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Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase.

Geiger T, Lara-Tejero M, Xiong Y, Galán JE.

Elife. 2020 Jan 20;9. pii: e53473. doi: 10.7554/eLife.53473.


Bacterial injection machines: Evolutionary diverse but functionally convergent.

Bleves S, Galán JE, Llosa M.

Cell Microbiol. 2019 Dec 31:e13157. doi: 10.1111/cmi.13157. [Epub ahead of print]


High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway.

Butan C, Lara-Tejero M, Li W, Liu J, Galán JE.

Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24786-24795. doi: 10.1073/pnas.1916331116. Epub 2019 Nov 19.


Alternate subunit assembly diversifies the function of a bacterial toxin.

Fowler CC, Stack G, Jiao X, Lara-Tejero M, Galán JE.

Nat Commun. 2019 Aug 15;10(1):3684. doi: 10.1038/s41467-019-11592-0.


A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion.

Guo EZ, Desrosiers DC, Zalesak J, Tolchard J, Berbon M, Habenstein B, Marlovits T, Loquet A, Galán JE.

PLoS Biol. 2019 Jul 1;17(7):e3000351. doi: 10.1371/journal.pbio.3000351. eCollection 2019 Jul.


Reconfiguration of a bacterial transport system generates a reverse gear.

Galán JE.

Nature. 2019 May;569(7754):44-45. doi: 10.1038/d41586-019-01320-5. No abstract available.


In Situ Structures of Polar and Lateral Flagella Revealed by Cryo-Electron Tomography.

Zhu S, Schniederberend M, Zhitnitsky D, Jain R, Galán JE, Kazmierczak BI, Liu J.

J Bacteriol. 2019 Jun 10;201(13). pii: e00117-19. doi: 10.1128/JB.00117-19. Print 2019 Jul 1.


Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen.

Chang SJ, Jin SC, Jiao X, Galán JE.

PLoS Pathog. 2019 Apr 5;15(4):e1007704. doi: 10.1371/journal.ppat.1007704. eCollection 2019 Apr.


The Injectisome, a Complex Nanomachine for Protein Injection into Mammalian Cells.

Lara-Tejero M, Galán JE.

EcoSal Plus. 2019 Mar;8(2). doi: 10.1128/ecosalplus.ESP-0039-2018. Review.


Role of SpaO in the assembly of the sorting platform of a Salmonella type III secretion system.

Lara-Tejero M, Qin Z, Hu B, Butan C, Liu J, Galán JE.

PLoS Pathog. 2019 Jan 22;15(1):e1007565. doi: 10.1371/journal.ppat.1007565. eCollection 2019 Jan.


Visualization of the type III secretion mediated Salmonella-host cell interface using cryo-electron tomography.

Park D, Lara-Tejero M, Waxham MN, Li W, Hu B, Galán JE, Liu J.

Elife. 2018 Oct 3;7. pii: e39514. doi: 10.7554/eLife.39514.


Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin.

Geiger T, Pazos M, Lara-Tejero M, Vollmer W, Galán JE.

Nat Microbiol. 2018 Nov;3(11):1243-1254. doi: 10.1038/s41564-018-0248-x. Epub 2018 Sep 24.


Salmonella stimulates pro-inflammatory signalling through p21-activated kinases bypassing innate immune receptors.

Sun H, Kamanova J, Lara-Tejero M, Galán JE.

Nat Microbiol. 2018 Oct;3(10):1122-1130. doi: 10.1038/s41564-018-0246-z. Epub 2018 Sep 17.


A protein secreted by the Salmonella type III secretion system controls needle filament assembly.

Kato J, Dey S, Soto JE, Butan C, Wilkinson MC, De Guzman RN, Galan JE.

Elife. 2018 Jul 17;7. pii: e35886. doi: 10.7554/eLife.35886.


Protein-Injection Machines in Bacteria.

Galán JE, Waksman G.

Cell. 2018 Mar 8;172(6):1306-1318. doi: 10.1016/j.cell.2018.01.034. Review.


Decoding a Salmonella Typhi Regulatory Network that Controls Typhoid Toxin Expression within Human Cells.

Fowler CC, Galán JE.

Cell Host Microbe. 2018 Jan 10;23(1):65-76.e6. doi: 10.1016/j.chom.2017.12.001.


