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Items: 37

1.

Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago.

Neves JLB, Imperial JS, Morgenstern D, Ueberheide B, Gajewiak J, Antunes A, Robinson SD, Espino S, Watkins M, Vasconcelos V, Olivera BM.

Mar Drugs. 2019 Jul 24;17(8). pii: E432. doi: 10.3390/md17080432.

2.

α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors.

van Hout M, Valdes A, Christensen SB, Tran PT, Watkins M, Gajewiak J, Jensen AA, Olivera BM, McIntosh JM.

Neuropharmacology. 2019 Oct;157:107691. doi: 10.1016/j.neuropharm.2019.107691. Epub 2019 Jun 28.

PMID:
31255696
3.

PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors.

Hone AJ, Fisher F, Christensen S, Gajewiak J, Larkin D, Whiteaker P, McIntosh JM.

J Med Chem. 2019 Jul 11;62(13):6262-6275. doi: 10.1021/acs.jmedchem.9b00566. Epub 2019 Jun 27.

PMID:
31194549
4.

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor.

Ahorukomeye P, Disotuar MM, Gajewiak J, Karanth S, Watkins M, Robinson SD, Flórez Salcedo P, Smith NA, Smith BJ, Schlegel A, Forbes BE, Olivera B, Hung-Chieh Chou D, Safavi-Hemami H.

Elife. 2019 Feb 12;8. pii: e41574. doi: 10.7554/eLife.41574.

5.

Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors.

Hone AJ, Talley TT, Bobango J, Huidobro Melo C, Hararah F, Gajewiak J, Christensen S, Harvey PJ, Craik DJ, McIntosh JM.

J Biol Chem. 2018 Nov 16;293(46):17838-17852. doi: 10.1074/jbc.RA118.005649. Epub 2018 Sep 24.

PMID:
30249616
6.

Conopeptides promote itch through human itch receptor hMgprX1.

Espino SS, Robinson SD, Safavi-Hemami H, Gajewiak J, Yang W, Olivera BM, Liu Q.

Toxicon. 2018 Nov;154:28-34. doi: 10.1016/j.toxicon.2018.09.002. Epub 2018 Sep 21.

PMID:
30243794
7.

Structure and Biological Activity of a Turripeptide from Unedogemmula bisaya Venom.

Omaga CA, Carpio LD, Imperial JS, Daly NL, Gajewiak J, Flores MS, Espino SS, Christensen S, Filchakova OM, López-Vera E, Raghuraman S, Olivera BM, Concepcion GP.

Biochemistry. 2017 Nov 14;56(45):6051-6060. doi: 10.1021/acs.biochem.7b00485. Epub 2017 Nov 1.

PMID:
29090914
8.

Conorfamide-Sr3, a structurally novel specific inhibitor of the Shaker K+ channel.

Campos-Lira E, Carrillo E, Aguilar MB, Gajewiak J, Gómez-Lagunas F, López-Vera E.

Toxicon. 2017 Nov;138:53-58. doi: 10.1016/j.toxicon.2017.07.024. Epub 2017 Jul 31.

PMID:
28774677
9.

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.

Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL, Olivera BM, McIntosh JM.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1825-E1832. doi: 10.1073/pnas.1621433114. Epub 2017 Feb 21.

10.

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.

Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC.

Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12.

PMID:
27617429
11.

Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.

Green BR, Gajewiak J, Chhabra S, Skalicky JJ, Zhang MM, Rivier JE, Bulaj G, Olivera BM, Yoshikami D, Norton RS.

J Biol Chem. 2016 Mar 25;291(13):7205-20. doi: 10.1074/jbc.M115.697672. Epub 2016 Jan 27.

12.

Hormone-like peptides in the venoms of marine cone snails.

Robinson SD, Li Q, Bandyopadhyay PK, Gajewiak J, Yandell M, Papenfuss AT, Purcell AW, Norton RS, Safavi-Hemami H.

