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Items: 38


Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.

Mujalli A, Chicanne G, Bertrand-Michel J, Viars F, Stephens L, Hawkins P, Viaud J, Gaits-Iacovoni F, Severin S, Gratacap MP, Terrisse AD, Payrastre B.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1121-1131. doi: 10.1016/j.bbalip.2018.06.009. Epub 2018 Jun 12.


Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets.

Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra KT, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, Nieswandt B.

Blood Adv. 2018 May 8;2(9):1040-1045. doi: 10.1182/bloodadvances.2017014001. No abstract available.


Local production of tenascin-C acts as a trigger for monocyte/macrophage recruitment that provokes cardiac dysfunction.

Abbadi D, Laroumanie F, Bizou M, Pozzo J, Daviaud D, Delage C, Calise D, Gaits-Iacovoni F, Dutaur M, Tortosa F, Renaud-Gabardos E, Douin-Echinard V, Prats AC, Roncalli J, Parini A, Pizzinat N.

Cardiovasc Res. 2018 Jan 1;114(1):123-137. doi: 10.1093/cvr/cvx221.


The importance of blood platelet lipid signaling in thrombosis and in sepsis.

Vardon Bounes F, Mujalli A, Cenac C, Severin S, Le Faouder P, Chicanne G, Gaits-Iacovoni F, Minville V, Gratacap MP, Payrastre B.

Adv Biol Regul. 2018 Jan;67:66-73. doi: 10.1016/j.jbior.2017.09.011. Epub 2017 Sep 29. Review.


A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

Valet C, Levade M, Chicanne G, Bilanges B, Cabou C, Viaud J, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S.

Blood. 2017 Nov 2;130(18):2032-2042. doi: 10.1182/blood-2017-04-781641. Epub 2017 Sep 13.


Protein-Lipid Interaction by Fluorescence (PLIF) to Characterize and Screen for Inhibitors of Protein-Phosphoinositide Interactions.

Ceccato L, Mansat M, Payrastre B, Gaits-Iacovoni F, Viaud J.

Curr Protoc Protein Sci. 2017 Aug 1;89:19.31.1-19.31.10. doi: 10.1002/cpps.35.


A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B.

Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.


Mass Assays to Quantify Bioactive PtdIns3P and PtdIns5P During Autophagic Responses.

Viaud J, Chicanne G, Solinhac R, Hnia K, Gaits-Iacovoni F, Payrastre B.

Methods Enzymol. 2017;587:293-310. doi: 10.1016/bs.mie.2016.09.061. Epub 2016 Nov 18.


Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.

Ismail S, Gherardi MJ, Froese A, Zanoun M, Gigoux V, Clerc P, Gaits-Iacovoni F, Steyaert J, Nikolaev VO, Fourmy D.

Biochem Pharmacol. 2016 Nov 15;120:33-45. doi: 10.1016/j.bcp.2016.09.009. Epub 2016 Sep 15.


The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction.

Picas L, Gaits-Iacovoni F, Goud B.

F1000Res. 2016 Mar 31;5. pii: F1000 Faculty Rev-422. doi: 10.12688/f1000research.7537.1. eCollection 2016. Review.


PLIF: A rapid, accurate method to detect and quantitatively assess protein-lipid interactions.

Ceccato L, Chicanne G, Nahoum V, Pons V, Payrastre B, Gaits-Iacovoni F, Viaud J.

Sci Signal. 2016 Mar 29;9(421):rs2. doi: 10.1126/scisignal.aad4337.


Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes.

Antkowiak A, Viaud J, Severin S, Zanoun M, Ceccato L, Chicanne G, Strassel C, Eckly A, Leon C, Gachet C, Payrastre B, Gaits-Iacovoni F.

J Thromb Haemost. 2016 Jun;14(6):1268-84. doi: 10.1111/jth.13318. Epub 2016 Apr 21.


The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis.

Valet C, Severin S, Chicanne G, Laurent PA, Gaits-Iacovoni F, Gratacap MP, Payrastre B.

Adv Biol Regul. 2016 May;61:33-41. doi: 10.1016/j.jbior.2015.11.008. Epub 2015 Dec 2. Review.


Phosphoinositides: Important lipids in the coordination of cell dynamics.

