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Items: 40

1.

Manufacturing and Delivering Genome-Editing Proteins.

Liu J, Liang YJ, Ren PL, Gaj T.

Methods Mol Biol. 2018;1867:253-273. doi: 10.1007/978-1-4939-8799-3_19.

PMID:
30155829
2.

hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.

Adil MM, Gaj T, Rao AT, Kulkarni RU, Fuentes CM, Ramadoss GN, Ekman FK, Miller EW, Schaffer DV.

Stem Cell Reports. 2018 May 8;10(5):1481-1491. doi: 10.1016/j.stemcr.2018.03.007. Epub 2018 Apr 5.

3.

Innovations in CRISPR technology.

Brooks AK, Gaj T.

Curr Opin Biotechnol. 2018 Aug;52:95-101. doi: 10.1016/j.copbio.2018.03.007. Epub 2018 Apr 5. Review.

PMID:
29626736
4.

A Hypothalamic Switch for REM and Non-REM Sleep.

Chen KS, Xu M, Zhang Z, Chang WC, Gaj T, Schaffer DV, Dan Y.

Neuron. 2018 Mar 7;97(5):1168-1176.e4. doi: 10.1016/j.neuron.2018.02.005. Epub 2018 Feb 22.

PMID:
29478915
5.

In vivo genome editing improves motor function and extends survival in a mouse model of ALS.

Gaj T, Ojala DS, Ekman FK, Byrne LC, Limsirichai P, Schaffer DV.

Sci Adv. 2017 Dec 20;3(12):eaar3952. doi: 10.1126/sciadv.aar3952. eCollection 2017 Dec.

6.

Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.

Rodrigues GMC, Gaj T, Adil MM, Wahba J, Rao AT, Lorbeer FK, Kulkarni RU, Diogo MM, Cabral JMS, Miller EW, Hockemeyer D, Schaffer DV.

Stem Cell Reports. 2017 Jun 6;8(6):1770-1783. doi: 10.1016/j.stemcr.2017.04.027. Epub 2017 May 25.

7.

Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery.

Gaj T, Staahl BT, Rodrigues GMC, Limsirichai P, Ekman FK, Doudna JA, Schaffer DV.

Nucleic Acids Res. 2017 Jun 20;45(11):e98. doi: 10.1093/nar/gkx154.

8.

Genome-Editing Technologies: Principles and Applications.

Gaj T, Sirk SJ, Shui SL, Liu J.

Cold Spring Harb Perspect Biol. 2016 Dec 1;8(12). pii: a023754. doi: 10.1101/cshperspect.a023754. Review.

PMID:
27908936
9.

Adeno-Associated Virus-Mediated Delivery of CRISPR-Cas Systems for Genome Engineering in Mammalian Cells.

Gaj T, Schaffer DV.

Cold Spring Harb Protoc. 2016 Nov 1;2016(11). doi: 10.1101/pdb.prot086868.

PMID:
27803249
10.

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.

Tervo DG, Hwang BY, Viswanathan S, Gaj T, Lavzin M, Ritola KD, Lindo S, Michael S, Kuleshova E, Ojala D, Huang CC, Gerfen CR, Schiller J, Dudman JT, Hantman AW, Looger LL, Schaffer DV, Karpova AY.

Neuron. 2016 Oct 19;92(2):372-382. doi: 10.1016/j.neuron.2016.09.021. Epub 2016 Oct 6.

11.

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

Perdig√£o P, Gaj T, Santa-Marta M, Barbas CF 3rd, Goncalves J.

PLoS One. 2016 Mar 2;11(3):e0150037. doi: 10.1371/journal.pone.0150037. eCollection 2016.

12.

CRISPR-mediated Activation of Latent HIV-1 Expression.

Limsirichai P, Gaj T, Schaffer DV.

Mol Ther. 2016 Mar;24(3):499-507. doi: 10.1038/mt.2015.213. Epub 2015 Nov 26.

13.

Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells.

Liu J, Gaj T, Yang Y, Wang N, Shui S, Kim S, Kanchiswamy CN, Kim JS, Barbas CF 3rd.

Nat Protoc. 2015 Nov;10(11):1842-59. doi: 10.1038/nprot.2015.117. Epub 2015 Oct 22.

PMID:
26492140
14.

Redesigning Recombinase Specificity for Safe Harbor Sites in the Human Genome.

Wallen MC, Gaj T, Barbas CF 3rd.

PLoS One. 2015 Sep 28;10(9):e0139123. doi: 10.1371/journal.pone.0139123. eCollection 2015.

15.

Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications.

Gaj T, Epstein BE, Schaffer DV.

Mol Ther. 2016 Mar;24(3):458-64. doi: 10.1038/mt.2015.151. Epub 2015 Sep 16. Review.

16.
17.

Improved cell-penetrating zinc-finger nuclease proteins for precision genome engineering.

Liu J, Gaj T, Wallen MC, Barbas CF 3rd.

Mol Ther Nucleic Acids. 2015 Mar 10;4:e232. doi: 10.1038/mtna.2015.6.

18.

Genome engineering with custom recombinases.

Gaj T, Barbas CF 3rd.

Methods Enzymol. 2014;546:79-91. doi: 10.1016/B978-0-12-801185-0.00004-0.

PMID:
25398336
19.

Site-selective labeling of a lysine residue in human serum albumin.

Asano S, Patterson JT, Gaj T, Barbas CF 3rd.

Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11783-6. doi: 10.1002/anie.201405924. Epub 2014 Sep 4.

PMID:
25196737
20.