Gen Comp Endocrinol. 2017 Apr 1;244:11-18. doi: 10.1016/j.ygcen.2015.07.012. Epub 2015 Aug 22.

13.

Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ.

Zhang MM, Gajewiak J, Azam L, Bulaj G, Olivera BM, Yoshikami D.

Biochemistry. 2015 Jun 30;54(25):3911-20. doi: 10.1021/acs.biochem.5b00390. Epub 2015 Jun 18.

PMID:
26039939
14.

Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.

Wilson MJ, Zhang MM, Gajewiak J, Azam L, Rivier JE, Olivera BM, Yoshikami D.

J Neurophysiol. 2015 Apr 1;113(7):2289-301. doi: 10.1152/jn.01004.2014. Epub 2015 Jan 28.

15.

Specialized insulin is used for chemical warfare by fish-hunting cone snails.

Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass AD, Schlegel A, Imperial JS, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L, Olivera BM.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1743-8. doi: 10.1073/pnas.1423857112. Epub 2015 Jan 20.

16.

A family of excitatory peptide toxins from venomous crassispirine snails: using Constellation Pharmacology to assess bioactivity.

Imperial JS, Cabang AB, Song J, Raghuraman S, Gajewiak J, Watkins M, Showers-Corneli P, Fedosov A, Concepcion GP, Terlau H, Teichert RW, Olivera BM.

Toxicon. 2014 Oct;89:45-54. doi: 10.1016/j.toxicon.2014.06.014. Epub 2014 Jul 2.

17.

A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.

Gajewiak J, Azam L, Imperial J, Walewska A, Green BR, Bandyopadhyay PK, Raghuraman S, Ueberheide B, Bern M, Zhou HM, Minassian NA, Hagan RH, Flinspach M, Liu Y, Bulaj G, Wickenden AD, Olivera BM, Yoshikami D, Zhang MM.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2758-63. doi: 10.1073/pnas.1324189111. Epub 2014 Feb 4.

18.

Characterization of the peptidylglycine α-amidating monooxygenase (PAM) from the venom ducts of neogastropods, Conus bullatus and Conus geographus.

Ul-Hasan S, Burgess DM, Gajewiak J, Li Q, Hu H, Yandell M, Olivera BM, Bandyopadhyay PK.

Toxicon. 2013 Nov;74:215-24. doi: 10.1016/j.toxicon.2013.08.054. Epub 2013 Aug 29.

19.

Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.

Hone AJ, Ruiz M, Scadden M, Christensen S, Gajewiak J, Azam L, McIntosh JM.

J Biol Chem. 2013 Aug 30;288(35):25428-39. doi: 10.1074/jbc.M113.482059. Epub 2013 Jul 11.

20.

Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency.

Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS.

ACS Chem Biol. 2013;8(6):1344-51. doi: 10.1021/cb300674x. Epub 2013 Apr 16.

21.

Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxins.

Zhang MM, Wilson MJ, Gajewiak J, Rivier JE, Bulaj G, Olivera BM, Yoshikami D.

Br J Pharmacol. 2013 May;169(1):102-14. doi: 10.1111/bph.12119.

22.

Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins.

Zhang MM, Wilson MJ, Azam L, Gajewiak J, Rivier JE, Bulaj G, Olivera BM, Yoshikami D.

Br J Pharmacol. 2013 Apr;168(7):1597-610. doi: 10.1111/bph.12051.

23.

α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors.

Hone AJ, Scadden M, Gajewiak J, Christensen S, Lindstrom J, McIntosh JM.

Mol Pharmacol. 2012 Nov;82(5):972-82. doi: 10.1124/mol.112.080853. Epub 2012 Aug 22.

24.

Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails.

Safavi-Hemami H, Gorasia DG, Steiner AM, Williamson NA, Karas JA, Gajewiak J, Olivera BM, Bulaj G, Purcell AW.

