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Items: 27

1.

Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

Tria GS, Abrams T, Baird J, Burks HE, Firestone B, Gaither LA, Hamann LG, He G, Kirby CA, Kim S, Lombardo F, Macchi KJ, McDonnell DP, Mishina Y, Norris JD, Nunez J, Springer C, Sun Y, Thomsen NM, Wang C, Wang J, Yu B, Tiong-Yip CL, Peukert S.

J Med Chem. 2018 Apr 12;61(7):2837-2864. doi: 10.1021/acs.jmedchem.7b01682. Epub 2018 Mar 22.

PMID:
29562737
2.

TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.

Kulkarni S, Bill A, Godse NR, Khan NI, Kass JI, Steehler K, Kemp C, Davis K, Bertrand CA, Vyas AR, Holt DE, Grandis JR, Gaither LA, Duvvuri U.

Genes Chromosomes Cancer. 2017 Jun;56(6):460-471. doi: 10.1002/gcc.22450. Epub 2017 Apr 3.

3.

Quantitative Proteomic Verification of Membrane Proteins as Potential Therapeutic Targets Located in the 11q13 Amplicon in Cancers.

Hoover H, Li J, Marchese J, Rothwell C, Borawoski J, Jeffery DA, Gaither LA, Finkel N.

J Proteome Res. 2015 Sep 4;14(9):3670-9. doi: 10.1021/acs.jproteome.5b00508. Epub 2015 Jul 29.

PMID:
26151158
4.

ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.

Bill A, Gutierrez A, Kulkarni S, Kemp C, Bonenfant D, Voshol H, Duvvuri U, Gaither LA.

Oncotarget. 2015 Apr 20;6(11):9173-88.

5.

Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation.

Bill A, Popa MO, van Diepen MT, Gutierrez A, Lilley S, Velkova M, Acheson K, Choudhury H, Renaud NA, Auld DS, Gosling M, Groot-Kormelink PJ, Gaither LA.

J Biol Chem. 2015 Jan 9;290(2):889-903. doi: 10.1074/jbc.M114.618140. Epub 2014 Nov 25.

6.

To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN.

Shiwarski DJ, Shao C, Bill A, Kim J, Xiao D, Bertrand CA, Seethala RS, Sano D, Myers JN, Ha P, Grandis J, Gaither LA, Puthenveedu MA, Duvvuri U.

Clin Cancer Res. 2014 Sep 1;20(17):4673-88. doi: 10.1158/1078-0432.CCR-14-0363. Epub 2014 Jun 11.

7.

High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function.

Bill A, Rosethorne EM, Kent TC, Fawcett L, Burchell L, van Diepen MT, Marelli A, Batalov S, Miraglia L, Orth AP, Renaud NA, Charlton SJ, Gosling M, Gaither LA, Groot-Kormelink PJ.

PLoS One. 2014 Jun 2;9(6):e97973. doi: 10.1371/journal.pone.0097973. eCollection 2014.

8.

The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1.

Niemi NM, Sacoman JL, Westrate LM, Gaither LA, Lanning NJ, Martin KR, MacKeigan JP.

PLoS One. 2014 Apr 7;9(4):e93896. doi: 10.1371/journal.pone.0093896. eCollection 2014.

9.

Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics.

Bill A, Hall ML, Borawski J, Hodgson C, Jenkins J, Piechon P, Popa O, Rothwell C, Tranter P, Tria S, Wagner T, Whitehead L, Gaither LA.

J Biol Chem. 2014 Apr 18;289(16):11029-41. doi: 10.1074/jbc.M114.549188. Epub 2014 Mar 5.

10.

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.

Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy CT, Wetzel K, George E, Popa MO, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither LA, Bentires-Alj M.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E1026-34. doi: 10.1073/pnas.1217072110. Epub 2013 Feb 19.

11.

FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.

Guagnano V, Kauffmann A, Wöhrle S, Stamm C, Ito M, Barys L, Pornon A, Yao Y, Li F, Zhang Y, Chen Z, Wilson CJ, Bordas V, Le Douget M, Gaither LA, Borawski J, Monahan JE, Venkatesan K, Brümmendorf T, Thomas DM, Garcia-Echeverria C, Hofmann F, Sellers WR, Graus-Porta D.

Cancer Discov. 2012 Dec;2(12):1118-33. doi: 10.1158/2159-8290.CD-12-0210. Epub 2012 Sep 20.

12.

Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors.