Protein delivery using Cys2-His2 zinc-finger domains.

Gaj T, Liu J, Anderson KE, Sirk SJ, Barbas CF 3rd.

ACS Chem Biol. 2014 Aug 15;9(8):1662-7. doi: 10.1021/cb500282g. Epub 2014 Jun 19.

21.

Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies.

Gersbach CA, Gaj T, Barbas CF 3rd.

Acc Chem Res. 2014 Aug 19;47(8):2309-18. doi: 10.1021/ar500039w. Epub 2014 May 30.

22.

Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign.

Gaj T, Sirk SJ, Tingle RD, Mercer AC, Wallen MC, Barbas CF 3rd.

J Am Chem Soc. 2014 Apr 2;136(13):5047-56. doi: 10.1021/ja4130059. Epub 2014 Mar 20.

23.

Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering.

Liu J, Gaj T, Patterson JT, Sirk SJ, Barbas CF 3rd.

PLoS One. 2014 Jan 20;9(1):e85755. doi: 10.1371/journal.pone.0085755. eCollection 2014.

24.

Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants.

Sirk SJ, Gaj T, Jonsson A, Mercer AC, Barbas CF 3rd.

Nucleic Acids Res. 2014 Apr;42(7):4755-66. doi: 10.1093/nar/gkt1389. Epub 2014 Jan 21.

25.

Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors.

Mercer AC, Gaj T, Sirk SJ, Lamb BM, Barbas CF 3rd.

ACS Synth Biol. 2014 Oct 17;3(10):723-30. doi: 10.1021/sb400114p. Epub 2013 Nov 22.

26.

Expanding the scope of site-specific recombinases for genetic and metabolic engineering.

Gaj T, Sirk SJ, Barbas CF 3rd.

Biotechnol Bioeng. 2014 Jan;111(1):1-15. doi: 10.1002/bit.25096. Epub 2013 Sep 13. Review.

27.

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.

Gaj T, Gersbach CA, Barbas CF 3rd.

Trends Biotechnol. 2013 Jul;31(7):397-405. doi: 10.1016/j.tibtech.2013.04.004. Epub 2013 May 9. Review.

28.

A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells.

Gaj T, Mercer AC, Sirk SJ, Smith HL, Barbas CF 3rd.

Nucleic Acids Res. 2013 Apr 1;41(6):3937-46. doi: 10.1093/nar/gkt071. Epub 2013 Feb 7.

29.

Chimeric TALE recombinases with programmable DNA sequence specificity.

Mercer AC, Gaj T, Fuller RP, Barbas CF 3rd.

Nucleic Acids Res. 2012 Nov;40(21):11163-72. doi: 10.1093/nar/gks875. Epub 2012 Sep 26.

30.

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins.

Gaj T, Guo J, Kato Y, Sirk SJ, Barbas CF 3rd.

Nat Methods. 2012 Jul 1;9(8):805-7. doi: 10.1038/nmeth.2030.

31.

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase.

Gersbach CA, Gaj T, Gordley RM, Mercer AC, Barbas CF 3rd.

Nucleic Acids Res. 2011 Sep 1;39(17):7868-78. doi: 10.1093/nar/gkr421. Epub 2011 Jun 7.

32.

Structure-guided reprogramming of serine recombinase DNA sequence specificity.

Gaj T, Mercer AC, Gersbach CA, Gordley RM, Barbas CF 3rd.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):498-503. doi: 10.1073/pnas.1014214108. Epub 2010 Dec 27.

33.

Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases.

Guo J, Gaj T, Barbas CF 3rd.

J Mol Biol. 2010 Jul 2;400(1):96-107. doi: 10.1016/j.jmb.2010.04.060. Epub 2010 May 4.

34.

Directed evolution of recombinase specificity by split gene reassembly.

Gersbach CA, Gaj T, Gordley RM, Barbas CF 3rd.

Nucleic Acids Res. 2010 Jul;38(12):4198-206. doi: 10.1093/nar/gkq125. Epub 2010 Mar 1.

35.

Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor of protein kinase A.

Meyer SC, Shomin CD, Gaj T, Ghosh I.

J Am Chem Soc. 2007 Nov 14;129(45):13812-3. Epub 2007 Oct 18. No abstract available.

PMID:
17944472
36.

The AviD-tag, a NeutrAvidin/avidin specific peptide affinity tag for the immobilization and purification of recombinant proteins.

Gaj T, Meyer SC, Ghosh I.

Protein Expr Purif. 2007 Nov;56(1):54-61. Epub 2007 Jul 30.

PMID:
17697784
37.

Highly selective cyclic peptide ligands for NeutrAvidin and avidin identified by phage display.

Meyer SC, Gaj T, Ghosh I.

Chem Biol Drug Des. 2006 Jul;68(1):3-10.

PMID:
16923020
38.

[Familial atrophic form of spinocerebellar ataxia].

Gaj T, Grendus-Tota B.

Neurol Neurochir Pol. 1973 Sep-Oct;7(5):679-83. Polish. No abstract available.

PMID:
4763007
39.

[Fisher's syndrome or acute ophthalmoplegia with ataxia and areflexia].

Brzecki A, Gaj T.

Neurol Neurochir Pol. 1972 Sep-Oct;6(5):805-8. Polish. No abstract available.

PMID:
4638177
40.

[Devic's syndrome of rheumatic etiology].

Gaj T, Grendus-Tota B.

Neurol Neurochir Pol. 1969 Sep-Oct;3(5):659-62. Polish. No abstract available.

PMID:
5307948

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