Viaud J, Mansour R, Antkowiak A, Mujalli A, Valet C, Chicanne G, Xuereb JM, Terrisse AD, Séverin S, Gratacap MP, Gaits-Iacovoni F, Payrastre B.

Biochimie. 2016 Jun;125:250-8. doi: 10.1016/j.biochi.2015.09.005. Epub 2015 Sep 25. Review.


Essential role of class II PI3K-C2α in platelet membrane morphology.

Valet C, Chicanne G, Severac C, Chaussade C, Whitehead MA, Cabou C, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S.

Blood. 2015 Aug 27;126(9):1128-37. doi: 10.1182/blood-2015-03-636670. Epub 2015 Jun 24.


Human white and brite adipogenesis is supported by MSCA1 and is impaired by immune cells.

Estève D, Boulet N, Volat F, Zakaroff-Girard A, Ledoux S, Coupaye M, Decaunes P, Belles C, Gaits-Iacovoni F, Iacovoni JS, Rémaury A, Castel B, Ferrara P, Heymes C, Lafontan M, Bouloumié A, Galitzky J.

Stem Cells. 2015 Apr;33(4):1277-91. doi: 10.1002/stem.1916.


BIN1/M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin.

Picas L, Viaud J, Schauer K, Vanni S, Hnia K, Fraisier V, Roux A, Bassereau P, Gaits-Iacovoni F, Payrastre B, Laporte J, Manneville JB, Goud B.

Nat Commun. 2014 Dec 9;5:5647. doi: 10.1038/ncomms6647.


Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.

Viaud J, Lagarrigue F, Ramel D, Allart S, Chicanne G, Ceccato L, Courilleau D, Xuereb JM, Pertz O, Payrastre B, Gaits-Iacovoni F.

Nat Commun. 2014 Jun 6;5:4080. doi: 10.1038/ncomms5080.


Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.

Viaud J, Boal F, Tronchère H, Gaits-Iacovoni F, Payrastre B.

Bioessays. 2014 Mar;36(3):260-72. doi: 10.1002/bies.201300132. Epub 2013 Dec 21. Review.


CIP4 controls CCL19-driven cell steering and chemotaxis in chronic lymphocytic leukemia.

Malet-Engra G, Viaud J, Ysebaert L, Farcé M, Lafouresse F, Laurent G, Gaits-Iacovoni F, Scita G, Dupré L.

Cancer Res. 2013 Jun 1;73(11):3412-24. doi: 10.1158/0008-5472.CAN-12-3564. Epub 2013 May 3.


A confocal-based morphometric analysis shows a functional crosstalk between the actin filament system and microtubules in thrombin-stimulated platelets.

Severin S, Gaits-Iacovoni F, Allart S, Gratacap MP, Payrastre B.

J Thromb Haemost. 2013 Jan;11(1):183-6. doi: 10.1111/jth.12053. No abstract available.


A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples.

Chicanne G, Severin S, Boscheron C, Terrisse AD, Gratacap MP, Gaits-Iacovoni F, Tronchère H, Payrastre B.

Biochem J. 2012 Oct 1;447(1):17-23. doi: 10.1042/BJ20120945.


Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination.

Colomba A, Giuriato S, Dejean E, Thornber K, Delsol G, Tronchère H, Meggetto F, Payrastre B, Gaits-Iacovoni F.

Blood Cancer J. 2011 Jun;1(6):e21. doi: 10.1038/bcj.2011.19. Epub 2011 Jun 3.


Regulation of the DH-PH tandem of guanine nucleotide exchange factor for Rho GTPases by phosphoinositides.

Viaud J, Gaits-Iacovoni F, Payrastre B.

Adv Biol Regul. 2012 May;52(2):303-14. doi: 10.1016/j.jbior.2012.04.001. Epub 2012 Apr 11. Review.


ALK+ALCLs induce cutaneous, HMGB-1-dependent IL-8/CXCL8 production by keratinocytes through NF-κB activation.

Dejean E, Foisseau M, Lagarrigue F, Lamant L, Prade N, Marfak A, Delsol G, Giuriato S, Gaits-Iacovoni F, Meggetto F.

Blood. 2012 May 17;119(20):4698-707. doi: 10.1182/blood-2011-10-386011. Epub 2012 Mar 6.


