H, Tanaka S, Ryll R, Freudenberg MA, Galanos C, Kumazawa Y.

J Endotoxin Res. 2001;7(6):421-9.

PMID:
11753211
37.
38.

MALP-2, a Mycoplasma lipopeptide with classical endotoxic properties: end of an era of LPS monopoly?

Galanos C, Gumenscheimer M, Mühlradt P, Jirillo E, Freudenberg M.

J Endotoxin Res. 2000;6(6):471-6.

PMID:
11521073
39.

A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.

Poltorak A, Merlin T, Nielsen PJ, Sandra O, Smirnova I, Schupp I, Boehm T, Galanos C, Freudenberg MA.

J Immunol. 2001 Aug 15;167(4):2106-11.

40.

Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers.

Schuld A, Mullington J, Friess E, Hermann DM, Galanos C, Holsboer F, Pollmächer T.

J Clin Endocrinol Metab. 2000 Dec;85(12):4624-9.

PMID:
11134118
41.

Inherited IL-12 unresponsiveness contributes to the high LPS resistance of the Lps(d) C57BL/10ScCr mouse.

Merlin T, Sing A, Nielsen PJ, Galanos C, Freudenberg MA.

J Immunol. 2001 Jan 1;166(1):566-73.

42.

Dose-dependent effects of endotoxin on human sleep.

Mullington J, Korth C, Hermann DM, Orth A, Galanos C, Holsboer F, Pollmächer T.

Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R947-55.

43.

Bacterial induction of beta interferon in mice is a function of the lipopolysaccharide component.

Sing A, Merlin T, Knopf HP, Nielsen PJ, Loppnow H, Galanos C, Freudenberg MA.

Infect Immun. 2000 Mar;68(3):1600-7.

44.

Lactoferrin-lipid A-lipopolysaccharide interaction: inhibition by anti-human lactoferrin monoclonal antibody AGM 10.14.

Caccavo D, Afeltra A, Pece S, Giuliani G, Freudenberg M, Galanos C, Jirillo E.

Infect Immun. 1999 Sep;67(9):4668-72.

45.

Dose-dependence of bacterial lipopolysaccharide (LPS) effects on peak response and time course of the immune-endocrine host response in humans.

Vedder H, Schreiber W, Yassouridis A, Gudewill S, Galanos C, Pollmächer T.

Inflamm Res. 1999 Feb;48(2):67-74.

PMID:
10202991
46.
47.

Bloodstream infections: epidemiology, pathophysiology and therapeutic perspectives.

Salomão R, Rigato O, Pignatari AC, Freudenberg MA, Galanos C.

Infection. 1999 Jan-Feb;27(1):1-11. Review. No abstract available.

PMID:
10027099
48.

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B.

Science. 1998 Dec 11;282(5396):2085-8.

49.

Endotoxin-induced changes in sleep and sleepiness during the day.

Hermann DM, Mullington J, Hinze-Selch D, Schreiber W, Galanos C, Pollmächer T.

Psychoneuroendocrinology. 1998 Jul;23(5):427-37.

PMID:
9802118
50.

Reconciling the concepts of endotoxin sensitization and tolerance.

Freudenberg MA, Salômao R, Sing A, Mitov I, Galanos C.

Prog Clin Biol Res. 1998;397:261-8. Review. No abstract available.

PMID:
9575567

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