J Biol Chem. 2012 Oct 5;287(41):34288-303. doi: 10.1074/jbc.M112.366781. Epub 2012 Aug 13.

25.

Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits.

Gowd KH, Han TS, Twede V, Gajewiak J, Smith MD, Watkins M, Platt RJ, Toledo G, White HS, Olivera BM, Bulaj G.

Biochemistry. 2012 Jun 12;51(23):4685-92. doi: 10.1021/bi300055n. Epub 2012 May 30.

26.

Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors.

Platt RJ, Han TS, Green BR, Smith MD, Skalicky J, Gruszczynski P, White HS, Olivera B, Bulaj G, Gajewiak J.

J Biol Chem. 2012 Jun 8;287(24):20727-36. doi: 10.1074/jbc.M112.350462. Epub 2012 Apr 19.

27.

Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications.

He J, Gajewiak J, Scott JL, Gong D, Ali M, Best MD, Prestwich GD, Stahelin RV, Kutateladze TG.

Chem Biol. 2011 Oct 28;18(10):1312-9. doi: 10.1016/j.chembiol.2011.07.022.

28.

Characterization of a venom peptide from a crassispirid gastropod.

Cabang AB, Imperial JS, Gajewiak J, Watkins M, Corneli PS, Olivera BM, Concepcion GP.

Toxicon. 2011 Dec 1;58(8):672-80. doi: 10.1016/j.toxicon.2011.09.001. Epub 2011 Sep 12.

29.

μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve.

Wilson MJ, Yoshikami D, Azam L, Gajewiak J, Olivera BM, Bulaj G, Zhang MM.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. doi: 10.1073/pnas.1107027108. Epub 2011 Jun 7.

30.

Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo.

Zhang H, Xu X, Gajewiak J, Tsukahara R, Fujiwara Y, Liu J, Fells JI, Perygin D, Parrill AL, Tigyi G, Prestwich GD.

Cancer Res. 2009 Jul 1;69(13):5441-9. doi: 10.1158/0008-5472.CAN-09-0302. Epub 2009 Jun 9.

31.

Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer.

Prestwich GD, Gajewiak J, Zhang H, Xu X, Yang G, Serban M.

Biochim Biophys Acta. 2008 Sep;1781(9):588-94. doi: 10.1016/j.bbalip.2008.03.008. Epub 2008 Apr 8. Review.

32.

Synthesis, pharmacology, and cell biology of sn-2-aminooxy analogues of lysophosphatidic acid.

Gajewiak J, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD.

Org Lett. 2008 Mar 20;10(6):1111-4. doi: 10.1021/ol7030747. Epub 2008 Feb 20.

33.

Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor.

Gajewiak J, Tsukahara R, Tsukahara T, Fujiwara Y, Yu S, Lu Y, Murph M, Mills GB, Tigyi G, Prestwich GD.

ChemMedChem. 2007 Dec;2(12):1789-98. Erratum in: ChemMedChem. 2008 Feb;3(2):200. Fujiwara, Yuko [added].

PMID:
17952880
34.

Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA.

Jiang G, Xu Y, Fujiwara Y, Tsukahara T, Tsukahara R, Gajewiak J, Tigyi G, Prestwich GD.

ChemMedChem. 2007 May;2(5):679-90.

35.

Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate.

Gajewiak J, Xu Y, Lee SA, Kutateladze TG, Prestwich GD.

Org Lett. 2006 Jun 22;8(13):2811-3.

36.

Aminooxy pluronics: synthesis and preparation of glycosaminoglycan adducts.

Gajewiak J, Cai S, Shu XZ, Prestwich GD.

Biomacromolecules. 2006 Jun;7(6):1781-9.

PMID:
16768398
37.

New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors.

Prestwich GD, Xu Y, Qian L, Gajewiak J, Jiang G.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1357-61. Review.

PMID:
16246118

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