Phosphoinositides and cellular pathogens.

Payrastre B, Gaits-Iacovoni F, Sansonetti P, Tronchère H.

Subcell Biochem. 2012;59:363-88. doi: 10.1007/978-94-007-3015-1_12. Review.


The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development.

Colacios C, Casemayou A, Dejean AS, Gaits-Iacovoni F, Pedros C, Bernard I, Lagrange D, Deckert M, Lamouroux L, Jagodic M, Olsson T, Liblau RS, Fournié GJ, Saoudi A.

J Exp Med. 2011 Oct 24;208(11):2183-91. doi: 10.1084/jem.20102191. Epub 2011 Sep 26.


Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling.

Ramel D, Lagarrigue F, Pons V, Mounier J, Dupuis-Coronas S, Chicanne G, Sansonetti PJ, Gaits-Iacovoni F, Tronchère H, Payrastre B.

Sci Signal. 2011 Sep 20;4(191):ra61. doi: 10.1126/scisignal.2001619.


The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.

Dupuis-Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits-Iacovoni F, Payrastre B, Tronchère H.

J Biol Chem. 2011 Sep 16;286(37):32105-14. doi: 10.1074/jbc.M111.227512. Epub 2011 Jul 7.


Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions.

Gratacap MP, Guillermet-Guibert J, Martin V, Chicanne G, Tronchère H, Gaits-Iacovoni F, Payrastre B.

Adv Enzyme Regul. 2011;51(1):106-16. doi: 10.1016/j.advenzreg.2010.09.011. Epub 2010 Oct 28. Review.


Matrix metalloproteinase-9 is upregulated in nucleophosmin-anaplastic lymphoma kinase-positive anaplastic lymphomas and activated at the cell surface by the chaperone heat shock protein 90 to promote cell invasion.

Lagarrigue F, Dupuis-Coronas S, Ramel D, Delsol G, Tronchère H, Payrastre B, Gaits-Iacovoni F.

Cancer Res. 2010 Sep 1;70(17):6978-87. doi: 10.1158/0008-5472.CAN-10-0861. Epub 2010 Aug 10.


PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

Ramel D, Lagarrigue F, Dupuis-Coronas S, Chicanne G, Leslie N, Gaits-Iacovoni F, Payrastre B, Tronchère H.

Biochem Biophys Res Commun. 2009 Sep 11;387(1):127-31. doi: 10.1016/j.bbrc.2009.06.139. Epub 2009 Jul 1.


Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas.

Thornber K, Colomba A, Ceccato L, Delsol G, Payrastre B, Gaits-Iacovoni F.

Oncogene. 2009 Jul 23;28(29):2690-6. doi: 10.1038/onc.2009.125. Epub 2009 Jun 8.


Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.

Colomba A, Courilleau D, Ramel D, Billadeau DD, Espinos E, Delsol G, Payrastre B, Gaits-Iacovoni F.

Oncogene. 2008 Apr 24;27(19):2728-36. Epub 2007 Nov 12.


PtdIns5P: a little phosphoinositide with big functions?

Coronas S, Ramel D, Pendaries C, Gaits-Iacovoni F, Tronchère H, Payrastre B.

Biochem Soc Symp. 2007;(74):117-28. Review.


Proteomic analysis of anaplastic lymphoma cell lines: identification of potential tumour markers.

Cussac D, Pichereaux C, Colomba A, Capilla F, Pont F, Gaits-Iacovoni F, Lamant L, Espinos E, Burlet-Schiltz O, Monsarrat B, Delsol G, Payrastre B.

Proteomics. 2006 May;6(10):3210-22.


PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.

Pendaries C, Tronchère H, Arbibe L, Mounier J, Gozani O, Cantley L, Fry MJ, Gaits-Iacovoni F, Sansonetti PJ, Payrastre B.

EMBO J. 2006 Mar 8;25(5):1024-34. Epub 2006 Feb 16.


Emerging roles of phosphatidylinositol monophosphates in cellular signaling and trafficking.

Pendaries C, Tronchère H, Racaud-Sultan C, Gaits-Iacovoni F, Coronas S, Manenti S, Gratacap MP, Plantavid M, Payrastre B.

Adv Enzyme Regul. 2005;45:201-14. Epub 2005 Jul 15.


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