Author Correction: Evolution of host adaptation in the Salmonella typhoid toxin.

Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE.

Nat Microbiol. 2017 Dec;2(12):1697. doi: 10.1038/s41564-017-0070-x.


Evolution of host adaptation in the Salmonella typhoid toxin.

Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE.

Nat Microbiol. 2017 Dec;2(12):1592-1599. doi: 10.1038/s41564-017-0033-2. Epub 2017 Oct 9. Erratum in: Nat Microbiol. 2017 Dec;2(12 ):1697.


Salmonella enterica serovar-specific transcriptional reprogramming of infected cells.

Hannemann S, Galán JE.

PLoS Pathog. 2017 Jul 24;13(7):e1006532. doi: 10.1371/journal.ppat.1006532. eCollection 2017 Jul.


Taking control: Hijacking of Rab GTPases by intracellular bacterial pathogens.

Spanò S, Galán JE.

Small GTPases. 2018 Mar 4;9(1-2):182-191. doi: 10.1080/21541248.2017.1336192. Epub 2017 Jul 5. Review.


Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni.

Gao B, Vorwerk H, Huber C, Lara-Tejero M, Mohr J, Goodman AL, Eisenreich W, Galán JE, Hofreuter D.

PLoS Biol. 2017 May 19;15(5):e2001390. doi: 10.1371/journal.pbio.2001390. eCollection 2017 May.


Visualization and characterization of individual type III protein secretion machines in live bacteria.

Zhang Y, Lara-Tejero M, Bewersdorf J, Galán JE.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6098-6103. doi: 10.1073/pnas.1705823114. Epub 2017 May 22.


In Situ Molecular Architecture of the Salmonella Type III Secretion Machine.

Hu B, Lara-Tejero M, Kong Q, Galán JE, Liu J.

Cell. 2017 Mar 9;168(6):1065-1074.e10. doi: 10.1016/j.cell.2017.02.022.


Emerging insights into the biology of typhoid toxin.

Fowler CC, Chang SJ, Gao X, Geiger T, Stack G, Galán JE.

Curr Opin Microbiol. 2017 Feb;35:70-77. doi: 10.1016/j.mib.2017.01.012. Epub 2017 Feb 16. Review.


Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus.

Dietsche T, Tesfazgi Mebrhatu M, Brunner MJ, Abrusci P, Yan J, Franz-Wachtel M, Schärfe C, Zilkenat S, Grin I, Galán JE, Kohlbacher O, Lea S, Macek B, Marlovits TC, Robinson CV, Wagner S.

PLoS Pathog. 2016 Dec 15;12(12):e1006071. doi: 10.1371/journal.ppat.1006071. eCollection 2016 Dec.


Receptor-Mediated Sorting of Typhoid Toxin during Its Export from Salmonella Typhi-Infected Cells.

Chang SJ, Song J, Galán JE.

Cell Host Microbe. 2016 Nov 9;20(5):682-689. doi: 10.1016/j.chom.2016.10.005.


Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.

Galán JE.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6338-44. doi: 10.1073/pnas.1606335113. Epub 2016 May 24. Review.


The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members.

Kamanova J, Sun H, Lara-Tejero M, Galán JE.

PLoS Pathog. 2016 Apr 8;12(4):e1005552. doi: 10.1371/journal.ppat.1005552. eCollection 2016 Apr.


A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis.

Sun H, Kamanova J, Lara-Tejero M, Galán JE.

PLoS Pathog. 2016 Mar 2;12(3):e1005484. doi: 10.1371/journal.ppat.1005484. eCollection 2016 Mar.


Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi.

Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F.

Cell. 2016 Feb 25;164(5):827-8. doi: 10.1016/j.cell.2016.02.015. No abstract available.


Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach.

Zilkenat S, Franz-Wachtel M, Stierhof YD, Galán JE, Macek B, Wagner S.

Mol Cell Proteomics. 2016 May;15(5):1598-609. doi: 10.1074/mcp.M115.056598. Epub 2016 Feb 21.


A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.

Spanò S, Gao X, Hannemann S, Lara-Tejero M, Galán JE.

Cell Host Microbe. 2016 Feb 10;19(2):216-26. doi: 10.1016/j.chom.2016.01.004.


Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates.

Tsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán JE, Hang HC.

J Am Chem Soc. 2016 Feb 24;138(7):2209-18. doi: 10.1021/jacs.5b11575. Epub 2016 Feb 16.


Role of autocleavage in the function of a type III secretion specificity switch protein in Salmonella enterica serovar Typhimurium.

Monjarás Feria JV, Lefebre MD, Stierhof YD, Galán JE, Wagner S.

mBio. 2015 Oct 13;6(5):e01459-15. doi: 10.1128/mBio.01459-15.


Structural Features Reminiscent of ATP-Driven Protein Translocases Are Essential for the Function of a Type III Secretion-Associated ATPase.

Kato J, Lefebre M, Galán JE.

J Bacteriol. 2015 Sep;197(18):3007-14. doi: 10.1128/JB.00434-15. Epub 2015 Jul 13.


Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi.

Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, Varki A.

Cell. 2014 Dec 4;159(6):1290-9. doi: 10.1016/j.cell.2014.10.057.


Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells.

Galán JE, Lara-Tejero M, Marlovits TC, Wagner S.

Annu Rev Microbiol. 2014;68:415-38. doi: 10.1146/annurev-micro-092412-155725. Epub 2014 Jun 18. Review.


Novel components of the flagellar system in epsilonproteobacteria.

Gao B, Lara-Tejero M, Lefebre M, Goodman AL, Galán JE.

mBio. 2014 Jun 24;5(3):e01349-14. doi: 10.1128/mBio.01349-14.


NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system.

Rathinavelan T, Lara-Tejero M, Lefebre M, Chatterjee S, McShan AC, Guo DC, Tang C, Galan JE, De Guzman RN.

J Mol Biol. 2014 Aug 12;426(16):2958-69. doi: 10.1016/j.jmb.2014.06.009. Epub 2014 Jun 18.


Structural and enzymatic characterization of a host-specificity determinant from Salmonella.

Kohler AC, Spanò S, Galán JE, Stebbins CE.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):384-91. doi: 10.1107/S1399004713028393. Epub 2014 Jan 29.


The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system.

Lefebre MD, Galán JE.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):817-22. doi: 10.1073/pnas.1319698111. Epub 2013 Dec 30.


A novel anti-microbial function for a familiar Rab GTPase.

Spanò S, Galán JE.

Small GTPases. 2013 Oct-Dec;4(4):252-4. doi: 10.4161/sgtp.27282. Epub 2013 Dec 9. Review.


Salmonella modulation of host cell gene expression promotes its intracellular growth.

Hannemann S, Gao B, Galán JE.

PLoS Pathog. 2013;9(10):e1003668. doi: 10.1371/journal.ppat.1003668. Epub 2013 Oct 3.


Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin.

Song J, Gao X, Galán JE.

Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377. Epub 2013 Jul 10.


Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors.

Hicks SW, Galán JE.

Nat Rev Microbiol. 2013 May;11(5):316-26. doi: 10.1038/nrmicro3009. Review.


An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA.

Chen X, Taylor DW, Fowler CC, Galan JE, Wang HW, Wolin SL.

Cell. 2013 Mar 28;153(1):166-77. doi: 10.1016/j.cell.2013.02.037.


Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery.

Carleton HA, Lara-Tejero M, Liu X, Galán JE.

Nat Commun. 2013;4:1590. doi: 10.1038/ncomms2594.


Contribution of amino acid catabolism to the tissue specific persistence of Campylobacter jejuni in a murine colonization model.

Hofreuter D, Mohr J, Wensel O, Rademacher S, Schreiber K, Schomburg D, Gao B, Galán JE.

PLoS One. 2012;7(11):e50699. doi: 10.1371/journal.pone.0050699. Epub 2012 Nov 30.


A Salmonella Typhi homologue of bacteriophage muramidases controls typhoid toxin secretion.

Hodak H, Galán JE.

EMBO Rep. 2013 Jan;14(1):95-102. doi: 10.1038/embor.2012.186. Epub 2012 Nov 23.


A Rab32-dependent pathway contributes to Salmonella typhi host restriction.

Spanò S, Galán JE.

Science. 2012 Nov 16;338(6109):960-3. doi: 10.1126/science.1229224.

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