Lamarche MJ, Borawski J, Bose A, Capacci-Daniel C, Colvin R, Dennehy M, Ding J, Dobler M, Drumm J, Gaither LA, Gao J, Jiang X, Lin K, McKeever U, Puyang X, Raman P, Thohan S, Tommasi R, Wagner K, Xiong X, Zabawa T, Zhu S, Wiedmann B.

Antimicrob Agents Chemother. 2012 Oct;56(10):5149-56. doi: 10.1128/AAC.00946-12. Epub 2012 Jul 23.

13.

Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling.

Chen J, Shen Q, Labow M, Gaither LA.

Cancer Res. 2011 Jun 15;71(12):4280-91. doi: 10.1158/0008-5472.CAN-10-3761. Epub 2011 Apr 28.

14.

MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis.

Niemi NM, Lanning NJ, Klomp JA, Tait SW, Xu Y, Dykema KJ, Murphy LO, Gaither LA, Xu HE, Furge KA, Green DR, MacKeigan JP.

Mol Cell Biol. 2011 Apr;31(7):1357-68. doi: 10.1128/MCB.00788-10. Epub 2011 Jan 24.

15.

Multiple cyclophilins involved in different cellular pathways mediate HCV replication.

Gaither LA, Borawski J, Anderson LJ, Balabanis KA, Devay P, Joberty G, Rau C, Schirle M, Bouwmeester T, Mickanin C, Zhao S, Vickers C, Lee L, Deng G, Baryza J, Fujimoto RA, Lin K, Compton T, Wiedmann B.

Virology. 2010 Feb 5;397(1):43-55. doi: 10.1016/j.virol.2009.10.043. Epub 2009 Nov 24.

16.

Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.

Borawski J, Troke P, Puyang X, Gibaja V, Zhao S, Mickanin C, Leighton-Davies J, Wilson CJ, Myer V, Cornellataracido I, Baryza J, Tallarico J, Joberty G, Bantscheff M, Schirle M, Bouwmeester T, Mathy JE, Lin K, Compton T, Labow M, Wiedmann B, Gaither LA.

J Virol. 2009 Oct;83(19):10058-74. doi: 10.1128/JVI.02418-08. Epub 2009 Jul 15.

17.

Cholesterol biosynthesis modulation regulates dengue viral replication.

Rothwell C, Lebreton A, Young Ng C, Lim JY, Liu W, Vasudevan S, Labow M, Gu F, Gaither LA.

Virology. 2009 Jun 20;389(1-2):8-19. doi: 10.1016/j.virol.2009.03.025. Epub 2009 May 5.

18.

Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death.

Elis W, Triantafellow E, Wolters NM, Sian KR, Caponigro G, Borawski J, Gaither LA, Murphy LO, Finan PM, Mackeigan JP.

Mol Cancer Res. 2008 Apr;6(4):614-23. doi: 10.1158/1541-7786.MCR-07-0262.

19.

Chemogenomics approaches to novel target discovery.

Gaither LA.

Expert Rev Proteomics. 2007 Jun;4(3):411-9. Review.

PMID:
17552925
20.

Optimization procedure for small interfering RNA transfection in a 384-well format.

Borawski J, Lindeman A, Buxton F, Labow M, Gaither LA.

J Biomol Screen. 2007 Jun;12(4):546-59. Epub 2007 Apr 13.

PMID:
17435168
21.

Eukaryotic zinc transporters and their regulation.

Gaither LA, Eide DJ.

Biometals. 2001 Sep-Dec;14(3-4):251-70. Review.

PMID:
11831460
22.

The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.

Gaither LA, Eide DJ.

J Biol Chem. 2001 Jun 22;276(25):22258-64. Epub 2001 Apr 11.

23.

Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast.

Lyons TJ, Gasch AP, Gaither LA, Botstein D, Brown PO, Eide DJ.

Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7957-62.

24.

Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae.

MacDiarmid CW, Gaither LA, Eide D.

EMBO J. 2000 Jun 15;19(12):2845-55.

25.

Functional expression of the human hZIP2 zinc transporter.

Gaither LA, Eide DJ.

J Biol Chem. 2000 Feb 25;275(8):5560-4.

26.

Synaptic organization of the human striatum: a postmortem ultrastructural study.

Roberts RC, Gaither LA, Peretti FJ, Lapidus B, Chute DJ.

J Comp Neurol. 1996 Oct 28;374(4):523-34.

PMID:
8910733
27.

Ultrastructural correlates of haloperidol-induced oral dyskinesias in rat striatum.

Roberts RC, Gaither LA, Gao XM, Kashyap SM, Tamminga CA.

Synapse. 1995 Jul;20(3):234-43.

PMID:
7570355

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